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| 1 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 2 | Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype显示文摘 | Anna Abulí Xavier Bessa Juan Ramón González Clara Ruiz–Ponte Alejandro Cáceres Jenifer Mu?oz Victoria Gonzalo Francesc Balaguer Ceres Fernández–Rozadilla Dolors González Luisa de Castro Juan Clofent Luís Bujanda Joaquín Cubiella Josep M a Re?é Juan Diego | 2010 | Gastroenterology2010，，3： | 2 |
| 3 | Genetic and Epigenetic Silencing of MicroRNA-203 Enhances ABL1 and BCR-ABL1 Oncogene Expression显示文摘 | María J. Bueno Ignacio Pérez de Castro Marta Gómez de Cedrón Javier Santos George A. Calin Juan C. Cigudosa Carlo M. Croce José Fernández-Piqueras Marcos Malumbres | 2008 | Cancer Cell2008，，： | 2 |
| 4 | Business and so- cial reputation: Exploring the concept and main Dimen- sions of corporate reputation 显示文摘 | De Castro G M Lopez J E N Sdez P L | 2006 | Journal of Business Ethics2006，63，4： | 1 |
| 5 | The Construction of a Boolean Competitive Neural Network Using Ideas from Immunology显示文摘 | Von Zuben F J De Deus J G A | 2003 | Neurocomputing2003，50，： | 1 |
| 6 | Learning and optimization using the clonal selection 显示文摘 | De Castro L N Zuben V | 2002 | Artificial Immune System (AIS)2002，6，3： | 1 |
| 7 | Immune and neural network models: theoretical and empirical comparisons 显示文摘 | de CASTRO L N van ZUBEN F J | 2001 | International Journal of Computational Intelligence and Applications2001，1，3： | 1 |
| 8 | Learning and Optimization Using the Clonal Selection Principle显示文摘 | De Castro L N Von Zuben F J | 2002 | IEEE Trans on Evolutionary Computation2002，6，3： | 1 |
| 9 | Learning and optimization using the clonal selection principle 显示文摘 | DE CASTRO L N VON ZUBEN F J | 2002 | IEEE Trans Evolutionary Computation Special Issue on Artificial Immune Systems2002，6，3： | 1 |
| 10 | An architecture for making recommendations to courseware authors using association rule mining and collaborative filtering显示文摘 | Enrique García Cristóbal Romero Sebastián Ventura Carlos de Castro | 2009 | User Modeling and User-Adapted Interaction2009，，1： | 1 |
| 11 | Learning and Optimization Using the Clone Selection Principle显示文摘 | Leandro N De Castro Fernando J Von Zuben | 2002 | lEE Transactions on Evolutionary Computation Special Issue one Artificial Immune Suystems2002，6，3： | 1 |
| 12 | Learning and Optimization Usingthe Clonal Selection Principle显示文摘 | De Castro L N Von Zuben F J | 2000 | IEEE Transactions on Evolu-tionary Computation2000，6，3： | 1 |
| 13 | Variants at the promoter of the interleukin-6gene are associated with severity and outcome of pneumococcal community-acquired pneumonia显示文摘 | Ignacio Marítn-Loeches Jordi Solé-Violán Felipe Rodríguez de Castro | 2012 | Intensive Care Medicine2012，38，2： | 1 |
| 14 | Learning and optimization using the clonal selection principle显示文摘 | De CASTRO L N Von ZUBEN F J | 2002 | IEEE Transactions on Evolutionary Computation2002，6，3： | 1 |
| 15 | Pro- posing new variables for the identification of strategic groups in franchising 显示文摘 | Rondan Cataluna F J Garcia A N Diez de Castro E C | 2007 | International Entrepreneurship and Man- agement Journal2007，3，4： | 1 |
| 16 | Artificial Immune Systems as a Novel Soft Computing Paradigm显示文摘 | L N de Castro Timmis J | 2003 | Soft Computing2003，7，8： | 1 |
| 17 | Learning and optimization using the clonal selection principle显示文摘 | De Castro L N Von Zuben F J | 2002 | IEEE Transactions on Evolutionary Computation2002，6，3： | 1 |
| 18 | Learning and Optimization Using the Clone Selection Prineiple显示文摘 | de Castro L N von Zuben F J | 2002 | IEEE Trans on Evolutionary Computation2002，6，3： | 1 |
| 19 | Studies on the density,heat capacity,surface tension and infinite dilution diffu-sion with the ionic liquids , , and 显示文摘 | de CASTRO C A N LANGA E MORAIS A L | 2010 | Fluid Phase Equilibria2010，294，12： | 1 |
| 20 | Does music perception have an impact on quality of life following cochlear implantation?显示文摘 | Luis Lassaletta Alejandro Castro Marta Bastarrica Rosa Pérez-Mora Rosario Madero Josefa De Sarriá Javier Gavilán | 2007 | Acta Oto-Laryngologica2007，，7： | 1 |
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