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| 1 | Application of computational fluid dynamic to model the hydraulic performance of subsurface flow wetlands显示文摘A subsurface flow wetland(SSFW)was simulated using a commercial computational fluid dynamic(CFD)code.The constructed media was simulated using porous media and the liquid resident time distribution(RTD)in the SSFW was obtained using the particle trajectory model.The effect of wetland configuration and operating conditions on the hydraulic performance of the SSFW were investigated.The results indicated that the hydraulic performance of the SSFW was predominantly affected by the wetland configuration.The hydraulic effciency of the SSFW with an inlet at the middle edge of the upper media was 0.584 and the best among the SSFWs with an inlet at the top,the middle,and the bottom edge of the upper media.The constructed media affected the hydraulic performance by the ratio(K)of the upper and lower media resistance.The selection of appropriate media resistance in the protection layer can improve the hydraulic effciency.When the viscous resistance coeffcient of the media in the protection layer changed from 2.315×105 to 1.200×108,the hydraulic effciency of the SSFW increased from 0.301 to 0.751.However,the effect of operating conditions on the hydraulic effciency of the SSFW was slight. | Liwei FAN Hai Reti Wenxing WANG Zexiang LU Zhiming YANG | 2008 | Journal of Environmental Sciences2008，20，12： | 17 |
| 2 | Association of KIR Genotypes and Haplotypes with Susceptibility to Chronic Hepatitis B Virus Infection in Chinese Han Population显示文摘Killer immunoglobulin-like receptor (KIR) genes can regulate the activation of NK and T cells upon interaction with HLA class I molecules. Hepatitis B virus (HBV) infection has been regarded as a multi-factorial disorder disease. Previous studies revealed that KIRs were involved in HCV and HIV infection or clearance. The aim of this study was to explore the possibility of the inheritance of KIR genotypes and haplotypes as a candidate for susceptibility to persistent HBV infection or HBV clearance. The sequence specific primer polymerase chain reaction (SSP-PCR) was employed to identify the KIR genes and pseudogenes in 150 chronic hepatitis B (CHB) patients, 251 spontaneously recovered (SR) controls, and 412 healthy controls. The frequencies of genotype G, M, FZ1 increased in CHB patients compared with healthy control subjects. The frequency of genotype AH was higher in SR controls than that in both CHB patients and healthy controls. The carriage frequencies of genotype G and AH were higher; while, the frequencies of AF and AJ were lower in SR controls than those in healthy control subjects. The frequency of A haplotype was lower, whereas, the frequency of B haplotype was higher in CHB patients and SR controls than those in healthy controls. In healthy controls, haplotype 4 was found lower compared with that in CHB patients and SR controls and the frequency of haplotype 5 was higher in SR controls than that in other two groups. Based on these findings, it seems that the genotypes M and FZ1 are HBV susceptive genotypes; AH, on the other hand, may be protective genotypes that facilitate the clearance of HBV. It appears that the haplotype 4 is HBV susceptive haplotype, whereas, haplotype 5 may be the protective haplotype that facilitates the clearance of HBV. | Zhiming Lu Bingchang Zhang Shijun Chen Zhongtao Gai Zhaolei Feng Xiangdong Liu Yiqing Liu Xin Wen Li Li Yulian Jiao Chunyan Ma Song Shao Xiangfa Cui Guojian Chen Jianfeng Li Yneran Zhao | 2008 | Cellular & Molecular Immunology2008，5，6： | 13 |
