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| 1 | Importance of systems biology in engineering microbes for biofuel production 显示文摘 | MUKHOPADHYAY AINDRILA KEASLING JD | 2008 | Current Opinion in Bioteehnology2008，，19： | 1 |
| 2 | Biofuel alterna- tives to ethanol: pumping the microbial well显示文摘 | Fortman L J Swapnil C Aindrila M | 2008 | Cell Trends Biotechnol2008，26，： | 1 |
| 3 | A comprehensive review of tools for exploratory analysis of tabular industrial datasets显示文摘Exploratory data analysis plays a major role in obtaining insights from data.Over the last two decades,researchers have proposed several visual data exploration tools that can assist with each step of the analysis process.Nevertheless,in recent years,data analysis requirements have changed significantly.With constantly increasing size and types of data to be analyzed,scalability and analysis duration are now among the primary concerns of researchers.Moreover,in order to minimize the analysis cost,businesses are in need of data analysis tools that can be used with limited analytical knowledge.To address these challenges,traditional data exploration tools have evolved within the last few years.In this paper,with an in-depth analysis of an industrial tabular dataset,we identify a set of additional exploratory requirements for large datasets.Later,we present a comprehensive survey of the recent advancements in the emerging field of exploratory data analysis.We investigate 50 academic and non-academic visual data exploration tools with respect to their utility in the six fundamental steps of the exploratory data analysis process.We also examine the extent to which these modern data exploration tools fulfill the additional requirements for analyzing large datasets.Finally,we identify and present a set of research opportunities in the field of visual exploratory data analysis. | Aindrila Ghosh Mona Nashaat James Miller Shaikh Quader Chad Marston | 2018 | Visual Informatics2018，2，4： | 0 |
| 4 | Scalable and automated CRISPR-based strain engineering using droplet microfluidics显示文摘We present a droplet-based microfluidic system that enables CRISPR-based gene editing and high-throughput screening on a chip.The microfluidic device contains a 10x10 element array,and each element contains sets of electrodes for two electric field-actuated operations:electrowetting for merging droplets to mix reagents and electroporation for transformation.This device can perform up to 100 genetic modification reactions in parallel,providing a scalable platform for generating the large number of engineered strains required for the combinatorial optimization of genetic pathways and predictable bioengineering.We demonstrate the system's capabilities through the CRISPR-based engineering of two test cases:(1)disruption of the function of the enzyme galactokinase(galK)in£coli and(2)targeted engineering of the glutamine synthetase gene(glnA)and the blue-pigment synthetase gene(bpsA)to improve indigoidine production in£coli. | Kosuke Iwai Maren Wehrs Megan Garber Jess Sustarich Lauren Washburn Zachary Costello Peter W.Kim David Ando William R.Gaillard Nathan J.Hillson Paul D.Adams Aindrila Mukhopadhyay Hector Garcia Martin Anup K.Singh | 2022 | Microsystems & Nanoengineering2022，8，2： | 0 |
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