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| 1 | 血糖控制良好的2型糖尿病患者血清VEGF-A及其受体VEGFR1和VEGFR2含量检测(英文)显示文摘研究目的:探讨血糖控制良好的2型糖尿病患者血管内皮生长因子-A(VEGF-A)及其受体VEGFR1和VEGFR2含量及其临床意义。研究方法:本文以31例血糖得到良好控制且没有明显大血管或微血管病变的2型糖尿病患者作为研究对象(实验组),30位健康志愿者为对照组,同期检测患者及健康志愿者的空腹血糖、血脂、糖化血红蛋白水平,及血清VEGF-A、VEGFR1和VEGFR2含量,并加以比较和统计学分析。重要结论:研究结果表明,血糖控制良好的2型糖尿病患者血清中的VEGF-A及其受体VEGFR1和VEGFR2的含量和健康志愿者基本一致,两者无统计学意义,这可能显示血糖水平的合理控制能延缓血管并发症的产生。同时,2型糖尿病患者的血清VEGFR2含量和高密度脂蛋白胆固醇水平之间存在负相关,而血清VEGF-A、VEGFR2含量和甘油三脂水平之间存在正相关,这也表明糖尿病患者的血脂紊乱可能参与了血管生成的调节。 | Barbara RUSZKOWSKA-CIASTEK Alina SOKUP Maciej W. SOCHA Zofia RUPRECHT Lidia HALAS Barbara GóRALCZYK Krzysztof GóRALCZYK Grazyna GADOMSKA Danuta ROSC | 2014 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2014，15，6： | 2 |
| 2 | Parallel watershed transformation algorithms for image segmentation显示文摘 | Alina N M Bogdan C Moneef G | 1998 | Parallel Computing1998，24，： | 1 |
| 3 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 4 | 成人及儿童结节性淋巴细胞为主型霍奇金淋巴瘤的LP细胞中可表达EBV显示文摘结节性淋巴细胞为主型霍奇金淋巴瘤(NLPHL)与经典型霍奇金淋巴瘤(CHL)虽有相似之处,但其流行病学、临床、病理及预后特征不同,故被独立进行分类。二者鉴别:在25%~70%的CHL瘤细胞中可检测到EBV,而在大多数NL—PHL则不然。目前仅在亚洲及拉丁美洲的一些文献中报道了少数EBV^+ NLPHL病例,在北美地区尚无EBV^+ NLPHL发病率的大宗病例报道。 | Huppmann A R Alina N Slack G W 陈远钦(摘译) 余英豪(审校) | 2014 | 临床与实验病理学杂志2014，30，5： | 1 |
| 5 | A preliminary evaluation of VEGF-A, VEGFR1 and VEGFR2 in patients with well-controlled type 2 diabetes mellitus显示文摘 | Barbara Ruszkowska-Ciastek Alina Sokup Maciej W. Socha Zofia Ruprecht Lidia Ha?as Barbara Góralczyk Krzysztof Góralczyk Gra?yna Gadomska Danuta Ro?? | 2014 | Journal of Zhejiang University SCIENCE B2014，，6： | 1 |
| 6 | Short-term prog-nostic value of serum neuron specific enolase and S100B inacute stroke patients 显示文摘 | SERGIO G ALINA G OTMAN F | 2012 | Clin Biochem2012，45，7： | 1 |
| 7 | Electronic structure of hydrogenated carbon nanotubes stud- ied by core level spectroscopy显示文摘 | BrzhezinskayaMaria Shmatko Valentina Yalovega G Alina | 2014 | Journal of Electron Spectros- copy and Related Phenomena2014，196，： | 1 |
| 8 | Enzymatic hydrolysis of waste fats 显示文摘 | Tadeusz A Alina K Edwrd G | 2000 | Biotechnologia2000，，2： | 1 |
| 9 | Cellular recognition of tri-/di-palmitoylated peptides is independent from a domain encompassing the N-terminal seven leucine-rich repeat (LRR)/LRR-like motifs of TLR2显示文摘 | Guangxun M Alina G Mario V | 2003 | J Biol Chem2003，278，39： | 1 |
| 10 | Enzymatic hydrolysis of waste fats显示文摘 | Tadeusz A Alina K Edward G | 2000 | Biotechnologia2000，，2： | 1 |
| 11 | Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: Cross -sectional and interventional studies 显示文摘 | Alina G Jean LC Nikos Y | 2003 | The Journal of Clinical Endocrinology & Metabolism2003，88，10： | 1 |
| 12 | Phase diagram and dissolution studies of the fenofibrate-acetylsalicylic acid system显示文摘 | Agata G Alina W Bozena K | 2011 | J Therm Anal Calorim2011，104，： | 1 |
| 13 | Diurnal and ultradian dynamics of serum adiponectin in health men显示文摘 | Peng CK Jean L | 2003 | Clin Endocrinol Metab2003，88，66： | 1 |