| 3 | The change in population density from 2000 to 2010 and its influencing factors in China at the county scale显示文摘在人口分发和密度学习变化能为地区性的开发提供重要基础并且计划。空间模式和在在中国的人口密度的变化的开车因素还不是清楚的。用在 2000 和 2010 的人口普查数据,因此,这研究第一在中国分析了人口密度的变化并且在所有 2353 个县把变化划分了成 4 种类型,由快速的增加,慢增加,慢减少和快速的减少组成。随后,基于部分最少的平方(请) 回归方法,我们认出了重要因素(在 11 个自然、社会经济的因素之中) 为有人口变化的不同类型的整个国家和县的影响人口密度变化。结果显示出那:( 1 )在 2010 ,与在 2000 的人口密度相比,在大多数县(超过60%)的人口密度每 km 由 21 个人增加了<啜class=“ a-plus-plus ”> 2 平均,当在另外的县的人口密度每 km 由 13 个人减少了时<啜class=“ a-plus-plus ”> 2 。所有 2353 个县,当 458 和 446 个县分别地在人口密度显示出慢、快速的减少时, 860 和 589 个县分别地在人口密度显示出快速、慢的增加。(2 ) 在 11 个因素之中,社会经济的因素比自然因素更显著地影响了人口密度变化。更高经济的发展水平,更好医药的条件和更强壮的通讯能力是人口增加的主要的拉因素。稠密的人口密度是人口减少的主要的推因素。这些结论在过去的 10 年在中国澄清了人口变化和它的影响因素的空间模式并且能为计划的未来人口提供有用参考。 | WANG Lu FENG Zhiming YANG Yanzhao | 2015 | Journal of Geographical Sciences2015，25，4： | 8 |
| 4 | Boosting electrocatalytic water splitting via metal-metalloid combined modulation in quaternary Ni-Fe-P-B amorphous compound显示文摘Design and synthesis of highly efficient and cost-effective bifunctional catalysts for hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)remain a big challenge.Herein,a quaternary amorphous nanocompound Ni-Fe-P-B has been synthesized by a facile,scalable co-reduction method.The Ni-Fe-P-B exhibits high electrocatalytic activity and outstanding durability for both HER and OER,delivering a current density of 10 mA·cm^-2 at overpotentials of 220 and 269 mV,respectively.When loaded on carbon fiber paper(CFP)as a bifunctional catalyst,the Ni-Fe-P-B@CFP electrode requires a low cell voltage of 1.58 V to obtain 10 mA·cm^-2 for overall water splitting with negligible recession over 60 h.The excellent catalytic performances of Ni-Fe-P-B mainly benefit from the metal-metalloid combined composition modulation and the unique amorphous structure.This work provides new insights into the design of robust bifunctional catalysts for water splitting,and may promote the development of multicomponent amorphous catalysts. | Wukui Tang Xiaofang Liu Ya Li Yanhui Pu Yao Lu Zhiming Song Qiang Wang Ronghai Yu Jianglan Shui | 2020 | Nano Research2020，13，2： | 8 |
| 5 | Micro-droplet Digital Polymerase Chain Reaction and Real-Time Quantitative Polymerase Chain Reaction Technologies Provide Highly Sensitive and Accurate Detection of Zika Virus显示文摘The establishment of highly sensitive diagnostic methods is critical in the early diagnosis and control of Zika virus(ZIKV)and in preventing serious neurological complications of ZIKV infection. In this study, we established micro-droplet digital polymerase chain reaction(ddPCR) and real-time quantitative PCR(RT-qPCR) protocols for the detection of ZIKV based on the amplification of the NS5 gene. For the ZIKV standard plasmid, the RT-qPCR results showed that the cycle threshold(Ct) value was linear from 10~1 to 10~8 copy/l L, with a standard curve R^2 of 0.999 and amplification efficiency of 92.203%;however, a concentration as low as 1 copy/l L could not be detected. In comparison with RT-qPCR, the dd PCR method resulted in a linear range of 10~1–10~4 copy/l L and was able to detect concentrations as low as 1 copy/l L. Thus, for detecting ZIKV from clinical samples, RT-qPCR is a better choice for high-concentration samples(above 10~1 copy/l L),while ddPCR has excellent accuracy and sensitivity for low-concentration samples. These results indicate that the ddPCR method should be of considerable use in the early diagnosis, laboratory study, and monitoring of ZIKV. | Yuan Hui Zhiming Wu Zhiran Qin Li Zhu Junhe Liang Xujuan Li Hanmin Fu Shiyu Feng Jianhai Yu Xiaoen He Weizhi Lu Weiwei Xiao Qinghua Wu Bao Zhang Wei Zhao | 2018 | Virologica Sinica2018，33，3： | 6 |
