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| 1 | Antibacterial approaches in tissue engineering using metal ions and nanoparticles:From mechanisms to applications显示文摘Bacterial infection of implanted scaffolds may have fatal consequences and,in combination with the emergence of multidrug bacterial resistance,the development of advanced antibacterial biomaterials and constructs is of great interest.Since decades ago,metals and their ions had been used to minimize bacterial infection risk and,more recently,metal-based nanomaterials,with improved antimicrobial properties,have been advocated as a novel and tunable alternative.A comprehensive review is provided on how metal ions and ion nanoparticles have the potential to decrease or eliminate unwanted bacteria.Antibacterial mechanisms such as oxidative stress induction,ion release and disruption of biomolecules are currently well accepted.However,the exact antimicrobial mechanisms of the discussed metal compounds remain poorly understood.The combination of different metal ions and surface decorations of nanoparticles will lead to synergistic effects and improved microbial killing,and allow to mitigate potential side effects to the host.Starting with a general overview of antibacterial mechanisms,we subsequently focus on specific metal ions such as silver,zinc,copper,iron and gold,and outline their distinct modes of action.Finally,we discuss the use of these metal ions and nanoparticles in tissue engineering to prevent implant failure. | Maria Godoy-Gallardo Ulrich Eckhard Luis M.Delgado Yolanda J.D.de Roo Puente Mireia Hoyos-Nogués F.Javier Gil Roman A.Perez | 2021 | Bioactive Materials2021，6，12： | 14 |
| 2 | Treatment of psoriasis with adalimumab显示文摘 | G.Pitarch J. L.Sanchez‐Carazo L.Mahiques M. A.Perez‐Ferriols J. M.Fortea | 2006 | Clinical dermatology2006，，1： | 1 |
| 3 | Interactions Between Human Mesenchymal Stem Cells and Natural Killer Cells显示文摘 | Panagiota A.Sotiropoulou Sonia A.Perez Angelos D.Gritzapis Constantin N.Baxevanis MichaelPapamichail | 2009 | STEM CELLS2009，，1： | 1 |
| 4 | Final 5‐year results of Z‐FAST trial显示文摘 | Adam M.Brufsky W. GraydonHarker J. ThaddeusBeck LindaBosserman CharlesVogel ChristopherSeidler LixianJin GhulamWarsi ElizaArgonza‐Aviles JohnHohneker Solveig G.Ericson Edith A.Perez | 2012 | Cancer2012，，： | 1 |
| 5 | Design of functional biomaterials as substrates for corneal endothelium tissue engineering显示文摘Corneal endothelium defects are one of the leading causes of blindness worldwide.The actual treatment is transplantation,which requires the use of human cadaveric donors,but it faces several problems,such as global shortage of donors.Therefore,new alternatives are being developed and,among them,cell therapy has gained interest in the last years due to its promising results in tissue regeneration.Nevertheless,the direct administration of cells may sometimes have limited success due to the immune response,hence requiring the combination with extracellular mimicking materials.In this review,we present different methods to obtain corneal endothelial cells from diverse cell sources such as pluripotent or multipotent stem cells.Moreover,we discuss different substrates in order to allow a correct implantation as a cell sheet and to promote an enhanced cell behavior.For this reason,natural or synthetic matrixes that mimic the native environment have been developed.These matrixes have been optimized in terms of their physicochemical properties,such as stiffness,topography,composition and transparency.To further enhance the matrixes properties,these can be tuned by incorporating certain molecules that can be delivered in a sustained manner in order to enhance biological behavior.Finally,we elucidate future directions for corneal endothelial regeneration,such as 3D printing,in order to obtain patient-specific substrates. | Begona M.Bosch Elia Bosch-Rue Marina Perpiñan-Blasco Roman A.Perez | 2022 | Regenerative Biomaterials2022，9，1： | 0 |
| 6 | Impact of prehospital medical evacuation (MEDEVAC) transport time on combat mortality in patients with noncompressible torso injury and traumatic amputations: a retrospective study显示文摘Background: In combat operations, patients with traumatic injuries require expeditious evacuation to improve survival. Studies have shown that long transport times are associated with increased morbidity and mortality. Limited data exist on the influence of transport time on patient outcomes with specific injury types. The objective of this study was to determine the impact of the duration of time from the initial request for medical evacuation to arrival at a medical treatment facility on morbidity and mortality in casualties with traumatic extremity amputation and noncompressible torso injury(NCTI).Methods: We completed a retrospective review of MEDEVAC patient care records for United States military personnel who sustained traumatic amputations and NCTI during Operation Enduring Freedom between January 2011 and March 2014. We grouped patients as traumatic amputation and NCTI(AMP+NCTI), traumatic amputation only(AMP),and neither AMP nor NCTI(Non-AMP/NCTI). Analysis was performed using