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| 1 | 肝纤维化中西医结合诊疗指南显示文摘 | Zhong Xi Yi Jie He Xue Bao Chinese Association of Integrative Medicine, Liver Disease Committee | 2006 | 中西医结合学报2006，4，6： | 29 |
| 2 | Postoperative adjuvant antiviral therapy for hepatitis B/C virus-related hepatocellular carcinoma:A meta-analysis显示文摘AIM:To investigate the impact of postoperative antiviral treatment on tumor recurrence and survival of patients with chronic hepatitis B virus(HBV) or hepatitis C virus(HCV) infection-related primary hepatocellular carcinoma(HCC) after curative therapy.METHODS:We performed a meta-analysis of randomized and non-randomized control trials from electronic search and manual search.The fixed effect model of Mantel-Haenszel method and the random effect model of Der Simonian and Laird method were used for homogeneous and heterogeneous studies,respectively.Seven HCV-related studies,three HBV-related studies and three studies on HBV or HCV-related HCC were identified.RESULTS:A total of 1224 patients were included in this analysis.The estimated odds ratios(OR) for the 1-,2-,3-and 5-year recurrence were 0.54 [15.4% vs 24.1%,95% confidence interval(CI):0.32-0.89,P=0.02],0.42(36.9% vs 58.0%,95% CI:0.19-0.90,P=0.03),0.37(47.9% vs 63.8%,95% CI:0.19-0.71,P=0.003),and 0.32(66.7% vs 74.3%,95% CI:0.15-0.66,P=0.002),respectively;and the OR for the 1-,2-,3-,5-and 7-year mortality were 0.23(1.2% vs 9.1%,95% CI:0.07-0.71,P=0.01),0.31(6.4% vs 22.1%,95% CI:0.12-0.79,P=0.01),0.43(12.7% vs 20.8%,95% CI:0.21-0.89,P=0.02),0.42(25.1% vs 42.0%,95% CI:0.27-0.66,P=0.0002) and 0.28(31.9% vs 52.2%,95% CI:0.13-0.59,P=0.0008).CONCLUSION:This meta-analysis indicates the postoperative antiviral therapy,interferon in particular,may serve as a favorable alternative to reduce recurrence and mortality in patients with HBV/HCV related HCCs. | Miao, Ruo-Yu Zhao, Hai-Tao Yang, Hua-Yu Mao, Yi-Lei Lu, Xin Zhao, Yi Liu, Chang-Ning Zhong, Shou-Xian Sang, Xin-Ting Huang, Jie-Fu | 2010 | World Journal of Gastroenterology2010，16，23： | 26 |
| 3 | Association of serum omentin-1 levels with coronary artery disease显示文摘目的: Omentin-1,在内脏的脂肪质的织物表示的新奇 adipokine,否定地与胰岛素抵抗和肥胖被相关。减少的 omentin-1 表示在许多长期的煽动性的疾病被发现了。然而,在冠的动脉疾病(CAD ) 的 omentin-1 的角色没被阐明。现在的学习的目的是决定 omentin-1 的浆液集中是否独立地与 CAD 被联系。 | Xia ZHONG Hai-yang ZHANG Hui TAN Yi ZHOU Fu-li LIU Fu-qin CHEN De-ya SHANG | 2011 | Acta Pharmacologica Sinica2011，32，7： | 26 |
| 4 | KRAS and BRAF gene mutations and DNA mismatch repair status in Chinese colorectal carcinoma patients显示文摘AIM:To investigate gene mutations and DNA mismatch repair(MMR) protein abnormality in Chinese colorectalcarcinoma(CRC) patients and their correlations with clinicopathologic features.METHODS:Clinical and pathological information for 535 patients including 538 tumors was reviewed and recorded.Mutation analyses for exon 2 of KRAS gene and exon 15 of BRAF gene were performed by Sanger sequencing except that in 9 tumors amplification refractory mutation system PCR was used.Expression of MMR proteins including MHL1,MSH2,MSH6 and PMS2 was evaluated by immunohistochemistry.Correlations of KRAS and BRAF mutation status and the expression status of MMR proteins with age,gender,cancer stage,location,and histology were analyzed.Correlations between KRAS or BRAF mutations and MMR protein expression were also explored.RESULTS:The overall frequencies of KRAS and BRAF mutations were 37.9% and 4.4%,respectively.KRAS mutations were more common in patients ≥ 50 years old(39.8% vs 22% in patients < 50 years