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	题名	作者	年代	出处	被引量
1	miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。	van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊	2018	神经损伤与功能重建2018，13，12：	3
2	Development of a functional magnetic resonance imaging protocol for intraoperative localization of critical temporoparietal language areas显示文摘	Ruttan GJ Ramsey NF Van Rijen PC	2002	Ann Neurol2002，51，：	1
3	fMRI-determined language lateralization in patients with unilateral or mixed language dominance according to the Wada test 显示文摘	Rutten GJM Ramsey NF van Rijen PC	2002	Neuroimage2002，17，：	1
4	Health-related quality of life and self-perceived competence of children assessed before and up to two years after epilepsy surgery显示文摘	Van Empelen R Jennekens-Schinkel A Van Rijen PC	2005	Epilepsia2005，46，2：	1
5	Health-related quality of life and self-perceived competence of children assessed before and up to two years after epilepsy surgery显示文摘	van Empelen R Jennekens-Schinkel A van Rijen PC	2005	Epilepsia2005，46，2：	1
6	Age-dependent changes in localized proton and phosphorus MR spectroscopy of the brain显示文摘	van der Knaap MS van der Grond J van Rijen PC	1990	Radiology1990，176，2：	1
7	Age-dependent changes in location proton and phosphorus MR spectroscopy of the brain显示文摘	van der Knaap MS van der Grond J van Rijen PC	1990	Radiology1990，176，：	1
8	Evidence of activated microglia in focal cortical dysplasia显示文摘	Boer K Spliet WG van Rijen PC	2006	J Neuroimmunol2006，173，：	1
9	FMRI-determined language lateralization in patientswith unilateral or mixed language dominance according tothe Wada test显示文摘	Rutten GJ Ramsey NF van Rijen PC	2002	Neuroimage2002，17，1：	1
10	Interhemispheric reorganization ofmotor hand function to the primarymotor cortex predicted withfurtclionalmagnetic resonance imaging and transcranial magnetic stimulation 显示文摘	Rutten GJ Ramsey NF van Rijen PC	2002	Child Neuro2002，17，：	1
11	Development of a functional magnetic resonance imaging protocol for intraoperative localization of critical temporoparietal language areas显示文摘	Rutten GJ Ramsey NF van Rijen PC	2002	Ann Neurol2002，51，：	1
12	Evidence of activated microglia in focal cortical dysplasia显示文摘	Boer K Spliet WG van Rijen PC		0，，1：	1
13	Interhemispheric reorganization of motor hand function to the primary motor cortex predicted with functionalmagnetic resonance imaging and transcranial magnetic stimulation显示文摘	Ramsey NF van Rijen PC	2002	Child Neurol2002，17，：	1
14	Age-dependent changes in localized proton and phosphorus MR spectroscopy of the brain显示文摘	Van der Knaap MS van der Grond J van Rijen PC	1990	Radiology1990，176，：	1
15	Effect of valproic acid on sodium currents in cortical neurons from patients with pharmaco-resistant temporal lobe epilepsy显示文摘	Vreugdenhil M van Veelen CW van Rijen PC	1998	Epilepsy Res1998，32，12：	1
16	Age- dependent changes in localized proton and phosphorus MR spectroscopy of tile brain显示文摘	Van der Knaap MS va der Grond J van Rijen PC etal	1990	Radiology1990，176，：	1
17	A grading system for hippocampal sclerosis based on the degree of hippocampal mossy fiber sprouting显示文摘	Proper EA Jansen GH van Veelen CW van Rijen PC Gispen WH de Graan PN		0，，04：	1
18	Age-dependent changes in localized proton and phosphorus MR spectroscopy of the brain显示文摘	van der Knaap MS van der GJ van Rijen PC	1990	Radiology1990，176，2：	1
19	Language area localization with three-dimensional functional magnectic resonance imaging matches intrasulcal electrostimulation in Broca's area显示文摘	Rutten GJ van Rijen PC van Veelen CW	1999	Ann Neurol1999，46，：	1
20	MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response 显示文摘	Iyer A Zurolo E Prabowo A Huiter K Spliet WG van Rijen PC Gorter JA Aronica E	2012	PLoS One2012，7，44：	1

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