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| 1 | Preparation and cytocompatibility of polylactic acid/hydroxyapatite/graphene oxide nanocomposite fibrous membrane显示文摘A series of polylactic acid (PLA) based nanocomposite fibrous membranes,including neat PLA,PLA/hydroxyapatite (HA) and PLA/HA/graphene oxide (GO),were fabricated via electrospinning method.The morphology and composition were investigated by scanning electron microscopy (SEM),X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) respectively.The thermal stability was determined by thermogravimetric analysis (TGA).To estimate the cytocompatibility of asprepared PLA/HA/GO fibrous membrane,MC3T3-E1 cells were cultured,and the corresponding cell adhesion and differentiation capability were investigated by fluorescence microscopy,SEM and MTT test.The electrospun ternary PLA/HA/GO membrane exhibited three-dimensional fibrous structure with relatively rough surface morphology,which made itself ideal for cell attachment and proliferation in bone tissue regeneration.The fluorescence microscopy,SEM and MTT test confirmed that the PLA/HA/GO nanocomposite fibrous membrane created a proper environment for the seeding and proliferation of MC3T3-E1 cells. | MA HaiBin SU WenXin TAI ZhiXin SUN DongFei YAN XingBin LIU Bin XUE QunJi | 2012 | Chinese Science Bulletin2012，57，23： | 11 |
| 2 | Effect of Starch/Polylactic Acid Ratio on the Interdependence of Two-Phase and the Properties of Composites显示文摘Starch/polylactic acid(PLA) composites were prepared by melt extrusion, with corn starch and PLA as raw materials, glycerol as the plasticizer. Effects of starch/PLA ratio on the interdependence of two-phase and other properties of the composites were studied. The combination of results of TGA with SEM indicated that the interdependence between starch and PLA was increased gradually as the starch/PLA ratio reduced. DSC results showed that the glass transition temperature(Tg), melting temperature(Tm) and degree of crystallinity of PLA in composites were increased gradually, whereas the cold crystallization temperature(Tc) was gradually decreased as the starch/PLA ratio reduced. The rheological properties of composites were closely related with the interdependence of two-phase, with reducing starch/PLA proportion, the interdependence was increased, and then the strain for storage modulus was firstl reduced and then gradually increased. Frequency scanning showed that the storage modulus and complex viscosity were decreased with reducing starch content. As the starch/PLA ratio reduced, the matrix phase PLA was increased, so that the strength of composites was increased gradually, whereas water absorption rate was decreased gradually. | 左迎峰 GU Jiyou CAO Jun WEI Shuangying TAN Haiyan 张彦华 | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，5： | 3 |
| 3 | Preparation Process and Mechanical Properties of PLA/PCL Intravascular Stent显示文摘A hand-made biodegradable intravascular stent with zig- zag structure has been developed, which made from polylactic acid ( PLA ) braided thread and poly-eaprolactone ( PCL ) tube. This paper showed the preparation process of the PLA braded thread and stent, and discussed the heat setting process of the stents. The sixteen groups of stents were made for the heat setting experiments, discussing two factors on four levels. Radial compression behavior of stents was tested by plate compression method. The result showed that both the heat setting temperature and time had significant effects on stent compression strength. The compression recovery rate was mainly affected by heat setting temperature. The optimized heat setting condition should be 90-100℃ for 45 rain. | WANG Cong-er | 2014 | Journal of Donghua University(English Edition)2014，31，5： | 2 |
| 4 | Fabrication of core-shell PLGA/PLA-pNIPAM nanocomposites for improved entrapment and release kinetics of antihypertensive drugs显示文摘Polylactic acid (PLA)and poly(lactic-co-glycolic)acid (PLGA)are two commonly applied biodegrad- able polymers for the preparation of nanocomposites used in drug-delivery systems.However,these polymers lack desirable attributes such as resistance to aggregation during long-term storage due to lyophilisation.To improve their efficacy,in this work,PLA and PLGA were encapsulated within a shell of poly(N-isopropylacrylamide)(pNIPAM)using a single emulsion technique followed by an aqueous free radical precipitation polymerisation process,yielding core-shell PLA/PLGA-pNIPAM nanocomposites. The nanocomposites were cbaracterised using zeta potential,dynamic light scattering,and transmission electron microscopy analyses and were further applied as a delivery system for ramipril,an antihypertensive drug.The drug-loaded PLGA-pNIPAM core-shell nanoparticles exhibited a higher drug content (91%)and entrapment efficiency (78%)than their PLA counterparts.An in vitro release study of the formulations at pH 7.3in phosphate-buffered saline indicated that PLGA was more efficient than PLA with a sustained release of 86% of ramipril from the polymer matrix within 24h.Furthermore,to determine the release kinetics,the data were fitted to Korsmeyer-Peppas and Higuchi models;the release of ramipril from the polymer matrix followed zero-order rate kinetics and an anomalous (non-Fickian)diffusion mechanism. | Tanushree Basu Bonamali Pal Satnam Singh | 2018 | Particuology2018，16，5： | 1 |