old,P < 0.05).The frequencies of BRAF mutants were higher in tumors from females(6.6% vs males 2.8%,P < 0.05),located in the right colon(9.6% vs 2.1% in the left colon,1.8% in the rectum,P < 0.01),with mucinous differentiation(9.8% vs 2.8% without mucinous differentiation,P < 0.01),or being poorly differentiated(9.5% vs 3.4% well/moderately differentiated,P < 0.05).MMR deficiency was strongly associated with proximal location(20.5% in the right colon vs 9.2% in the left colon and 5.1% in the rectum,P < 0.001),early cancer stage(15.0% in stages Ⅰ-Ⅱ vs 7.7% in stages Ⅲ-Ⅳ,P < 0.05),and mucinous differentiation(20.2% vs 9.2% without mucin,P < 0.01).A higher frequency of MLH1/PMS2 loss was found in females(9.2% vs 4.4% in males,P < 0.05),and MSH2/MSH6 loss tended to be seen in younger(<50 years old) patients(12.0% vs 4.0% ≥ 50 years old,P < 0.05).MMR deficient tumors were less likely to have KRAS mutations(18.8% vs 41.7% in MMR proficient tumors,P < 0.05) and tumorswith abnormal MLH1/PMS2 tended to harbor BRAF mutations(15.4% vs 4.2% in MMR proficient tumors,P < 0.05).CONCLUSION:The frequency of sporadic CRCs having BRAF mutation,MLH1 deficiency and MSI in Chinese population may be lower than that in the Western population. | Ju-Xiang Ye Yan Liu Yun Qin Hao-Hao Zhong Wei-Ning Yi Xue-Ying Shi | 2015 | World Journal of Gastroenterology2015，21，5： | 26 |
| 5 | Indoor Allergen Levels and Household Distributions in Nine Cities Across China显示文摘Objective Chinese allergic subjects have high levels of sensitization to house dust mite(HDM) and other indoor allergens. This study quantifies common indoor allergen levels in Chinese households. Methods Dust samples were collected from nine cities. Major allergens Der p 1 and Der f 1 from Dermatophagoides pteronyssinus and D. farinae, and specific antigens of Blomia tropicalis, Tyrophagus putrescentiae, Acarus siro, and cockroach species Blattella germanica and Periplaneta americana were measured by ELISA. Results HDM allergens were found in dust samples from bedding in 95% of the Chinese households. The median levels varied from <0.006 to 9.2 μg/g of dust, depending on the city. The percentages of households having HDM allergen levels associated with the risk of developing allergy sensitization and asthma were 65% and 25%, respectively. Specific antigens of the storage mite and cockroach were only found in samples from the southern and tropical regions of China. Levels of mite allergens were generally higher in samples from bedding compared to samples from the living room, even for storage mites, whereas levels of cockroach antigens were higher in the living room samples. Conclusion HDM allergens are present in bedding dust samples from most Chinese households. Cities in southern and central China have relatively high levels of HDM major allergens compared to cities in northern and western China. Antigens of storage mites and cockroaches are not as common as HDM allergens. | ZHENG Yi Wu LAI Xu Xin ZHAO De Yu ZHANG Chun Qing CHEN Jian Jun ZHANG Luo WEI Qing Yu CHEN Shi LIU En Mei NORBACK Dan GJESING Birgitte ZHONG Nan Shan SPANGFORT D.Michael | 2015 | Biomedical and Environmental Sciences2015，28，10： | 24 |
| 6 | The Role of Fibrocyte in the Pathogenesis of Silicosis显示文摘Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells.Fibrocytes can differentiate into myofibroblast.Therefore,the present study was designed to investigate whether | LI Juan YAO Wu HOU Jian Yong ZHANG Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao YU Xing Hao ZHANG Jian Hui QU Ya Qian HAO Chang Fu | 2018 | Biomedical and Environmental Sciences2018，31，4： | 20 |
