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| 1 | WONCA研究论文摘要汇编——COPD第1秒用力呼气末容积/用力肺活量固定值与参考值下限的关系:基于人群的加拿大COPD队列研究报告显示文摘目的呼吸量测定的方法可以导致COPD的误诊,甚至造成不当治疗。本研究比较两种标准的临床指标的相关性,即第1秒用力呼气末容积/用力肺活量(FEV1/FVC)的固定值及其参考值下限。方法分析基于人群的加拿大COPD队列研究的数据,分析测量气流受限的呼吸量测定标准与患者报告的不良后果的关系,包括呼吸道症状、残疾、健康状况、病情加重、心血管疾病。用敏感性分析探索年龄及气流受限严重程度对上述指标相关性的影响。结果对4 882例40岁以上患者的数据进行分析。FEV1/FVC固定值测定的气流受限发生率为17%,参考值下限为11%。由FEV1/FVC固定值测定的气流受限的患者发生不良后果的可能性增高不明显;由FEV1/FVC固定值联合参考值下限测定为气流受限且患者FEV1低于预测值80%与发生不良后果的可能性更大。结论研究结果表明,单独使用FEV1/FVC固定值可能导致COPD的误诊。由FEV1/FVC固定值和参考值下限得出的诊断与低FEV1、临床后果有着密切关系。指南应考虑两种呼吸量测量法的异常,从而减少COPD的过度诊断。 | van Dijk W Tan W Li P 本刊编辑部 | 2015 | 中国全科医学2015，18，8： | 10 |
| 2 | Crystal structureof an ACh-binding protein reveals the ligandbinding domain ofnicotinic receptors显示文摘 | Brejc K van Dijk W J Klaassen R V | 2001 | Nature2001，411，： | 1 |
| 3 | Modeling gamma radiation dose in dwellings due to building materials显示文摘 | De Jong P Van Dijk W | 2008 | Health Phys2008，94，1： | 1 |
| 4 | When people fall from grace:Reconsidering the role of envy in schadenfreude显示文摘 | van Dijk W W Ouwerkerk J W Goslinga S | | 0，，01： | 1 |
| 5 | Pharmacokinetic properties of mirabegron, a beta3-adrenoceptor agonist: results from two phase I, randomized, multiple-dose studies in healthy young and elderly men and women显示文摘 | KRAUWINKEL W VAN DIJK J SCHADDELEE M | 2012 | Clin T- her2012，34，10： | 1 |
| 6 | The energy approach to fatigue for pavement design显示文摘 | van DIJK W VISSER W | 1977 | Journal of the Association of Asphalt Paving Technologists1977，46，： | 1 |
| 7 | Behavior of Metallic Iron Catalysts During Fischer-Tropsch Synthesis Studied with Moessbauer Spectroscopy, X-Ray Diffraction, Carbon Content Determination, and Reaction Kinetic Measurements显示文摘 | Niemantsverdriet J W Van der Kraan A M Van Dijk W L | 1980 | J Phys Chem Lett1980，84，25： | 1 |
| 8 | Cloning and expression of a functional estrogen recep- tor-α from African catfish (Clarias gariepinus) pitui- tary 显示文摘 | Teves A C C Granneman J C M Van Dijk W | 2003 | J Mol Endocrinol2003，30，： | 1 |
| 9 | Toward a model of text comprehension andproduction 显示文摘 | Kintsch W Van Dijk T A | 1978 | Psychological review1978，85，5： | 1 |
| 10 | Antigen test for early diagnosis of active cytomegalovirus infection in heart transplant recipients显示文摘 | Vall der Bij W Van Dijk RB Van Son WJ | 1988 | Heart Transplant1988，7，2： | 1 |
| 11 | Transforming growth factor beta 1 to the bone显示文摘 | Kten Dijke P Janssens S Van Hul W | 2005 | Endocr Rev2005，26，6： | 1 |
| 12 | SUMO modification of the ubiquitin-conjugating en- zyme E2-25K 显示文摘 | Pichler A Knipscheer P Oberhofer E van Dijk W J K6rner R Olsen JV Jentsch S Melchior F Sixma T K | 2005 | Nature Struet Mol Biol2005，12，： | 1 |
| 13 | Plasma concentration o f C-reactive protein is increased in type I diabetic patients without clinical macroangiopathy and correlates with markers of endothelial dysfunction:evidence for chronic inflammation显示文摘 | Schalkwijk CG Poland DC van Dijk W | 1999 | Diabetologia1999，42，3： | 1 |
| 14 | Synthesis and characterization of poly-L-lysine with controlled low molecular weight显示文摘 | WENDELMOED N E van DIJK W Leon van de Water | 1997 | Macromol Chem Phys1997，198，： | 1 |
| 15 | Toward a model of text comprehension and production显示文摘 | Kintsch W van Dijk T.A | | 0，，85： | 1 |
| 16 | Correction factors for the NMi free-air ionization chamber for medium-energy x-rays calculated with the Monte Carlo method显示文摘 | Grimbergen T W van'Dijk E de Vries W | 1998 | Physics in Medicine and Biology1998，43，11： | 1 |
| 17 | A comparison of onpump and off-pump coronary bypass surgery in low-risk patients显示文摘 | Nathoe H M van Dijk D Jansen E W L | 2003 | N Engl J Med2003，348，5： | 1 |
| 18 | Symptoms and signs of syncope:A review of the link between physiology and clinical clues显示文摘 | Wieling W Thijs RD Van Dijk N | 2009 | Brain2009，132，10： | 1 |
| 19 | Crystal Structure of an ACh-binding Protein Reveals the Ligand-Binding Domain of Nicotinic Receptors 显示文摘 | BREJC K van DIJK W J KLAASSEN R V | 2001 | Nature2001，411，： | 1 |
| 20 | Taking up the Challenge of Measuring Prolonged Pain in (Premature) Neonates:the COMFORTneo Scale Seems Promising显示文摘 | Van Dijk M Roofthooft D W Anand K J | | 0，，07： | 1 |
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