| 6 | Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling显示文摘室的肥大是心血管的疾病的事件的一个强大、独立的预言者。低剂量的乙酰水杨酸酸(阿司匹林) 的脉管的性质通过血小板 cyclooxygenase 的不可逆的抑制提供心血管的好处 1;然而,可能的 anti-hypertrophic 性质和阿司匹林的潜在的机制没详细被调查。在这研究,健康野类型的雄的老鼠随机被划分成三个组并且使遭到了到横向的大动脉的收缩(TAC ) 或假冒的操作。操作 TAC 的老鼠与低剂量的阿司匹林的人的等价物被对待(10 mg 吗? | Samuel Chege Gitau Xuelian Li Dandan Zhao Zhenfeng Guo Haihai Liang Ming Qian Lifang Lv Tianshi Li Bozhi Xu Zhiguo Wang Yong Zhang Chaoqian Xu Yanjie Lu Zhiming Du Hongli Shan Baofeng Yang | 2015 | Frontiers of Medicine2015，9，4： | 6 |
| 7 | Research on the suitability of population distribution at the provincial scale in China显示文摘在人口分发和资源,环境和社会经济的开发之间的关系在人的发展有重要影响。这篇论文建立了一套索引为对在人口和资源,环境和社会经济的开发之间的协作的评价的系统和模型方法,并且它份量上分别地在 2000 和 2010 在省的规模评估了这协作。在省的规模基于索引系统,适用性度和人口分发的空间时间的模式的这个集合小心地被描绘。在省的规模的人口分发的限制被分级并且分类,并且人口,资源,环境和社会经济的协调发展策略最后被提出。结果显示出那:(1 ) 在省的规模的人口分发的环境适用性在中国通常高,它趋于从 2000 ~ 2010 稳定。(2 ) 在省的规模的水和陆地资源的限制在中国通常是强壮的,但是它趋于从 2000 ~ 2010 弱。(3 ) 在在省的规模的社会经济的发展和人口分发之间的协作度主要在中间的水平,它在从 2000 ~ 2010 的积极向上的路径。(4 ) 在省的规模的人口分发的适用性主要在中间的水平,所有哪个从 2000 ~ 2010 正在升起。(5 ) 在在省的规模的人口分发和资源,环境和社会经济的开发之间的协作度被划分成四个等级,包括基本协作,相对协作,等候的协作和迫切需要的协作。(6 ) 在中国在不同区域支持人口,资源和环境的协调发展的基本方法能是被总结:实现人口凝块和撤退的策略,指导人口的有序的流动,优化人口的空间分发并且起草人口开发的空间计划。 | YANG Yanzhao FENG Zhiming WANG Lu YOU Zhen | 2014 | Journal of Geographical Sciences2014，24，5： | 5 |
| 8 | Ascorbate antagonizes nickel ion to regulate JMJD1A expression in kidney cancer cells显示文摘histone demethylase Jumonji 包含域的蛋白质 1A (JMJD1A ) 的反常表示与许多种癌症被联系。JMJD1A 也是 hypoxic 反应基因,它的表示被组织缺氧可诱导的 factor-1 (HIF-1 ) 调整。在这研究,我们在开发和组织缺氧小径决定了 JMJD1A 的角色。我们也测量了 JMJD1A 和二组织缺氧因素葡萄糖 transporter 的表示 1 ( GLUT1 )并且在 786-0 和 HEK293 细胞的脉管的 endothelial 生长因素( VEGF )为 24 h 与 NiCl2 ( 2.5100 M )的不同集中对待,并且发现 JMJD1A mRNA 和蛋白质与 NiCl2 的增加的集中是起来调整的。我们然后观察到 ascorbate 能延迟以通过减少的一种剂量依赖者方式的导致 NiCl2 的 JMJD1A 表示的起来调整的效果 HIF-1 的稳定性蛋白质。Immunohistochemical 分析进一步证明 ascorbate 在 786-0, HEK293,和 OS-RC-2 房间反对了 JMJD1A 表示的导致 Ni2+ 的起来规定。这些调查结果建议 Ni2+ 和 ascorbate 能调整 histone demethylase JMJD1A 的表示,它为癌症开发或抑制是重要的。 | Xiaoqiang Guo Jingxiao Lu Yuejia Wang Yaoting Gui Xianglin Duan Zhiming Cai | 2012 | Acta Biochimica et Biophysica Sinica2012，44，4： | 5 |
| 9 | Electrocatalytic N_(2) reduction to NH3 with high Faradaic efficiency enabled by vanadium phosphide nanoparticle on V foil显示文摘To develop highly efficient electrochemical catalysts for N2 fixation is important to sustainable ambient NH_(3) production through the N_(2) reduction reaction(NRR).Herein,we demonstrate the development of vanadium phosphide nanoparticle on V foil as a high-efficiency and stable catalyst for ambient NH3 production with excellent selectivity.The high Faradaic efficiency of 22%with a large NH3 yield of 8.35×10^(−11) mol·s^(−1)·cm^(−2)was obtained at 0 V vs.the reversible hydrogen electrode in acid solution,superior to all previously studied V-based NRR catalysts.Density functional theory calculations are also utilized to have an insight into the catalytic mechanism. | Peipei Wei Qin Geng Ali Imran Channa Xin Tong Yongsong Luo Siyu Lu Guang Chen Shuyan Gao Zhiming Wang Xuping Sun | 2020 | Nano Research2020，13，11： | 4 |
