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| 1 | Moment-independent importance measure of basic random variable and its probability density evolution solution显示文摘To analyze the effect of basic variable on failure probability in reliability analysis,a moment-independent importance measure of the basic random variable is proposed,and its properties are analyzed and verified.Based on this work,the importance measure of the basic variable on the failure probability is compared with that on the distribution density of the response.By use of the probability density evolution method,a solution is established to solve two importance measures,which can efficiently avoid the difficulty in solving the importance measures.Some numerical examples and engineering examples are used to demonstrate the proposed importance measure on the failure probability and that on the distribution density of the response.The results show that the proposed importance measure can effectively describe the effect of the basic variable on the failure probability from the distribution density of the basic variable.Additionally,the results show that the established solution on the probability density evolution is efficient for the importance measures. | CUI LiJie,Lü ZhenZhou & ZHAO XinPan School of Aeronautics,Northwestern Polytechnical University,Xi’an 710072,China | 2010 | Science China(Technological Sciences)2010，53，4： | 41 |
| 2 | Nataf transformation based point estimate method显示文摘Structural probabilistic analysis quantifies the effect of input random variables, such as material proper- ties, geometrical parameters and loading conditions, on the structural responses. The point estimate method (PEM) is a direct and easy-used way to perform the structural probabilistic analysis in practice. In this paper, a novel and efficient point estimate method is proposed for computing the first four statistical moments of structural response which is a function of input random variables. The method adopts Nataf transformation to replace Rosenblatt transformation in conventional point estimate method. Because of the nature of engineering problems and limited statistical data, the joint probability density function (PDF) of all input random variables is hard to acquire, but it must be known in Rosenblatt transformation. A more common case is that the marginal PDF of each random variable and the correlation matrix are available, which just satisfy the service condition of Nataf transformation. Hence the Nataf transformation based point estimate method is particularly suitable for engineering applications. The comparison between the proposed method and the conventional point estimate method shows that (1) they are equivalent when all random variables are mutually independent; (2) if the marginal PDFs and the correlation matrix are known, the conventional PEM cannot be applicable, but the proposed method can give a rational approximation. Finally, the procedure is demonstrated in detail through a simple illustration. | LI HongShuang LU ZhenZhou YUAN XiuKai | 2008 | Chinese Science Bulletin2008，53，17： | 34 |
| 3 | National Epidemiology and Evolutionary History of Four Hand, Foot and Mouth Disease-Related Enteroviruses in China from 2008 to 2016显示文摘Hand, foot and mouth disease(HFMD) is a major public health concern in China. The most predominant enteroviruses that cause HFMD have traditionally been attributed to enterovirus A71(EVA71) and coxsackievirus A16(CVA16). Since its first large outbreak in 2008, the dominant HFMD pathogens are constantly changing. In 2013 and 2015, CVA6 exceeded both EVA71 and CVA16 to become the leading cause of HFMD in some provinces. However, there still lacks a comprehensive overview on the molecular epidemiology and evolution of HFMD-related enteroviruses at the national level. In this study, we performed systematic epidemiological analyses of HFMD-related enteroviruses using the data of 64 published papers that met the inclusion criteria, and conducted phylogenetic analyses based on 12,080 partial VP1 sequences identified in China before 31 st June 2018. We found that EVA71 prevalence has decreased sharply but other enteroviruses have increased rapidly from 2008 to 2016 