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| 1 | 血糖控制良好的2型糖尿病患者血清VEGF-A及其受体VEGFR1和VEGFR2含量检测(英文)显示文摘研究目的:探讨血糖控制良好的2型糖尿病患者血管内皮生长因子-A(VEGF-A)及其受体VEGFR1和VEGFR2含量及其临床意义。研究方法:本文以31例血糖得到良好控制且没有明显大血管或微血管病变的2型糖尿病患者作为研究对象(实验组),30位健康志愿者为对照组,同期检测患者及健康志愿者的空腹血糖、血脂、糖化血红蛋白水平,及血清VEGF-A、VEGFR1和VEGFR2含量,并加以比较和统计学分析。重要结论:研究结果表明,血糖控制良好的2型糖尿病患者血清中的VEGF-A及其受体VEGFR1和VEGFR2的含量和健康志愿者基本一致,两者无统计学意义,这可能显示血糖水平的合理控制能延缓血管并发症的产生。同时,2型糖尿病患者的血清VEGFR2含量和高密度脂蛋白胆固醇水平之间存在负相关,而血清VEGF-A、VEGFR2含量和甘油三脂水平之间存在正相关,这也表明糖尿病患者的血脂紊乱可能参与了血管生成的调节。 | Barbara RUSZKOWSKA-CIASTEK Alina SOKUP Maciej W. SOCHA Zofia RUPRECHT Lidia HALAS Barbara GóRALCZYK Krzysztof GóRALCZYK Grazyna GADOMSKA Danuta ROSC | 2014 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2014，15，6： | 2 |
| 2 | Gestational diabetes mellitusan important clinical syndrome with unclear and interesting etiopathogenesis显示文摘 | Sokup A Swiatkowski M | 1999 | Przegl Lek1999，56，5： | 1 |
| 3 | Gestational diabetes mellitus worsens the profile of cardiometabolic risk markers and decrease indexes of beta-cell function independently of insulin resistance in nondiabetic women with a parental history of type 2 diabetes显示文摘 | Sokup A Ruszkowska-Ciastek B Walentowicz-Sadlecka M | 2014 | J Diabetes Res2014，2014，74： | 1 |
| 4 | Triglycerides as an early pathophysiological marker of endothelial dysfunction in nondiabetic women with a previous history of gestational diabetes 显示文摘 | Sokup A G6ralczyk B G6ralczyk K | 2012 | Acta Obstet Gynecol Scand2012，91，2： | 1 |
| 5 | Adhesion molecules in type 2 diabetes 显示文摘 | Sokup A | 2005 | Przegl Lek2005，62，4： | 1 |
| 6 | A preliminary evaluation of VEGF-A, VEGFR1 and VEGFR2 in patients with well-controlled type 2 diabetes mellitus显示文摘 | Barbara Ruszkowska-Ciastek Alina Sokup Maciej W. Socha Zofia Ruprecht Lidia Ha?as Barbara Góralczyk Krzysztof Góralczyk Gra?yna Gadomska Danuta Ro?? | 2014 | Journal of Zhejiang University SCIENCE B2014，，6： | 1 |
| 7 | A preliminary evaluation of VEGF - A, VEGFR1 and VEGFR2 in patients with well -controlled type 2 diabetes mellitus显示文摘 | Rnszkowska - Ciastek B Sokup A Socha MW | 2014 | J Zhejiang Univ Sci B2014，15，6： | 1 |
| 8 | Insulin resistance as estimated by the homeostatic method at diagnosis of gestational diabetes:estimation crf disease severity and therapeutic needs in a population-based study显示文摘 | SOKUP A RUSZKOWSKA-CIASTEK B GORALCZYK K | 2013 | BMC Endocr Disord2013，13，12： | 1 |
| 9 | Heterogeneity of cardiovascular risk tactors profile in non-diabetic women 2-24 months postgestational diabetes mellitns 显示文摘 | Sokup A Ruszkowska-Ciastek B Walentowicz-Sad Ecka M | 2014 | Gynecol Endocrinol2014，30，5： | 1 |
| 10 | A preliminary e- valuation of VEGF- A,VEGFR1 and VEGFR2 in patients with well - controlled type 2 diabetes mellitus 显示文摘 | Ruszkowska - Ciastek B Sokup A Socha MW | 2014 | J Zhejiang Univ Sci B2014，15，6： | 1 |
| 11 | Insulin resistance as estimated by the homeostatic method at diagnosis of gestational diabetes:estimation of disease severity and therapeutic needs in a population-based study显示文摘 | Sokup A Ruszkowska-Ciastek B Góralczyk K | 2013 | BMC Endocr Disord2013，13，1： | 1 |
| 12 | Triglycerides as an early pathophysiological marker of endothelial dysfunction in nondiabetic women with a previous history of gestational diabetes显示文摘 | Sokup A Goralczyk B Goralczyk K | 2012 | Acta Obstet Gynecol Scand2012，91，2： | 1 |
