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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | Antenna-assisted picosecond control of nanoscale phase transition in vanadium dioxide显示文摘Nanoscale devices in which the interaction with light can be configured using external control signals hold great interest for next-generation optoelectronic circuits.Materials exhibiting a structural or electronic phase transition offer a large modulation contrast with multi-level optical switching and memory functionalities.In addition,plasmonic nanoantennas can provide an efficient enhancement mechanism for both the optically induced excitation and the readout of materials strategically positioned in their local environment.Here,we demonstrate picosecond all-optical switching of the local phase transition in plasmonic antenna-vanadium dioxide(VO_(2))hybrids,exploiting strong resonant field enhancement and selective optical pumping in plasmonic hotspots.Polarization-and wavelength-dependent pump–probe spectroscopy of multifrequency crossed antenna arrays shows that nanoscale optical switching in plasmonic hotspots does not affect neighboring antennas placed within 100 nm of the excited antennas.The antenna-assisted pumping mechanism is confirmed by numerical model calculations of the resonant,antenna-mediated local heating on a picosecond time scale.The hybrid,nanoscale excitation mechanism results in 20 times reduced switching energies and 5 times faster recovery times than a VO_(2) film without antennas,enabling fully reversible switching at over two million cycles per second and at local switching energies in the picojoule range.The hybrid solution of antennas and VO_(2) provides a conceptual framework to merge the field localization and phase-transition response,enabling precise,nanoscale optical memory functionalities. | Otto L Muskens Luca Bergamini Yudong Wang Jeffrey M Gaskell Nerea Zabala CH de Groot David W Sheel Javier Aizpurua | 2016 | Light(Science & Applications)2016，5，1： | 5 |
| 3 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 4 | Catheter ablation of atrial fibrillation in patients with diabetes mellitus type 2 : results from a randomized study comparing puhnonary vein isolation antiarrhythmic drug therapy 显示文摘 | Forleo GB Mantica M De Luca L | 2009 | J Cardiovasc Elecuphysiol2009，20，1： | 1 |
| 5 | Influence of the Ion Exchanged Metal (Cu, Co, Ni and Mn) on the Se- lective Catalytic Reduction of NOz Over Mordenite and ZSM-5 显示文摘 | De Lucas A Valverde J L Dorado F | 2005 | Journal of Molecular Catalysis A: Chemical2005，225，1： | 1 |
| 6 | The contingent value of marketing strategy innovativeness for product development performance in Chinese new technology ventures显示文摘 | Atuahene-Gima K Li H Y de Luca L M | | 0，，03： | 1 |
| 7 | Market Knowledge Dimensions and Cross-Functional Collab- oration: Examining the Different Routes to Product Innovation Performance显示文摘 | DE LUCA L M ATUAHENE-GIMA K | 2007 | Journal of Marketing2007，71，1： | 1 |
| 8 | Endostatin inhibits murine colon carcinoma sinusoidal-type metastases by preferential targeting of hepatic sinusoidal endothelium 显示文摘 | Solaun MS Mendoza L De Luca M | 2002 | Hepatology2002，35，5： | 1 |
| 9 | 查看详情显示文摘 | Marco de Lucas M C Fabreguette F Linsavanh M Imhoff L Heintz O Josse-Courty C Mesnier M T Potin V Bourgeois S Sacilotti M | | 0，，： | 1 |
| 10 | Endoscopic treatment of pancreatico-biliary malignancies 显示文摘 | Conio M Demarquay JF De Luca L | 2001 | Crit Rev OncolHematol2001，37，2： | 1 |
| 11 | Alteration of the bcl-2:bax ratio in the placenta as pregnancy proceeds显示文摘 | De Falco M De Luca L Acanfora F | 2001 | Histochem J2001，33，7： | 1 |
| 12 | Reassessment of dobu-tamine, dopamine, and milrinone in the management of acute heartfailure syndromes显示文摘 | Bayram M De Luca L Massie MB | 2005 | Am J Cardiol2005，96，6： | 1 |
| 13 | Expression and functional role of CRIPTO-1 in cutaneous melanoma 显示文摘 | De Luca A Lamura L Strizzi L | 2011 | Br J Cancer2011，105，7： | 1 |
| 14 | Zoledronic acid blocks the interaction between mesenchymal stem cells and breast cancer cells: implications for adjuvant therapy of breast cancer显示文摘 | GaJIo M De Luca A Lamura L | 2012 | Ann Oncol2012，23，3： | 1 |
| 15 | Acute heart failure syndromes in patients with coronary artery disease early assessment and treatment显示文摘 | Flaherty JD Bax JJ De Luca L | 2009 | J Am Coil Cardiol2009，53，3： | 1 |
| 16 | Apelin expression in normal human tissues 显示文摘 | De Falco M De Luca L Onori N | 2002 | In Vivo2002，16，5： | 1 |
| 17 | Behavioral changes andmitochondrial dysfunction in a rat model of schizophrenia induced byketamine 显示文摘 | de Oliveira L Fraga DB De Luca RD | 2011 | Metab Brain Dis2011，26，1： | 1 |
| 18 | Pharmacokinetic evaluation of zoledronic acid 显示文摘 | DE LUCA A LAMURA L GALLO M | 2011 | Expert Opin Drug Metab Toxicol2011，7，7： | 1 |
| 19 | MicroRNAs: new players in multiple myeloma显示文摘 | Pichiorri F De Luca L Aqeilan RI | 2011 | Front Genet2011，2，： | 1 |
| 20 | Laparoscopic ventral rectopexy for internal rectal prolapse using biological mesh: postoperative and short-term functional results显示文摘 | Sileri P Franceschilli L De Luca E | 2012 | J Gastrointest Surg2012，16，3： | 1 |
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