and that one subtype of each enterovirus is represented during the epidemic. In addition, four genotypes EVA71_C4, CVA16_B1, CVA6_D and CVA10_C are the most predominant enterovirus strains and collectively they cause over 90% of all HFMD cases in China according to the phylogenetic trees using representative partial VP1 sequences. These four major enterovirus genotypes have different geographical distributions, and they may cocirculate with other genotypes and serotypes. These results suggest that more molecular epidemiological studies should be performed on several enteroviruses simultaneously, and such information should have implications for virological surveillance, disease management, vaccine development and policy-making on the prevention and control of HFMD. | Xuemin Fu Zhenzhou Wan Yanpeng Li Yihong Hu Xia Jin Chiyu Zhang | 2020 | Virologica Sinica2020，35，1： | 31 |
| 4 | Hypoglycemic effect of catalpol on high-fat diet/streptozotocin-induced diabetic mice by increasing skeletal muscle mitochondrial biogenesis显示文摘Catalpol, iridoid glycoside,在根值 Rehmanniae 的根存在。一些研究证明了 catalpol 为这效果在导致 streptozotocin 的糖尿病的模型,而是内在的机制有显著血糖过低的效果充分没被阐明。因为 mitochondrial 机能障碍在糖尿病的病理起一个重要作用并且因为改善 mitochondrial 功能可以为糖尿病的处理提供一条新途径,这研究被设计。Catalpol 口头上地予导致的高脂肪的 diet/streptozotocin (HFD/STZ ) 和 metformin 被以为 4 个星期的糖尿病的老鼠日报。身体重量(BW )(IPGTT ) , fasting 血葡萄糖(FBG ) 水平,和葡萄糖处理被测量在期间或在处理以后。结果整个 catalpol 管理的四个连续星期在 BW 没有明显的变化显示出 FBG 水平的剂量依赖者减小。Catalpol 治疗实质地在糖尿病的老鼠减少了浆液总数胆固醇和 triglyceride 层次。另外, catalpol 高效地增加了 mitochondrial ATP 生产并且在骨胳的肌肉织物颠倒了 mitochondrial 膜潜力和 mtDNA 拷贝数字的减少。而且, catalpol (200 mg/kg ) 在骨胳的肌肉救了 mitochondrial 超微结构,与传播电子显微镜学检测了。peroxisome 的相对 mRNA 水平(PGC1 ) 当这效果被 catalpol 颠倒时,激活 proliferator 的受体 gamma 激活剂 1 显著地在糖尿病的老鼠的肌肉组织被减少,导致一条剂量依赖者起来规定。一起拿,我们发现 catalpol 能够经由在 HFD/STZ-induced 糖尿病的老鼠的骨胳的肌肉改进 mitochondrial 功能的阴沉的 FBG 水平。 | Xia Li Zhimeng Xu Zhenzhou Jiang Lixin Sun Jinzi Ji Jingshan Miao Xueji Zhang Xiaojie Li Shan Huang Tao Wang Luyong Zhang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，9： | 16 |
| 5 | ACE2/Ang-(1-7) signaling and vascular remodeling显示文摘The renin-angiotensin system(RAS)regulates vascular tone and plays a critical role in vascular remodeling,which is the result of a complex interplay of alterations in vascular tone and structure.Inhibition of the RAS has led to important pharmacological tools to prevent and treat vascular diseases such as hypertension,diabetic vasculopathy and atherosclerosis.Angiotensin converting enzyme 2(ACE2)was recently identified as a multifunctional monocarboxypeptidase responsible for the conversion of angiotensin(Ang)II to Ang-(1-7).The ACE2/Ang-(1-7)signaling has been shown to prevent cellular proliferation,pathological hypertrophy,oxidative stress and vascular fibrosis.Thus,the ACE2/Ang-(1-7)signaling is deemed to be beneficial to the cardiovascular system as a negative regulator of the RAS.The addition of the ACE2/Ang-(1-7)signaling to the complexities of the RAS may lead to the development of novel therapeutics for the treatment of hypertension and other vascular diseases.The present review considers recent findings regarding the ACE2/Ang-(1-7)signaling and focuses on its regulatory roles in processes related to proliferation,inflammation,vascular fibrosis and remodeling,providing proof of principle for the potential use of ACE2 as a novel therapy for vascular disorders related to vascular remodeling. | ZHANG ZhenZhou CHEN LaiJiang ZHONG JiuChang GAO PingJin OUDIT Gavin Y. | 2014 | Science China(Life Sciences)2014，57，8： | 14 |
| 6 | Distribution of correlation dimensions of synchronous 12-lead ECG signals显示文摘Correlation dimensions D2 of the synchronous 12-lead ECG signals have been investigated for the first time by distributed multi-sensor (multi-electrode) technique. The results show that correlation dimension of heart has the distributed characteristics. D2 calculated from different lead ECG signals is not a constant regardless of a healthy person or a coronary heart disease (CHD) patient with sinus rhythm. But with the same lead signal, D2 of CHD patients is evidently smaller than that of a healthy person except I, II, III leads. A healthy person and CHD patient can be identified by D2 statistically and D2 shows the potential application in the diagnosis of the CHD patients. | WANG Zhenzhou NING Xinbao ZHANG Yu DU Gonghuan | 2000 | Chinese Science Bulletin2000，45，17： | 13 |
