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| 1 | Comparative study of esomeprazole and lansoprazole in triple therapy for eradication of Helicobacter pylori in Japan显示文摘AIM:To evaluate the efficacy and safety of esomeprazole-based triple therapy compared with lansoprazole therapy as first-line eradication therapy for patients with Helicobacter pylori(H.pylori)in usual post-marketing use in Japan,where the clarithromycin(CAM)resistance rate is 30%.METHODS:For this multicenter,randomized,openlabel,non-inferiority trial,we recruited patients(≥20years of age)with H.pylori infection from 20 hospitals in Japan.We randomly allocated patients to esomeprazole therapy(esomeprazole 20 mg,CAM 400 mg,amoxicillin(AC)750 mg for the first 7 d,with all drugs given twice daily)or lansoprazole therapy(lansoprazole30 mg,CAM 400 mg,AC 750 mg for the first 7 d,with all drugs given twice daily)using a minimization method with age,sex,and institution as adjustment factors.Our primary outcome was the eradication rate by intention-to-treat(ITT)and per-protocol(PP)analyses.H.pylori eradication was confirmed by a urea breath test from 4 to 8 wk after cessation of therapy.RESULTS:ITT analysis revealed the eradication rates of 69.4%(95%CI:61.2%-76.6%)for esomeprazole therapy and 73.9%(95%CI:65.9%-80.6%)for lansoprazole therapy(P=0.4982).PP analysis showed eradication rate of 76.9%(95%CI:68.6%-83.5%)for esomeprazole therapy and 79.8%(95%CI:71.9%-86.0%)for lansoprazole therapy(P=0.6423).There were no differences in adverse effects between the two therapies.CONCLUSION:Esomeprazole showed non-inferiority and safety in a 7 day-triple therapy for eradication of H.pylori compared with lansoprazole. | Tsutomu Nishida Masahiko Tsujii Hirohisa Tanimura Shusaku Tsutsui Shingo Tsuji Akira Takeda Atsuo Inoue Hiroyuki Fukui Toshiyuki Yoshio Osamu Kishida Hiroyuki Ogawa Masahide Oshita Ichizo Kobayashi Shinichiro Zushi Makoto Ichiba Naoto Uenoyama Yuichi Yasunaga Ryu Ishihara Mamoru Yura Masato Komori Satoshi Egawa Hideki Iijima Tetsuo Takehara | 2014 | World Journal of Gastroenterology2014，20，15： | 13 |
| 2 | Percutaneous endoscopic gastrostomy under steadypressure automatically controlled endoscopy:First clinicalseries显示文摘AIM: To elucidate the safety of percutaneous endoscopic gastrostomy(PEG) under steady pressure automatically controlled endoscopy(SPACE) using carbon dioxide(CO_2).METHODS: Nine patients underwent PEG with a modified introducer method under conscious sedation. A T-tube was attached to the channel of an endoscope connected to an automatic surgical insufflator. The stomach was inflated under the SPACE system. The intragastric pressure was kept between 4-8 mmH g with a flow of CO_2 at 35 L/min. Median procedure time, intragastric pressure, median systolic blood pressure, partial pressure of CO_2, abdominal girth before and immediately after PEG, and free gas and small intestinal gas on abdominal X-ray before and after PEG were recorded. RESULTS: PEG was completed under stable pneumostomach in all patients, with a median procedural time of 22 min. Median intragastric pressure was 6.9 mmH g and median arterial CO_2 pressure before and after PEG was 42.1 and 45.5 Torr(NS). The median abdominal girth before and after PEG was 68.1 and 69.6 cm(NS). A mild free gas image after PEG was observed in two patients, and faint abdominal gas in the downstream bowel was documented in two patients.CONCLUSION: SPACE might enable standardized pneumostomach and modified introducer procedure of PEG. | Hiroyuki Imaeda Kiyokazu Nakajima Naoki Hosoe Masanori Nakahara Shinichiro Zushi Motohiko Kato Kazuhiro Kashiwagi Yasushi Matsumoto Kayoko Kimura Rieko Nakamura Norihito Wada Masahiko Tsujii Naohisa Yahagi Toshifumi Hibi Takanori Kanai Tetsuo Takehara Haruhiko Ogata | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，3： | 2 |