| 5 | Flexural strength of fused filament fabricated (FFF) PLA parts on an open-source 3D printer显示文摘Fused filament fabrication (FFF) has been widely used to develop prototypes as well as functional parts owing to its capability for creating parts with complex geometries in a short time without the specific requirement of tooling. The mechanical properties of parts produced by FFF exhibit 70%-80% of the mechanical properties of parts produced by injection molding. The mechanical properties of FFF-produced parts are primarily dependent on the selection of various process variables. The mechanical properties of the part can be enhanced through the proper selection of process variables. In the present experimental investigation, the effects of the process variables, viz. raster angle, layer height, and raster width on the flexural properties of FFF-printed polylactic acid (PLA) is studied. The result shows that flexural strength is primarily influenced by layer height followed by raster angle. The sample printed with 100-μm layer height and 0° raster angle exhibits a higher tensile strength. Further, the microscopic examination of the deformed specimen is performed to understand the mode of failure. Specimens printed at different raster angles show different modes of failure. | Shilpesh R. Rajpurohit Harshit K. Dave | 2018 | Advances in Manufacturing2018，6，4： | 0 |
| 6 | Inhibitory effect of three biopolymer materials on scar formation following trabeculectomy显示文摘AIM: To investigate the inhibitory effects of amniotic membrane, polylactic acid membrane and chitosan membrane on scar formation following trabeculectomy. METHODS: A total of 24 New Zealand white rabbits (48 eyes) were randomly divided into 4 groups: amniotic membrane group, polylactic acid membrane group, chitosan membrane group, and control group, with 6 rabbits (12 eyes) in each group. The left eyes underwent routine trabeculectomy, and the right eyes were considered as controls. Amniotic membrane, polylactic acid membrane and chitosan membrane were respectively installed under sclera flap in three groups, but any treatment was not applied in control group. Intraocular pressure, conjunctival filtering bleb, and anterior chamber inflammation responses were monitored at day 1, 3, 7, 14, 28 and 56 post-operatively. Eyeball tissue underwent histopathological examination at day 56 post-operatively. RESULTS: Fibrocytes and inflammatory cells were reduced in amniotic membrane, polylactic acid membrane and chitosan membrane groups compared to that in control group. At day 1 post-operatively, intraocular pressure was decreased in three membrane groups compared to that in control group. At day 14 post-operatively, the intraocular pressure was decreased significantly, while it of three membrane groups was significantly lower than that of preoperative (P <0.01). There were no significant differences among three membrane groups (P >0.05). Filtering bleb of four groups was clearly observed at day 7 post-operatively, but there was no significant difference in pair-wise comparison. At day 28 and 56 post-operatively, filtering bleb in control group was significantly narrowed compared to that in three membrane groups (P <0.05), but there was no significant difference in pair-wise comparison of three membrane groups. CONCLUSION: All amniotic membrane, polylactic acid membrane and chitosan membrane can effectively inhibit scar formation following trabeculectomy, the effect of amniotic membrane is the best. | Sha, Qian Jiao, Guang-Yu Cui, Hai-Bin Wang, Jie Sun, Li-Bin Chen, Ming Fu, Song-Bin | 2011 | International Journal of Ophthalmology(English edition)2011，4，4： | 0 |
| 7 | Mathematical modelling of drug permeability of biodegradable membrane for implant use显示文摘INTRODUCTIONDuringthepasttwodecades,asanewinterdisciplinaryscienceoferednovelap-proachestothedeliveryofdrug,thetechnologyofco... | LIU Jun yi 1,ZHANG Qing ying 1,LI Ling bing 1, XU Ming yu 1To whom correspondence should be addressed.,DONG Zhi feng 2 1 Research Center for Biomedical Engineering,Shandong University, Jinan 250100,China 2 China National Center | 1999 | Chinese Journal of Biomedical Engineering(English Edition)1999，8，1： | 0 |
