|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A hypothesis for treating inflammation and oxidative stress with hydrogen sulfide during age-related macular degeneration显示文摘Age-related macular degeneration(AMD) is a leading cause of blindness and is becoming a global crisis since affected people will increase to 288 million by 2040.Genetics,age,diabetes,gender,obesity,hypertension,race,hyperopia,iris-color,smoking,sun-light and pyroptosis have varying roles in AMD,but oxidative stress-induced inflammation remains a significant driver of pathobiology.Eye is a unique organ as it contains a remarkable oxygengradient that generates reactive oxygen species(ROS) which upregulates inflammatory pathways.ROS becomes a source of functional and morphological impairments in retinal pigment epithelium(RPE),endothelial cells and retinal ganglion cells.Reports demonstrated that hydrogen sulfide(H_2S) acts as a signaling molecule and that it may treat ailments.Therefore,we propose a novel hypothesis that H_2S may restore homeostasis in the eyes thereby reducing damage caused by oxidative injury and inflammation.Since H_2S has been shown to be a powerful antioxidant because of its free-radicals' inhibition properties in addition to its beneficial effects in age-relatedconditions,therefore,patients may benefit from H_2S salubrious effects not only by minimizing their oxidant and inflammatory injuries to retina but also by lowering retinal glutamate excitotoxicity. | Akash K George Mahavir Singh Rubens Petit Homme Avisek Majumder Harpal S SANDhu Suresh C Tyagi | 2018 | International Journal of Ophthalmology(English edition)2018，11，5： | 3 |
| 2 | Chemical composition, antioxidant activity and GC-MS analysis of juice and peel oil of grapefruit varieties cultivated in India显示文摘Citrus family especially Grapefruit,has attained considerable attention due to the presence of a number of essential components that have cardiovascular and anti-hypertensive properties.The juice and essential oil extracted from eight recently released grapefruit cultivars were used to study physicochemical and antioxidant properties.The total soluble solids(TSS),titratable acidity(TA) and pH of juice samples extracted from various grapefruit varieties differed significantly.The refractive index,specific gravity and optical rotation values for the oil varied from 1.473 to 1.396,0.863 to 0.847 and +93 to +86,respectively.The percent 2,2-diphenyl-1-picrylhydrazyl radical activity(% DPPH activity) and ferric reducing antioxidant power(FRAP) values for grapefruit juice and peel oil varied from 24.06 to 18.79,2.91 to 1.44 mmol g^–1 and 84.87 to 74.73,7.76 to 5.73 mmol g^-1,respectively.There were significant differences in physicochemical,antioxidant properties and volatile profiles of extracted juice and oil.The oil exhibited higher DPPH and FRAP values than the juice.Among different components identified which accounted for over 99% of the volatile fraction,limonene,myrcene,and benzopyran were major components in all oil samples. | Shahnawaz Ahmed H S Rattanpal Khalid Gul Rouf Ahmad Dar Akash Sharma | 2019 | Journal of Integrative Agriculture2019，18，7： | 3 |
| 3 | Complementary roles of interventional radiology and therapeutic endoscopy in gastroenterology显示文摘Acute upper and lower gastrointestinal bleeding, enteral feeding, cecostomy tubes and luminal strictures are some of the common reasons for gastroenterology service. While surgery was initially considered the main treatment modality, the advent of both therapeutic endoscopy and interventional radiology have resulted in the paradigm shift in the management of these conditions. In this paper, we discuss the patient's work up, indications, and complementary roles of endoscopic and angiographic management in the settings of gastrointestinal bleeding, enteral feeding, cecostomy tube placement and luminal strictures. These conditions often require multidisciplinary approaches involving a team of interventional radiologists, gastroenterologists and surgeons. Further, the authors also aim to describe how the fields of interventional radiology and gastrointestinal endoscopy are overlapping and complementary in the management of these complex conditions. | David M Ray Indu Srinivasan Shou-jiang Tang Andreas S Vilmann Peter Vilmann Timothy C McCowan Akash M Patel | 2017 | World Journal of Radiology2017，9，3： | 2 |
| 4 | Strategies for characterizing sildenafil, vardenafil, tadalafil and their analogues in herbal dietary supplements, and detecting counterfeit products containing these drugs 显示文摘 | SARANJIT S BHAGWAT P AKASH A | 2009 | Trends Anal Chem2009，28，1： | 1 |
| 5 | Association of antigen processing machinery and HLA class Ⅰ defects with clinicopathological outcome in cervical carcinoma显示文摘 | Akash M Ekaterina S | 2008 | Cancer Immunol Immunother2008，57，2： | 1 |
