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| 1 | Adverse events with bismuth salts for Helicobacter pylori eradication:Systematic review and meta-analysis显示文摘AIM: To assess the safety of bismuth used in Helico- bacter pylori (H pylori) eradication therapy regimens. METHODS: We conducted a systematic review and meta-analysis. MEDLINE and EMBASE were searched (up to October 2007) to identify randomised controlled tri- als comparing bismuth with placebo or no treatment, or bismuth salts in combination with antibiotics as part of eradication therapy with the same dose and duration of antibiotics alone or, in combination, with acid suppres- sion. Total numbers of adverse events were recorded. Data were pooled and expressed as relative risks with 95% confidence intervals (CI). RESULTS: We identified 35 randomised controlled tri- als containing 4763 patients. There were no serious adverse events occurring with bismuth therapy. There was no statistically significant difference detected in total adverse events with bismuth [relative risk (RR) = 1.01; 95% CI: 0.87-1.16], specific individual adverse events, with the exception of dark stools (RR = 5.06; 95% CI: 1.59-16.12), or adverse events leading to withdrawal of therapy (RR = 0.86; 95% CI: 0.54-1.37). CONCLUSION: Bismuth for the treatment of H pylori is safe and well-tolerated. The only adverse event oc- curring significantly more commonly was dark stools. | Alexander C Ford Peter Malfertheiner Monique Giguère José Santana Mostafizur Khan Paul Moayyedi | 2008 | World Journal of Gastroenterology2008，14，48： | 62 |
| 2 | Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery显示文摘AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes.METHODS This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy(RG), laparoscopic gastrectomy(LG), open gastrectomy(OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients(RG = 151; LG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery(P = 0.42) and stage of the disease(P = 0.16). Intraoperative blood loss was significantly lower in the LG(95.93 ± 119.22) and RG(117.91 ± 68.11) groups compared to the OG(127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG(27.78 ± 11.45), LG(24.58 ± 13.56) and OG(25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P < 0.0001). A similar complications rate was found(P = 0.13). The leakage rate was not different(P = 0.78) between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recovery. | Amilcare Parisi Daniel Reim Felice Borghi Ninh T Nguyen Feng Qi Andrea Coratti Fabio Cianchi Maurizio Cesari Francesca Bazzocchi Orhan Alimoglu Johan Gagnière Graziano Pernazza Simone D'Imporzano Yan-Bing Zhou Juan-Santiago Azagra Olivier Facy Steven T Brower Zhi-Wei Jiang Lu Zang Arda Isik Alessandro Gemini Stefano Trastulli Alexander Novotny Alessandra Marano Tong Liu Mario Annecchiarico Benedetta Badii Giacomo Arcuri Andrea Avanzolini Metin Leblebici Denis Pezet Shou-Gen Cao Martine Goergen Shu Zhang Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，13： | 17 |
| 3 | Fluorouracil-based adjuvant chemotherapy after preoperative chemoradiotherapy in rectal cancer: long-term results of the EORTC 22921 randomised study显示文摘 | Jean-Fran?ois Bosset Gilles Calais Laurent Mineur Philippe Maingon Suzana Stojanovic-Rundic René-Jean Bensadoun Etienne Bardet Alexander Beny Jean-Claude Ollier Michel Bolla Dominique Marchal Jean-Luc Van Laethem Vincent Klein Jordi Giralt Pierre Clavère | 2014 | Lancet Oncology2014，，2： | 2 |
| 4 | Dental extraction wound management:A case against medicating postexraction sockets显示文摘 | Alexander RE | 2000 | Oral Maxillofac Surg2000，58，5： | 1 |
| 5 | Dental extraction wound management:a case againstmedicating postextraction sockets显示文摘 | Alexander RE | 2000 | J Oral Maxillofa Surg2000，58，5： | 1 |
| 6 | Placental apoptosis in pre-clampsia 显示文摘 | Alexander D Allai re Kelly A | 2000 | Obstetrics & Gyn-ecology2000，96，2： | 1 |
| 7 | Caleineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with Cryptococcosis显示文摘 | KONTOYIANNIS DP LEWIS RE ALEXANDER BD | 2008 | Antimicrob Agents Chemother2008，52，2： | 1 |
| 8 | Antireflux Transoral Incisionless Fundoplication Using EsophyX: 12-Month Results of a Prospective Multicenter Study显示文摘 | Guy-Bernard Cadière Michel Buset Vinciane Muls Amin Rajan Thomas R?sch Alexander J. Eckardt Joseph Weerts Boris Bastens Guido Costamagna Michele Marchese Hubert Louis Fazia Mana Filip Sermon Anna K. Gawlicka Michael A. Daniel Jacques Devière | 2008 | World Journal of Surgery2008，，8： | 1 |
| 9 | Status quo of hybrid coronary revascularization for multi-vessel coronary artery disease显示文摘 | Harskamp RE Zheng Z Alexander JH | 2013 | Ann Thorac Surg2013，96，6： | 1 |
| 10 | A review of perioperative corticosteroid use in dentoalveolar surgery 显示文摘 | Alexander RE Throndson RR | 2000 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2000，90，4： | 1 |
| 11 | p16 expression is not associated with human papillomavirus in urinary bladder squamous cell carcinoma 显示文摘 | Alexander RE Hu Y Kum JB | 2012 | Mod Pathol2012，25，11： | 1 |
| 12 | Etiology,manifestations and therapy of acute epididymitis:Prospective study of 50 cases显示文摘 | Berger RE Alexander ER Harnisch JP | 1979 | J Urol1979，121，6： | 1 |
| 13 | Proteomic analysis of human cerebral endothelial cells activated by glutamate/MK --801: significance in ischemic stroke injury显示文摘 | Minagar A Alexander JS Kelley RE | 2009 | J Mol Neurosci2009，38，2： | 1 |
| 14 | Molecular pathology ol lung cancer: key to personalized medicine 显示文摘 | Cheng L Alexander RE Maclennan GT | 2012 | Mod Pathol2012，25，3： | 1 |
| 15 | Dentel extraction wound management:Acaseagainst medicating postxttaction socdetc 显示文摘 | Alexande RE | 2000 | Oral Maxillofacsurg2000，5，： | 1 |
| 16 | Placental apoptosis in pre-clampsia显示文摘 | Alexander D Allai RE Kelly A | | 0，，02： | 1 |
| 17 | FIGO stage ⅢC endometrial carcinoma: resection of macroscopic nodal disease and other determinants of survival 显示文摘 | Bristow RE Zahurak ML Alexander CJ | 2003 | Int J Gynecol Cancer2003，13，5： | 1 |
| 18 | Dental extraction wound management:a case against medi- cating postextraction sockets显示文摘 | Alexander RE | 2008 | Journal of Oral and Maxillofacial Surgery2008，43，4： | 1 |
| 19 | Dental extraction wound management:A case Against Medicating postextraction socket显示文摘 | | 2000 | J Oral Maxillofac Surg2000，58，5： | 1 |
| 20 | Dental extraction wound management: a case a gainst medicating postextraction sockets 显示文摘 | Alexander RE | 2000 | J Oral Maxillofac Surg2000，58，5： | 1 |
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