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| 1 | Interspinous posterior devices: What is the real surgical indication?显示文摘Interspinous posterior device(IPD) is a term used to identify a relatively recent group of implants used to treat lumbar spinal degenerative disease. This kind of device is classified as part of the group of the dynamic stabilization systems of the spine. The concept of dynamic stabilization has been replaced by that of dynamic neutralization of hypermobility, with the intention of clarifying that the primary aim of this kind of system is not the preservation of the movement, but the dynamic neutralization of the segmental hypermobility which is at the root of the pathological condition. The indications for the implantation of an IPD are spinal stenosis and neurogenic claudication, assuming that its function is the enlargement of the neural foramen and the decompression of the roots forming the cauda equina in the central part of the vertebral canal. In the last 10 years, use of these implants has been very common but to date, no long-term clinical follow-up regarding clinical and radiological aspects are available. The high rate of reoperation, recurrence of symptoms and progression of degenerative changes is evident in the literature. If these devices are effectively a miracle cure for lumbar spinal stenosis, why do the utilization and implantation of IPD remain extremely controversial and should they be investigated further? Excluding theproblems related to the high cost of the device, the main problem remains the pathological substrate on which the device is explicit in its action: the degenerative pathology of the spine. | Alessandro Landi | 2014 | World Journal of Clinical Cases2014，2，9： | 7 |
| 2 | Syringomyelia associated with cervical spondylosis: A rare condition显示文摘Spinal spondylosis is an extremely common condition that has only rarely been described as a cause of syringomyelia. We describe a case of syringomyelia associated with cervical spondylosis admitted at our division and treated by our institute. It is the case of a 66-yearold woman. At our observation she was affected by moderate-severe spastic tetraparesis. T2-weighted magnetic resonance imaging(MRI) showed an hyperintense signal within spinal cord from C3 to T1 with a more sharply defined process in the inferior cervical spinal cord. At the same level bulging discs, facets and ligamenta flava hypertrophy determined a compression towards subarachnoid space and spinal cord. Spinal cord compression was more evident in hyperextension rather than flexion. A 4-level laminectomy and subsequent posterior stabilization with intra-articular screws was executed. At 3-mo follow up there was a regression of tetraparesis but motor deficits of the lower limbs residuated. At the same follow up postoperative MRI was executed. It suggested enlargement of the syrinx. Perhaps hyperintensity within spinal cord appeared 'bounded' from C3 to C7 with clearer margins. At the level of surgical decompression, subarachnoid space and spinal cord enlargement were also evident. A review of the literature was executed using Pub Med database. The objective of the research was to find an etiopathological theory able to relate syringomyelia with cervical spondylosis. Only 6 articles have been found. At the origin of syringomyelia the mechanisms of compression and instability are proposed. Perhaps other studies assert the importance of subarachnoid space regard cerebrospinal fluid(CSF) dynamic. We postulate that cervical spine instability may be the cause of multiple microtrauma towards spinal cord and consequently may damage spinal cord parenchyma generating myelomalacia and consequently syrinx. Otherwise the hemorrhage within spinal cord central canal can cause an obstruction of CSF outflow, finally generating the syrinx. On the other hand in cervical spondylosis the stenotic elements can affect subarachnoid space. These elements rubbing towards spinal cord during movements of the neck can generate arachnoiditis, subarachnoid hemorrhages and arachnoid adhesions. Analyzing the literature these 'complications' of cervical spondylosis are described at the origin of syringomyelia. So surgical decompression, enlarging medullary canal prevents rubbings and contacts between the bone-ligament structures of the spine towards spinal cord and subarachnoid space therefore syringomyelia. Perhaps stabilization is also necessary to prevent instability of the cervical spine at the base of central cord syndrome or syringomyelia. Finally although patients affected by central cord syndrome are usually managed conservatively we advocate, also for them, surgical treatment in cases affected by advanced state of the symptoms and MRI. | Alessandro Landi Lorenzo Nigro Nicola Marotta Cristina Mancarella Pasquale Donnarumma Roberto Delfini | 2013 | World Journal of Clinical Cases2013，1，3： | 7 |
