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| 1 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 2 | A new ellagitannin from Cleidion bracteosum显示文摘A new ellagitannin, named bractin (1), had been isolated from the dried aerial part of Cleidion bracteosum. Its structure was determined based on various of spectral analysis. | Peng Ju Yi Fen Wang Qiong Wang Shi De Luo | 2007 | Chinese Chemical Letters2007，18，3： | 2 |
| 3 | 改良FOLFIRINOX方案一线化疗中国转移性胰腺癌患者的疗效与安全性研究显示文摘背景与目的奥沙利铂(oxaliplatin)、伊立替康(irinotecan)、5-氟尿嘧啶(5-fluorouracil)和1-醛氢叶酸(l-leucovorin)联合用药(即FOLFIRINOX方案)已成为晚期胰腺癌(pancreatic cancer,PC)的一线治疗方案之一。然而,与FOLFIRINOX标准剂量相关的3级或4级不良事件的较高发生率限制了该方案在临床上的广泛应用。在本研究中,我们对改良FOLFIRINOX方案一线化疗中国转移性PC患者的疗效和安全性进行了评价。方法将组织学证实为原发转移性胰腺癌,且东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)体能状态评分为0-2的患者纳入本研究。所有患者均接受改良FOLFIRINOX方案治疗(静脉滴注奥沙利铂65 mg/m^2、伊立替康150 mg/m^2、l-醛氢叶酸200 mg/m^2、5-氟尿嘧啶2400 mg/m^2,每2周重复1次)。治疗持续12个周期,除非患者出现疾病进展(progressive disease,PD)、症状恶化的疾病稳定(stable disease,SD)、不可耐受的不良事件或要求提前终止治疗。主要终点为客观缓解率(objective response rate,ORR)。结果2012年7月至2017年4月期间,共有来自3个机构的65例患者被纳入本研究。所有患者均接受了至少1个周期化疗,化疗周期中位数为8个周期(范围:1-12个周期)。本研究中未观察到完全缓解。21(32.3%)例患者为部分缓解,27(41.5%)例表现为SD。总体人群的ORR和疾病控制率(diseasecontrol rate,DCR)分别为32.3%和73.8%。中位总生存期和无进展生存期分别为11.60[95%置信区间(confidence interval,CI):8.76-14.44]个月和5.77(95%CI:5.00-6.54)个月。主要的3级或4级不良事件包括中性粒细胞减少(12.3%)和腹泻(6.2%)。未观察到与治疗相关的死亡。结论改良FOLFIRINOX具有良好的耐受性,可作为中国转移性PC中国患者的一线治疗方案。 | Zhi‑Qiang Wang Fei Zhang Ting Deng Le Zhang Fen Feng Feng‑Hua Wang Wei Wang De‑Shen Wang Hui‑Yan Luo Rui‑Hua Xu Yi Ba Yu‑Hong Li | 2019 | 癌症2019，38，8： | 2 |
| 4 | Value of radiotherapy after radical surgery for esophageal carcinoma: a report of 495 patients显示文摘 | Ze Fen Xiao Zong Yi Yang Jun Liang Yan Jun Miao Mei Wang Wei Bo Yin Xian Zhi Gu De Chao Zhang Ru Gang Zhang Liang Jun Wang | 2003 | The Annals of Thoracic Surgery2003，，2： | 2 |
| 5 | Sulfamic acid as a cost-effective and recyclable solid acid catalyst for Friedel-Crafts alkylation of indole withα,β-unsaturated carbonyl compound and benzyl alcohol显示文摘Sulfamic acid was proved to be a cost-effective and recyclable catalyst for Friedel-Crafts type reaction of indole withα,β-unsaturated carbonyl compound and benzyl alcohol.Various indoles,α,β-unsaturated carbonyl compounds and a benzyl alcohol were successfully used in this type of reaction,and the corresponding products were obtained in good to excellent yields. | Jing Yang Juan Zhang Tian Tian Chen De Mei Sun Ji Li Xue Fen Wu | 2011 | Chinese Chemical Letters2011，22，12： | 2 |
| 6 | Epidemiological Survey of Hemoglobinopathies Based on Next-Generation Sequencing Platform in Hunan Province,China显示文摘Objective This study was aimed at investigating the carrier rate of,and molecular variation in,α-andβ-globin gene mutations in Hunan Province.Methods We recruited 25,946 individuals attending premarital screening from 42 districts and counties in all 14 cities of Hunan Province.Hematological screening was performed,and molecular parameters were assessed.Results The overall carrier rate of thalassemia was 7.1%,including 4.83%forα-thalassemia,2.15%forβ-thalassemia,and 0.12%for bothα-andβ-thalassemia.The highest carrier rate of thalassemia was in Yongzhou(14.57%).The most abundant genotype ofα-thalassemia andβ-thalassemia was-α^(3.7)/αα(50.23%)andβ^(IVS-Ⅱ-654)/β^(N)(28.23%),respectively.Fourα-globin mutations[CD108(ACC>AAC),CAP+29(G>C),Hb Agrinio and Hb Cervantes]and sixβ-globin mutations[CAP+8(C>T),IVS-Ⅱ-848(C>T),-56(G>C),beta nt-77(G>C),codon 20/21(-TGGA)and Hb Knossos]had not previously been identified in China.Furthermore,this study provides the first