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| 1 | 急性缺血性卒中的机械取栓治疗:ESO、ESMINT、ESNR和EAN共同支持的2014/2015 ESO-卡罗林斯卡卒中更新会议共识声明显示文摘这份卒中后机械取栓治疗共识声明的原始版本于2014年11月16—18日在斯德哥尔摩召开的欧洲卒中组织(European Stroke Organisation, ESO)-卡罗林斯卡卒中更新会议期间得到批准。根据会议安排,在2015年利用新的临床试验数据对该声明进行了更新。2015年2月,在瑞士伯尔尼召开的ESO冬季培训会期间组织了面对面会议对共识声明进行修订,然后通过电子邮件交换意见,最终版本得到各学会的认可。推荐意见与原始版本一致,证据等级更新到2015年2月20日为止,在2015年5月15日获得确认。ESO-卡罗林斯卡卒中更新会议的目的在于总结卒中治疗研究的最新进展并探讨如何将这些最新研究结果应用于临床实践。共识会议选择了一些议题进行讨论,与会者草拟一份共识声明并进行讨论。该声明接受了ESO指南委员会的指导。这份共识声明包括对急性卒中后机械取栓治疗的推荐意见,得到欧洲卒中组织ESO、欧洲神经微创治疗学会(European Society of Minimally Invasive Neurological Therapy, ESMINT)、欧洲神经放射学学会(European Society of Neuroradiology, ESNR)和欧洲神经病学学会(European Academy of Neurology, EAN)的支持。 | Nils Wahlgren Tiago Moreira Patrik Michel Thorsten Steiner Olav Jansen Christophe Cognard Heinrich P Mattle Wim van Zwam Staffan Holmin Turgut Tatlisumak Jesper Petersson Valeria Caso Werner Hacke Mikael Mazighi Marcel Arnold Urs Fischer Istvan Szikora Laurent Pierot Jens Fiehler Jan Gralla Franz Fazekas Kennedy R Lees 高洁 徐格林 | 2016 | 国际脑血管病杂志2016，24，1： | 5 |
| 2 | Prevention of lactic acidosis due to metform in intox ication in contrastmedia nephropathy显示文摘 | Landewe-Cleuren S van Zwam W H de Bruin T W | 2000 | NedTudschr Geneeskd2000，144，40： | 1 |
| 3 | Surgical excision of CNS - draining lymph nodes reduces relapse severity in chronic -relapsing experimental autoimmune encephalomyelitis显示文摘 | van Zwam M Huizin R Heijmans N | 2009 | J Pathol2009，217，4： | 1 |
| 4 | The impact of resuscitated fecal peritonitis on the expression of the hepatic bile salt transporters in a porcine model显示文摘 | Wauters J Mesotten D van Zwam K | | 0，，05： | 1 |
| 5 | Reference frames fit for controlling pwm rectifiers显示文摘 | Duarte J L Zwam A V Wijnands C | 1999 | IEEE Transactions on Power Electronics1999，46，3： | 1 |
| 6 | Surgical excision of CNS-draining lymph nodes reduces relapse severity in chronic- relapsing experimental autoimmune encephalomyelitis 显示文摘 | van Zwam M Huizinga R Heijmans N | 2009 | J Pathol2009，217，4： | 1 |
| 7 | Reference frames fit for controlling PWM rectifiers显示文摘 | Duarte J L Van Zwam A Wijnands C | 1999 | IEEE Trans on Industrial Electronics1999，，46： | 1 |
| 8 | Prevention of lactic acidosis due to metform in intoxication in contrastmedia nephropathy 显示文摘 | Landewe-Cleuren S van Zwam W H de Bruin T W | 2000 | Ned Tudschr Geneeskd2000，144，40： | 1 |
| 9 | Prevention of lactic acidosis due to metformin intoxication in contrast media nephropathy显示文摘 | Landewe-Cleuren S van Zwam WH de Bruin TW | 2000 | Ned Tijdschr Geneeskd2000，144，40： | 1 |
| 10 | Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis显示文摘 | Boven L A Van Meurs M Van Zwam M | 2006 | Brain2006，129，2： | 1 |
| 11 | Mye- lin-laden macrophages are anti-inflammatory, consist- ent with foam cells in multiple sclerosis显示文摘 | Boven LA Van Meurs M Van Zwam M | 2006 | Brain2006，129，： | 1 |
| 12 | Endovascular treatment in anterior circulation stroke beyond 6.5 hours after onset or time last seen well:results from the MR CLEAN Registry显示文摘Background Randomised controlled trials with perfusion selection have shown benefit of endovascular treatment(EVT)for ischaemic stroke between 6 and 24 hours after symptom onset or time last seen well.However,outcomes after EVT in these late window patients without perfusion imaging are largely unknown.We assessed their characteristics and outcomes in routine clinical practice.Methods The Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry,a prospective,multicentre study in the Netherlands,included patients with an anterior circulation occlusion who underwent EVT between 2014 and 2017.CT perfusion was no standard imaging modality.We used adjusted ordinal logistic regression analysis to compare patients treated within versus beyond 6.5 hours after propensity score matching on age,prestroke modified Rankin Scale(mRS),National Institutes of Health Stroke Scale,Alberta Stroke Programme Early CT Score(ASPECTS),collateral status,location of occlusion and treatment with intravenous thrombolysis.Outcomes included 3-month mRS score,functional independence(defined as mRS 0-2),and death.Results Of 3264 patients who underwent EVT,106(3.2%)were treated beyond 6.5 hours(median 8.5,IQR 6.9-10.6),of whom 93(87.7%)had unknown time of stroke onset.CT perfusion was not performed in 87/106(80.2%)late window patients.Late