| 7 | reatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs显示文摘气喘的发炎被一种类型调停 2 助手 T 房间(Th2 ) cytokine 反应,和堵住的 Th2 cytokine 生产被证明有一个有势力治疗学对气喘的发炎的效果。用 IL-4-green 荧光灯蛋白质(GFP ) 记者老鼠,我们表明了那 Bavachinin,从中国植物孤立的单个混合物,显著地禁止的 Th2 cytokine 生产包括 IL-4, IL-5 和 IL-13。尤其是,在 ovalbumin (卵) 的这复合几乎完全堵住的发炎敏化动物气喘模型。而且,我们证明这化学药品有选择地影响 GATA-3 的水平,由影响 GATA-3 mRNA 的稳定性最可能。第一次,我们的结果证明这单个混合物的潜在的治疗学的价值源于中国植物。 | Xi Chen Ti Wen Jun Wei Zhenzhou Wu Puyue Wang Zhangyong Hong Liqing Zhao Bin Wang Richard Flavell Shumei Gao Min Wang Zhinan Yin | 2013 | Cellular & Molecular Immunology2013，10，6： | 9 |
| 8 | Importance measure system of fuzzy and random input variables and its solution by point estimates显示文摘For structure system with fuzzy input variables as well as random ones, a new importance measure system is presented for evaluating the effects of the two kinds of input variables on the output response. Based on the fact that the fuzziness of the output response is determined by that of the input variable, the presented measure system defines the importance measures which evaluate the effect of the fuzzy input variable. And for the random input variable, the importance measure system analyzes its effect from two aspects, i.e. its effect on the central distribution position and that on the fuzzy degree of the membership function of the output response. Taking the effects of the two kinds of input variables on the first moment and second one of the output response into account, the definitions of the importance measures of the input variables are given and their engineering significations are demonstrated. Combining with the advantages of the point estimates of Zhao and Ono, a solution of the proposed importance measures is provided. Several examples show that the proposed measure system is comprehensive and reasonable, and the proposed solution can improve computational efficiency considerably with acceptable precision. | LI LuYi LU ZhenZhou LI Wei | 2011 | Science China(Technological Sciences)2011，54，8： | 8 |
| 9 | Saddlepoint approximation based structural reliability analysis with non-normal random variables显示文摘The saddlepoint approximation (SA) can directly estimate the probability distribution of linear performance function in non-normal variables space. Based on the property of SA, three SA based methods are developed for the structural system reliability analysis. The first method is SA based reliability bounds theory (RBT), in which SA is employed to estimate failure probability and equivalent normal reliability index for each failure mode firstly, and then RBT is employed to obtain the upper and the lower bounds of system failure probability. The second method is SA based Nataf approximation, in which SA is used to estimate the probability density function (PDF) and cumulative distribution function (CDF) for the approximately linearized performance function of each failure mode. After the PDF of each failure mode and the correlation coefficients among approximately linearized performance functions are estimated, Nataf distribution is employed to approximate the joint PDF of multiple structural system performance functions, and then the system failure probability can be estimated directly by numerical simulation using the joint PDF. The third method is SA based line sampling (LS). The standardization transformation is needed to eliminate the dimensions of variables firstly in this case. Then LS method can express the system failure probability as an arithmetic average of a set of failure probabilities of the linear performance functions, and the probabilities of the linear performance functions can be estimated by the SA in the non-normal variables space. By comparing basic concepts, implementations and results of illustrations, the following conclusions can be drawn: (1) The first method can only obtain the bounds of system failure probability and it is only acceptable for the linear limit state function; (2) the second method can give the estimation of system failure probability, and its error mostly results from the