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| 1 | Apoptotic cell death and its relationship to gastric carcinogenesis显示文摘AIM: To investigate the apoptotic process of cells with in the intestinal metaplasia areas co-localizing with chronic gastritis and gastric carcinomas and to analyze the involvement of proteins regulating apoptosis in the process of intestinal metaplasia related gastric carcinogenesis. METHODS: Forty-two gastric carcinoma and seventeen chronic gastritis cases were included in this study. All cases were examined for the existence of intestinal metaplasia. Ten cases randomly selected from each group were processed for TUNEL assay. TUNEL positive cells within the intestinal metaplasia areas, co-localizing either to gastric carcinoma or chronic gastritis, were counted and converted to apoptotic indices. In addition, p53, bcl-2 and bax expression patterns within these tissues were analyzed on the basis of immunohistochemistry. RESULTS: Twenty-eight of the cases were intestinal and 14 of the cases were diffuse type adenocarcinomas. 64% (27/42) of the gastric carcinoma cases had intestinal metaplasia. Intestinal metaplasia co-localized more with intestinal type carcinomas compared with diffuse type carcinomas [75% (21/28) vs 42% (6/14), respectively; P ≤0.05]. The mean apoptotic index in tumor cells was 0.70±0.08. The mean apoptotic index in intestinal metaplasias co-localizing to tumors was significantly higher than that of intestinal metaplasias co-localizing to chronic gastritis (0.70±0.03 vs 0.09±0.01, respectively; P≤0.05). p53 positivity was not observed in areas of intestinal metaplasia adjacent to tumors or chronic gastritis. Intestinal metaplasia areas adjacent to tumors showed lower cytoplasmic bcl-2 positivity compared to intestinal metaplasia areas adjacent to chronic gastritis [55.5% (15/27) vs 70.5% (12/17), respectively]. On the other hand, intestinal metaplasia areas adjacent to tumors showed significantly higher cytoplasmic bax positivity compared to intestinal metaplasia areas adjacent to chronic gastritis [44.4% (12/27) vs 11.7% (2/17), respectively; P ≤0.05]. CONCLUSION: Existence of apoptotic cells on the basis of TUNEL positivity is shown in intestinal metaplasias co-localizing to both diffuse and intestinal type gastric cancers in this study. Our results also suggested bax expression dependent induction of apoptosis especially in intestinal metaplasia areas adjacent to tumors. These findings strongly support the involvement of apoptotic mechanisms in the process of gastric carcinogenesis especially in the transition from intestinal metaplasia to gastric cancer. It may be suggested that induction of apoptosis in intestinal metaplasia areas adjacent to tumors may involve different mechanisms than induction by chronic inflammation. | Ferda Bir Nese Calli-Demirkan A Cevik Tufan Metin Akbulut N Lale Satiroglu-Tufan | 2007 | World Journal of Gastroenterology2007，13，23： | 2 |
| 2 | Broadband all-order po- larization mode dispersion compensation using liquid-crystal modulator arrays显示文摘 | AKBULUT M WEINER A M MILLER P J | 2006 | Journal of Lightwave Technology2006，24，1： | 1 |
| 3 | Production and characterization of silicon carbide particulate reinforced aluminumcopper alloy matrix composites by direct squeeze casting method 显示文摘 | ONAT A AKBULUT H | 2007 | Journal of Alloys and Compounds2007，436，1： | 1 |
| 4 | Sprouty pro- teins inhibit receptor mediated activation of phosphatidylinositol specific phospholipase C显示文摘 | AKBULUT S REDDI A L AGGARWAL P | 2010 | Molecular Biology of the Cell2010，21，19： | 1 |
| 5 | Serum vascular endothelial growth factor levels in patients with non small cell lung cancer显示文摘 | DEMIRKAZIK A AKBULUT H ULGER A F | 2004 | Ann Saudi Med2004，24，6： | 1 |
| 6 | Improvement of electrochemical and structural proper-ties of LiMn2O4 spinel based electrode materials for Li-ion batteries显示文摘 | Guler M O Akbulut A Cetinkaya T | 2014 | International Journal of Hydrogen Energy2014，39，21： | 1 |
| 7 | Petrochemical wastewater treatment by means of clean electrochemical technologies 显示文摘 | Dimoglo A Akbulut H Y Cihan F | 2004 | Clean Techn Environ Policy2004，6，： | 1 |
| 8 | Giant renal oncocytoma:a case report and review of the literature显示文摘 | Akbulut S Senol A Cakabay B | | 0，，： | 1 |
| 9 | Performance characteristics and energy-exergy analysis of solar-assisted heat pump system显示文摘 | Dikici A Akbulut A | | 0，，11： | 1 |
| 10 | Changes in hepatic TNF-alpha levels,antioxi-dant status,and oxidation products after renal ischemia/reperfusion injury in mice显示文摘 | Serteser M Koken T Kahraman A Yilmaz K Akbulut G Dilek ON | 2002 | J Surg Res2002，107，2： | 1 |
| 11 | Linear physical programming:a new approach to multiple objective optimization 显示文摘 | Messac A Gupta S Akbulut B | 1996 | Transactions on Operational Research1996，8，10： | 1 |
| 12 | Serum vascular endothelial growth factor levels in patients with non small cell lung cancer显示文摘 | Demirkazik A Akbulut H Uiger AF | 2004 | Ann Saudi Med2004，24，6： | 1 |
| 13 | Can laparoscopic hernia repair alter function and volume of testis? Randomized clinic trial 显示文摘 | Akbulut G Serteser M Yiicel A | 2003 | Surg Laparosc Endosc Percutan Tech2003，6，13： | 1 |
| 14 | Linear physical programming: a new approach to multiple objective optimization显示文摘 | MESSAC A GUPTA S M AKBULUT B | 1996 | Transactions on Operational Research1996，8，10： | 1 |
| 15 | The effects of intra- operative amiodarone loading on the systemic inflammatory response syndrome induced by cardiopulmonary bypass 显示文摘 | Rahman A Akbulut H Bayar MK | 2009 | Anadolu Kardiyol Derg2009，9，4： | 1 |
| 16 | Energy and exergy analyses of thin layer drying of mulberry in a forced solar dryer 显示文摘 | AKBULUT A DURMUS A | 2015 | Energy2015，35，4： | 1 |
| 17 | An unusual cause of a- cute appendicitis: Appendiceal endometriosis 显示文摘 | EMRE A AKBULUT S YILMAZ M | 2013 | Int J Surg CaseRep2013，4，1： | 1 |
| 18 | Primary neuroend- crine carcinoma of the breast : a case report 显示文摘 | YAREN A KELTEN C AKBULUT M | 2007 | Tumori2007，93，5： | 1 |
| 19 | Immobilization of tyrosi- nase on modified diatom biosilica: Enzymatic removal of phenolic compounds from aqueous solution 显示文摘 | Bayramoglu G Akbulut A Arica M Y | 2013 | Journal of Hazardous Ma- terials2013，，244245： | 1 |
| 20 | Boundedness of the fractional maximal operator in local Morrey type spaces显示文摘 | Akbulut A Gulivev V Mustafavev R | | 0，，08： | 1 |
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