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| 1 | Human papillomavirus in esophageal squamous cell carcinoma in Colombia and Chile显示文摘AIM: To examine the presence of human papillomavirus (HPV) in esophageal squamous cell carcinoma (ESCC) specimens collected from Colombia and Chile located in the northern and southern ends of the continent, respectively. METHODS: We examined 47 and 26 formalin-fixed and paraffin-embedded ESCC specimens from Colombia and Chile, respectively. HPV was detected using GP5+/GP6+ primer pair for PCR, and confirmed by Southern blot analysis. Sequencing analysis of L1 region fragment was used to identify HPV genotype. In addition, P16INK4A protein immunostaining of all the specimens was conducted. RESULTS: HPV was detected in 21 ESCC specimens (29%). Sequencing analysis of L1 region fragment identified HPV-16 genome in 6 Colombian cases(13%) and in 5 Chilean cases (19%). HPV-18 was detected in 10 cases (21%) in Colombia but not in any Chilean case. Since Chilean ESCC cases had a higher prevalence of HPV-16 (without statistical significance), but a significantly lower prevalence of HPV-18 than in Colombian cases (P = 0.011) even though the two countries have similar ESCC incidence rates, the frequency of HPV-related ESCC may not be strongly affected by risk factors affecting the incidence of ESCC. HPV-16 genome was more frequently detected in p16 positive carcinomas, although the difference was not statistically significant. HPV-18 detection rate did not show any association with p16 expression. Well-differentiated tumors tended to have either HPV-16 or HPV-18 but the association was not statistically significant. HPV genotypes other than HPV-16 or 18 were not detected in either country. CONCLUSION: HPV-16 and HPV-18 genotypes can be found in ESCC specimens collected from two South American countries. Further studies on the relationship between HPV-16 presence and p16 expression in ESCC would aid understanding of the mechanism underlying the presence of HPV in ESCC. | Andres Castillo Francisco Aguayo Chihaya Koriyama Miyerlandi Torres Edwin Carrascal Alejandro Corvalan Juan P Roblero Cecilia Naquira Mariana Palma Claudia Backhouse Jorge Argandona Tetsuhiko Itoh Karem Shuyama Yoshito Eizuru Suminori Akiba | 2006 | World Journal of Gastroenterology2006，12，38： | 11 |
| 2 | Automatic generation and publication of web services for the access and integration of distributed data sources 显示文摘 | Luiz Gonzalez Escalante Alejandro Botello Castillo Leandro Balladares Ocana | 2005 | Computer Scinence2005，，6： | 1 |
| 3 | Real-time stabilization and tracking of a four-rotor min rotorcraft 显示文摘 | Pedro Castillo Alejandro Dzul | 2004 | IEEE Transactions on Con- trol Systems Technology2004，12，51： | 1 |
| 4 | BWR Fuel Reloads Design Using a Tabu Search Technique 显示文摘 | Castillo Alejandro Alonso Gustavo Morales Luis B | 2004 | Ann Nucl Energy2004，31，2： | 1 |
| 5 | Surrogates for validation of electron beam irradiation of foods 显示文摘 | Oscar Rodriguez Elena Castel-Perez M Nont Ekpanyaskun Rosana Moreira G Alejandro Castillo | 2006 | Food Microbiology2006，110，： | 1 |
| 6 | Real-time stabilization and tracking of a four-rotor mini rotorcraft 显示文摘 | Castillo Pedro Dzul Alejandro Lozano Rogelio | 2004 | Control Systems Technology2004，12，4： | 1 |
| 7 | Inexpensive and flexible nanographene-based electrodes for ubiquitous electrocardiogram monitoring显示文摘Flexible electronics is one of the fundamental technologies for the development of electronic skin,implant wearables,or ubiquitous biosensing.In this context,graphene-derived materials have attracted great interest due to their unique properties to fulfill the demands of these applications.Here we report a simple one-step method for the fabrication of electrophysical electrodes based on the photothermal production of porous nanographene structures on the surface of flexible polyimide substrates.This approach constitutes an inexpensive alternative to the commercial medical electrodes,leading to a lower and much more stable skin–electrode contact resistance and providing comparable signal transduction.This technology has been framed inside the IoT paradigm through the development of a denoising and signal classification clustering algorithm suitable for its implementation in wearable devices.The experiments have shown promising achievements regarding noise reduction,increasing the crest factor~3.7 dB,as well as for the over 90%heart rate-monitoring accuracy. | Francisco J.Romero Encarnacion Castillo Almudena Rivadeneyra Alejandro Toral-Lopez Markus Becherer Francisco G.Ruiz Noel Rodriguez Diego P.Morales | 2019 | npj Flexible Electronics2019，3，1： | 0 |
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