approximation of Nataf distribution for the joint PDF of the structural system performance functions and the linearization of the performance functions; (3) the SA based LS method can obtain the estimator of system failure probability, which converges to the actual value along with the increase of sample size. The SA based LS method considers the influence of nonlinearity of limit state function on the failure probability, and it is acceptable for the structural system both with a single failure mode and with multiple failure modes, therefore it has the widest applicability. | SONG ShuFang & LU ZhenZhou School of Aeronautics, Northwestern Polytechnical University, Xi’an 710072, China | 2010 | Science China(Technological Sciences)2010，53，2： | 8 |
| 10 | Correction to:Development of a Novel Reverse Transcription Loop-Mediated Isothermal Amplification Method for Rapid Detection of SARS-CoV-2显示文摘In the original version of this article,the legend to Figure 1 was incorrect.The corrected legend is given below.Fig.1 A Location of the primers in SARS-CoV-2 genome.B Sequence comparison among seven human coronaviruses(SARS-CoV-2,SARS-CoV,MERS-CoV,HCoVOC43,HCoV-HKU-1,HCoV-NL63 and HCoV-229E).C Cross-reactivity test of the novel SARS-CoV-2 RTLAMP assay to other common respiratory viruses.Tested common respiratory viruses include HCoV-HKU-1,HCoV-NL63,HCoV-OC43,HCoV-229E,influenza A,B,and C viruses,parainfluenza viruses type 1-3,enterovirus,respiratory syncytial virus A and B groups,human rhinovirus,human metapneumovirus,adenovirus and bocavirus. | Renfei Lu Xiuming Wu Zhenzhou Wan Yingxue Li Lulu Zuo Jianru Qin Xia Jin Chiyu Zhang | 2020 | Virologica Sinica2020，35，4： | 8 |
| 11 | Conditional probability Markov chain simulation based reliability analysis method for nonnormal variables显示文摘Based on fast Markov chain simulation for generating the samples distributed in failure region and saddlepoint approximation(SA) technique,an efficient reliability analysis method is presented to evaluate the small failure probability of non-linear limit state function(LSF) with non-normal variables.In the presented method,the failure probability of the non-linear LSF is transformed into a product of the failure probability of the introduced linear LSF and a feature ratio factor.The introduced linear LSF which approximately has the same maximum likelihood points as the non-linear LSF is constructed and its failure probability can be calculated by SA technique.The feature ratio factor,which can be evaluated on the basis of multiplicative rule of probability,exhibits the relation between the failure probability of the non-linear LSF and that of the linear LSF,and it can be fast computed by utilizing the Markov chain algorithm to directly simulate the samples distributed in the failure regions of the non-linear LSF and those of the linear LSF.Moreover,the expectation and variance of the failure probability estimate are derived.The results of several examples demonstrate that the presented method has wide applicability,can be easily implemented,and possesses high precision and high efficiency. | YUAN XiuKai,LU ZhenZhou & QIAO HongWei School of Aeronautics,Northwestern Polytechnical University,Xi’an 710072,China | 2010 | Science China(Technological Sciences)2010，53，5： | 8 |
| 12 | Bevacizumab plus capecitabine and cisplatin in Chinese patients with inoperable locally advanced or metastatic gastric or gastroesophageal junction cancer: randomized, double-blind, phase III study (AVATAR study)显示文摘 | Lin Shen Jin Li Jianming Xu Hongming Pan Guanghai Dai Shukui Qin Liwei Wang Jinwan Wang Zhenzhou Yang Yongqian Shu Ruihua Xu Lei Chen Yunpeng Liu Shiying Yu Lilian Bu Yongzhe Piao | 2015 | Gastric Cancer2015，，1： | 7 |
| 13 | Development of a Novel Reverse Transcription Loop-Mediated Isothermal Amplification Method for Rapid Detection of SARS-CoV-2显示文摘Dear Editor,Since early December 2019, a large outbreak of pneumonia caused by a novel coronavirus(COVID-19) had emerged in Wuhan, China(Wu et al. 2020 a, b;Zhou et al. 2020;Zhu et al. 2020;Jiang and Shi 2020). Similar to severe acute respiratory syndrome coronavirus(SARS-CoV) and Middle East respiratory syndrome coronavirus(MERS-CoV),the new coronavirus also belongs to Betacoronavirus。 | Renfei Lu Xiuming Wu Zhenzhou Wan Yingxue Li Lulu Zuo Jianru Qin Xia Jin Chiyu Zhang | 2020 | Virologica Sinica2020，35，3： | 7 |
