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| 1 | Epigenetics of gastroenteropancreatic neuroendocrine tumors:A clinicopathologic perspective显示文摘Gastroenteropancreatic neuroendocrine tumors(GEP-NETs) are a heterogeneous group of rare tumors whose site-specific tumor incidence and clinical behavior vary widely. Genetic alterations associated with familial inherited syndromes have been well defined; however, the genetic profile of sporadic tumors is less clear as their tumorigenesis does not appear to be controlled by classic oncogenes such as P53, RB, or KRAS. Even within GEP-NETs, there are no common oncogenic drivers; for example, DAXX/ATRX mutations are strongly implicated in the tumorigenesis of pancreatic but not small bowel NETs. Accordingly, the dysregulation of epigenetic mechanisms has been hypothesized as a potential regulator of GEPNET tumorigenesis and has become a major focus of recent studies. Despite the heterogeneity of tumor cohorts evaluated in these studies, it is obvious that there are methylation patterns, chromatin remodeling alterations, and microR NA and long non-coding RNA(lncR NA) differential expression profiles that are distinctive of GEPNETs, some of which are correlated with significant differences in clinical outcomes. Several translational studies have provided convincing data identifying potential prognostic biomarkers, and some of these have demonstrated preliminary success as serum biomarkers that can be used clinically. Nevertheless, there are many opportunities to further define the mechanisms by which these epigenetic modifications influence tumorigenesis, and this will provide better insight into their prognostic and therapeutic utility. Furthermore, these findings form the foundation for future studies evaluating the clinical efficacy of epigenetic modifications as prognostic biomarkers, as well as potential therapeutic targets. | Brendan M Finnerty Katherine D Gray Maureen D Moore Rasa Zarnegar Thomas J FaheyⅢ | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 4 |
| 2 | Gastroesophageal reflux disease:A review of surgical decision making显示文摘Gastroesophageal reflux disease(GERD) is a very common disorder with increasing prevalence. It is estimated that up to 20%-25% of Americans experience symptoms of GERD weekly. Excessive reflux of acidic often with alkaline bile salt gastric and duodenal contents results in a multitude of symptoms for the patient including heartburn, regurgitation, cough, and dysphagia. There are also associated complications of GERD including erosive esophagitis, Barrett's esophagus, stricture and adenocarcinoma of the esophagus. While first line treatments for GERD involve mainly lifestyle and non-surgical therapies, surgical interventions have proven to be effective in appropriate circumstances. Anti-reflux operations are aimed at creating an effective barrier to reflux at the gastroesophageal junction and thus attempt to improve physiologic and mechanical issues that may be involved in the pathogenesis of GERD. The decision for surgical intervention in the treatment of GERD, moreover, requires an objective confirmation of the diagnosis. Confirmation is achieved using various preoperative evaluations including: ambulatory p H monitoring, esophageal manometry, upper endoscopy(esophagogastroduodenoscopy) and barium swallow. Upon confirmation of the diagnosis and with appropriate patient criteria met, an antireflux operation is a good alternative to prolonged medical therapy. Currently, minimally invasive gastroesophageal fundoplication is the gold standard for surgical intervention of GERD. Our review outlines the many factors that are involved in surgical decisionmaking. We will review the prominent features that reflect appropriate anti-reflux surgery and present suggestions that are pertinent to surgical practices, based on evidence-based studies. | maureen moore cheguevara afaneh daniel benhuri caroline antonacci jonathan abelson rasa zarnegar | 2016 | World Journal of Gastrointestinal Surgery2016，8，1： | 3 |
| 3 | Inhibition of the Hedgehog Pathway Targets the Tumor-Associated Stroma in Pancreatic Cancer显示文摘 | Rosa F. Hwang Todd T. Moore Maureen Mertens Hattersley Meghan Scarpitti Bin Yang Erik Devereaux Vijaya Ramachandran Thiruvengadam Arumugam Baoan Ji Craig D. Logsdon Jeffrey L. Brown Robert Godin | 2012 | Molecular Cancer Research2012，，9： | 2 |
| 4 | A Survey of Vision Screening Policy of Preschool Children in the United States显示文摘 | Elise B Ciner Velma Dobson Paulette P Schmidt Dale Allen Lynn Cyert Maureen Maguire Bruce Moore Deborah Orel-Bixler Janet Schultz | 1999 | Survey of Ophthalmology1999，，5： | 1 |
| 5 | Comparison of 2,4-D and picloram for selection of long-term totipotent green callus cultures of sugarcane显示文摘 | Maureen M. M. Fitch Paul H. Moore | 1990 | Plant Cell Tissue and Organ Culture1990，，3： | 1 |
| 6 | Is Dual-Chamber Programming Inferior to Single-Chamber Programming in an Implantable Cardioverter-Defibrillator?: Results of the INTRINSIC RV (Inhibition of Unnecessary RV Pacing With AVSH in ICDs) Study显示文摘 | Brian Olshansky John D. Day Stephen Moore Lawrence Gering Murray Rosenbaum Maureen McGuire Scott Brown Darin R. Lerew | 2007 | Circulation2007，，1： | 1 |
| 7 | 加强对肥胖的初级预防:群体随机试验显示文摘目的:对一个面向全科医师,旨在加强肥胖初级预防的培训项目进行评估。 设计:群体随机试验。 地点:英格兰北部及约克郡地区。 | Helen Moore Carolyn D Summerbell Darren C Greenwood Philip Tovey Jacqui Griffiths Maureen Henderson Kate Hesketh Sally Woolgar Ashley J Adamson 顾佳 | 2004 | 英国医学杂志中文版2004，7，2： | 0 |
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