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| 1 | TAT-Gap19通过抑制啮齿动物星形胶质细胞的连接蛋白43半通道发挥抗惊厥作用显示文摘越来越多的证据表明,星形胶质细胞连接蛋白43(Cx43)信号在癫痫中发挥至关重要的作用。但是,由于通过实验方法鉴别Cx43间隙连接通道(GJCs)和半通道(HCs)的技术尚不成熟,导致目前尚无法确定哪个通道在癫痫的发生中发挥更重要的作用。因此,本研究观察TAT-Gap19(Cx模拟肽)是否通过抑制Cx43半通道而非Cx43间隙连接通道影响实验诱导的啮齿动物癫痫发作。急性海马切片小鼠染料摄取实验表明,星形胶质Cx43半通道响应化学惊厥毛果芸香碱的作用而开放,并且可被TAT-Gap19抑制。体内实验中,毛果芸香碱诱导的癫痫发作及相伴随的D-丝氨酸微透析液的增长水平被Cx43半通道的抑制所抑制。此外,TAT-Gap19的抗惊厥作用被外源性D-丝氨酸给药逆转,这表明,抑制Cx43半通道可以通过降低细胞外D-丝氨酸水平来防止癫痫发作。抑制Cx43半通道的抗惊厥特性在电癫痫小鼠模型(如急性6 Hz难治性癫痫发作模型和慢性6 Hz角膜点燃模型)中得到了进一步的证实。总而言之,这些结果表明,Cx43半通道在癫痫发作中可以起到一定作用,并且有成为癫痫治疗中新型用药靶点的潜力。 | Walrave L Pierre A Albertini G Aourz N De Bundel D Van Eeckhaut A Vinken M Giaume C Leybaert L Smolders I 聂昊 | 2018 | 神经损伤与功能重建2018，13，6： | 5 |
| 2 | Computational comparison of the bending behavior of aortic stent-grafts显示文摘 | Nicolas Demanget Stéphane Avril Pierre Badel Laurent Orgéas Christian Geindreau Jean-No?l Albertini Jean-Pierre Favre | 2011 | Journal of the Mechanical Behavior of Biomedical Materials2011，，1： | 1 |
| 3 | Distinct cerebrospinal fluid amyloid-beta peptide signatures in cognitive decline associated with Alzheimer's disease and schizophrenia显示文摘 | ALBERTINI V BENUSSI L PATERLINI A | 2012 | Electrophoresis2012，33，24： | 1 |
| 4 | Static magnetic fields affect cell size, shape, orientation, and membrane surface of human glioblastoma cells, as demonstrated by electron, optic, and atomic force microscopy 显示文摘 | Teodori L Albertini M C Uguccioni F | 2006 | Cytometry A2006，69，2： | 1 |
| 5 | Commensurate and incommensurate '5M' modulated crystal structures in Ni- Mn-Gamartensitie phases 显示文摘 | RIGHI L ALBERTINI F PARETI L | 2007 | Acta Mater2007，55，15： | 1 |
| 6 | Hprt mutant frequency and p53 gene status in mice chronically exposed by inhalation to benzene显示文摘 | ALBERTINI R J JUDICE S A RECIO L | 2010 | Chem Biol Interact2010，184，12： | 1 |
| 7 | Changes in organic acids and sugars during early stages of development of acidic and acidless citrus fruit显示文摘 | Albertini MV Carcouet E Pailly O Gambotti C Luro F Berti L | 2006 | J Agric Food Chem2006，54，21： | 1 |
| 8 | Neuromelanin can protect a-gainst iron-mediated oxidative damage in system modeling iron over-load of brain aging and Parkinson’s disease显示文摘 | Zecca L Casella L Albertini A | 2008 | J Neurochem2008，106，： | 1 |
| 9 | Evolution of quality of life,mental health,and coping strategies in amyotrophic lateral sclerosis:a pilot study显示文摘 | Montel S Albertini L Desnuelle C | 2012 | J Palliat Med2012，15，11： | 1 |
| 10 | Melatonin reduces endo- plasmic reticulum stress and preserves sirtuin 1 expression in neuro- nal cells of newborn rats after hypoxia-ischemia 显示文摘 | Carloni S Albertini MC Galluzzi L | 2014 | J Pineal Res2014，57，2： | 1 |
| 11 | Preparation and characterisation of ibuprofen-poloxamer 188 granules obtained by melt granulation显示文摘 | Passerini N Albertini B Marisa L | 2002 | Eur J Pharm Sci2002，15，2： | 1 |
| 12 | Radiation quality af- fects the efficiency of induction and the molecular spectrum of I-IPRT mutations in human T cells显示文摘 | Albertini R J Clark L S Nicklas J A | 1997 | Radiat Res1997，148，5： | 1 |
| 13 | A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease显示文摘 | Zecca L Zucca FA Albertini A | 2006 | Neurology2006，67，72： | 1 |
| 14 | Melatonin reduces en- doplasmic reticulum stress and preserves sirtuin 1 expression in neuronal cells of newborn rats after hypoxia-ischemia显示文摘 | Carloni S Albertini M C Galluzzi L et aI | 2014 | J Pineal Res2014，57，2： | 1 |
| 15 | Composition and Tem- perature Dependence of the Magnetoerystalline Anisotropy in Ni2+xMn1+yGat+z(x+y+z=0) Heusler Alloys显示文摘 | Albertini F Pareti L Paoluzi A | | 0，，21： | 1 |
| 16 | 查看详情显示文摘 | Albertini A V P Cadena P G Silva J L | | 0，，： | 1 |
| 17 | Static magnetic fields af-fect cell size,shape,orientation,and membrane surface of human glio-blastoma cells,as demonstrated by electron,optic,and atomic fort:emicroscopy显示文摘 | Teodori L Albertini MC Uguccioni F | 2006 | Cytometry A2006，69，2： | 1 |
| 18 | Commensurate and Incom- mensurate '5M' Modulated Crystal Structures in Ni-Mn-Ga Mar- tensitic Phases显示文摘 | Righi L Albertini F Pareti L | | 0，，15： | 1 |
| 19 | Distinct cerebrospinal fluid amyloid-beta peptide signatures in cognitive decline associated with Alzheimer' s disease and schizophrenia 显示文摘 | Albertini V Benussi L Paterlini A | 2012 | Electrophoresis2012，33，24： | 1 |
| 20 | A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease显示文摘 | Zecca L Zucca FA Albertini A | 2006 | Neurology2006，67，72： | 1 |
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