| 14 | Reliability Sensitivity Algorithm Based on Stratified Importance Sampling Method for Multiple Failure Modes Systems显示文摘Combining the advantages of the stratified sampling and the importance sampling,a stratified importance sampling metho(SISM) is presented to analyze the reliability sensitivity for structure with multiple failure modes.In the presented method,th variable space is divided into several disjoint subspace by n-dimensional coordinate planes at the mean point of the random vec tor,and the importance sampling functions in the subspaces are constructed by keeping the sampling center at the mean poin and augmenting the standard deviation by a factor of λ.The sample size generated from the importance sampling function i each subspace is determined by the contribution of the subspace to the reliability sensitivity,which can be estimated by iterativ simulation in the sampling process.The formulae of the reliability sensitivity estimation,the variance and the coefficient o variation are derived for the presented SISM.Comparing with the Monte Carlo method,the stratified sampling method and th importance sampling method,the presented SISM has wider applicability and higher calculation efficiency,which i demonstrated by numerical examples.Finally,the reliability sensitivity analysis of flap structure is illustrated that the SISM ca be applied to engineering structure. | Zhang Feng Lu Zhenzhou Cui Lijie Song Shufang | 2010 | Chinese Journal of Aeronautics2010，23，6： | 7 |
| 15 | X-ray scintillation in lead-free double perovskite crystals显示文摘Metal halide perovskites have shown great performance for various applications,including solar cells,light emitting diodes,and radiation detectors,but they still suffer from the toxicity of lead and instability.Here we report the use of lanthanide series as trivalent metals to obtain low toxicity and highly stable double perovskites(Cs_2NaLnCl_6,Ln=Tb or Eu)with high scintillation light yield.The crystals exhibit typical f-f transitions of lanthanide cations,while Cs_2NaTbCl_6exhibits strong green photoluminescence,and Cs_2NaEuCl_6exhibits red photoluminescence.Under X-ray radiations,the light yield of Cs_2NaTbCl_6reaches46600 photons MeV^(-1),much higher than that of the commercially used(Lu,Y)_2SiO_5:Ce^(3+)crystals(LYSO,28500 photons MeV^(-1)),and previously reported lead-based perovskites(14000 photons MeV^(-1)).As a new member of lead-free perovskites,lanthanide-based double perovskites open up a new route toward radiation detections and potential medical imaging. | Qingsong Hu Zhenzhou Deng Manchen Hu Anjiang Zhao Yaqi Zhang Zhifang Tan Guangda Niu Haodi Wu Jiang Tang | 2018 | Science China Chemistry2018，61，12： | 7 |
| 16 | Reliability and Sensitivity Analysis of Transonic Flutter Using Improved Line Sampling Technique显示文摘考虑飞机机翼结构参数的随机性,提供了一种有效的可靠性数字模拟方法—改进线抽样方法,来进行跨声速机翼颤振的概率和灵敏性分析。线抽样方法适用于高维、小失效概率和隐式极限状态方程的可靠性问题的概率和灵敏度分析,而不用引入任何隐式极限状态方程的近似替代函数。考虑机翼结构参数,如固有频率、重心位置参数和质量比等的不确定性,将改进线抽样技术应用于带有操纵面机构的二元机翼颤振问题的不确定性分析。采用基于计算流体动力学(CFD)技术的非定常气动力降阶方法,可得到基于结构模态坐标的非定常气动力模型,耦合结构状态方程和气动状态方程得到气动弹性系统的状态方程,通过求解状态方程中矩阵的特征值得到颤振的临界速度,并建立颤振的安全裕度方程。分别采用Monte Carlo模拟法和改进线抽样法进行随机不确定性分析,改进线抽样方法的计算效率比Monte Carlo模拟法有很大程度的提高。此外,灵敏度分析所得的灵敏度因子能够定量地反映随机参数对颤振临界速度的影响程度,从而为提高颤振临界速度的结构优化设计提供依据。 | Song Shufang Lu Zhenzhou Zhang Weiwei Ye Zhengyin | 2009 | Chinese Journal of Aeronautics2009，22，5： | 7 |
| 17 | Estimation method for a skip-stop operation strategy for urban rail transit in China显示文摘The skip-stop operation strategy(SOS) is rarely applied to Chinese urban rail transit networks because it is a simple scheme and a less universally popular transportation service. However, the SOS has performance advantages, in that the total trip time can be reduced depending on the number of skipped stations, crowds of passengers can be rapidly evacuated at congested stations in peak periods, and the cost to transit companies is reduced. There is a contradiction between reducing the trip time under the SOS and increasing the passengers' waiting times under an all-stop scheme. Given this situation, the three