| 14 | Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans:cross-sectional and interventional studies显示文摘 | ALINA G JEAN L C NIKOS Y | 2003 | J Clin Endocrinol Metab2003，88，10： | 1 |
| 15 | A flexible protruding microelectrode array for neural interfacing in bioelectronic medicine显示文摘Recording neural signals from delicate autonomic nerves is a challenging task that requires the development of a lowinvasive neural interface with highly selective,micrometer-sized electrodes.This paper reports on the development of a three-dimensional(3D)protruding thin-film microelectrode array(MEA),which is intended to be used for recording low-amplitude neural signals from pelvic nervous structures by penetrating the nerves transversely to reduce the distance to the axons.Cylindrical gold pillars(O 20 or 50μm,~60μm height)were fabricated on a micromachined polyimide substrate in an electroplating process.Their sidewalls were insulated with parylene C,and their tips were optionally modified by wet etching and/or the application of a titanium nitride(TiN)coating.The microelectrodes modified by these combined techniques exhibited low impedances(~7 kΩ at 1 kHz for ∅ 50μm microelectrode with the exposed surface area of~5000μm^(2))and low intrinsic noise levels.Their functionalities were evaluated in an ex vivo pilot study with mouse retinae,in which spontaneous neuronal spikes were recorded with amplitudes of up to 66μV.This novel process strategy for fabricating flexible,3D neural interfaces with low-impedance microelectrodes has the potential to selectively record neural signals from not only delicate structures such as retinal cells but also autonomic nerves with improved signal quality to study neural circuits and develop stimulation strategies in bioelectronic medicine,e.g.,for the control of vital digestive functions. | Helen Steins Michael Mierzejewski Lisa Brauns Angelika Stumpf Alina Kohler Gerhard Heusel Andrea Corna Thoralf Herrmann Peter D.Jones Günther Zeck Rene von Metzen Thomas Stieglitz | 2022 | Microsystems & Nanoengineering2022，8，6： | 0 |
| 16 | COVID-19 impact on the liver显示文摘The coronavirus disease 2019(COVID-19)pandemic imposed arestructuring of global health systems by rethinking spaces used for the care of these patients and the additions of intensive care,infectious diseases and pneumology departments.This paper provides evidence on the presence of severe acute respiratory syndrome coronavirus 2 in hepatocytes and its direct cytopathic activity,as well as the degree of liver damage due to drug toxicity,inflammation and hypoxia in COVID-19.A review of clinical trials has quantified liver damage through both pathology and biochemistry studies.Additionally,we briefly present the results of a study conducted in our clinic on 849 patients admitted for COVID-19 treatment,of which 31 patients had pre-existing chronic liver disease and 388 patients had values above the normal limit for alanine aminotransferase,aspartate