| 3 | Flexible sheet with radiophotolu- minescence glass beads for remotely monitoring high beta - surface - contamination显示文摘 | Zushi N Sato F Kato Y | 2014 | Radiat Meas2014，71，： | 1 |
| 4 | Identification and distribution of antbocyanins in strawberry cultivars 显示文摘 | Kawanobu S Yamaguchi MA Zushi K | 2011 | Journal of Food Agriculture & Environment2011，9，1： | 1 |
| 5 | Measurement of beta - radioac- tivity distribution in soil by use of fiber - type radiophotolumines- cence glass dosimeter显示文摘 | Zushi N Ikeda Y Sato F | 2013 | Radiat Meas2013，55，： | 1 |
| 6 | STAT3 mediates the survival signal in oncogenic ras-transfected intestinal epithelial cells显示文摘 | Zushi S Shinomura Y KiyoharaT | 1998 | Int J Cancer1998，78，3： | 1 |
| 7 | GIS-based source identification and apportionment of diffuse water pollution : Perfluorinated compound pollution in the Tokyo Bay basin 显示文摘 | Zushi Y Masunaga S | 2011 | Chemosphere2011，85，8： | 1 |
| 8 | Effect of soil water defieit on vitamin C, sugar, ogranic acid, amino acid and carotene contents of large-fruit tomato显示文摘 | Zushi K Matsuzoe N | 1998 | J JaPan Soe Hort Sci1998，67，： | 1 |
| 9 | Spatially Detailed Survey on Pollution by Multiple Pcffluorinated Compounds in the Tokyo Bay Basin of Japan显示文摘 | Zushi Y Ye F Motegi M | 2011 | Environmental Science & Technology2011，45，7： | 1 |
| 10 | Establishment of nude mouse transplantable model of a human adenoid cystic carcinoma of the oral floor showing metastasis to the lymph node and lung显示文摘 | Hashitani S Urade M Zushi Y | 2007 | Oncol Rep2007，17，： | 1 |
| 11 | Developmental and tissue-specific changes in oxidative parameters and antioxidant systems in tomato fruits grown under salt stress显示文摘 | Zushi K Matsuzoe N Kitano M | 2009 | Sci Hortic2009，122，3： | 1 |
| 12 | Effect of soil water deficit on vitamin C, suger, organic acid, amino acid and carotene contents of large-fruited tomatoes 显示文摘 | ZUSHI K MALSUZOE N | 1998 | J Japan Soc SCI1998，67，： | 1 |
| 13 | Induction of hy- pertrophic chondrocyte-like phenotypes by oxidized LDL in cultured bovine articular chondrocytes through in- crease in oxidative stress显示文摘 | Kishimoto H Akagi M Zushi S | 2010 | Osteoarthritis Cartilage2010，18，10： | 1 |
| 14 | Establishment of nude mouse transplantable model of a human adenoid cystic carcinoma of the oral floor showing metastasis to the lymph node and lung显示文摘 | Hashitani S Urade M Zushi Y | 2007 | Oncol Rep2007，17，1： | 1 |
| 15 | Molecular dynamics of Aurora- A kinase in living mitotic cells simultaneously visualized with histone h3 and nuclear membrane protein importinalpha 显示文摘 | Sugimoto K Urano T Zushi H | 2002 | Cell Struct Funct2002，27，6： | 1 |
| 16 | Role of heparin-binding EGF-related peptides in proliferation and apoptosis of activated ras-stimulated intestinal epithelial cells显示文摘 | Zushi S Shinomura Y Kiyohara T | 1997 | Int J Cancer1997，73，6： | 1 |
| 17 | Study on growth of Sabina vulgaris under long term water stress显示文摘 | Wen G S Zushi M Sakamoto K | 2000 | J Jpn Soc Reveget Tech2000，25，3： | 1 |
| 18 | First flush loads of perfluorinated compounds in storm wa- ter runoff from hayabuchi river basin, Ja- pan served by separated sewerage system 显示文摘 | Zushi Y Masunaga S | 2009 | Chemosphere2009，76，： | 1 |
| 19 | Effect of soil water deficit on Vitamin C,sugar, organic acid, amino acid and carotene contents of large-fruited tomatoes 显示文摘 | Zushi K Matsuzoe N | 1998 | Japan Soc Hort Sci1998，67，6： | 1 |
| 20 | Utilization of correlation network analysis to identify differences in sensory attributes and organoleptic compositions of tomato eultivars grown under salt stress 显示文摘 | Zushi Kazufumi Matsuzoe Naotaka | 2011 | Scientia Horticulturae2011，129，1： | 1 |
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