| 6 | The fertility of cryopre- served Deccan Mahseer, Torkhodree (Sykes) spermatozoa 显示文摘 | Basavaraja N Hegde S N Akash N | 2002 | Asian Fishedes Science2002，15，： | 1 |
| 7 | Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus 显示文摘 | Akash M S Rehman K Chert S | 2013 | J Cell Biochem2013，114，3： | 1 |
| 8 | Oral bioavailability enhancement of exemestane from self- microemulsifying drug delivery system 显示文摘 | Ajeet K S Akash C Anshumali A | 2009 | Pharm Sci Tech2009，10，3： | 1 |
| 9 | Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus显示文摘 | Akash MS Rehman K Chen S | 2013 | J Cell Biochem2013，114，3： | 1 |
| 10 | Multi-criteria selection of electric power plants using the analytic hierarchy process显示文摘 | Rustom Mamlook Mousa S Mohsen | 1999 | Electric Power Systems Research1999，52，： | 1 |
| 11 | Some prospects of ener- gy savings in buildings 显示文摘 | MOHSEN M S AKASH B A | 2001 | Energy Conversion and Man- agement2001，42，11： | 1 |
| 12 | Some prospects of energy savings in buildings显示文摘 | Mohsen M S Akash B A | 2001 | Energy Conversion and Management2001，42，： | 1 |
| 13 | Strategies for characterizing sildenafil,vardenafil, tadalafil and their analogues in herbaldietary supplements, and detecting counterfeitproducts containing these drugs 显示文摘 | SARANJIT S BHAGWAT P AKASH A | 2009 | Trends inAnalytical Chemistry2009，28，1： | 1 |
| 14 | Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus显示文摘 | AKASH M S REHMAN K CHEN Shuqing | 2013 | Journal of Cellular Biochemistry2013，114，3： | 1 |
| 15 | Some prospect of energy savings in buildings显示文摘 | Akash B A | 2001 | (4):1307-13152001，，4： | 1 |
| 16 | The fertility of cryopreserved Deccan Mahseer,Tor khudree Sykes) spermatozoa显示文摘 | Basavaraja N Hegde S N Akash N | 2002 | Asian Fisheries Science2002，15，： | 1 |
| 17 | Value of neutrophil-lymphocyte ratio in evaluating response to percutaneous catheter drainage in patients with acute pancreatitis显示文摘BACKGROUND Early prediction of response to percutaneous catheter drainage(PCD)of necrotic collections in acute pancreatitis(AP)using simple and objective tests is critical as it may determine patient prognosis.The role of white blood cell(WBC)count and neutrophil-lymphocyte ratio(NLR)has not been assessed as a tool of early prediction of PCD success and is the focus of this study.AIM To assess the value of WBC and NLR in predicting response to PCD in AP.METHODS This retrospective study comprised consecutive patients with AP who underwent PCD between June 2018 and December 2019.Severity and fluid collections were classified according to the revised Atlanta classification and organ failure was defined according to the modified Marshall Score.WBC and NLR were monitored 24 h prior PCD(WBC-0/NLR-0)and 24 h(WBC-1/NLR-1),48 h(WBC-2/NLR-2)and 72 h(WBC-3/NLR-3)after PCD.NLR was calculated by dividing the number of neutrophils by the number of lymphocytes.The association of success of PCD(defined as survival without the need for surgery)with WBC and NLR was assessed.The trend of WBC and NLR was also assessed post PCD.RESULTS One hundred fifty-five patients[median age 40±13.6(SD),64.5%males,53.5%severe AP]were included in the final analysis.PCD was done for acute necrotic collection in 99(63.8%)patients and walled-off necrosis in 56(36.1%)patients.Median pain to PCD interval was 24±69.89 d.PCD was successful in 109 patients(group 1)and 46 patients(group 2)who failed to respond.There was no significant difference in the baseline characteristics between the two groups except the severity of AP and frequency of organ failure.Both WBC and NLR showed an overall decreasing trend.There was a significant difference between WBC-0 and WBC-1(P=0.0001).WBC-1 and NLR-1 were significantly different between the two groups(P=0.048 and 0.003,respectively).The area under the curve of WBC-1 and NLR-1 for predicting the success of PCD was 0.602 and 0.682,respectively.At a cut-off value of 9.87 for NLR-1,the sensitivity and specificity for predicting the success of PCD were calculated to be 75%and 65.4%respectively.CONCLUSION WBC and NLR can be used as simple tests for predicting response to PCD in patients with acute necrotizing pancreatitis. | Pankaj Gupta Gaurav Chayan Das Akash Bansal Jayanta Samanta Harshal S Mandavdhare Vishal Sharma Shano Naseem Vikas Gupta Thakur Deen Yadav Usha Dutta Neelam Varma Manavjit Singh Sandhu Rakesh Kochhar | 2022 | World Journal of Clinical Cases2022，10，1： | 1 |
| 18 | Efficiency of Miller engine at maximum power density显示文摘 | Al-Sarkhi A Akash B A Jaber J O Mohsen M S Abu-Nada E | | 0，，08： | 1 |
| 19 | Experimental performance of a heat pipe显示文摘 | Said S A Akash B A | 1999 | Int Comm Heat Mass Transfer1999，26，5： | 1 |
| 20 | Enhanced 5-HT(2A) receptor status in the hypothalamus and corpus striatum of ethanol-treated rats 显示文摘 | Akash K G Balarama K S Paulose C S | 2008 | Cell Mol Neurobiol2008，28，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员