| 7 | Review on photocatalytic and electrocatalytic artificial nitrogen fixation for ammonia synthesis at mild conditions: Advances,challenges and perspectives显示文摘The ammonia synthesis from nitrogen and water under ambient conditions is one of the most inviting but challenging reaction routes.Although nitrogen is abundant in the atmosphere and the ammonia synthesis reaction is exothermic on the thermodynamics,the conversion of N2 to ammonia is actually hard to proceed owing to the chemical inertness and stability of N2 molecules.In industry,ammonia synthesis is carried out by the Haber-Bosch process under harsh conditions (300-500 ℃,20-30 MPa) associated with the requirement of substantial energy input and the enormous emission of greenhouse gases (e.g.,CO2).Recently,a growing number of studies on photo(electro)catalytic and electrocatalytic nitrogen reduction reaction (NRR) in aqueous solution have attracted extensive attention,which holds great promise for nitrogen fixation under room temperature and atmospheric pressure.However,the very low efficiency and ambiguous mechanism still remain as the major hurdles for the development of photochemical and electrochemical NRR systems.Here we provide an overview of the latest progresses,remaining challenges and future prospects in photocatalytic and electrocatalytic nitrogen fixation.Moreover,this review offers a helpful guidance for the reasonable design of photocatalysts and electrocatalysts towards NRR by combining theory predictions and experiment results.We hope this review can stimulate more research interests in the relatively understudied but highly promising research field of NRR. | Xiaolan Xue Renpeng Chen Changzeng Yan Peiyang Zhao Yi Hu Wenjun Zhang Songyuan Yang Zhong Jin | 2019 | Nano Research2019，12，6： | 20 |
| 8 | Application of an acrylic vessel supported by a stainless-steel truss for the JUNO central detector显示文摘在 Daya 海湾实验的成功以后, Jiangmen 地下的中微子天文台(Jupiter 之妻) 被发射测量中微子团层次和摆动参数并且学习另外的中微子物理。它的中央察觉者从反应堆,地球,空气,和阳光被放为反中微子。中央察觉者的主要要求是液体闪烁器的 20 kt 的抑制,作为目标团,和 3% 精力分辨率。它关于有它的内部表面上的 PMT 的 75% 范围的 38.5 m 的一个球形状察觉者。因为它必须为物理测量的几种不同类型满足要求并且在它的结构和工程拥有可行性和可靠性,如此的一个巨大的察觉者的设计是大挑战,都在合理时间和费用。为 JUNO 中央察觉者的一种选择是超丙烯酸的球在水里沉没了防护背景。这份报纸为如此的一个丙烯酸的球建议一个结构的计划那被支持由一不锈钢捆绑,在土木工程由支持点的眼镜窗帘墙启发了。计划的初步的设计被有限元素(FE ) 用 ABAQUS 完成并且验证方法。FE 分析证明计划能在 5 ~ 10 MPa 的限制以内控制丙烯酸的球的压力水平,根据中央察觉者的设计目的需求。计划具有突出的全球稳定性并且在本地连接上允许各种各样的选择。我们证明计划可行性好并且应该是为中央察觉者的一种合理选择。 | WANG Yuan Qing ZONG Liang HENG Yue Kun WANG Zong Yi ZHOU Yan HOU Shao Jing QIN Zhong Hua MA Xiao Yan | 2014 | Science China(Technological Sciences)2014，57，12： | 19 |
| 9 | First identification of kdr allele F1534S in VGSC gene and its association with resistance to pyrethroid insecticides in Aedes albopictus populations from Haikou City,Hainan Island,China显示文摘Background:Aedes albopictus is distributed widely in China,as a primary vector of Dengue fever and Chikungunya fever in south of China.Chemical insecticide control is one of the integrated programmes to prevent mosquito-borne diseases.Long-term applications of pyrethroids have resulted in the development of resistance in Ae.albopictus populations in China.However,the susceptibility of Ae.albopictus to pyrethroids in Hainan Island was unclear.Knockdown resistance(kdr),caused by point mutations in the VGSC gene,is one of the mechanisms that confer resistance to DDT and pyrethroids.This study was to investigate the resistance level of Ae.albopictus populations