| 13 | Assessment of ghrelin and leptin receptor levels in postmenopausal women who received oral or transdermal menopausal hormonal therapy显示文摘Objective:In postmenopausal women,an increased leptin concentration and reduced levels of ghrelin and adiponectin were observed.The aim of this study was to evaluate the concentrations of the active form of ghrelin,total ghrelin,leptin receptor,lipoprotein(a)(Lp(a)),and plasminogen activator inhibitor type 1(PAI-1) in postmenopausal women who received oral or transdermal menopausal hormonal therapy(MHT).Methods:The study involved 76 healthy women:46 women aged from 44 to 58 years who received oral(26) or transdermal(20) MHT;the control group consisted of 30 women aged from 44 to 54 years who did not receive MHT.The plasma concentrations of total ghrelin,the active form of ghrelin,Lp(a),and PAI-1:Ag were measured by enzyme-linked immunosorbent assay(ELISA).The concentration of the leptin receptor was measured by enzyme immunometric assay(EIA).Results:We observed a significantly higher concentration of total ghrelin and the active form of ghrelin in women who received transdermal MHT in comparison with those who took oral MHT.We also found a significantly lower concentration of total ghrelin in women who received oral MHT compared with the control group.A higher concentration of PAI-1:Ag was found in the group of women who took transdermal MHT in comparison with those who took oral MHT and with the control group.The differences were statistically significant.Additionally,we found a significant negative correlation between the concentrations of total ghrelin and PAI-1:Ag and a positive correlation between the concentrations of total ghrelin and leptin receptor in women who received transdermal MHT.Conclusions:The study showed that women who used transdermal MHT had higher levels of total ghrelin than women who took oral MHT.This indicates a beneficial effect of the transdermal route of MHT.However,transdermal therapy was associated with adverse effects with regard to the observed higher levels of PAI-1:Ag,which in turn,can lead to a reduction in fibrinolytic activity. | Barbara RUSZKOWSKA Alina SOKUP Arleta KULWAS Maciej W.SOCHA Krzysztof GóRALCZYK Barbara GóRALCZYK Danuta ROS | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，1： | 0 |
| 14 | 2型糖尿病患者高凝血状态的研究显示文摘目的:评估糖尿病病人的止血参数和血管内皮生长因子的浓度。方法:62例糖尿病患者分成两组:第一组包括35个血糖控制良好的糖尿病患者,第二组包括27个未控制血糖并伴有微蛋白尿的糖尿病患者。对照组由25名健康志愿者组成。测定血浆中组织因子(TF)、组织因子途径抑制剂(TFPI)、凝血酶抗凝血酶复合物(TAT)和D-二聚体的浓度。同时测定血清中内皮生长因子A(VEGF-A)、血脂、肌酐和血浆空腹血糖及糖化血红蛋白(HbA1c)的浓度。结论:研究表明,未控制血糖并伴有微蛋白尿的糖尿病患者具有更高的浓度的TF和TFPI,这与凝血酶形成的快速中和有关。TAT复合物和D-二聚体的正确形成,能保证患者具有一个相对较低级凝血风险,但同时会带来更高的血管并发症的风险。 | Barbara RUSZKOWSKA-CIASTEK Alina SOKUP Tomasz WERNIK Piotr RHONE Krzysztof GORALCZYK Kornel BIELAWSKI Agata FIJALKOWSKA Aleksandra NOWAKOWSKA Elzbieta RHONE Danuta ROSC | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，9： | 0 |
| 15 | 未受控制的高血糖对2型糖尿病患者粘附分子的影响(英文)显示文摘目的:评估可溶性血管细胞间黏附分子(s VCAM-1)、可溶性细胞间黏附分子(s ICAM-1)、可溶性选择素E和可溶性血栓调节蛋白在血糖控制良好和不受控制的2型糖尿病患者中的水平。创新点:对2型糖尿病患者的血管内皮炎症标记物进行评估。方法:62例糖尿病患者分成两组:第一组包括35个血糖控制良好的糖尿病患者,第二组包括27个未控制血糖并伴有微蛋白尿的糖尿病患者。对照组由25名健康志愿者组成。测定血浆中s VCAM-1、s ICAM-1、可溶性选择素E和可溶性血栓调节蛋白的浓度,同时测定血清肌酐及血浆中空腹血糖和糖化血红蛋白(Hb A1c)的浓度。结论:与血糖控制良好的糖尿病组相比,未控制血糖组具有相对低的ICAM-1水平和更高的VCAM-1水平。未控制血糖组中患者的糖化血红蛋白和ICAM-1之间呈正相关,肾小球滤过率和可溶性选择素E之间呈正相关,而肌酐和ICAM-1之间呈负相关。研究证实2型糖尿病的发病机理中炎症过程的出现与血管内皮功能受损有关。未受控制的高血糖对粘附分子的反向作用表明,在糖尿病的并发症中VCAM-1和ICAM-1具有不同功能。 | Barbara RUSZKOWSKA-CIASTEK Alina SOKUP Tomasz WERNIK Zofia RUPRECHT Barbara GóRALCZYK Krzysztof GóRALCZYK Grazyna GADOMSKA Danuta RO | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，5： | 0 |
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