report of the carrier rates of abnormal hemoglobin variants andα-globin triplication in Hunan Province,which were 0.49%and 1.99%,respectively.Conclusion Our study demonstrates the high complexity and diversity of thalassemia gene mutations in the Hunan population.The results should facilitate genetic counselling and the prevention of severe thalassemia in this region. | XI Hui LIU Qin XIE Dong Hua ZHOU Xu TANG Wang Lan TANG De Guo ZENG Chun Yan WANG Qiong NIE Xing Hui PENG Jin Ping GAO Xiao Ya WU Hong Liang ZHANG Hao Qing QIU Li FENG Zong Hui WANG Shu Yuan ZHOU Shu Xiang HE Jun ZHOU Shi Hao ZHOU Fa Qun ZHENG Jun Qing WANG Shun Yao CHEN Shi Ping ZHENG Zhi Fen MA Xiao Yuan FANG Jun Qun LIANG Chang Biao WANG Hua | 2023 | Biomedical and Environmental Sciences2023，36，2： | 1 |
| 7 | Value of radiotherapy after radical surgery for esophageal carcinoma: a report of 495 patients显示文摘 | Ze Fen Xiao Zong Yi Yang Jun Liang Yan Jun Miao Mei Wang Wei Bo Yin Xian Zhi Gu De Chao Zhang Ru Gang Zhang Liang Jun Wang | 2003 | The Annals of Thoracic Surgery2003，，2： | 1 |
| 8 | Global and robtust stability of interval Hopfield neural networks with timevarying delays显示文摘 | Liao Xiao- fen Wang Jun Cao Jin- de | 2003 | International Journal of Neural System2003，13，3： | 1 |
| 9 | Effect of amphotericin B treatment on kinetics of cytokines and parameters on fungal load in neutropeaic rats with invasive pulmonary aspergillosis显示文摘 | MARTIN I B SIEM DE MARIE MARCEL H A M FENS | 2003 | J Antib Chem2003，52，2： | 1 |
| 10 | Effect of amphotericin B treatment on kinetics of cytokines and parameters of fungal load in neutropenic rats with invasive pulmonary aspergillosis显示文摘 | Becker MJ de Marie S Fens MH | | 0，，03： | 1 |
| 11 | Incidental venous thromboembolism in ambulatory Cancer patients receiving chemotherapy 显示文摘 | Di Nisio M Fen'ante N De Tursi M | 2010 | Thromb Haemost2010，104，5： | 1 |
| 12 | Stroke subtype and mortality: a follow-up study in 998 patients with a first cerebral infarct 显示文摘 | Goose De J Lisette Van R Fens K | 2003 | J Clin Epidemiol2003，，56： | 1 |
| 13 | Effect of amphotericin B treatment on kinetics of cytokines and parameters on fungal load in neutropenic rats with invasive pulmonary aspergillosis 显示文摘 | MARTIN J BECKER SIEM DE MARIE MARCEL H A M FENS | 2003 | J Antib Chem2003，52，2： | 1 |
| 14 | The Global Deterioration Scale (GDS) 显示文摘 | Reisberg B Fen'is SH De Leon MJ | 1988 | Psychopharmacol Bull1988，24，4： | 1 |
| 15 | C-reactive protein and cardiovascular diseaset:a review of risk prediction and intertentions显示文摘 | de Fen'anti S Rifai N | 2002 | Clin Chim Acta2002，317，12： | 1 |
| 16 | C-reactive protein and cardiovascular disease:a review of risk prediction and interventions 显示文摘 | de Fen'anti SD Rifai N | 2002 | Clin Chim Acta2002，317，12： | 1 |
| 17 | Airway inflammation and mannitol challenge test in COPD显示文摘 | DE NIJS S B FENS N LUTrER R | 2011 | Respiratory Research2011，12，1： | 1 |
| 18 | An-giogenic endothelium shows lactadherin-dependent phagocytosis of aged erythrocytes and apoptotic cells显示文摘 | FENS M H MASTROBATTISTA E DE GRAAFF A M | 2008 | Blood2008，111，： | 1 |
| 19 | Tumor necrosis factor-or induces transforming growth factor? 1 expression in lung fibroblasts through the cxtracellular signal regulated kinase pathway显示文摘 | Sullivan DE Fen'is M Pociask D | 2005 | Am J Respir Cell Mol Biol2005，32，4： | 1 |
| 20 | IL-17A and IL-17RCExpression in the Macula of the Human Eye with Age-Related Mac-ular Degeneration显示文摘 | Stanley Park De Fen Shen Lai Wei | 2012 | Invest Ophthalmol Vis Sci2012，53，3： | 1 |
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