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| 1 | Genetic ancestry analysis in non-alcoholic fatty liver disease patients from Brazil and Portugal显示文摘AIM:To study the association between genetic ancestry,non-alcoholic fatty liver disease(NAFLD) metabolic characteristics in two cohorts of patients,from Brazil and Portugal. METHODS:We included 131 subjects from Brazil [(n = 45 with simple steatosis(S. Steatosis) and n = 86 with nonalcoholic steatohepatitis(NASH)] and 90 patients from Portugal(n = 66,S. Steatosis; n = 24,NASH). All patients had biopsy-proven NAFLD. In histologic evaluation NAFLD activity score was used to assess histology and more than 5 points defined NASH in this study. Patients were divided into two groups according to histology diagnosis:simple steatosis or non-alcoholic statohepatitis. Genetic ancestry was assessed using real-time polymerase chain reaction. Seven ancestry informative markers(AT3-I/D,LPL,Sb19.3,APO,FYNull,PV92,and CKMM) with the greatest ethnicgeographical differential frequencies(≥ 48%) were used to define genetic ancestry. Data were analyzed using R PROJECTS software. Ancestry allele frequencies between groups were analyzed by GENEPOP onlineand the estimation of genetic ancestry contribution was evaluated by ADMIX-95 software. The 5% alpha-error was considered as significant(P < 0.05). RESULTS:In the Brazilian sample,NASH was significantly more frequent among the elderly patients with diabetes(NASH 56 ± 1.1 years old vs S. Steatosis 51 ± 1.5 years old,P = 3.7 x 10-9),dyslipidemia(NASH 63% vs S. Steatosis 37%,P = 0.009),higher fasting glucose levels(NASH 124 ± 5.2 vs S. Steatosis 106 ± 5.3,P = 0.001) and Homeostatic Model of Assessment index > 2.5 [NASH 5.3(70.8%) vs S. Steatosis 4.6(29.2%) P = 0.04]. In the Portuguese study population,dyslipidemia was present in all patients with NASH(P = 0.03) and hypertension was present in a larger percentage of subjects in the S. Steatosis group(P = 0.003,respectively). The genetic ancestry contribution among Brazilian and Portuguese individuals with NASH was similar to those with S. Steatosis from each cohort(Brazilian cohort:P = 0.75; Portuguese cohort:P = 0.97). Nonetheless,the genetic ancestry contribution of the Brazilian and Portuguese population were different,and a greater European and Amerindian ancestry contribution was detected in the Portuguese population while a higher African genetic ancestry contribution was observed in Brazilian population of both NASH and S. Steatosis groups.CONCLUSION:There was no difference between the genetic ancestry contribution among Brazilian and Portuguese individuals with NASH and S. Steatosis from each cohort. | Lourianne Nascimento Cavalcante Jose Tadeu Stefano Mariana V Machado Daniel F Mazo Fabiola Rabelo Kiyoko Abe Sandes Flair Jose Carrilho Helena Cortez-Pinto Andre Castro Lyra Claudia P de Oliveira | 2015 | World Journal of Hepatology2015，7，10： | 2 |
| 2 | Sequential(step-by-step) detection,identification and quantization of extra virgin olive oil adulteration by chemo metric treatment of chromatographic profiles显示文摘 | CAPOTE F P JIMINEZ J R LUQUE de CASTRO M D | 2007 | Analytical and Bioanalytical Chemistry2007，338，8： | 1 |
| 3 | Artificial Immune Systems as Complex Adaptive Systems显示文摘 | P A Vargas L N de Castro F J Von Zuben | 2002 | Proceedings of International Conference on Artificial Immune Systems2002，1，： | 1 |
| 4 | An overview on fatigue analysis of aeronautical structural details: open hole, single rivet lap-joint, and lap-joint panel显示文摘 | De Castro P M S T De Matos P F P Moreira P M G P | 2007 | Materials Science and Engineering: A2007，，： | 1 |
| 5 | A Phase II trial of gemcitabine and mitoxantrone for patients with acute myeloid leukemia in first relapse显示文摘 | ADVANI A S SHADMAN M ALI-OSMAN F BARKER A RYBICKI L KALAYCIO M SEKERES M A de CASTRO C M DIEHL L F MOORE J O BEAVEN A COPELAN E SOBECKS R TALEA P RIZZIERI D A | 2010 | Clinical lymphoma Myeloma & Leukemia2010，10，6： | 1 |
| 6 | Determination of phenolic compounds in grape skin by capillary electrophoresis with simultaneous dual fluorescence and diode array absorption detection after dynamic superheated liquid leaching显示文摘 | Capote F P Rodríguez J M L Luque de Castro M D | 2007 | J Chromatogr A2007，1139，： | 1 |
| 7 | Toward equitable and sustainable rural water supplies: a contingent valuation study in Brazil显示文摘 | Briscoe J de Castro P F Griffin C | 1990 | The World Bank Economic Review1990，4，2： | 1 |
