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| 1 | Plasma interleukin-18 reflects severity of ulcerative colitis显示文摘AIM: The aim of this study was to evaluate the association between ulcerative colitis activity and plasma or mucosal concentrations of interleukin (IL)-18.METHODS:Il-18 concentrations were measured in plasma and mucosal samples from 15 patients with active ulcerative colitis (UC).RESULTS: The mean plasma concentration of IL-18 measured in all patients (422±88 pg/mL) doubled the mean value in healthy controls (206±32 pg/mL); however,the difference was not statistically significant. Plasma IL-18 levels revealed a significant positive correlation with scored endoscopic degree of mucosal injury, disease activity index, clinical activity index and C-reactive protein concentration. The mean concentration of plasma IL-18 was significantly higher in patients with severe ulcerative colitis (535±115 pg/mL) than in patients with mild ulcerative colitis (195±41 pg/mL), and in healthy controls.Although the mucosal mean IL-18 concentration in severe ulcerative colitis (2 523±618 pg/mg protein) doubled values observed in mild one (1 347±308 pg/mg protein), there was no statistically significant difference.CONCLUSION: Plasma IL-18 can be considered as a surrogate marker helpful in evaluation of ulcerative colitis activity. | Alicja Wiercinska-Drapalo Flobert Flisiak Jerzy Jaroszewicz Danuta Prokopowicz | 2005 | World Journal of Gastroenterology2005，11，4： | 16 |
| 2 | Severe osteopenia in symptom-free adults with a childhood diagnosis of celiac disease 显示文摘 | Cellier C Flobert C Cormier C | 2000 | Lancet2000，355，9206： | 1 |
| 3 | 中铝为何收购力拓股份?显示文摘中国铝业收购力拓公司股份可以被视为:中国政府为了保证国内矿石供应,而阻止必和必拓公司收购力拓所做的努力。 | Dexter floberts Chi-Chu Tschang 符佳林(编译) | 2008 | 财经文摘2008，，6： | 1 |
| 4 | Right colonic involvement is associated with severe forms of ischemic colitis and occurs frequently in patients with chronic renal failure requiring hemodialysis 显示文摘 | FLOBERT C CELLIER C BERGER A | 2000 | Am J Gastrenterol2000，95，1： | 1 |
| 5 | Right colonic involvement is associated with severe forms of ischemic colitis and occurs frequently in patients with chronic renal failure requiring hemodialysis显示文摘 | Flobert C Cellier C Berger A | 2000 | Am J Gastroenterol2000，95，： | 1 |
| 6 | High efficacy of chlorfenapyr-based net Interceptor■G2 against pyrethroid-resistant malaria vectors from Cameroon显示文摘Background The increasing reports of resistance to pyrethroid insecticides associated with reduced efficacy of pyrethroid-only interventions highlight the urgency of introducing new non-pyrethroid-only control tools.Here,we investigated the performance of piperonyl-butoxide(PBO)-pyrethroid[Permanet 3.0(P3.0)]and dual active ingredients(AI)nets[Interceptor G2(IG2):containing pyrethroids and chlorfenapyr and Royal Guard(RG):containing pyrethroids and pyriproxyfen]compared to pyrethroid-only net Royal Sentry(RS)against pyrethroid-resistant malaria vectors in Cameroon.Methods The efficacy of these tools was firstly evaluated onAnopheles gambiae s.l.andAnopheles funestus s.l.from Gounougou,Mibellon,Mangoum,Nkolondom,and Elende using cone/tunnel assays.In addition,experimental hut trials(EHT)were performed to evaluate the performance of unwashed and 20 times washed nets in semi-field conditions.Furthermore,pyrethroid-resistant markers were genotyped in dead vs alive,blood-fed vs unfed mosquitoes after exposure to the nets to evaluate the impact of these markers on net performance.The XLSTAT software was used to calculate the various entomological outcomes and the Chi-square test was used to compare the efficacy of various nets.The odds ratio and Fisher exact test were then used to establish the statistical significance of any association between insecticide resistance markers and bed net efficacy.Results Interceptor G2 was the most effective net against wild pyrethroid-resistantAn.funestus followed by Permanet 3.0.In EHT,this net induced up to 87.8%mortality[95%confidence interval(CI):83.5-92.1%)and 55.6%(95%CI:48.5-62.7%)after 20 washes whilst unwashed pyrethroid-only net(Royal Sentry)killed just 18.2%(95%CI:13.4-22.9%)of host-seekingAn.funestus.The unwashed Permanet 3.0 killed up to 53.8%(95%CI:44.3-63.4%)of field-resistant mosquitoes and 47.2%(95%CI:37.7-56.7%)when washed 20 times,and the Royal Guard 13.2%(95%CI:9.0-17.3%)for unwashed net and 8.5%(95%CI:5.7-11.4%)for the 20 washed net.Interceptor G2,Permanet 3.0,and Royal Guard provided better personal protection(blood-feeding inhibition 66.2%,77.8%,and 92.8%,respectively)compared to pyrethroid-only net Royal Sentry(8.4%).Interestingly,a negative association was found betweenkdrw and the