aminotransferase,and total bilirubin.It was observed that patients with abnormal liver tests were significantly statistically older,had more comorbidities and had a higher percentage of unfavourable evolution(death or transfer to intensive care).The conclusion of this paper is that the main causes of liver damage are direct viral aggression,coagulation dysfunction and endothelial damage,and patients with impaired liver function develop more severe forms of COVID-19 which requires special care by a multidisciplinary team that includes a hepatologist. | Liliana Baroiu Caterina Dumitru Alina Iancu Ana-Cristina Leșe Miruna Drăgănescu Nicușor Baroiu Lucreția Anghel | 2021 | World Journal of Clinical Cases2021，9，16： | 0 |
| 17 | Assessment of ghrelin and leptin receptor levels in postmenopausal women who received oral or transdermal menopausal hormonal therapy显示文摘Objective:In postmenopausal women,an increased leptin concentration and reduced levels of ghrelin and adiponectin were observed.The aim of this study was to evaluate the concentrations of the active form of ghrelin,total ghrelin,leptin receptor,lipoprotein(a)(Lp(a)),and plasminogen activator inhibitor type 1(PAI-1) in postmenopausal women who received oral or transdermal menopausal hormonal therapy(MHT).Methods:The study involved 76 healthy women:46 women aged from 44 to 58 years who received oral(26) or transdermal(20) MHT;the control group consisted of 30 women aged from 44 to 54 years who did not receive MHT.The plasma concentrations of total ghrelin,the active form of ghrelin,Lp(a),and PAI-1:Ag were measured by enzyme-linked immunosorbent assay(ELISA).The concentration of the leptin receptor was measured by enzyme immunometric assay(EIA).Results:We observed a significantly higher concentration of total ghrelin and the active form of ghrelin in women who received transdermal MHT in comparison with those who took oral MHT.We also found a significantly lower concentration of total ghrelin in women who received oral MHT compared with the control group.A higher concentration of PAI-1:Ag was found in the group of women who took transdermal MHT in comparison with those who took oral MHT and with the control group.The differences were statistically significant.Additionally,we found a significant negative correlation between the concentrations of total ghrelin and PAI-1:Ag and a positive correlation between the concentrations of total ghrelin and leptin receptor in women who received transdermal MHT.Conclusions:The study showed that women who used transdermal MHT had higher levels of total ghrelin than women who took oral MHT.This indicates a beneficial effect of the transdermal route of MHT.However,transdermal therapy was associated with adverse effects with regard to the observed higher levels of PAI-1:Ag,which in turn,can lead to a reduction in fibrinolytic activity. | Barbara RUSZKOWSKA Alina SOKUP Arleta KULWAS Maciej W.SOCHA Krzysztof GóRALCZYK Barbara GóRALCZYK Danuta ROS | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，1： | 0 |