objectives of our study were to minimize the waiting and trip times of all passengers and the travel times of trains. A comprehensive estimation model is presented for the SOS. The mechanism through which the trip time for all passengers is affected by the SOS is analyzed in detail. A 0–1 integer programming formulation is established for the three objectives, and is solved using a tabu search algorithm.Finally, an example is presented to demonstrate that the estimation method for the SOS is capable of optimizing the timetable and operation schemes for a Chinese urban rail transit network. | Zhichao Cao Zhenzhou Yuan Dewei Li | 2014 | Journal of Modern Transportation2014，22，3： | 7 |
| 18 | Lyapunov exponents for synchronous 12-lead ECG signals显示文摘The Lyapunov exponents of synchronous 12-lead ECG signals have been investigated for the first time using a multi-sensor (electrode) technique. The results show that the Lyapunov exponents computed from different locations on the body surface are not the same, but have a distribution characteristic for the ECG signals recorded from coronary artery disease (CAD) patients with sinus rhythms and for signals from healthy older people. The maximum Lyapunov exponent L1 of all signals is positive. While all the others are negative, so the ECG signal has chaotic characteristics. With the same leads, L1 of CAD patients is less than that of healthy people, so the CAD patients and healthy people can be classified by L1, L1 therefore has potential values in the diagnosis of heart disease. | WANG Zhenzhou LI Zheng WEI Yixiang NING Xinbao LIN Yuzheng | 2002 | Chinese Science Bulletin2002，47，21： | 7 |
| 19 | Dynamic Response Analysis of Bird Strike on Aircraft Windshield Based on Damage-modified Nonlinear Viscoelastic Constitutive Relation显示文摘Damage-modified nonlinear viscoelastic constitutive equation and failure criterion are introduced and the three-dimensional incremental forms are deduced based on the updated Lagrangian approach. A simple tensile test model and a split Hopkinson pressure bar model are built to verify the accuracy of the subroutine implemented within the non-linear finite element program LS-DYNA. A numerical model of bird strike on windshield is established to study the responses of windshield under three different bird velocities at three sites. The bird is represented by a cylinder with a hemisphere at each end and the contact-impact coupling algorithm is used in this study. It is found that the implemented subroutine can properly describe the mechanical behavior of polymethyl methacrylate under low and high strain rates and large deformation, and can be used validly. | Wang Xinjun Feng Zhenzhou Wang Fusheng Yue Zhufeng | 2007 | Chinese Journal of Aeronautics2007，20，6： | 7 |
| 20 | State dependent parameter method for importance analysis in the presence of epistemic and aleatory uncertainties显示文摘For the structure system with epistemic and aleatory uncertainties,a new state dependent parameter(SDP) based method is presented for obtaining the importance measures of the epistemic uncertainties.By use of the marginal probability density function(PDF) of the epistemic variable and the conditional PDF of the aleatory one at the fixed epistemic variable,the epistemic and aleatory uncertainties are propagated to the response of the structure firstly in the presented method.And the computational model for calculating the importance measures of the epistemic variables is established.For solving the computational model,the high efficient SDP method is applied to estimating the first order high dimensional model representation(HDMR) to obtain the importance measures.Compared with the direct Monte Carlo method,the presented method can considerably improve computational efficiency with acceptable precision.The presented method has wider applicability compared with the existing approximation method,because it is suitable not only for the linear response functions,but also for nonlinear response functions.Several examples are used to demonstrate the advantages of the presented method. | LI LuYi LU ZhenZhou LI Wei | 2012 | Science China(Technological Sciences)2012，55，6： | 6 |
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