Preparation and cytocompatibility of polylactic acid/hydroxyapatite/graphene oxide nanocomposite fibrous membrane

查看全文 作　　者：MA [1,3]HaiBin;SU [2]WenXin;TAI [1]ZhiXin;SUN [1]DongFei;YAN [1]XingBin;LIU [2]Bin;XUE [1]QunJi

机构地区：[1]State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China;[2]School of Stomatology, Lanzhou University, Lanzhou 730000, China;[3]Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China

出　　处：《Chinese Science Bulletin》索引2012年第57卷第23期,共8页

基　　金：supported by the Hundred Talents Program of Chinese Academy of Sciences and the National Natural Science Foundation of China(51005225) 摘　　要：A series of polylactic acid (PLA) based nanocomposite fibrous membranes,including neat PLA,PLA/hydroxyapatite (HA) and PLA/HA/graphene oxide (GO),were fabricated via electrospinning method.The morphology and composition were investigated by scanning electron microscopy (SEM),X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) respectively.The thermal stability was determined by thermogravimetric analysis (TGA).To estimate the cytocompatibility of asprepared PLA/HA/GO fibrous membrane,MC3T3-E1 cells were cultured,and the corresponding cell adhesion and differentiation capability were investigated by fluorescence microscopy,SEM and MTT test.The electrospun ternary PLA/HA/GO membrane exhibited three-dimensional fibrous structure with relatively rough surface morphology,which made itself ideal for cell attachment and proliferation in bone tissue regeneration.The fluorescence microscopy,SEM and MTT test confirmed that the PLA/HA/GO nanocomposite fibrous membrane created a proper environment for the seeding and proliferation of MC3T3-E1 cells. 关键词：polylactic acid HYDROXYAPATITE graphene OXIDE FIBROUS membranes

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Preparation and cytocompatibility of polylactic acid/hydroxyapatite/graphene oxide nanocomposite fibrous membrane

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