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| 1 | Survival and outcomes for co-infection of chronic hepatitis C with and without cirrhosis and COVID-19: A multicenter retrospective study显示文摘BACKGROUND Chronic liver disease,particularly cirrhosis,is associated with worse outcomes in patients infected with coronavirus disease 2019(COVID-19).AIM To assess outcomes of COVID-19 infection among patients with pre-existing hepatitis C with or without liver cirrhosis.METHODS This multicenter,retrospective cohort study included all cases of confirmed coinfection of severe acute respiratory syndrome coronavirus 2 and chronic hepatitis C with or without liver cirrhosis who were admitted to six hospitals(Al-Sahel Hospital,Al-Matareya Hospital,Al-Ahrar Hospital,Ahmed Maher Teaching Hospital,Al-Gomhoreya Hospital,and the National Hepatology and Tropical Medicine Research Institute)affiliated with the General Organization for Teaching Hospitals and Institutes in Egypt.Patients were recruited from May 1,2020,to July 31,2020.Demographic,laboratory,imaging features,and outcomes were collected.Multivariate regression analysis was performed to detect factors affecting mortality.RESULTS This retrospective cohort study included 125 patients with chronic hepatitis C and COVID-19 co-infection,of which 64(51.20%)had liver cirrhosis and 40(32.00%)died.Fever,cough,dyspnea,and fatigue were the most frequent symptoms in patients with liver cirrhosis.Cough,sore throat,fatigue,myalgia,and diarrhea were significantly more common in patients with liver cirrhosis than in noncirrhotic patients.There was no difference between patients with and without cirrhosis regarding comorbidities.Fifteen patients(23.40%)with liver cirrhosis presented with hepatic encephalopathy.Patients with liver cirrhosis were more likely than non-cirrhotic patients to have combined ground-glass opacities and consolidations in CT chest scans:28(43.75%)vs 4(6.55%),respectively(P value<0.001).These patients also were more likely to have severe COVID-19 infection,compared to patients without liver cirrhosis:29(45.31%)vs 11(18.04%),respectively(P value<0.003).Mortality was higher in patients with liver cirrhosis,compared to those with no cirrhosis:33(51.56%)vs 9(14.75%),respectively(P value<0.001).All patients in Child-Pugh class A recovered and were discharged.Cirrhotic mortality occurred among decompensated patients only.A multivariate regression analysis revealed the following independent factors affecting mortality:Male gender(OR 7.17,95%CI:2.19–23.51;P value=0.001),diabetes mellitus(OR 4.03,95%CI:1.49–10.91;P value=0.006),and liver cirrhosis(OR 1.103,95%CI:1.037–1.282;P value<0.0001).We found no differences in liver function,COVID-19 disease severity,or outcomes between patients who previously received direct-acting antiviral therapy(and achieved sustained virological response)and patients who did not receive this therapy.CONCLUSION Patients with liver cirrhosis are susceptible to higher severity and mortality if infected with COVID-19.Male gender,diabetes mellitus,and liver cirrhosis are independent factors associated with increased mortality risk. | Shimaa Afify Basem Eysa Fatma Abdel Hamid Omnia M Abo-Elazm Mohamed A Edris Rabab Maher Ahmed Abdelhalim Muhammad Mostafa Abdel Ghaffar Dalia A Omran Hend Ibrahim Shousha | 2021 | World Journal of Gastroenterology2021，27，42： | 2 |
| 2 | Molecular polymorphisms between populations of Pseudoperonosporacubensis from Greece and the Czech Republic and the phytopatho-logical and phylogenetic implications显示文摘 | SAHRIS P ABDELHALIM M KITNER M SKANDALIS N | 2009 | Plant Pathology2009，58，5： | 1 |
| 3 | Image classification and retrieval using optimized pulse-coupled neural network 显示文摘 | MOHAMMED M M BADR A ABDELHALIM M B | 2015 | Expert Systems with Applications2015，42，49： | 1 |
| 4 | Intranasal dexmedetomidine vs midazolam for premedication in children undergoing complete dental rehabilitation: a double- blinded randomized controlled trial 显示文摘 | SHETA S A AL-SARHEED M A ABDELHALIM A A | 2014 | Paediatr Anaesth2014，24，2： | 1 |
| 5 | Synthesis of novel steroidal heterocyclie derivatives as antibacterial agents 显示文摘 | ABDELHALIM M M E1-SAIDI M M T RABIE S T | 2007 | STEROIDS2007，72，5： | 1 |
| 6 | The effects of carbon dioxide in exhaust gas recirculation on diesel engine emissions显示文摘 | Ladommatos N Abdelhalim S M Zhao H | 1998 | Proceedings of the Institu- tion of Mechanical Engineers Part D-Journal of Auto- mobile Engineering1998，212，1： | 1 |
| 7 | Intranasal dexme- detomidine vs midazolam for premedication in children undergoing complete dental rehabilitation: a double-blin- ded randomized controlled trial 显示文摘 | Sa ST A1-Sarheed M Abdelhalim AA | 2014 | Paediatr Anaesth2014，24，2： | 1 |
| 8 | Speeding-up Phased-locked Loops Based on Adaptive Loop Bandwidth 显示文摘 | Dina M Abdelhalim Zekry Mohamed Abouelatta | 2013 | International Journal of Computer Applications2013，61，3： | 1 |
| 9 | The effects of carbon dioxide in exhaust gas recirculation on diesel engine emissions显示文摘 | Ladammatos N Abdelhalim S M Zhao H | 1998 | Journal of Automobile En- giens1998，，： | 1 |
| 10 | The Effects of Carbon Dioxide in Exhaust Gas Recirculation on Diesel Engine Emission显示文摘 | Ladommatos N Abdelhalim S M Zhao H | 1998 | Proc Instn Mech Engrs Part D J Autom Engng1998，1998，212： | 1 |
| 11 | An integrated highlevel hardware/software partitioning methodology显示文摘 | Abdelhalim M B Habib S ED | 2011 | Des Autom Embed Syst2011，15，1： | 1 |
| 12 | 64-Channel UWB wireless neural vector analyzer SOC with a closed-loop phase synchrony-triggered neurostimulator显示文摘 | ABDELHALIM K JAFARI H M KOKAROVTSEVA L | 2013 | IEEE J Solid-State Circuits2013，48，10： | 1 |
| 13 | Synthesis of novel steroidal heterocyclic derivatives as antibacterial agents显示文摘 | Abdelhalim M M Rabie S T Saidi M M | 2007 | Steroids2007，72，5： | 1 |
| 14 | Physical prop- erties of different gold nanoparticles : ultraviolet-visible and fluo- rescence measurements 显示文摘 | ABDELHALIM M MADY M GHANNAM M | 2012 | J Nanomed Nanotechol2012，3，100133： | 1 |
| 15 | Image classifi- eation and retrieval using optimized pulse-eoupled neural network 显示文摘 | MOHAMMED M M BADR A ABDELHALIM M B | 2015 | Expert Systems with Applieations2015，42，11： | 1 |
| 16 | An Integrated High-Level Hardware/Software Partitioning Methodology显示文摘 | Abdelhalim M B Habib S E-D | 2011 | Des Autom Embed Syst2011，15，1： | 1 |
| 17 | An integrated high-level hard- ware/software partitioning methodology显示文摘 | Abdelhalim M B Habib S E-D | 2011 | Design Automation for Embedded Systems2011，15，1： | 1 |
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