in Haikou City to three pyrethroid insecticides,and elucidate the relationship between the resistant phenotype and kdr mutations.Methods:The Aedes albopictus samples were collected in Xinbu Island(XI),Longtang Town(LT),Shishan Town(ST),Baishamen Park(BP),and Flower Market(FM)from Haikou City,Hainan Island,China.The larval susceptibility to deltamethrin,permethrin and beta-cypermethrin was tested by larval bioassays,and adult susceptibility to deltamethrin and DDT was determined by adult bioassays.The degree of resistance was determined by resistance ratio value(RR50>3)for larvae and by mortality for adult.The kdr alleles at codon 1534 of the VGSC gene were genotyped.The relationship between kdr genotypes and resistant phenotypes was analyzed by Chi-square test.Results:Out of five populations,assessed by larval bioassays,XI was susceptible to deltamethrin and permethrin;LT was susceptible to permethrin and beta-cypermethrin;and ST was susceptible to permithrin.FM and BP both were resistant to all of the three pyrethroids,and FM showed the highest degree of resistance,with RR50 values from 65.17 to 436.36.A total of 493 individuals from the larval bioassays were genotyped for kdr alleles.Five alleles were detected,including two wildtype alleles,TTC(F)(67.04%)and TTT(F)(0.41%),and three mutant alleles,TGC(C)(0.30%),TCC(S)(31.54%)and TTG(L)(0.71%).There was a clear correlation between mutant alleles(or F1534S)and resistant phenotypes(P<0.01).Conclusion:Two novel kdr mutant alleles F1534S and F1534L were detected in the pyrethroid resistant populations of Ae.albopictus in Haikou Hainan,China.For the first time,the mutant F1534S was associated with pyrethroid resistance in Ae.albopictus. | Huiying Chen Kaili Li Xiaohua Wang Xinyan Yang Yi Lin Fang Cai Wenbin Zhong Chunyan Lin Zhongling Lin Yajun Ma | 2016 | Infectious Diseases of Poverty2016，5，1： | 19 |
| 10 | Platinum-group element(PGE)geochemistry of the Emeishan basalts in the Pan-Xi area,SW China显示文摘在 Pan-Xi 区域的 Longzhoushan 和 Ertan 暗岩被部分融化的相对低的度产生(<7% ,在哪个期间当磅和 Pd 是不兼容的时,红外, Ru,和 Rh 是兼容的。大多数这些样品原始披风比那些有高 PGE 集中和大部分 higherPd/lr 和 Cu/Pd 比率。硫化物的小数量(~0.007%) 在部分融化期间留在披风来源,而岩浆的部分到达了硫化物浸透和分离 PGE 富有的硫化物(~0.020%-0.033 百分比) 在期间上升时期。锇,红外,和磅能形成在部分结晶化期间在铬铁矿或硫化物招待的金属性的合金处理的铂组,导致磅和 Pd 内容的去耦和红外内容的可观的变化。硫化物从玄武岩的岩浆分离了可以在岩浆水管附近在 themafic-ultramafic 侵入为 Cu-Ni-PGE 存款(矿化作用) 的形成提供重要材料来源。 | ZHONG Hong ZHU Weiguang QI Liang ZHOU Meifu SONG Xieyan ZHANG Yi | 2006 | Chinese Science Bulletin2006，51，7： | 18 |
| 11 | The cloning of 3'-truncated preS/S gene from HBV genomic DNA and its expression in transgenic mice显示文摘INTRODUCTIONHepatitis B virus (HBV) is regarded as one of themain etiologic factors involved in the developmentof human hepatocellular carcinoma (HCC).The open reading frame (orf)of X gene of HBVencoded a transactivating factor is the evidence thatstrongly supported the notion that the X gene ofHBV DNA integrated in HCC genomic DNA couldcontribute to the carcinogenesis of liver cells byactivation of some related cellular genes | Yi Ping Hu~1 Yu Cheng Yao~1 Jian Xiu Li~1 Xin Min Wang~1 Hong Li~2 Zhong Hua Wang~1 Zhang Heng Lei~3 1 Department of Cell Biology,Second Military Medical University,Shanghai 200433,China 2 Department of Biology,Department of Basic Medicine,West-China University of Medical Sciences,Chengdu 610041,China 3 Department of Biology,North Sichuan Medical College,Nanchong 637007,China | 2000 | World Journal of Gastroenterology2000，6，5： | 18 |
