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| 1 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 2 | RNA virus populations as quasispecies显示文摘 | Holland J J de la Torre J C Steinhauer D A | 1992 | Curr Top Microbiol Immunol1992，176，： | 2 |
| 3 | Isolation and mapping of novel candidate genes for retinal disorders using suppression subtractive hybridization显示文摘 | Van Driel MA De KOK YJ | 1999 | Genomics1999，58，3： | 1 |
| 4 | Surgical and visual outcomes of the type I Boston Kera- toprosthesis for the management of aniridic fibrosis syndrome in congenital aniridia 显示文摘 | Bakhtiari P Chan C Welder JD de la Cruz J Holland E J Djalil- ian AR | 2012 | Am J Ophthalmol2012，153，5： | 1 |
| 5 | Mineral trioxide aggregate repair of lateral root perforation 显示文摘 | Holland R Filho JA de Souza V | 2001 | J Endod2001，27，4： | 1 |
| 6 | An aggregate of public health indicator to response the impact of multiple environmental exposures 显示文摘 | Augustinus E M de Hollander Johan M Melse Erie Lebret | 1999 | Epidemiology1999，10，5： | 1 |
| 7 | Brominated flame retardants and perfluorinated compounds in indoor dust from homes and offices in Flanders, Belgium显示文摘 | Wendy D’Hollander Laurence Roosens Adrian Covaci Christa Cornelis Hans Reynders Karen Van Campenhout Pim de Voogt Lieven Bervoets | 2010 | Chemosphere2010，，4： | 1 |
| 8 | Specific cell targeting with nanobody conjugated branched gold nanop- articles for photothermal therapy显示文摘 | Van de Broek B Devoogdt N Hollander A D | 2011 | ACS Nano2011，5，6： | 1 |
| 9 | Specific Cell Targeting with Nanobody Conjugated Branched Gold Nanoparti cles for Photothermal Therapy显示文摘 | Van de Broek B Devoogdt N D' Hollander A | 2011 | ACS Nano2011，5，6： | 1 |
| 10 | High - temperature conditioning induces chilling tolerance in mandarin fruit: a cell wall approach 显示文摘 | Holland N Nunes F L de Medeiros I U D | 2012 | Journal of the Science of Food and Agriculture2012，92，15： | 1 |
| 11 | Perflu-orinated substances in human food and other sources of human exposure显示文摘 | D'Hollander W de Voogt P De Coen W | 2010 | Reviews of Environmental Con-tamination and Toxicology2010，208，： | 1 |
| 12 | Seeing the whole person: feasibility of using the Omaha System to describe strengths of older adults with chronic illness 显示文摘 | Monsen KA Holland DE FH Ping | 2014 | Research & Theory for Nursing Practice2014，28，4： | 1 |
| 13 | Cardiovascular risk factors and atherosclerosis in children and young adults显示文摘 | Perrone J Hollander JE De Roos F | 1998 | N Engl J Med1998，339，： | 1 |
| 14 | Delta effieian- cies of running and cyding显示文摘 | BIJKER K E DE GROOT G HOLLANDER A P | 2001 | Med Sci Sports Exe2001，33，9： | 1 |
| 15 | Maize HapMap2 identifies extant variation from a genome in flux 显示文摘 | Jer-Ming Chia Chi Song Peter J Bradbury Denise Cos- tich Natalia de Leon John Doebley Robert J Elshire Brandon Gaut Laura Geller Jeffrey C Glaubitz Michael Gore Kate E Guill Jim Holland Matthew B Hufford Jinsheng Lai Meng Li Xin Liu Yanli Lu Richard Mc- Combie Rebecca Nelson Jesse Poland Boddupalli M Prasanna Tanja Pyhajarvi Tingzhao Rong Rajandeep S Sekhon Qi Sun Maud I Tenaillon Feng Tian Jun Wang Xun Xu Zhiwu Zhang Shawn M Kaeppler Jef- frey Ross-lbarra Michael D McMullen Edward S Buck- ler Gengyun Zhang Yunbi Xu Doreen Ware | 2012 | Nat Genet2012，，44： | 1 |
| 16 | Urban environmental quality and human well-being Towards a conceptual framework and demarcation of concepts; a literature study 显示文摘 | Irene van Kamp Kees Leidelmeijer Gooitske Marsman Augus- tinus de Hollander | 2003 | Landscape and Urban Plan- ning2003，，65： | 1 |
| 17 | Survival of patients with the acquired immune deficiency syndrome after development of cytomegalovirus retinopathy显示文摘 | Holland GN Sison RF Jatulis DE | 1990 | Ophthalmology1990，97，2： | 1 |
| 18 | A comparison of one versus two appointment endodontic therapy in dogs' teeth with apical periodontitis显示文摘 | Holland R Otoboni Filho JA de Souza V | 2003 | J Endod2003，29，2： | 1 |
| 19 | Problems and unmet needs of patients discharged 'home to self-care' 显示文摘 | Holland DE Mistiaen P Bowles KH | 2011 | Prof Case Manag2011，16，5： | 1 |
| 20 | Characterisation of perfluorooctane sulfonate (PFOS) in a terrestrial ecosystem near a fluorochemical plant in Flanders, Belgium显示文摘 | D'Hollander W De Bruyn L Hagenaars A | 2014 | Environ Sci Pollut Res Int2014，21，11： | 1 |
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