| 8 | Properties of Scaffold Reinforcement for Tendon Tissue Engineering in vitro Degradation显示文摘Four kinds of braided yarns were produced with different proportions of polyglycolic acid( PGA) and polylactic acid( PLA)multifilaments( 2PGA /1PLA, 2PGA /2PLA, 3PGA /1PLA, and3PGA /2PLA). A novel artificial plain stitch scaffold reinforcement was manufactured by braiding technology and knitting technology respectively. Tendon scaffold reinforcements were investigated for 8weeks in phosphate buffered solution( PBS)( pH = 7. 4) at 37 ℃.The degradation was studied with regard to the mass loss,tensile properties,grams per square meter( g /m2),thickness,caliber,and porosity of scaffold reinforcements. The experimental showed that during the process of 8-week degradation,the mass losses of scaffold reinforcements were small in the first 3-week,but they increased rapidly after 3-week,and the speeds tended to be small gradually after 6-week; the tensile properties dropped rapidly in the first 2-week; the grams per square meter and thicknesses speeded down obviously between 3-week to 6-week. The caliber and porosity of scaffold reinforcements first decreased and then increased gradually. The porosity can reach more than 97%. | 龚泽 张佩华 王文祖 罗云蔚 | 2013 | Journal of Donghua University(English Edition)2013，30，5： | 0 |
| 9 | Development of Composite Textile Structures for Wound Dressing Applications显示文摘The main objective of this research work was the development of novel and responsive nonwoven composite structures containing gelling materials for wound management. The development of novel all inclusive collagen booster(CB) therapeutic nonwoven wound dressings was mainly focused on. It provides essential functional properties such as high absorption,vertical and lateral wicking,and antibacterial and acidic pH properties. The developed composite wound dressing consisted of carboxymethylcellulose(CMC) fibre and also it was reinforced with polylactic acid( PLA) fibre. The produced composite wound dressings were treated with two different CBs at 4% by using the spray method. The details of the CBs have not been disclosed in this paper due to the Intellectual Property Rights( IPR) issues. The important benefit of using CB treatment is that it allows the maintenance of an acidic pH environment at the wound area. It is well known that acidic pH reduces the wound healing time and enhances the wound healing process. Furthermore,one of the CBs not only promotes the proliferation of the epithelial cells in wounds but also can provide antibacterial action. The PLA fibre reinforced CMC composite dressing has enhanced wicking properties which help to minimise the pooling of exudate on the wound bed and as a result maceration is prevented. The CBs treated dressings maintain the wound bed in an acidic pH condition which also improves the wound healing process. In addition to the above-mentioned properties,the CB treatment imparts antimicrobial activity against Gram-positive and Gram-negative bacteria,thus resulting in the reduction in the propensity for wound infection. Ultimately,the research has proved that the 4% CB treatment enhances the antimicrobial activity and the acidic pH characteristics of the developed CMC /PLA composite wound dressings. | ANAND Subhash UZUN Muhammet SHAH Tahir RAJENDRAN Subbiyan | 2013 | Journal of Donghua University(English Edition)2013，30，5： | 0 |
| 10 | Preparation and in vitro Release of Donepezil Hydrochloride Microspheres显示文摘[Objectives]To prepare donepezil hydrochloride microspheres and evaluate their quality.[Methods]The donepezil hydrochloride microspheres were prepared by emulsification-solvent evaporation method.The morphology was observed by scanning electron microscopy and the particle size distribution was determined by Laser Diffraction Method.The encapsulation efficiency,drug loading capacity,and in vitro release were determined by HPLC.[Results]The prepared donepezil hydrochloride microspheres were spherical with the average particle diameter of 15.927 μm.The drug loading capacity was 35.62%.The encapsulation efficiency was 90.32%.The drug release in vitro lasted for14 d.The release curve accorded with the first-order kinetic equation.[Conclusions]The prepared donepezil hydrochloride microspheres performed good sustained release effect in vitro,and it was expected to be used for research on Parkinson's disease. | Yingzhou WANG Hao QI Dongze ZHANG Zixuan ZHAO Chunyan ZHANG | 2018 | Medicinal Plant2018，9，6： | 0 |
| 11 | Effect of PLA Knitted Structure on the Mechanical Properties of Composite Vascular Scaffold显示文摘A new entire biodegradable scaffold has been developed which does not require precelluiarization before transplantation. This new kind of vascular scaffold prototype made from porous poly- e-caprolactone (PCL) membrane to provide three-dimensional environment for cell growth, and embedded with weft-knitted polylactic acid (PLA) fabric to support mechanics. The aim of this paper is to study the variation tendency of mechanical properties with the fabric spacing changing. The basic geometrical parameters were measured to characterize properties of the samples. The tensile and compressive elastic recovery of the samples were tested by the universal mechanical tester and radial compression apparatus, respectively. Both tensile and compressive properties enhanced when reducing the fabric spacing of the composite vascular scaffold. | LI Chao-jing LI Xuan WANG Fu-jun GE Peng MAO Ying WANG Lu MARTIN W. King | 2014 | Journal of Donghua University(English Edition)2014，31，5： | 0 |
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