| 10 | Ductile and ultrahigh-strength eutectic high-entropy alloys by large-volume 3D printing显示文摘1.Introduction Additive manufacturing or 3D printing outweighs conventional casting methods in the aspect of complex parts fabrication,which can realize one-step formation without the need of complicated cast dies.3D printing significantly promotes industrial production for making near-net shaped components.However,this promising technique is not always ideally applicable for metals and alloys.For example,titanium alloys prepared by 3D printing often suf-fer from poor plasticity,and usually require further complex heat treatment or hot isostatic pressing treatment,in order to remove internal stress and regulate plasticity and strength[1,2],which de-feats the original intention of employing additive manufacturing.One of the fundamental causes for such issues is the low fluidity of the alloys upon melting,leading to great chemical heterogeneity,high porosity content and residual stresses.This limitation hinders further design and fabrication of high-performance printable alloys from large scale production and application. | Yiping Lu Xiaoxiang Wu Zhenghong Fu Qiankun Yang Yong Zhang Qiming Liu Tianxin Li Yanzhong Tian Hua Tan Zhiming Li Tongmin Wang Tingju Li | 2022 | Journal of Materials Science & Technology2022，，31： | 4 |
| 11 | Preparation and analysis of active rat model of rheumatoid arthritis with features of TCM toxic heat-stasis painful obstruction显示文摘Objective:To establish a collagen type II-induced rat model of rheumatoid arthritis(RA)presenting characteristics of the human form of the traditional Chinese syndrome pattern of toxic heat-stasis painful obstruction(bi zheng;arthromyodynia)as well as pathologic features of active RA.The Chinese herbal medicine Tengmei decoction was used to validate the animal model.Methods:Ninety specific pathogen free Sprague-Dawley rats were randomly divided into a normal group of 6 rats and a model group of 84 rats.To establish the rat model of collageninduced arthritis(CIA),bovine type II collagen in complete Freund’s adjuvant was injected into the model group rats as a priming dose(Day 0)and boosting dose(Day 9).Changes in arthritic index(AI)scores,including limb swelling,were monitored.Thereafter,24 successfullyestablished CIA rats were randomly assigned to 4 groups with 6 animals each:model,positive control drug,high-dose traditional Chinese herbal medicine,and traditional Chinese herbal medicine.A blank control group of 6 rats was included.After 12 weeks of intervention with Tengmei decoction,articular synovial tissue and serum specimens were collected to detect interleukin-2(IL-2)and IL-17 transcription and protein expression levels. | Yanan Wang Yan Lu Jie Wang Zhiming Shen Hui Liu Weiguo Ma Jisheng Zhang Xuehong Ma Kang Wang Fengxian Meng | 2015 | Journal of Traditional Chinese Medical Sciences2015，2，3： | 3 |
| 12 | Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair显示文摘连接器 histone H1 在 DNA 损坏反应是更高的顺序染色质结构,而是它的参与的一个主人管理者,修理是不清楚的。这里,我们报导连接器 histone H1.2 是混乱毛细管扩张的一个必要管理者变异(ATM ) 激活。我们证明 H1.2 通过和 ATM 热重复领域和 MRE11-RAD50-NBS1 (MRN ) 的抑制的直接相互作用保护染色质免受异常 ATM 激活的伤害复杂依赖者的 ATM 招募。在 DNA 损坏之上, H1.2 通过它的 C 终点和进一步的 proteasomal 降级的 poly-ADP-ribosylation (PARylation ) 经历快速的 PARP1 依赖的染色质分离。由 PARylation 死了的变化妥协 ATM 激活和 DNA 损坏修理的 PARP1 弄空或 H1.2 的 H1.2 排水量的抑制,因此导致损害了房间幸存。一起拿,我们的调查结果建议连接器 histone H1.2 作为一个生理的障碍工作因为指向染色质的 ATM,和调停 PARylation 的活跃 H1.2 周转为柔韧的 ATM 激活和 DNA 损坏修理被要求。 | Zhiming Li Yinglu Li Ming Tang Bin Peng Xiaopeng Lu Qiaoyan Yang Qian Zhu Tianyun Hou Meiting Li Chaohua Liu Lina Wang Xingzhi Xu Ying Zhao Haiying Wang Yang Yang Wei-Guo Zhu | 2018 | Cell Research2018，28，7： | 3 |