| 12 | Correlation of burial organic carbon and paleoproductivity in the Mesoproterozoic Hongshuizhuang Formation, northern North China显示文摘In general, total organic carbon (TOC) is directly used as a proxy for paleoproductivity, however, it is not only affected by paleoproductivity, but also controlled by redox conditions and terrigenous detrital matter influx. Major and trace elements were analysed with the purpose of investigating the redox potential and paleoproductivity during deposition of the Hongshuizhuang Formation. In the present study, C-S relationship, V/Cr ratio and Mo concentration indicate that the dolomites were deposited in oxic environments, however, most of the black shales were accumulated in euxinic environments. P/Ti values in the Hongshuizhuang samples can be compared with those in the Japanese Ubara Permian-Triassic section which were regarded to be deposited under a moderate to high paleoproductivity. Ba/Al values are slightly lower than that of the laminated sediments from the continental margins of Central California (CCAL) which were thought to be accumulated under a high paleoproductivity. These results indicate that the paleoproductivity was moderate to high during deposition of the Hongshuizhuang Formation. Burial organic carbon shows positive correlations with V/Cr and Mo, but shows only weakly or no correlation with P/Ti and Ba/Al, respectively, suggesting that although the paleoproductivity was moderate to high during deposition of the Hongshuizhuang Formation, its organic-rich sediments were predominantly controlled by redox conditions and had no direct relationship with paleoproductivity. | LUO QingYong ZHONG NingNing ZHU Lei WANG YanNian QIN Jing QI Lin ZHANG Yi MA Yong | 2013 | Chinese Science Bulletin2013，58，11： | 17 |
| 13 | Effects of Magnesium and Ferric Ions on Crystallization of Calcium Sulfate Dihydrate Under the Simulated Conditions of Wet Flue-gas Desulfurization显示文摘The influences of magnesium and ferric ions in their different ratios on the rate of gypsum crystallization were studied under the conditions similar to those of wet flue-gas desulfurization(WFGD). The results show that addition of both Mg2+ and Fe3+ increased induction time and decreased the growth efficiency up to 50% compared with the baseline(without impurities) depending on the concentration and the type of impurity. The effects of Mg2+ and Fe3+ on the surface energy and the rate of nucleation were estimated by employing the classical nucleation theory. The surface energy decreased by 8% and 14% with the addition of 0.02 mol/L magnesium or ferric ions, respectively, compared to the baseline. Mg2+ and Fe3+ made the growth rate of the (020), (021) and (040) faces of gypsum crystal a much greater reduction, which leads to the formation of needle crystals compared to the baseline which favors the formation of plate or flakes. Furthermore, an edge detection program was developed to quantify the effects of impurities on the filtration rate of gypsum product. The results show that the inhibition efficiency of the presence of 0.02 mol/L Mg2+ and Fe3+ on the filtration rate of gypsum crystal ranges from 22% to 39%. | GAO Xiang HUO Wang ZHONG Yi LUO Zhong-yang CEN Ke-fa NI Ming-jiang CHEN Le-ming | 2008 | Chemical Research in Chinese Universities2008，24，6： | 16 |