| 3 | Magnetic resonance diffusion tensor imaging and fibertracking diffusion tensor tractography in the management of spinal astrocytomas显示文摘Some specially imaging of magnetic resonance imaging,the diffusion-weighted imaging(DWI),the diffusion tensor imaging and fractional anisotropy(FA),are useful to described,detect,and map the extent of spinal cord lesions.FA measurements may are used to predicting the outcome of patients who have spinal cord lesions.Fiber tracking enable to visualizing the integrity of white matter tracts surrounding some lesions,and this information could be used to formulating a differential diagnosis and planning biopsies or resection.In this article,we will describe the current uses for DWI and fiber tracking and speculate on others in which we believe these techniques will be useful in the future. | Alessandro Landi Valeria Palmarini Alessandro D'Elia Nicola Marotta Maurizio Salvati Antonio Santoro Roberto Delfini | 2016 | World Journal of Clinical Cases2016，4，1： | 6 |
| 4 | Trans-sacral screw fixation in the treatment of high dyplastic developmental spondylolisthesis显示文摘We describe the case of a 67-year-old woman with L5-S1 ontogenetic spondylolisthesis treated with pedicle fixation associated with interbody arthrodesis performed with S1-L5 trans-sacral screwing according to the technique of Bartolozzi. The procedure was followed by a wide decompressive laminectomy. The patient had a progressive improvement of the symptoms which gradually disappeared in 12 mo. The radiograph at 6 and 12 mo showed complete fusion system. The choice of treatment in L5-S1 ontogenetic spondylolithesis is related to a correct clinical and diagnostic planning(X-ray, computer tomography magnetic resonance imaging, Measurement). In particular, the severity index and the square of unstable zone, and the standard measurements already described in the literature, are important to understand and to plane the correct surgical strategy, that require, in most of the times, fusion and interbody artrodesis. | Alessandro Landi Nicola Marotta Cristina Mancarella Roberto Tarantino Roberto Delfini | 2013 | World Journal of Clinical Cases2013，1，3： | 4 |
| 5 | 360° fusion for realignment of high grade cervical kyphosis by one step surgery: Case report显示文摘Surgical treatment for cervical kyphotic deformity is still controversial. Circumferential approach has been well described in the literature but long terms outcomes are not well reported. Important to decide the correct treatment option is the preoperative radiological exams to value the type of deformity(flexible or fixed). We report the case of a 67-year-old woman affected by a severe cervical kyphotic deformity who underwent combined anterior/posterior surgical approach, getting a good reduction of the deformity and an optimal stability in a long term follow up. | Alessandro Landi Nicola Marotta Cristina Mancarella Demo Eugenio Dugoni Roberto Tarantino Roberto Delfini | 2014 | World Journal of Clinical Cases2014，2，7： | 4 |
| 6 | First description of cervical intradural thymoma metastasis显示文摘Thymoma and thymic carcinoma are rare epithelial tumors, which originate from the thymus gland. According to the World Health Organization there are 'organotypic'(types A, AB, B1, B2, and B3) and 'non-organotypic'(thymic carcinomas) thymomas. Type B3 thymomas are aggressive tumors, which can metastasize. Due to the rarity of these lesions, only 7 cases of extradural metastasis are described in the literature. We report the first and unique case of a man with cervical intradural B3 thymoma metastasis. A 46-year-old man underwent thymoma surgical removal. The year after the procedure he was treated for a parietal pleura metastasis. In 2006 he underwent cervical-dorsal extradural metastasis removal and C5-Th1 