| 13 | Online single particle measurement of fireworks pollution during Chinese New Year in Nanning显示文摘Time-resolved single-particle measurements were conducted during Chinese New Year in Nanning, China. Firework displays resulted in a burst of SO_2, coarse mode, and accumulation mode(100–500 nm) particles. Through single particle mass spectrometry analysis, five different types of particles(fireworks-metal, ash, dust, organic carbon-sulfate(OC-sulfate), biomass burning) with different size distributions were identified as primary emissions from firework displays. The fireworks-related particles accounted for more than70% of the total analyzed particles during severe firework detonations. The formation of secondary particulate sulfate and nitrate during firework events was investigated on single particle level. An increase of sulfite peak(80SO_3^-) followed by an increase of sulfate peaks(97HSO_4^-+ 96SO_4^-) in the mass spectra during firework displays indicated the aqueous uptake and oxidation of SO_2 on particles. High concentration of gaseous SO_2, high relative humidity and high particle loading likely promoted SO_2 oxidation. Secondary nitrate formed through gas-phase oxidation of NO_2 to nitric acid, followed by the condensation into particles as ammonium nitrate. This study shows that under worm, humid conditions, both primary and secondary aerosols contribute to the particulate air pollution during firework displays. | Jingyan Li Tingting Xu Xiaohui Lu Hong Chen Sergey A.Nizkorodov Jianmin Chen Xin Yang Zhaoyu Mo Zhiming Chen Huilin Liu Jingying Mao Guiyun Liang | 2017 | Journal of Environmental Sciences2017，29，3： | 3 |
| 14 | Experiment and analysis on microscopic characteristics of pedestrian movement in building bottleneck显示文摘In this paper, evacuation experiments are carried out to study pedestrian movement behaviors in building bottleneck. An image processing method based on mean-shift algorithm is used to extract pedestrian movement trajectory. Based on the extracted trajectory, we analyze the microscopic movement characteristics of pedestrians such as lane formation, change of velocity and distance between two sequential pedestrians. A pedestrian lane is a group of pedestrians moving in a column. The lane formation is verified by the pedestrian trajectory and distribution of pedestrian’s lateral positions (x direction in the paper): lane number changes from one to two, three or even more with the increasing bottleneck width when pedestrians pass through the bottleneck. By analyzing the pedestrian movement behaviors in the same pedestrian lane, we find three typical movement modes in the bottleneck: time-lag acceleration, synchronous acceleration, and avoiding deceleration. Through analyzing the time intervals when successive pedestrians pass through the bottleneck, we find that most pedestrians adjust their velocities according to the distance to the forward pedestrians. Results also indicate that due to different cultures, pedestrians flux in China and Germany may have some differences besides their similarities. | TIAN Wei SONG WeiGuo LU Wei FANG ZhiMing | 2011 | Science China(Technological Sciences)2011，54，7： | 3 |
| 15 | Identifying human body states by using a flexible integrated sensor显示文摘Flexible sensors are required to be lightweight,compatible with the skin,sufficiently sensitive,and easily integrated to extract various kinds of body vital signs during continuous healthcare monitoring in daily life.For this,a simple and low-cost flexible temperature and force sensor that uses only two carbon fiber beams as the sensing layer is reported in this work.This simple,flexible sensor can not only monitor skin temperature changes in real time but can also extract most pulse waves,including venous waves,from most parts of the human body.A pulse diagnostic glove containing three such flexible sensors was designed to simulate pulse diagnostic methods used in traditional Chinese medicine.Wearable equipment was also designed in which four flexible sensors were fixed onto different body parts(neck,chest,armpit,and fingertip)to simultaneously monitor body temperature,carotid pulse,fingertip artery pulse,and respiratory rate.Four important physiological indicators—body temperature(BT),blood pressure(BP),heart rate(HR),and respiratory rate(RR)—were extracted by the wearable equipment and analyzed to identify exercise,excited,tired,angry,and frightened body states. | Ying Jin Guoning Chen Kete Lao Songhui Li Yong Lu Yufeng Gan Zhundong Li Jiajia Hu Jingcheng Huang Jinxiu Wen Honggui Deng Min Yang Zhiming Chen Xiaoyan Hu Baowen Liang Jianyi Luo | 2020 | npj Flexible Electronics2020，4，1： | 2 |
