|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prognostic significance of combining high mobility group Box-1 and OV-6 expression in hepatocellular carcinoma显示文摘The inflammatory environment and existence of cancer stem cells are critical for progression and intrahepatic recurrence of hepatocellular carcinoma(HCC) after curative resections. Here, we investigated the prognostic significance of combining high mobility group box 1(HMGB1) expression and hepatic progenitor marker OV6 in hepatocellular carcinoma. Expression of HMGB1 and OV6 was evaluated using immunohistochemistry profiling in tissue microarrays containing samples from 208 HCC patients. Invasive clinical or pathological factors were found in patients with high expression of HMGB1 or OV6. Higher HMGB1 was associated with poorer clinical outcomes, and independently related to elevated 5-year recurrence incidence(85.5% vs. 62.4%, P<0.001). We also found that more OV6 positive staining was correlated with poor prognosis of HCC patients(P<0.001). Notably, expression of HMGB1 was positively correlated with OV6 in density(R2=0.032, P<0.001) and reversely related to HCC outcomes. Abnormal expression of HMGB1 in combination with positive staining of OV6 displayed poorer prognostic performance than single biomarker alone(area under curve(AUC) survival=0.696). Therefore, HMGB1 and OV6 positive staining are promising prognostic parameters for HCC, and we propose that HMGB1 and OV6 may cooperate with each other and predict poor prognosis of HCC. | Jihui Zhu Han Yu Shuzhen Chen Pinghua Yang Zihui Dong Yan Ling Hao Tang Shilei Bai Wen Yang Liang Tang Feng Shen Hongyang Wang Wen Wen | 2018 | Science China(Life Sciences)2018，61，8： | 4 |
| 2 | Exome sequencing reveals genetic architecture in patients with isolated or syndromic short stature显示文摘Short stature is among the most common endocrinological disease phenotypes of childhood and may occur as an isolated finding or in conjunction with other clinical manifestations.Although the diagnostic utility of clinical genetic testing in short stature has been implicated,the genetic architecture and the utility of genomic studies such as exome sequencing(ES)in a sizable cohort of patients with short stature have not been investigated systematically.In this study,we recruited 561 individuals with short stature from two centers in China during a 4-year period.We performed ES for all patients and available parents.All patients were retrospectively divided into two groups:an isolated short stature group(group I,n=257)and an apparently syndromic short stature group(group II,n=304).Causal variants were identified in 135 of 561(24.1%)patients.In group I,29 of 257(11.3%)of the patients were solved by variants in 24 genes.In group II,106 of 304(34.9%)patients were solved by variants in 57 genes.Genes involved in fundamental cellularprocess played an important role in the genetic architecture of syndromic short stature.Distinct genetic architectures and pathophysiological processes underlie isolated and syndromic short stature. | Xin Fan Sen Zhao Chenxi Yu Di Wu Zihui Yan Lijun Fan Yanning Song Yi Wang Chuan Li Yue Ming Baoheng Gui Yuchen Niu Xiaoxin Li Xinzhuang Yang Shiyu Luo Qiang Zhang Xiuli Zhao Hui Pan Mei Li Weibo Xia Guixing Qiu Pengfei Liu Shuyang Zhang Jianguo Zhang Zhihong Wu James R.Lupski Jennifer E.Posey Shaoke Chen Chunxiu Gong Nan Wu | 2021 | Journal of Genetics and Genomics2021，48，5： | 2 |
| 3 | PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy显示文摘 | Jing Tan Zhimei Li Puay Leng Lee Peiyong Guan Mei Yee Aau Shuet Theng Lee Min Feng Cheryl Zihui Lim Eric Yong Jing Lee Zhen Ning Wee Yaw Chyn Lim R.K. Murthy Karuturi Qiang Yu | 2013 | Cancer Discovery2013，，10： | 1 |
| 4 | Viscoelastic micromechanical modeling of free edge and time effects in glass fiber/epoxy cross-ply laminates显示文摘 | Fernand Ellyin Zihui Xia Yu Chen | 2002 | Composites2002，33，： | 1 |
| 5 | Viscoelastic micromechanical modeling of free edge and time effects in glass fiber/epoxy cross-ply laminates显示文摘 | Fernand Ellyin Xia Zihui Chen Yu | 2002 | Composite: Part A2002，33，3： | 1 |
| 6 | A meso/micro-mechanical model for damage progression in glass fiber/epoxy cross-ply laminates by finite element analysis显示文摘 | Xia Zihui Yu Chen Fernand E | 2000 | Composites Science and Technology2000，60，8： | 1 |