chi-squared tests, Fisher's exact tests,Cochran-Armitage Trend tests, Shapiro-Wilks tests, Wilcoxon and Kruskal-Wallis techniques and Cox proportional hazards regression modeling.Results: We reviewed 1267 records, of which 669 had an injury severity score(ISS) of 10 or greater and were included in the analysis. In the study population, 15.5% sustained only amputation injuries(n=104, AMP only), 10.8% sustained amputation and NCTI(n=72, AMP+NCTI), and 73.7% did not sustain either an amputation or an NCTI(n=493,Non-AMP/NCTI). AMP+NCTI had the highest mortality(16.7%) with transport time greater than 60 min. While the AMP+NCTI group had decreasing survival with longer transport times, AMP and Non-AMP/NCTI did not exhibit the same trend.Conclusions: A decreased transport time from the point of injury to a medical treatment facility was associated with decreased mortality in patients who suffered a combination of amputation injury and NCTI. No significant association between transport time and outcomes was found in patients who did not sustain NCTI. Priority for rapid evacuation of combat casualties should be given to those with NCTI. | Joseph K.Maddry Crystal A.Perez Alejandra G.Mora Jill D.Lear Shelia C.Savell Vikhyat S.Bebarta | 2019 | Military Medical Research2019，6，1： | 0 |
| 7 | Self-reported dietary supplement use in deployed United States service members pre-deployment vs.during deployment,Afghanistan,2013-2014显示文摘Background: Dietary supplement use(protein/amino acids, weight-loss supplements, performance enhancers) is common among U.S. military members. Reported dietary supplement use in deployed troops is limited and is of concern in settings where troops are exposed to high ambient temperatures, increased physical demands, and dehydration. Our objective was to describe dietary supplement use and adverse events(AEs) among deployed U.S. service members compared with their pre-deployment use.Methods: We conducted an institutional review board(IRB) approved, descriptive study in Afghanistan using a written questionnaire and collected demographic information, dietary supplement use before and during deployment, AEs associated with supplement use, and physical workout routines. Participants were U.S. military personnel of all branches of service deployed to Afghanistan. They were recruited in high-traffic areas in the combat theater. We analyzed the data with descriptive statistics. Paired t-test/Wilcoxon signed-rank test was conducted to examine the before/during deployment changes for continuous data, and Mc Nemar's chi-square test was conducted for categorical data. We constructed separate logistic regression models to determine the best predictors of increases or decreases in dietary supplement use, with demographic information, reasons for using supplements, and education requested/received as covariates in each model. All statistical tests were two-sided at a significance level of 5%(P<0.05).Results: Data were collected on 1685 participants. Ninety-seven of the participants were in the Army or Air Force. The participants were more likely to work out daily or more than once a day during deployment. Thirty-five percent of the participants reported no supplement use before or during deployment. The remaining 65% of participants reported increased use and increased frequency of use of supplements(e.g., daily) during deployment compared with predeployment. Additionally, more people followed label instructions strictly during deployment vs. predeployment. Overall, the frequency of self-reported AEs among supplement users remained consistent before and during deployment. The only significant difference noted was in problems falling or staying asleep, which increased during deployment. In the adjusted logistic regression models, the level of formal education, military branch, occupational specialty, education about dietary supplements, and certain reasons for using supplements(to boost energy, lose weight, gain muscle strength and mass, and as a meal replacement) were significant predictors of changes in supplement use.Conclusion: Deployed U.S. service members were more likely to use dietary supplements, use more than one supplement and use supplements more frequently during deployment than pre-deployment. No serious AEs were reported, but problems falling or staying asleep increased during deployment. | Shawn M.Varney Patrick C.Ng Crystal A.Perez Allyson A.Arana Edwin R.Austin Rosemarie G.Ramos Vikhyat S.Bebartas | 2018 | Military Medical Research2018，5，3： | 0 |
| 8 | IMPLANT OF EX-PRESS MINI GLAUCOMA SHUNT. SURGICAL TECHNIQUE AND RE-SULTS显示文摘Purpose: To determine the effectiveness of the Ex-Press mini glaucoma shunt. Methods: We implanted the new device for treatment of glaucoma in ten patients, following the standard surgical procedure. Results: After a three months follow-up, two patients mantained safe intraocular pressure range without complications. The rest showed a high variability of pressure and a diversity of complications such as fibrosis and | M.L.Hernandez D.Salom F.Morais A.Perez M.Garcia | 2003 | 国际眼科杂志2003，3，1： | 0 |
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