| 14 | On comparison of modified ADRCs for nonlinear uncertain systems with time delay显示文摘To tackle systems with both uncertainties and time delays, several modified active disturbance rejection control(ADRC) methods, including delayed designed ADRC(DD-ADRC), polynomial based predictive ADRC(PP-ADRC), Smith predictor based ADRC(SP-ADRC) and predictor observer based ADRC(PO-ADRC), have been proposed in the past years. This paper is aimed at rigorously investigating the performance of these modified ADRCs, such that the improvements of each method can be demonstrated.The capability to tackle time delay, the necessity of stable open loop and the performance of rejecting uncertainties for these methods are fully studied and compared. It is proven that large time delay cannot be tolerated for the stability of the closed-loop systems based on DD-ADRC and PP-ADRC. Moreover, stable open loop is shown to be necessary for stabilizing the closed-loop systems based on SP-ADRC. Furthermore,the performance of rejecting the 'total disturbance' at low frequency for these modified ADRCs is evaluated and quantitatively discussed. Finally, the simulations of a boiler turbine system illustrate the theoretical results. | Sen CHEN Wenchao XUE Sheng ZHONG Yi HUANG | 2018 | Science China(Information Sciences)2018，61，7： | 16 |
| 15 | A prospective study comparing endoscopic subcutaneous mastectomy plus immediate reconstruction with implants and breast conserving surgery for breast cancer显示文摘保存外科(英国计算机学会) 的背景胸是为早乳癌的治疗的标准外科的过程。加立即的重建与的内视镜的下的乳房切除术(ESM ) 植入是一个新兴的过程。这未来的研究的目的是评估这的临床的结果在我们到 2007 年 10 月的从 2004 年 3 月的临床的 setting.Methods 的二个外科的过程,有乳癌的 43 个病人加腋的淋巴节点解剖和立即的重建经历了 ESM 与植入,当 54 个病人经历了英国计算机学会时。临床、病理学的特征,外科的安全,和治疗学的效果在二个组之间被比较。在那里的结果不是在年龄,临床的阶段,肿瘤的组织病理学说的类型,起作用的血损失,手术后的排水时间,和在二个组之间的手术后的复杂并发症的重要差别( P > 0.05 )手术后的复杂并发症是的 .The 在 ESM 病人的乳头和表面的皮肤拍动的部分坏死,并且在在 BCS 病人的腋下和剩余洞的水肿。处于在 ESM 之间的令人满意的手术后的化妆结果的率没有重要差别(88.4% , 38/43 ) 并且英国计算机学会(92.6% , 50/54 ) 病人(P > 0.05 ) 。在到 4 年的 6 个月的后续期间,与 ESM 对待的所有病人是没有疾病的,但是经历了英国计算机学会的 3 个病人把这些病人的转移或复发一个在为使用,高外科的安全,和有利化妆结果考虑宽指示以后多重机关 metastasis.Conclusions 死了,我们结束那 ESM 正腋的淋巴节点解剖和立即的重建与植入--为胸癌症保证的选择的新外科严肃的考虑作为 | FAN Lin-jun JIANG Jun YANG Xin-hua ZHANG Yi LI Xing-gang CHEN Xian-chun ZHONG Ling | 2009 | Chinese Medical Journal2009，，24： | 14 |
| 16 | Overview of 5G security technology显示文摘The 5 th-generation mobile communication system(5 G) has higher security requirements than previous systems. Accordingly, international standard organizations, operators, and equipment manufacturers are focusing extensively on 5 G security technology. This paper analyzes the security requirements of 5 G business applications, network architecture, the air interface, and user privacy. The development trends of5 G security architecture are summarized, with a focus on endogenous defense architecture, which represents a new trend in 5 G security development. Several incremental 5 G security technologies are reviewed, including physical layer security, lightweight encryption, network slice security, user privacy protection, and block chain technology applied to 5 G. | Xinsheng JI Kaizhi HUANG Liang JIN Hongbo TANG Caixia LIU Zhou ZHONG Wei YOU Xiaoming XU Hua ZHAO Jiangxing WU Ming YI | 2018 | Science China(Information Sciences)2018，61，8： | 14 |
| 17 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 18 | Random Weighting Estimation Method for Dynamic Navigation Positioning显示文摘This paper presents a new random weighting estimation method for dynamic navigation positioning.This method adopts the concept of random weighting estimation to estimate the covariance matrices of system state noises and observation noises for controlling the disturbances of singular observations and the kinematic model errors.It satisfies the practical requirements of the residual vector and innovation vector