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| 1 | A review of Leishmaniasis in Eastern Africa显示文摘The review presents the epidemiology of leishmaniasis in the Eastern Africa region. We searched PUB MED and MEDLINE with several key words-namely,'leishmaniasis';'cutaneous','diffuse cutaneous','mucosal', and'visceral leishmaniasis'; 'kala azar'and 'post kala azar dermal leishmaniasis'-for recent clinical and basic science articles related to leishmaniasis in countries in the Eastern Africa region. Poverty, wars, conflicts and migration have significantly aggravated leishmaniases in Eastern Africa. Of particular concern is the increasing incidence of Leishmania-HIV co-infection in Ethiopia where 20~40% of the persons affected by visceral leishmaniasis are HIV-co-infected. Sudan has the highest prevalence rate of post kala-azar dermal leishmaniasis(PKDL) in the world, a skin complication of visceral leishmaniasis(VL) that mainly afflicts children below age ten. In view of its spread to previously non-endemic areas and an increase in imported cases, leishmaniasis in Eastern Africa should be considered a health emergency. | Peter K.Ngure Albert Kimutai Zipporah W.Ng'ang'a Geoffrey Rukunga Willy K.Tonui | 2009 | Journal of Nanjing Medical University2009，23，2： | 2 |
| 2 | Spatio–Temporal Dynamics of Wetland Landscape Patterns Based on Remote Sensing in Yellow River Delta, China显示文摘 | Guilin Liu Luocheng Zhang Qian Zhang Zipporah Musyimi Qinghu Jiang | 2014 | Wetlands2014，，4： | 1 |
| 3 | Isolation of Trypanosoma brucei from the monitor lizard ( Varanus niloticus ) in an endemic focus of rhodesian sleeping sickness in Kenya显示文摘 | Zipporah Njagu Steve Mihok Elizabeth Kokwaro Didier Verloo | 1999 | Acta Tropica1999，，2： | 1 |
| 4 | Improving access to analgesic drugs for patients with cancer in sub-Saharan Africa显示文摘 | Megan O’Brien Faith Mwangi-Powell Isaac F Adewole Olaitan Soyannwo Jacinto Amandua Elizabeth Ogaja Mary Okpeseyi Zipporah Ali Rose Kiwanuka Anne Merriman | 2013 | Lancet Oncology2013，，4： | 1 |
| 5 | Epigenetic regulation−The guardian of cellular homeostasis and lineage commitment显示文摘Stem cells constitute the source of cells that replenishes the worn out or damaged cells in our tissue and enable the tissue to carry out the destined function.Tissue-specific stem cells are compartmentalized in a niche,which keeps the stem cells under quiescent condition.Thus,understanding the molecular events driving the successful differentiation of stem cells into several lineages is essential for its better manipulation of human applications.Given the developmental aspects of the cell,the cellular function is greatly dependent on the epigenomics signature that in turn governs the expression profile of the cell.The stable inheritance of the epigenome is crucial for the development,modulation,and maintenance of the cell and its complex tissue-specific function.Emerging evidence suggesting that stem cell chromatin comprises a specialized state in which self-renewing genes and its downstream lineage-specific genes are kept paralleled poised for activation.Thus,the epigenetic regulatory network and pathway dictate lineage commitment and differentiation.It mainly modifies the chromatin landscape to facilitate euchromatin and heterochromatin architecture,which in turn alters the accessibility of transcription factors to the gene loci.DNA methylation and histone marks are the two widely studied epigenetic modifications regulating the transcriptome profile of a specific lineage.Abnormalities in the epigenetic landscape lead to diseases or disorders.Here,we emphasize the prominence of the epigenetic network and its regulation in normal tissue functioning and in the diseased state.Furthermore,we highlighted the emerging role of epigenetic modifiers in lineage differentiation and epigenetic markers as novel druggable targets for cancer therapy. | KAVITHA GOVARTHANAN PIYUSH K UMAR GUPTA BINITA ZIPPORAHE REKHA GAHTORI SOUMYA PANDIT RAM PRASAD | 2021 | BIOCELL2021，45，3： | 0 |
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