stabilization. Seven years after he came to our observation complaining left cervicobrachialgia and a reduction of strength of the left arm. He underwent a cervical spine magnetic resonance imaging, which showed a new lesion at the C5-C7 level. The patient underwent a surgery for the intradural B3 thymoma metastasis. Neurological symptoms improved although the removal was subtotal. He went through postoperative radiation therapy with further mass reduction. Spinal metastases are extremely rare. To date, only 7 cases of spinal extradural metastasis have been described in the literature. This is the first case of spinal intradural metastasis. Early individuation of these tumors and surgical treatment improve neurological outcome in patients with spinal cord compression. A multimodal treatment including neoadjuvant chemotherapy, surgery and postoperative radiation therapy seems to improve survival in patients with metastatic thymoma. | Nicola Marotta Cristina Mancarella Davide Colistra Alessandro Landi Demo Eugenio Dugoni Roberto Delfini | 2015 | World Journal of Clinical Cases2015，3，11： | 3 |
| 7 | Triiodothyronine levels for risk stratification of patients with chronic heart failure显示文摘 | Alessandro Pingitore Patrizia Landi Maria Chiara Taddei Andrea Ripoli Antonio L’Abbate Giorgio Iervasi | 2005 | The American Journal of Medicine2005，，2： | 2 |
| 8 | Triiodothyronine levels for risk stratification of patients with chronic heart failure显示文摘 | Alessandro Pingitore Patrizia Landi Maria Chiara Taddei Andrea Ripoli Antonio L’Abbate Giorgio Iervasi | 2005 | The American Journal of Medicine2005，，2： | 1 |
| 9 | Guillain-Barre syndrome after exogenous gangliosides in Italy显示文摘 | Landi G Alessandro RD Dossi BC | | 0，，6917： | 1 |
| 10 | Low-T3 Syndrome: A Strong Prognostic Predictor of Death in Patients With Heart Disease显示文摘 | Giorgio Iervasi Alessandro Pingitore Patrizia Landi Mauro Raciti Andrea Ripoli Maria Scarlattini Antonio L’Abbate Luigi Donato | 2003 | Circulation: Journal of the American Heart Association2003，，5： | 1 |
| 11 | Guillain-Barre syndrome after exogenous gangliosides in Italy 显示文摘 | Landi GD Alessandro R Dossi BC | 1993 | BMJ1993，307，6917： | 1 |
| 12 | Atlantoaxial rotatory dislocation (AARD) in pediatric age: MRI study on conservative treatment with Philadelphia collar—experience of nine consecutive cases显示文摘 | Alessandro Landi Andrea Pietrantonio Nicola Marotta Cristina Mancarella Roberto Delfini | 2012 | European Spine Journal2012，，1： | 1 |
| 13 | Low-T3 Syndrome: A Strong Prognostic Predictor of Death in Patients With Heart Disease显示文摘 | Giorgio Iervasi Alessandro Pingitore Patrizia Landi Mauro Raciti Andrea Ripoli Maria Scarlattini Antonio L’Abbate Luigi Donato | 2003 | Circulation: Journal of the American Heart Association2003，，： | 1 |
| 14 | Guillain Barre syn- drome after exogenous gangliosides in Italy显示文摘 | Landi GD Alessandro R Dossi BC | 1993 | BMJ1993，307，6917： | 1 |
| 15 | Prognostic Value of Combined Measurement of Brain Natriuretic Peptide and Triiodothyronine in Heart Failure显示文摘 | Claudio Passino Alessandro Pingitore Patrizia Landi Marianna Fontana Luc Zyw Aldo Clerico Michele Emdin Giorgio Iervasi | 2009 | Journal of Cardiac Failure2009，，1： | 1 |
| 16 | Guillain-Barr6 syndrome after exogenous gangliosides in Italy 显示文摘 | Landi G D'Alessandro R Dossi BC | 1993 | BMJ1993，307，6917： | 1 |
| 17 | Low-T3 syndrome a strong prognostic predictor of death in patients with heart disease显示文摘 | Giorgio Iervasi Alessandro Pingitore Patrizia Landi | 2003 | Circulation2003，107，： | 1 |
| 18 | Therapeutic cerclage may be more efficacious in women who develop cervical insufficiency after a term delivery显示文摘 | Sarah H. Poggi Nisha Vyas John C. Pezzullo Helain J. Landy Alessandro Ghidini | 2009 | American Journal of Obstetrics and Gynecology2009，，1： | 1 |
| 19 | Solubilization methods and reference 2-DE map of cow milk fat globules显示文摘 | Laura Bianchi Michele Puglia Claudia Landi Silvia Matteoni Daniele Perini Alessandro Armini Margherita Verani Claudia Trombetta Patrizia Soldani Paola Roncada Gianfranco Greppi Vitaliano Pallini Luca Bini | 2008 | Journal of Proteomics2008，，5： | 1 |
| 20 | Guillain-Barr6 syndronme af- ter exogenous gangliosides in Italy显示文摘 | Landi G D' Alessandro R Dossi B C | 1993 | BM31993，307，6917： | 1 |
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