| 8 | Modeling compression failure after low velocity impact on laminated composites using interface elements 显示文摘 | M F S F de Moura J P M Goncalves A T Marques P M S T de Castro | 1997 | Journal of Composite Materials1997，31，15： | 1 |
| 9 | Fatigue behaviour of notched specimens of friction stir welded aluminium alloy 6063-T6显示文摘 | Moreira P M G P de Oliveira F M F de Castro P M S T | 2008 | Journal of Materials Processing Technology2008，207，13： | 1 |
| 10 | Fatty acid composition of three freshwater fishes under different storage and cooking processes显示文摘 | de CASTRO F A F SANT'ANA H M P CAMPOS F M | 2007 | Food Chemistry2007，103，： | 1 |
| 11 | Cardiorenal syndrome and its pathophysiotogieal implications 显示文摘 | DE CASTRO F D CHAVES P C LEITE-MOREIRA A F | 2010 | RevPort Cardiol2010，29，10： | 1 |
| 12 | Clonal distribution of an atypical MRP-4-, EF' , and suilysin-]- phenotype of virulent Streptococcus suis se rotype 2 strains in Brazil显示文摘 | Martinez G Pestana de Castro A F Ribeiro P K J | 2003 | Can J Vet Res2003，67，1： | 1 |
| 13 | Extenden cervical mediastinoscopy in the staging of bronchogenic carcinoma 显示文摘 | Freixinet Gilart J Garia P G de Castro F R | 2000 | Ann Thorac Surg2000，70，5： | 1 |
| 14 | An overview on fatigue analysis of aeronautical structural details:open hole,single rivet lap-joint,and lap-joint panel显示文摘 | de Castro P M S T de Matos P F P Moreira P M G P | 2007 | Materials Science and Engineering:A2007，，： | 1 |
| 15 | Friction stir welded joints of A1 - Li alloys for aeronautical applications : Butt - joints and tailor welded blanks 显示文摘 | Tavares S M O dos Santos J F de Castro P M S T | 2013 | Theoretical and Applied Frac- ture Mechanics2013，65，： | 1 |
| 16 | DAPI Binding to the DNA Minor Groove: a Continuum Solvent Analysis 显示文摘 | DE CASTRO L F P ZACHARIAS M | 2002 | Journal of Molecular Recognition2002，，15： | 1 |
| 17 | Diversity of soil fungal communities of Cerrado and its closely surrounding agriculture fields显示文摘 | De Castro A P Quifino B F Pappas G | 2008 | Archives of Microbiology2008，，190： | 1 |
| 18 | Primary malignant melanoma of the biliary tract: A case report and literature review显示文摘BACKGROUND Primary malignant melanoma of the biliary tract (MBT) is a rare condition whose diagnosis requires excluding a primary origin in another location.This paper reviews the most important characteristics of MBT cases published in the literature and reports a new case.The patient reported here is the first case of primary malignant melanoma of the biliary tract with pulmonary metastasis treated with immunotherapy.This patient remains disease-free 36 mo after the treatment of metastatic lung lesions.CASE SUMMARY A 51-year-old man was admitted to the gastrointestinal department to study obstructive jaundice of a 1 wk clinical course.Magnetic resonance cholangiopancreatography revealed dilatation of the intrahepatic biliary tract and stenosis of the common hepatic duct.Given the suspicion of biliary tract neoplasia,cholecystectomy and resection of the common hepatic duct were performed with hepatic jejunostomy free of complications.Anatomo-pathological diagnosis was melanoma.After intervention,the patient was referred to the Department of Medical Oncology,where a primary origin was excluded in the skin,mucosa,and eyes.This confirmed diagnosis of primary biliary tract melanoma.Computed tomography was performed 12 mo after the procedure revealed several subcentimetric lung nodules.Wedge resection was performed.After confirming the diagnosis of pulmonary metastasis of primary melanoma of the biliary tract,the patient was started on immunotherapy with nivolumab.Tolerance to treatment was excellent.The patient remains disease-free 36 mo after the treatment of metastatic lung lesions.CONCLUSION The patient reported here is the first case of primary malignant melanoma of the biliary tract with lung metastases successfully treated with immunotherapy. | Soledad Cameselle-García José Luis Fírvida Pérez María C Areses Jesús Daniel Fernández de Castro Juan Mosquera-Reboredo Jesús García-Mata | 2019 | World Journal of Clinical Cases2019，7，16： | 1 |
| 19 | Fatigue behaviour of notched specimens of friction stir welded aluminium alloy 6063-T6显示文摘 | MOREIRA P M G P DE OLIVEIRA F M F DE CASTRO P M S T | 2008 | Journal of materials processing technology2008，27，13： | 1 |
| 20 | Properties and biotechnological applications ofporeine pancreatic lipase 显示文摘 | Mendesa A A Oliveimb P C De Castro H F | 2012 | J Mol Catal B-Enzym2012，78，： | 1 |
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