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| 1 | Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis显示文摘指导暗示的裂缝家庭绑在环岛(Robo ) 受体并且调制房间移植。我们这里报导 Slit2 的那宫外的表情和上皮的癌房间招募了的表示 Robo1 colorectal 的 Robo1 或 recombinant Slit2 处理为 E-cadherin (电子恶棍) ubiquitination 和 lysosomal 降级,上皮间充质的转变(EMT ) ,和肿瘤生长和肝转移的 ubiquitin ligase Hakai,它被救由 Hakai 击倒。相反,内长的 Robo1 或对 Robo1 有约束力的 Slit2 的特定的封锁击倒阻止的电子恶棍降级和颠倒的 EMT,导致减少的肿瘤生长和肝转移。Robo1 的宫外的表示也在 Slit2 积极的人的胚胎的肾触发了恶意的转变 293 个房间。重要地, Slit2 和 Robo1 的表示显著地在 colorectal 癌病人与增加的变形风险和更差的全面幸存被联系。我们断定由 Slit2 的 Robo1 的那个约会在 colorectal 期间通过调停 Hakai 的电子恶棍 ubiquitination 和 lysosomal 降级导致恶意的转变上皮的房间 carcinogenesis。 | Wei-Jie Zhou Zhen H Geng Shan Chi Wenli Zhang Xiao-Feng Niu Shu-Jue Lan Li Ma Xuesong Yang Li-Jing Wang Yan-Qing Ding Jian-Guo Geng | 2011 | Cell Research2011，21，4： | 14 |
| 2 | Aurora A orchestrates entosis by regulating a dynamic MCAK-TIP150 interaction显示文摘 | PengXia JinhuaZhou Xiaoyu Song BingWu XingLiu Di Li Shuyuan Zhang Zhikai Wang H uijuan Yu Tarsha Ward Jiancun Zhang Yinmei Li Xiaoning Wang YongChen Zhen Guo Xuebiao Yao | 2014 | Journal of Molecular Cell Biology2014，8，3： | 9 |
| 3 | A NEW FLAVONE C-GLYCOSIDE FROM SCUTELLARIA BAICALENSIS显示文摘ANEWFLAVONEC-GLYCOSIDEFROMSCUTELLARIABAICALENSIS￥YongYuZHANG;XianLI;YunZhenGOU(ShenyangPharmaceuticalUniversity,Shenyang11001... | Yong Yu ZHANG Xian LI Yun Zhen GOU(Shenyang Pharmaceutical University, Shenyang 110015)Yoshihiro HARIGAYA, Masayuki ONDASchool of Pharmaceutical Sciences, Kitasato University, Tokyo 108 ,JapanKadsunort H^SHIMO’rO, yukinobu iK EYA, Minoru OKAD^, cacao M^ | 1994 | Chinese Chemical Letters1994，5，10： | 3 |
| 4 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 5 | Nanoscopy reveals surface-metallic black phosphorus显示文摘Black phosphorus(BP)is an emerging two-dimensional material with intriguing physical properties.It is highly anisotropic and highly tunable by means of both the number of monolayers and surface doping.Here,we experimentally investigate and theoretically interpret the near-field properties of a-few-atomic-monolayer nanoflakes of BP.We discover near-field patterns of bright outside fringes and a high surface polarizability of nanofilm BP consistent with its surface-metallic,plasmonic behavior at mid-infrared frequencies o1176 cm−1.We conclude that these fringes are caused by the formation of a highly polarizable layer at the BP surface.This layer has a thickness of~1 nm and exhibits plasmonic behavior.We estimate that it contains free carriers in a concentration of n≈1.1×10^(20) cm^(−3).Surface plasmonic behavior is observed for 10–40 nm BP thicknesses but absent for a 4-nm BP thickness.This discovery opens up a new field of research and potential applications in nanoelectronics,plasmonics and optoelectronics. | Yohannes Abate Sampath Gamage Zhen Li Viktoriia Babicheva Mohammad H Javani Han Wang Stephen B Cronin Mark I Stockman | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 6 | The mechanical behavior of foamed aluminum显示文摘 | Fusheng H Zhen gang Z | 1999 | J Mater Sci1999，34，： | 1 |
| 7 | Numerical dispersion analysis of the unconditionally stable 3-D ADI-FDTD method显示文摘 | Zhen F H Chen Z Z | 2001 | IEEE Trans MTT2001，49，5： | 1 |
| 8 | Studv on the development of Pueraria lobata 显示文摘 | Zhen H | 2006 | A-mino Acids&Biotic Res2006，28，： | 1 |
| 9 | Prevention and cure of early complication of pneumatic lithotripsy under ureteroscope显示文摘 | QI H ZHEN SB TAN WL | 2003 | Chinese Journal of Urology2003，24，： | 1 |
| 10 | Real-time speech-driven face animation with expressions using neural networks显示文摘 | Hong Pengyu Wen Zhen Thomas S H | | 0，，04： | 1 |
| 11 | Battery performance and photocatalytic activity of mesoporous anatase TiO2 nanospheres/graphene composites by template-free self-assembly 显示文摘 | Li N Liu G Zhen C Li F Zhang L L Cheng H M | 2011 | Advanced Functional Materials2011，21，9： | 1 |
| 12 | Super smooth modification of Al2O3 ceramic substrate by high temperature glaze of CaO-Al2O3-SiO2 system显示文摘 | ZHANG J H ZHEN S X YANG L J | 2011 | Japanese Journal of Applied Physics2011，50，01： | 1 |
| 13 | On the mechanics of the grinding process,part Ⅰ: stochastic nature of the grinding proeess显示文摘 | Zhen B H Komanduri R | 2003 | International Journal of Mac- hine Tools & Manufacture2003，43，15： | 1 |
| 14 | Effects of the ancillary ligands of polypyridyl ruthenium (II) : complexes on the DNA-binding and photocleavage behaviors 显示文摘 | TAN L F CHAO H ZHEN K C | 2007 | Polyhedron2007，26，18： | 1 |
| 15 | Dual degradation signals control gli protein stability and tumor formation 显示文摘 | Huntzicker EG Estay IS Zhen H | 2006 | Genes Dev2006，20，3： | 1 |
| 16 | The Effect of Pre-aging on Microstructure and Tensile Properties of Al-Mg-Si Alloys 显示文摘 | ZHEN L KANG S B KIM H W | 1997 | Mater Sci & Tech1997，13，： | 1 |
| 17 | Towards semantic e-science for traditional Chinese medicine显示文摘 | Chen H Mao Y Zhen X | 2007 | BMC Bioinformatics2007，8，3： | 1 |
| 18 | Effects of salt- tolerant rootstock grafting on ultrastructure, photosynthetic capacity, and H2 02 - scavenging system in chloroplasts of cucumber seedlings under NaC1 stress 显示文摘 | ZHEN A BIE Z -h HUANG Y | 2011 | Acta Physiologiae Plantarum2011，33，6： | 1 |
| 19 | Electricity production coupled to ammonium in a microbial fuel cell显示文摘 | Zhen H Jinjun K Yanbing W | 2009 | Environmental Science&Technology2009，43，9： | 1 |
| 20 | Influence of transverse normal strain and temperature profile on thermo-elasticity of sandwiches显示文摘 | Wu Zhen S H Lo K Y Sze | 2013 | J Thermal Stresses2013，，36： | 1 |
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