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| 1 | Speckle tracking echocardiography to assess regional ventricular function in patients with apical hypertrophic cardiomyopathy显示文摘AIM To explore regional systolic strain of midwall and endocardial segments using speckle tracking echocardiography in patients with apical hypertrophic cardiomyopathy(HCM).METHODS We prospectively assessed 20 patients(mean age 53 ± 16 years,range:18-81 years,10 were male),with apical HCM. We measured global longitudinal peak systolic strain(GLPSS) in the midwall and endocardium of the left ventricle. RESULTS The diastolic thickness of the 4 apical segments was 16.25 ± 2.75 mm. All patients had a normal global systolicfunction with a fractional shortening of 50% ± 8%. In spite of supernormal left ventricular(LV) systolic function,midwall GLPSS was decreased in all patients,more in the apical(-7.3% ±-8.8%) than in basal segments(-15.5% ±-6.93%),while endocardial GLPPS was significantly greater and reached normal values(apical:-22.8% ±-7.8%,basal:-17.9% ±-7.5%). CONCLUSION This study shows that two-dimensional strain was decreased mainly confined to the mesocardium,while endocardium myocardial deformation was preserved in HCM and allowed to identify subclinical LV dysfunction. This transmural heterogeneity in systolic strain had not been previously described in HCM and could be explained by the distribution of myofibrillar disarray in deep myocardial areas. The clinical application of this novel finding may help further understanding of the pathophysiology of HCM. | María Cristina Saccheri Tomás Francisco Cianciulli Luis Alberto Morita Ricardo JoséMéndez Martín Alejandro Beck Juan Enrique Guerra Alberto Cozzarin Luciana Jimena Puente Lorena Romina Balletti Jorge Alberto Lax | 2017 | World Journal of Cardiology2017，9，4： | 7 |
| 2 | Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study显示文摘 | Hedy L Kindler Tatsuya Ioka Dirk J Richel Jaafar Bennouna Richard Létourneau Takuji Okusaka Akihiro Funakoshi Junji Furuse Young Suk Park Shinichi Ohkawa Gregory M Springett Harpreet S Wasan Peter C Trask Paul Bycott Alejandro D Ricart Sinil Kim Eric Van | 2011 | Lancet Oncology2011，，3： | 4 |
| 3 | Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype显示文摘 | Anna Abulí Xavier Bessa Juan Ramón González Clara Ruiz–Ponte Alejandro Cáceres Jenifer Mu?oz Victoria Gonzalo Francesc Balaguer Ceres Fernández–Rozadilla Dolors González Luisa de Castro Juan Clofent Luís Bujanda Joaquín Cubiella Josep M a Re?é Juan Diego | 2010 | Gastroenterology2010，，3： | 2 |
| 4 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 5 | Marine pharmacology in 1999 : compounds with antibacterial, anticoagulant, anti fungal, anthelmintic, anti-inflammatory, antiplatelet, anti protozoal and antiviral activities affecting the cardiovascular, endocrine, immune and nervors systems, and other miscella- neous mechanisms of action 显示文摘 | Alejandro M Mayer S Hamann M T | 2002 | Cornp Biochem Physiol Part C2002，132，： | 1 |
| 6 | Full scale self-propulsion computations using discretized propeller for the kriso eontainer ship KCS 显示文摘 | ALEJANDRO M C PABLO M C FREDERICK S | 2011 | Computers & Fluids2011，51，： | 1 |
| 7 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs显示文摘 | Altschul S F Thomas L M Alejandro A S | 1997 | Nucleic Acids Res1997，25，17： | 1 |
| 8 | Regulation of nonsymbiotic and truncated hemoglobin genes of Lotus japonicus in plant organs and in response to nitric oxide and hormones 显示文摘 | Pilar B S Alejandro T M Martin C | 2011 | New Phytologist2011，189，： | 1 |
| 9 | Use of high-boiling point organicsolvents for pulping oil palm empty fruit bunches 显示文摘 | Alejandro R Luis S Ana M | 2008 | BioresourceTechnology2008，99，： | 1 |
| 10 | Clinical practice guideline: otitis media with effusion显示文摘 | Richard M Rosenfeld Larry Culpepper Karen J Doyle Kenneth M Grundfast Alejandro Hoberman Margaret A Kenna Allan S Lieberthal Martin Mahoney Richard A Wahl Charles R Woods Barbara Yawn | 2004 | Otolaryngology - Head and Neck Surgery2004，，5： | 1 |
| 11 | Performance evaluation of MAC transmission power control in wireless sensor networks 显示文摘 | Javier V A Esteban E L Alejandro M S | 2007 | Computer Networks2007，51，6： | 1 |
| 12 | Marine pharmacology in 2003-2004: Anti-tumour and cytotoxic compounds显示文摘 | Alejandro M S Mayer Kirk R Gustafsonb | 2006 | Eur J Cancer2006，42，： | 1 |
| 13 | Marine pharmacology in 2005-2006: Anti-tumour and cytotoxic compounds显示文摘 | Alejandro M S Mayer | 2008 | Eur J Cancer2008，44，： | 1 |
| 14 | The Occurrence of a Maillard-type Protein-Polysaccharide Reaction between β- Laetoglobulin and Chitosan 显示文摘 | Beatriz M Adolfo FR Alejandro S | 2007 | Food Chemistry2007，100，10： | 1 |
| 15 | Gapped BLAST and PSI-BLAST:a new generation of protein database search programs 显示文摘 | Stephen F Thomas L M Alejandro A S Jinghui Zhang Zheng Zhang Webb M David J L | 1997 | Nucleic Acids Res1997，25，17： | 1 |
| 16 | Acqui-sition of resistance to carbapenems in multidrug-resistant clinicalstrains of Acinetobacter baumannii:natural insertional inactivationof a gene encoding a member of a novel family ofβ-barrel outermembrane proteins显示文摘 | María A Mussi Adriana S Limansky Alejandro M Viale | 2005 | Antimicrobial Agents and Chemotherap2005，49，4： | 1 |
| 17 | Achievement of insulin independence via pancreatic islet transplantation using a remote isolation center: a first-year review显示文摘 | N.R Barshes T Lee S Goodpasture F.C Brunicardi R Alejandro C Ricordi G Soltes M Barth D Hamilton J.A Goss | 2004 | Transplantation Proceedings2004，，4： | 1 |
| 18 | Evaluation of the antiviral activity of natural sulfated polyhydroxysteroids and their synthetie derivatives and analogs显示文摘 | Maria J C Marta S M Alejandro J R | 1999 | Steroids1999，64，： | 1 |
| 19 | Marine pharmacology in 2007--8: Marine compotmds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antipmtozoal, antituberculosis, and antiviral activities; affecting the immune and nervous system, and other miscellaneous mechanisms of action显示文摘 | ALEJANDRO M S M ABIMAEL D R ROBERTO G S B | 2011 | Comparative Biochemistry and Physiology: Part C2011，153，2： | 1 |
| 20 | Effect of aerobic Gram-positive heterotrophic bacteria associated with Artemia franciscana cysts on the survival and development of its larvae 显示文摘 | Orozco-Medina César Maeda-Martínez Alejandro M López-Cortés Alejandro | 2002 | Aqua2002，213，： | 1 |
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