| 16 | Large-scale multiferroic complex oxide epitaxy with magnetically switched polarization enabled by solution processing显示文摘Complex oxides with tunable structures have many fascinating properties,though high-quality complex oxide epitaxy with precisely controlled composition is still out of reach.Here we have successfully developed solution-based single-crystalline epitaxy for multiferroic(1-x)BiTi(1-y)/2FeyMg(1-y)/2O3–(x)CaTiO3(BTFM–CTO)solid solution in large area,confirming its ferroelectricity at the atomic scale with strong spontaneous polarization.Careful compositional tuning leads to a bulk magnetization of 0.07±0.035μB/Fe at room temperature,enabling magnetically induced polarization switching exhibiting a large magnetoelectric coefficient of 2.7–3.0×10^-7 s/m.This work demonstrates the great potential of solution processing in large-scale complex oxide epitaxy and establishes novel room-temperature magnetoelectric coupling in epitaxial BTFM–CTO film,making it possible to explore a much wider space of composition,phase,and structure that can be easily scaled up for industrial applications. | Cong Liu Feng An Paria S.M.Gharavi Qinwen Lu Junkun Zha Chao Chen Liming Wang Xiaozhi Zhan Zedong Xu Yuan Zhang Ke Qu Junxiang Yao Yun Ou Zhiming Zhao Xiangli Zhong Dongwen Zhang Nagarajan Valanoor Lang Chen Tao Zhu Deyang Chen Xiaofang Zhai Peng Gao Tingting Jia Shuhong Xie Gaokuo Zhong Jiangyu Li | 2020 | National Science Review2020，7，1： | 2 |
| 17 | Effects of supports and combined process on hydrogen purification over nickel supported catalysts显示文摘Hydrogen purification must be done to meet the different purposes of hydrogen utilization.In the present work,it is confirmed that the catalyst Ni/CeO2 has the highest activity for total methanation(Total MET) of CO and CO2,and is thus most suitable for hydrogen purification for ammonia synthesis.While,the catalyst Ni/ZrO2 appears the best one for selective methanation of CO(CO-SMET) in the H2-rich gas to produce clean fuel for proton exchange membrane fuel cell(PEMFC).In spite of this,the catalyst Ni/ZrO2 without adding chlorine ions as promoter is not yet capable of removing the CO in the reformate gas to below 10 ppm in a wide reaction temperature range by the way of CO-SMET.Adding chlorine ions as promoter is indeed not favorable for practical application due to its gradual loss in the catalytic reaction as proved in our previous work.Therefore,a step to decrease CO2 concentration(called as de-CO2 step) is suggested to be set prior to the CO-SMET step in this work.It is proved that such combination of de-CO2 step and CO-SMET step is efficient to achieve a deep removal of CO to below 10 ppm with a high selectivity more than 50% in a wide reaction temperature range of 220-280℃over the catalyst Ni/ZrO2 without adding chlorine ions as promoter.The combined process has potential for practical application,at least in the large-scale power plant of PEMFC. | Menglan Xiao Lu Zhang Yanyan Sang Zhiming Gao | 2020 | Journal of Rare Earths2020，38，1： | 2 |
