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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Improvement of Biohydrogen Production from Solid Wastes by Intermittent Venting and Gas Flushing of Batch Reactors Headspace显示文摘 | Idania V V Elvira R L Alessandro C M | 2006 | Environ Sci Technol2006，40，10： | 1 |
| 3 | Bronchopulmonary kctinomycosis Associated With Hiatal Hernia显示文摘 | Alessandro A Alberto C Alessandro M | 2009 | Mayo Clinic Proceedings2009，84，2： | 1 |
| 4 | A new modifier for silica in reinforcing SBR elastomers for the tyreindustry显示文摘 | Alessandro B Maila C Enrico M | 2011 | Macromolecular Materials and Engineering2011，296，： | 1 |
| 5 | A comparison of parathyroid hormone‐related protein (1‐36) and parathyroid hormone (1‐34) on markers of bone turnover and bone density in postmenopausal women: The PrOP study显示文摘 | Mara J Horwitz Marilyn Augustine Leila Kahn Emily Martin Christine C Oakley Raquel M Carneiro Mary Beth Tedesco Angela Laslavic Susan M Sereika Alessandro Bisello Adolfo Garcia‐Oca?a Caren M Gundberg Jane A Cauley Andrew F Stewart | 2013 | J Bone Miner Res2013，，11： | 1 |
| 6 | Inheritance of vernaliza- tion requirement in carrot显示文摘 | Alessandro M S Galmaririi C R | 2007 | Journal of the American So- ciety for Horticultural Science2007，132，4： | 1 |
| 7 | Molecu- lar mapping of vernalization requirement and fertility res- toration genes in carrot 显示文摘 | Alessandro M S Galmarini C R Iorizzo M | 2013 | Theoretical and Applied Ge- netics2013，126，： | 1 |
| 8 | Glove port technique for transanal endoseopic microsurgery显示文摘 | Alessandro C Daniela M Michele M | 2012 | Int J Surg Oncol2012，2012，38： | 1 |
| 9 | Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro显示文摘 | Tassone P Tagliaferri P Viscomi C Palmieri C Caraglia M D' Alessandro A | 2003 | Br J Cancer2003，88，： | 1 |
| 10 | Impmving Usage of Podiatric Information on the Internet:The Virtual Children's Hospital显示文摘 | D'Alessandro D M Kreiter C D | 1999 | PEDIATRICS1999，104，5： | 1 |
| 11 | Predominant-period site classification for response spectra Prediction equations in Italy显示文摘 | Alessandro C D Bonilla F L Boore D M | 2012 | Bulle- tin of the Seismological Society of America2012，102，2： | 1 |
| 12 | Signal transducers and activators of transcription 3 signaling pathway an essential mediator of inflammatory bowel disease and other forms of intestinal inflammation 显示文摘 | Alessandro M Patrizia D Alessandra C | 2005 | Inflamm Bowel Dis2005，11，2： | 1 |
| 13 | J/Ψ and Drell-Yan cross section in Pb-Pb interactions at 158 GeV/c per nucleon 显示文摘 | Abreu M C Alessandro B Alexa C | 1997 | Phys Lett1997，410，： | 1 |
| 14 | Complex event processing with T-REX显示文摘 | Gianpaolo C Alessandro M | 2012 | Journal of Systems and Software2012，85，8： | 1 |
| 15 | Nonenzy matically glycated albumin (Amadori adducts) enhances nitric oxide synthase activity and gene expression in endothelial cells 显示文摘 | Alessandro A Paola C Stefania M | 1997 | Kindey Int1997，51，： | 1 |
| 16 | )'-Glutamyltransferase activity in human atheroscle- rotic plaques-Biochemical similarities with the circu- lating enzyme显示文摘 | MARIA F ALESSANDRO C BARBARA M | 2009 | Atherosclerosis2009，202，： | 1 |
| 17 | Evidence for deconfinement of quarks and gluons from the J/ suppression pattern measured in Pb-Pb collisions at the CERN-SPS显示文摘 | ABREU M C ALESSANDRO B ALEXA C | 2000 | Phys Lett: B2000，477，： | 1 |
| 18 | Development an application of a complete multijet commomrail injection-system mathematical model for hydrodynamic analysis and diagnostics显示文摘 | Andrea E C Alessandro F Michele M | 2008 | Journal of Engineering for Gas Turbines and Power2008，130，6： | 1 |
| 19 | NCX-1000,a NO-releasing derivative of Ursodeoxycholic acid,selectively delivers NO to the liver and protects against development of portal hypertension显示文摘 | Stefano F Elisabetta A Olivia M Andrea M Alessandro C Tommaso M | 2001 | PANS2001，98，： | 1 |
| 20 | Experimental optimization of the impact energy absorption of epoxy-carbon laminates through controlled delamination显示文摘 | Alessandro P Ivan C Claudio M | | 0，，13： | 1 |
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