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		题名	作者	年代	出处	被引量
	1	The Reduction in Colorectal Cancer Mortality After Colonoscopy Varies by Site of the Cancer显示文摘	Harminder Singh Zoann Nugent Alain A. Demers Erich V. Kliewer Salaheddin M. Mahmud Charles N. Bernstein	2010	Gastroenterology2010，，4：	7
	2	Increased Risk of Nonmelanoma Skin Cancers Among Individuals With Inflammatory Bowel Disease显示文摘	Harminder Singh Zoann Nugent Alain A. Demers Charles N. Bernstein	2011	Gastroenterology2011，，5：	1
	3	Risk of Cervical Abnormalities in Women With Inflammatory Bowel Disease: A Population-Based Nested Case-Control Study显示文摘	Harminder Singh Alain A. Demers Zoann Nugent Salaheddin M. Mahmud Erich V. Kliewer Charles N. Bernstein	2009	Gastroenterology2009，，2：	1
	4	Nuclear TIGAR mediates an epigenetic and metabolic autoregulatory loop via NRF2 in cancer therapeutic resistance显示文摘Metabolic and epigenetic reprogramming play important roles in cancer therapeutic resistance.However,their interplays are poorly understood.We report here that elevated TIGAR(TP53-induced glycolysis and apoptosis regulator),an antioxidant and glucose metabolic regulator and a target of oncogenic histone methyltransferase NSD2(nuclear receptor binding SET domain protein 2),is mainly localized in the nucleus of therapeutic resistant tumor cells where it stimulates NSD2 expression and elevates global H3K36me2 mark.Mechanistically,TIGAR directly interacts with the antioxidant master regulator NRF2 and facilitates chromatin recruitment of NRF2,H3K4me3 methylase MLL1 and elongating Pol-II to stimulate the expression of both new(NSD2)and established(NQO1/2,PRDX1 and GSTM4)targets of NRF2,independent of its enzymatic activity.Nuclear TIGAR confers cancer cell resistance to chemotherapy and hormonal therapy in vitro and in tumors through effective maintenance of redox homeostasis.In addition,nuclear accumulation of TIGAR is positively associated with NSD2 expression in clinical tumors and strongly correlated with poor survival.These findings define a nuclear TIGAR-mediated epigenetic autoregulatory loop in redox rebalance for tumor therapeutic resistance.	Hong Wang Qianqian Wang Guodi Cai Zhijian Duan Zoann Nugent Jie Huang Jianwei Zheng Alexander D.Borowsky Jian Jian Li Peiqing Liu Hsing-Jien Kung Leigh Murphy Hong-Wu Chen Junjian Wang	2022	Acta Pharmaceutica Sinica B2022，12，4：	1
	5	Association Between Spring Season of Birth and Crohn’s Disease显示文摘	Souradet Y. Shaw Zoann Nugent Laura E. Targownik Harminder Singh James F. Blanchard Charles N. Bernstein	2014	Clinical Gastroenterology and Hepatology2014，，：	1
	6	Outcomes of Patients With Crohn’s Disease Improved From 1988 to 2008 and Were Associated With Increased Specialist Care显示文摘	Geoffrey C. Nguyen Zoann Nugent Souradet Shaw Charles N. Bernstein	2011	Gastroenterology2011，，1：	1
	7	Pathological reassessment of hyperplastic colon polyps in a city-wide pathology practice: implications for polyp surveillance recommendations显示文摘	Harminder Singh Diane Bay Stephen Ip Charles N. Bernstein Zoann Nugent Rodica Gheorghe Robert Wightman	2012	Gastrointestinal Endoscopy2012，，5：	1
	8	Outcomes of Patients With Crohn’s Disease Improved From 1988 to 2008 and Were Associated With Increased Specialist Care显示文摘	Geoffrey C. Nguyen Zoann Nugent Souradet Shaw Charles N. Bernstein	2011	Gastroenterology2011，，1：	1
	9	Inflammatory bowel disease and the risk of fracture after controlling for FRAX显示文摘	Laura E Targownik Charles N Bernstein Zoann Nugent Helena Johansson Anders Oden Eugene McCloskey John A Kanis William D Leslie	2013	J Bone Miner Res2013，，5：	1

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