| 18 | 未受控制的高血糖对2型糖尿病患者粘附分子的影响(英文)显示文摘目的:评估可溶性血管细胞间黏附分子(s VCAM-1)、可溶性细胞间黏附分子(s ICAM-1)、可溶性选择素E和可溶性血栓调节蛋白在血糖控制良好和不受控制的2型糖尿病患者中的水平。创新点:对2型糖尿病患者的血管内皮炎症标记物进行评估。方法:62例糖尿病患者分成两组:第一组包括35个血糖控制良好的糖尿病患者,第二组包括27个未控制血糖并伴有微蛋白尿的糖尿病患者。对照组由25名健康志愿者组成。测定血浆中s VCAM-1、s ICAM-1、可溶性选择素E和可溶性血栓调节蛋白的浓度,同时测定血清肌酐及血浆中空腹血糖和糖化血红蛋白(Hb A1c)的浓度。结论:与血糖控制良好的糖尿病组相比,未控制血糖组具有相对低的ICAM-1水平和更高的VCAM-1水平。未控制血糖组中患者的糖化血红蛋白和ICAM-1之间呈正相关,肾小球滤过率和可溶性选择素E之间呈正相关,而肌酐和ICAM-1之间呈负相关。研究证实2型糖尿病的发病机理中炎症过程的出现与血管内皮功能受损有关。未受控制的高血糖对粘附分子的反向作用表明,在糖尿病的并发症中VCAM-1和ICAM-1具有不同功能。 | Barbara RUSZKOWSKA-CIASTEK Alina SOKUP Tomasz WERNIK Zofia RUPRECHT Barbara GóRALCZYK Krzysztof GóRALCZYK Grazyna GADOMSKA Danuta RO | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，5： | 0 |
| 19 | 深圳能源大厦显示文摘深圳能源公司办公楼项目总建筑面积为96000m^2,旨在让人在深圳的文化、政治和商业中心感到亲切的同时,在城市主轴线上建造一座可持续的新公共地标。本项目的体量和高度由中心区城市总体规划决定。主体建筑由两座塔楼组成,北楼高220m,南楼高120m,两座塔楼与邻近建筑的塔楼一起在深圳的中心形成一个连续的弧形天际线。 | Bjarke Ingels Andreas Klok Pedersen Martin Voelkle He Song Andre Schmidt Alessio Zenaro Alina Tamosiunaite Alysen Hiller Ana Merino Andreas Geisler Johansen Annette Jensen Armor Rivas Balaj IIulian Brian Yang Baptiste Blot Buster Christiansen Cecilia Ho Christian Alvarez Christin Svensson Claudia Hertrich Claudio Moretti Cory Mattheis Dave Brown Dennis Rasmussen Doug Stechschulte Eskild Nordbud Felicia Guldberg Fred Zhou Gaetan Brunet Gül Ertekin Henrik Kania Iris Van der Heide James Schrader Jan Magasanik Jan Borgstr?m Jeppe Ecklon Jelena Vucic Jo?o Albuquerque Jonas M?nster Karsten Hansen Malte Kloe Mikkel Marcker Stubgaard Michael Andersen Michal Kristof Min Ter Lim Oana Simionescu Nicklas A. Rasch Philip Sima Rasmus Pedersen Rune Hansen Rui Huang Sofia Gaspar Stanley Lung Sun Ming Lee Takuya Hosokai Todd Bennett Xi Chen Xing Xiong Xiao Lu Xu Li Yijie Dan Zoltan Kalaszi | 2019 | 建筑实践2019，2，6： | 0 |
| 20 | 丹麦国家海事博物馆显示文摘丹麦海事博物馆位于独特的历史和空间环境中:在丹麦最重要和最著名的建筑之一克伦堡城堡和文化庭院——一个新的、雄心勃勃的文化中心之间。BIG建议将博物馆放在地下,就在船坞的墙壁外侧,以便将船坞保留为开放的户外展示空间,保存其强有力的结构作为海事博物馆中心。将博物馆这样设置,使它在成为与克伦堡城堡和邻近的文化庭院相联系的文化环境的一部分的同时,彰显自身. | John Pries Jensen Henrik Kania Ariel Joy Norback Wallner Rasmus Pedersen Annette Jensen Dennis Rasmussen Jan Magasanik Jeppe Ecklon Karsten Hammer Hansen Rasmus Rodam Rune Hansen Alina Tamosiunaite Alysen Hiller Ana Merino Armen Menendian Andy Yu Andreas Johansen Baptiste Blot Christian Alvarez Christin Svensson Claudia Hertrich Claudio Moretti Cory Mattheis Eskild Nordbud Felicia Guldberg Finn N■rkj■r Gül Ertekin Jan Borgstr■m James Schrader Johan Cool Jonas M■nster Kirstine Ragnhild Malte Kloe Michael Andersen Michal Kristof Marc Jay Maria Mavriku Masatoshi Oka Oana Simionescu Pablo Labra Peter Rieff Qianyi Lim Sara Sosio Sebastian Latz Tina Lund H■jgaard Tina Troster Todd Bennet Xi Chen Xing Xiong Xu Li Zoltan Kalaszi Iwan Baan Rasmus Hjortshoj Luca Santiago Mora Dragoer Luftfoto Jens Lindhe Lorenzon Boddi Thiks Wolzak 陈子钰(译) | 2019 | 城市环境设计2019，0，2： | 0 |
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