| 7 | FTO stabilizes MIS12 and counteracts senescence显示文摘Dear Editor, N6-methyladenosine(m6A)is an abundant epitranscriptomic modification that regulates messenger RNA(mRNA)biology.The m6A modification regulates mRNA splicing,transport,stability,and translation through coordinated activities by methyltransferases(writers),binding proteins(readers),and demethylases(erasers)(Huang et al.,2020;Wu et al.,2020).Among m6A regulators,fat mass of obesity-associ-ated protein(FTO),is the first discovered eraser with RNA m6A demethylation activity(Jia et al.,2011).Since then,FTO has been reported to play m6A-dependent roles in a variety of physiological processes including adipogenesis,neuro-genesis and tumorigenesis(Fischer et al.,2009;Li et al.,2017;Huang et al.,2020).Consequently,FTO deficiency in mice leads to dramatic phenotypes,such as decreased fat mass and impaired brain development(Fischer et al.,2009;Li et al.,2017).Similarly,inhibition of FTO reduces tumori-genesis in multiple types of cancer models,while FTO is highly expressed in many cancers(Huang et al.,2020). | Sheng Zhang Zeming Wu Yue Shi Si Wang Jie Ren Zihui Yu Daoyuan Huang Kaowen Yan Yifang He Xiaoqian Liu Qianzhao Ji Beibei Liu Zunpeng Liu Jing Qu Guang-Hui Liu Weimin Ci Xiaoqun Wang Weiqi Zhang | 2022 | Protein & Cell2022，13，12： | 0 |
| 8 | Quantitative characterization of filamentous fungal promoters on a single-cell resolution to discover cryptic natural products显示文摘Characterization of filamentous fungal regulatory elements remains challenging because of time-consuming transformation technologies and limited quantitative methods.Here we established a method for quantitative assessment of filamentous fungal promoters based on flow cytometry detection of the superfolder green fluorescent protein at single-cell resolution.Using this quantitative method,we acquired a library of 93 native promoter elements from Aspergillus nidulans in a high-throughput format.The strengths of identified promoters covered a 37-fold range by flow cytometry.P_(zipA) and P_(sltA)were identified as the strongest promoters,which were 2.9-and 1.5-fold higher than that of the commonly used constitutive promoter P_(gpdA).Thus,we applied P_(zipA)and P_(sltA)to activate the silent nonribosomal peptide synthetase gene Afpes1 from Aspergillus fumigatus in its native host and the heterologous host A.nidulans.The metabolic products of Afpes1 were identified as new cyclic tetrapeptide derivatives,namely,fumiganins A and B.Our method provides an innovative strategy for natural product discovery in fungi. | Peng-Lin Wei Jie Fan Jingwen Yu Zihui Ma Xian Guo Nancy PKeller Erwei Li Chunbo Lou Wen-Bing Yin | 2023 | Science China(Life Sciences)2023，66，4： | 0 |
| 9 | Asymmetry of Salinity Variability in the Tropical Pacific during Interdecadal Pacific Oscillation Phases显示文摘It has been recognized that salinity variability in the tropical Pacific is closely related to the Interdecadal Pacific Oscillation(IPO).Here,we use model simulations from 1900 to 2017 to illustrate obvious asymmetries of salinity variability in the tropical Pacific during positive and negative IPO phases.The amplitude of salinity variability in the tropical Pacific during positive IPO phases is larger than that during negative IPO phases,with a more westward shift of a large Sea Surface Salinity(SSS)anomaly along the equator.Salinity budget analyses show that the asymmetry of salinity variability during positive and negative IPO phases is dominated by the difference in the surface forcing associated with the freshwater flux[FWF,precipitation(P)minus evaporation(E)],with a contribution of 40%–50%near the dateline on the equator.Moreover,the relationships between the salinity variability and its budget terms also show differences in their leadlag correlations during positive and negative IPO phases.These differences in salinity variability during different IPO phases produce asymmetric effects on seawater density which can reduce or enhance upper-ocean stratification.Therefore,the salinity effects may modulate the intensity of El Nino-Southern Oscillation(ENSO),resulting in an enhanced(reduced)El Nino but a reduced(enhanced)La Ni?a during positive(negative)IPO phases by 1.6℃psu^(-1)(1.3℃psu^(-1)),respectively.It is suggested that the asymmetry of salinity variability may be related to the recent change in ENSO amplitude associated with the IPO,which can help elucidate ENSO diversity. | Hai ZHI Zihui YANG Rong-Hua ZHANG Pengfei LIN Jifeng QI Yu HUANG Meng DONG | 2023 | Advances in Atmospheric Sciences2023，40，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员