|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutants显示文摘Epidermal growth factor receptor(EGFR) controls a wide range of cellular processes, and aberrant EGFR signaling as a result of receptor overexpression and/or mutation occurs in many types of cancer. Tumor cells in non-small cell lung cancer(NSCLC) patients that harbor EGFR kinase domain mutations exhibit oncogene addiction to mutant EGFR, which confers high sensitivity to tyrosine kinase inhibitors(TKIs). As patients invariably develop resistance to TKIs, it is important to delineate the cell biological basis of mutant EGFR-induced cellular transformation since components of these pathways can serve as alternate therapeutic targets to preempt or overcome resistance. NSCLC-associated EGFR mutants are constitutively-active and induce ligandindependent transformation in nonmalignant cell lines. Emerging data suggest that a number of factors are critical for the mutant EGFR-dependent tumorigenicity, and bypassing the effects of TKIs on these pathways promotes drug resistance. For example, activation of downstream pathways such as Akt, Erk, STAT3 and Src is critical for mutant EGFR-mediated biological processes. It is now well-established that the potency and spatiotemporal features of cellular signaling by receptor tyrosine kinases such as EGFR, as well as the specific pathways activated, is determined by the nature of endocytic traffic pathways through which the active receptors traverse. Recent evidence indicates that NSCLCassociated mutant EGFRs exhibit altered endocytic trafficking and they exhibit reduced Cbl ubiquitin ligasemediated lysosomal downregulation. More recent work has shown that mutant EGFRs undergo ligand-independent traffic into the endocytic recycling compartment, a behavior that plays a key role in Src pathway activation and oncogenesis. These studies are beginning to delineate the close nexus between signaling and endocytic traffic of EGFR mutants as a key driver of oncogenicprocesses. Therefore, in this review, we will discuss the links between mutant EGFR signaling and endocytic properties, and introduce potential mechanisms by which altered endocytic properties of mutant EGFRs may alter signaling and vice versa as well as their implications for NSCLC therapy. | Byung Min Chung Eric Tom Neha Zutshi Timothy Alan Bielecki Vimla Band Hamid Band | 2014 | World Journal of Clinical Oncology2014，5，5： | 3 |
| 2 | Adoption and maintenance of environmental management systems critical success factors显示文摘 | Zutshi A and Sohal A S | 2004 | Management of Environmental Quality: An International Journal2004，15，4： | 1 |
| 3 | Randomized controlled trial comparing the controlled rehabilitation with early ambulation and diet pathway versus the controlled rehabilitation with early ambulation and diet with preemptive epidural anesthesia/analgesia after laparotomy and intestinal resection显示文摘 | Zutshi M Delaney CP Senagore A J | 2005 | Am J Surg2005，189，3： | 1 |
| 4 | Tardive dystonia and zipr'asidone: a case report 显示文摘 | Tibrewal P Zutshi A Math SB | 2008 | Prim Care Companion J Clin Psychiatry2008，0，1： | 1 |
| 5 | Surgery for slow transit con- stipation: are we helping patients? 显示文摘 | Zutshi M Hull T L Trzcinski R | 2007 | Int J Colorectal Dis2007，22，3： | 1 |
| 6 | Adoption and maintenance of environ- mental management systems:critical success factors显示文摘 | Zutshi A Sohal A S | 2004 | Management of Environmental Quality:An International Journal2004，15，4： | 1 |
| 7 | Surgery for slow transit constipation: are we helping patients? 显示文摘 | Zutshi M Hull TL Trzcinski R | 2007 | Int J Colorectal Dis2007，22，3： | 1 |
| 8 | A randomized multicenter trial to compare long-term functional outcome,quality of life,and complications of surgical procedures for low rectal cancers显示文摘 | Fazio VW Zutshi M Remzi FH | 2007 | Ann Surg2007，246，3： | 1 |
| 9 | Corporate social responsibility : why business should act re- sponsibly and be accountable显示文摘 | Zutshi A C | 2004 | Australian Accounting Review2004，，3： | 1 |
| 10 | Martius Flap Repair for Complex Rectovaginal Fistula显示文摘 | Cindy Kin Brooke Gurland Massarat Zutshi Tracy Hull Th. Krummel F. Remzi | 2012 | Polish Journal of Surgery2012，，11： | 1 |
| 11 | Piperine modulates permeability characteristics of intestine by including alterations in membrane dynamics:influence on brush border membrane fluidity,ultrastructure and enzyme kinetics显示文摘 | KHANJURIA A THUSU N ZUTSHI U | 2002 | Phytomedicine2002，9，： | 1 |
| 12 | Effect of heavy metal stress on proline, malondialdehyde, and superoxide dismutase activity in the cyanobacterium Spirulina platensis -S5显示文摘 | Meenakshi Choudhary Umesh Kumar Jetley Mohammed Abash Khan Sunaina Zutshi Tasneem Fatma | 2006 | Ecotoxicology and Environmental Safety2006，，2： | 1 |
| 13 | Singapore Venture Capitalists (VCs) Investment Evaluation Criteria: A Re-Examination显示文摘 | Ravinder K. Zutshi Wee Liang Tan Dattatreya G. Allampalli Patrick G. Gibbons | 1999 | Small Business Economics1999，，1： | 1 |
| 14 | Effects of Sphincterotomy and Pudendal Nerve Transection on the Anal Sphincter in a Rat Model显示文摘 | Zutshi M Salcedo LB Zaszczurynski PJ et ol | 2009 | Dis Colon Rectum2009，52，7： | 1 |
| 15 | Chromium (VI) induced oxidative stress in Hapalosiphon fontinalis 显示文摘 | Bano F Zutshi S Fatma T | 2012 | World Journal of Microbiology and Biotechnology2012，28，7： | 1 |
| 16 | Effects of sphincterotomy and pudendal nerve transection on the anal sphincter in a rat model显示文摘 | Zutshi M Salcedo LB Zaszczurynski PJ | 2009 | Dis Colon Rectum2009，52，7： | 1 |
| 17 | Processing, Microstructure, and Wear Behavior of Silicon Nitride Hot-Pressed with Alumina and Yttria 显示文摘 | Zutshi A Haber R A Niesz D E | 1994 | Journal of the American Ceramic Society1994，77，： | 1 |
| 18 | Prospective,randomized,controlled trial between a pathway of controlled rehabilitation with early ambulation and diet and traditional postoperative care after laparotomy and intestinal resection显示文摘 | Delaney CP Zutshi M Senagore AJ | 2003 | Dis Colon Rectum2003，46，7： | 1 |
| 19 | Surgery for slow transit constipation: are we helping patients显示文摘 | Zutshi M Hull T L Trzcinski R | 2007 | Int J Colorectal Dis2007，22，3： | 1 |
| 20 | Surgery for slow transit constipation:are we helping patients显示文摘 | Zutshi M Hull TL Trzcinski R | 2007 | Int J Colorectal Dis2007，22，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员