| 18 | Activation of the bitter taste sensor TRPM5 prevents high saltinduced cardiovascular dysfunction显示文摘High salt intake is a known risk factor of cardiovascular diseases. Our recent study demonstrated that long-term high salt intake impairs transient receptor potential channel M5(TRPM5)-mediated aversion to high salt concentrations, consequently promoting high salt intake and hypertension;however, it remains unknown whether TRPM5 activation ameliorates cardiovascular dysfunction. Herein we found that bitter melon extract(BME) and cucurbitacin E(CuE), a major compound in BME, lowered high salt-induced hypertension. Long-term BME intake significantly enhanced the aversion to high salt concentrations by upregulating TRPM5 expression and function, eventually decreasing excessive salt consumption in mice. Moreover, dietary BME ameliorated high salt-induced cardiovascular dysfunction and angiotensin II-induced hypertension in vivo. The mechanistic evidence demonstrated that dietary BME inhibited high salt-induced RhoA/Rho kinase pathway overactivation, leading to reduced phosphorylation levels of myosin light chain kinase and myosin phosphatase targeting subunit 1. Furthermore, CuE inhibited vasoconstriction by attenuating L-type Ca^(2+) channel-induced Ca^(2+) influx in vascular smooth muscle cells. To summarize, our findings indicate that dietary BME has a beneficial role in antagonizing excessive salt consumption and thus appears promising for the prevention of high salt-induced cardiovascular dysfunction. | Hao Wu Yuanting Cui Chengkang He Peng Gao Qiang Li Hexuan Zhang Yanli Jiang Yingru Hu Xiao Wei Zongshi Lu Tianyi Ma Daoyan Liu Zhiming Zhu | 2020 | Science China(Life Sciences)2020，63，11： | 2 |
| 19 | Cryogenic mechanical behavior of a TRIP-assisted dual-phase highentropy alloy显示文摘The recently developed dual-phase(DP)non-equiatomic Fe_(50)Mn_(30)Co_(10)Cr_(10)(at.%)high-entropy alloy(HEA)showed much higher strength and ductility compared to the single-phase equiatomic Fe_(20)Mn_(20)Ni_(20)Co_(20)Cr_(20)(at.%)HEA at room temperature.Herein we probe the cryogenic mechanical properties of the non-equiatomic DP-HEA with different grain sizes and compare with the equiatomic single-phase HEA.Our results show that the cryogenic ultimate tensile strengths of the coarse-grained(~200μm)and fine-grained(~4μm)DP-HEAs reach up to 1,133 and 1,342 MPa,respectively,which are significantly higher than that of the equiatomic single-phase HEAs with similar grain sizes.Furthermore,the fine-grained DP-HEA shows substantial improvement in both strength and ductility compared to the coarse-grained counterparts at cryogenic temperatures.Microstructural analysis reveals that the enhanced mechanical properties of the DP-HEA at cryogenic temperatures are attributed to a more extensive displacive transformation from the face-centered cubic(FCC)matrix into the hexagonal close-packed(HCP)phase compared to that at room temperature.Specifically,the HCP phase fraction in tensile tested fine-grained DP-HEAs increases from~39%to~79%with decreasing temperature from 298 to 77 K.The enhanced transformation behavior is enabled by the reduced stacking fault energy of the material with the decrease of deformation temperatures.The resulting outstanding combination of strength and ductility further suggests that the DP-HEAs are promising candidates as structural materials for cryogenic applications. | Dongyue Li Zhiming Li Lu Xie Yong Zhang Wenrui Wang | 2022 | Nano Research2022，15，6： | 2 |
| 20 | A simple kriging method incorporating multiscale measurements in geochemical survey显示文摘 | Changjiang Li Zhiming Lu Tuhua Ma | 2009 | Journal of Geochemical Exploration2009，101，2： | 1 |
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