to sufficiently utilize observation information,thus weakening the disturbing effect of the kinematic model error and observation model error on the state parameter estimation.Theories and algorithms of random weighting estimation are established for estimating the covariance matrices of observation residual vectors and innovation vectors.This random weighting estimation method provides an effective solution for improving the positioning accuracy in dynamic navigation.Experimental results show that compared with the Kalman filtering,the extended Kalman filtering and the adaptive windowing filtering,the proposed method can adaptively determine the covariance matrices of observation error and state error,effectively resist the disturbances caused by system error and observation error,and significantly improve the positioning accuracy for dynamic navigation. | GAO Shesheng GAO Yi ZHONG Yongmin WEI Wenhui | 2011 | Chinese Journal of Aeronautics2011，24，3： | 13 |
| 19 | C-reactive Protein Level,Apolipoprotein B-to-apolipoprotein A-1 Ratio,and Risks of Ischemic Stroke and Coronary Heart Disease among Inner Mongolians in China显示文摘Objective We aimed to investigate the cumulative effect of high CRP level and apolipoprotein B-to-apolipoprotein A-1(ApoB/ApoA-1) ratio on the incidence of ischemic stroke(IS) or coronary heart disease(CHD) in a Mongolian population in China.Methods From June 2003 to July 2012,2589 Mongolian participants were followed up for IS and CHD events based on baseline investigation.All the participants were divided into four subgroups according to C-reactive protein(CRP) level and ApoB/ApoA-1 ratio.Cox proportional hazard models were used to estimate the hazard ratios(HRs) and 95% confidence intervals(CIs) for the IS and CHD events in all the subgroups.Results The HRs(95% CI) for IS and CHD were 1.33(0.84-2.12),1.14(0.69-1.88),and 1.91(1.17-3.11) in the ‘low CRP level with high ApoB/ApoA-1',‘high CRP level with low ApoB/ApoA-1',and ‘high CRP level with high ApoB/ApoA-1' subgroups,respectively,in comparison with the ‘low CRP level with low ApoB/ApoA-1' subgroup.The risks of IS and CHD events was highest in the ‘high CRP level with high ApoB/ApoA-1' subgroup,with statistical significance.Conclusion High CRP level with high ApoB/ApoA-1 ratio was associated with the highest risks of IS and CHD in the Mongolian population.This study suggests that the combination of high CRP and ApoB/ApoA-1 ratio may improve the assessment of future risk of developing IS and CHD in the general population. | TIAN Yun Fan ZHOU Yi Peng ZHONG Chong Ke BUREN Batu XU Tian LI Hong Mei ZHANG Ming Zhi WANG Ai Li ZHANG Yong Hong | 2016 | Biomedical and Environmental Sciences2016，29，7： | 12 |
| 20 | Core-shell Au@MnO2 nanoparticles for enhanced radiotherapy via improving the tumor oxygenation显示文摘在稳固的肿瘤的本地组织缺氧经常导致抵抗到放射疗法(RT ) ,在哪个氧为提高 DNA 损坏的一个必要元素被电离引起放射。此处,我们开发了 gold@manganese 二氧化物(有聚乙烯乙二醇(木钉) 的 Au@MnO 2) 核心壳 nanoparticles 是的涂层在癌症治疗期间改进 RT 功效的一个新奇 radiosensitizing 代理人。在这 Au@MnO 2 nanostructure ,当金核心是著名 RT 时,交往与的 sensitizer X光检查为在 RT 下面杀死的改进癌症生产控告的粒子, MnO 2壳可以触发内长的 H 2在肿瘤微型环境到的 O 2产生氧并且克服 hypoxiaassociated RT 抵抗。是示威了由在 vitro 并且在 vivo 实验, Au@MnO 2-PEG nanoparticles 充当了有效 radiosensitizers 显著地在 RT 期间提高癌症治疗功效。而且, Au@MnO 2-PEG 的明显的副作用都没在老鼠被观察。因此,我们的工作为 hypoxic 肿瘤的提高的 RT 治疗与潜力介绍 radiosensitizer 的一种新类型。 | Xuan Yi Lei Chen Xiaoyan Zhong Roulin Gao Yitao Qian Fan Wu Guosheng Song Zhifang Chai Zhuang Liu Kai Yang | 2016 | Nano Research2016，9，11： | 12 |
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