window patients were younger(mean 67 vs 70 years,p<0.04)and had slightly lower ASPECTS(median 8 vs 9,p<0.01),but better collateral status(collateral score 2-3:68.3%vs 57.7%,p=0.03).No differences were observed in proportions of functional independence(43.3%vs 40.5%,p=0.57)or death(24.0%vs 28.9%,p=0.28).After matching,outcomes remained similar(adjusted common OR for 1 point improvement in mRS 1.04,95%CI 0.56 to 1.93).Conclusions Without the use of CT perfusion selection criteria,EVT in the 6.5-24-hour time window was not associated with poorer outcome in selected patients with favourable clinical and CT/CT angiography characteristics.randomised controlled trials with lenient inclusion criteria are needed to identify more patients who can benefit from EVT in the late window. | Luuk Dekker Esmee Venema F Anne V Pirson Charles B L M Majoie Bart J Emmer Ivo G H Jansen Maxim J H L Mulder Robin Lemmens Robert-Jan B Goldhoorn Marieke J H Wermer Jelis Boiten Geert J LycklamaàNijeholt Yvo B W E M Roos Adriaan C G M van Es Hester F Lingsma Diederik W J Dippel Wim H van Zwam Robert J van Oostenbrugge Ido R van den Wijngaard on behalf of the MR CLEAN Registry investigators | 2021 | Stroke & Vascular Neurology2021，6，4： | 1 |
| 13 | Myelin-laden macn~phages are anti-inflmnmatory,consistent with foam cells in multiple sclerosis 显示文摘 | Boven LA Van Meurs M Van Zwam M | 2006 | Brain2006，129，2： | 1 |
| 14 | Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE 显示文摘 | van Zwam M Huizinga R Mehef MJ | 2009 | J Mol Med(Berl)2009，87，3： | 1 |
| 15 | Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis显示文摘 | Boven LA Van Meurs M Van Zwam M | 2006 | Brain2006，129，2： | 1 |
| 16 | Prevention of lactic acidosis due to metform in intoxication in contrastmedia nephropathy显示文摘 | Landewe-Cleuren S van Zwam WH de Bruin TW | | 0，，40： | 1 |
| 17 | The Impact of Resuscitated Fecal Peritonitis on the Expression of the Hepatic Bile Salt Transporters in a Porcine Model显示文摘 | Joost Wauters Dieter Mesotten Kenny Van Zwam Jos van Pelt Steven Thiessen Anne-Sophie Dieudonné Sara Vander Borght Greet Van den Berghe Alexander Wilmer | 2010 | Shock2010，，： | 1 |
| 18 | Efficacy of laser punctual occlusion显示文摘 | Zwam J | 1997 | Ophthalmic Surg Lasers1997，28，： | 1 |
| 19 | 多项卒中血管内治疗试验高效再灌注评价工作组答疑:急性缺血性卒中血管内治疗的疑问显示文摘2015年NEJM发表了5项急性缺血性卒中血管内治疗的临床试验,都取得了很好的结果,奠定了支架取栓治疗在急性缺血性卒中的地位。但是,临床上的很多有关急性缺血性卒中血管内治疗的疑问仍然存在,比如以下情况血管内治疗的价值:治疗延迟、老年患者、症状较轻、不适合静脉溶栓等。 | 杨中华 Goyal M Menon BK van Zwam WH | 2017 | 中国卒中杂志2017，12，1： | 1 |
| 20 | Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE显示文摘Drainage of central nervous system(CNS) antigens to the brain-draining cervical lymph nodes(CLN) is likely crucial in the initiation and control of autoimmune responses during multiple sclerosis(MS). We demonstrate neuronal antigens within CLN of MS patients. In monkeys and mice with experimental autoimmune encephalomyelitis(EAE) and in mouse models with non-inflammatory CNS damage, the type and extent of CNS damage was associated with the frequencies of CNS antigens within the cervical lymph nodes. In addition, CNS antigens drained to the spinal-cord-draining lumbar lymph nodes. In human MS CLN, neuronal antigens were present in pro-inflammatory antigen-presenting cells(APC), whereas the majority of myelincontaining cells were anti-inflammatory. This may reflect a different origin of the cells or different drainage mechanisms. Indeed, neuronal antigen-containing cells in human CLN did not express the lymph node homing receptor CCR7, whereas myelin antigen-containing cells in situ and in vitro did. Nevertheless, CLN from EAE-affected CCR7-deficient mice contained equal amounts of myelin and neuronal antigens as wild-type mice. We conclude that the type and frequencies of CNS antigens within the CLN are determined by the type and extent of CNS damage. Furthermore, the presence of myelin and neuronal antigens in functionally distinct APC populations within MS CLN suggests that differential immune responses can be evoked. | Marloes van Zwam Ruth Huizinga Marie-José Melief Annet F.Wierenga-Wolf Marjan van Meurs Jane S.Voerman Knut P.H.Biber Hendrikus W.G.M.Boddeke Uta E.Hopken Christian Meisel Andreas Meisel Ingo Bechmann Rogier Q.Hintzen Bert A.‘t Hart Sandra Amor Jon D.Laman Leonie A.Boven | 2016 | 世界最新医学信息文摘2016，16，11： | 0 |
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