chlorfenapyr-based net Interceptor G2(χ^(2)=138;P<0.0001)with homozygote-resistant mosquitoes predominantly found in the dead ones.Conclusions The high mortality recorded with Interceptor G2 against pyrethroid-resistant malaria vectors in this study provides first semi-field evidence of high efficacy against these major malaria vectors in Cameroon encouraging the implementation of this novel net for malaria control in the country.However,the performance of this net should be established in other locations and on other major malaria vectors before implementation at a large scale. | Magellan Tchouakui Riccado F.Thiomela Elysee Nchoutpouen Benjamin D.Menze Cyrille Ndo Dorothy Achu Raymond N.Tabue Flobert Njiokou Ateba Joel Charles S.Wondji | 2023 | Infectious Diseases of Poverty2023，12，4： | 0 |
| 7 | Persistent interstitial pregnancy diagnosed after two unsuccessful attempts of clandestine abortion: A case report and literature review显示文摘Dear editor,Ectopic pregnancy is a medico-surgical emergency requiring prompt diagnostic and therapeutic measures.It is defined as the implantation of the embryo outside its normal site within the endometrial cavity.1 The fallopian tube is the most common site of ectopic implantations(96%),followed by the ovary(1%),caesarean section scar(1%–3%),cervix(1%)and viscera of the abdominal cavity(1%).2 Among tubal locations,the interstitium is the least described implantation site(2.6%),whereas the ampulla,isthmus and fimbriated infundibulum have the following respective frequencies:73.3%,12.5%and 11.6%.3 Heterotopic pregnancies are extremely rare cases. | Landry W.Tchuenkam Anicet FN.NGate Joel Noutakdie Tochie Fetsus T.Wirwah Flobert Titcheu Axel S.Nwaha Makon | 2022 | Gynecology and Obstetrics Clinical Medicine2022，2，3： | 0 |
| 8 | First detection of F1534C knockdown resistance mutation in Aedes aegypti(Diptera:Culicidae)from Cameroon显示文摘Background: Aedes borne viral diseases,notably dengue,are increasingly reported in Cameroon with Aedes aegypti being a major vector.Data on insecticide resistance of this vector and underlying mechanisms needed for outbreak preparedness remain scarce in Cameroon.Here,we present the nationwide distribution of insecticide resistance in Ae.aegypti and investigate the potential resistance mechanisms involved.Methods:: Immature stages of Ae.aegypti were collected between March and July 2017 in 13 locations across Cameroon and reared until G1/G2/G3 generation.Larval,adult bioassays,and piperonyl butoxide(PBO)synergist assays were carried out according to World Health Organization guidelines.F1534C mutation was genotyped using allele specific polymerase chain reaction in field collected adults(Go)and the polymorphism of the sodium channel gene was assessed.Theχ2 test was used to compare the mortality rate between bioassays with insecticides only and bioassays after preexposure to PBO synergist.Results: Larval bioassay revealed that all the three populations tested with temephos were susceptible.Adult bioassays showed a good level of susceptibility toward both pyrethroids tested,0.25%permethrin and 0.05%deltamethrin,with six out of 10 populations susceptible.However,two populations(Douala and Edéa)were resistant(deltamethrin[73.2–92.5%mortality],permethrin[2.6–76.3%mortality]).The resistance to 4%dichlorodiphenyltrichloroethane was observed in four out of 10 populations tested(16.8–87.1%mortality).Resistance was also reported to carbamates including 0.1%propoxur(60.8–87.1%mortality)and to 0.1%bendiocarb(82.9%mortality).All populations tested were fully susceptible to 1%fenitrothion.A partial recovery of susceptibility was observed in the pyrethroid resistant population of Douala after pre-exposed to PBO suggesting the implication of cytochrome P450 monoxygenases permethrin resistance.Genotyping and sequencing detected the F1534C kdr mutation in the two pyrethroid resistant locations of Edéa and Douala,with allelic frequency of 3.3%and 33.3%respectively.However,the high genetic diversity of the sodium channel gene supports the recent introduction of this mutation in Cameroon.Conclusions: This study revealed the contrasting resistance profiles to insecticides of Ae.aegypti populations in Cameroon suggesting that,instead of a unique nationwide control approach,a regionally adapted strategy will be needed to control this vector.The localised distribution of the F1534C kdr mutation supports this region-specific control strategy. | Aurelie P.Yougang Basile Kamgang Theodel A.Wilson Bahun Armel N.Tedjou Daniel Nguiffo-Nguete Flobert Njiokou Charles S.Wondji | 2020 | Infectious Diseases of Poverty2020，9，6： | 0 |
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