|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Genome survey uncovers the secrets of sex and lifestyle in caterpillar fungus显示文摘The caterpillar fungus Ophiocordyceps sinensis (best known as Cordyceps sinensis) mummifies ghost moth larvae exclusively in Tibetan Plateau alpine ecosystems. Touted as 'Himalayan Viagra', the fungus is highly prized due to its medical benefits and dwindling supplies. Attempts to culture the sexual fruiting-body have failed and the huge market demand has led to severe devastation of local ecosystems and to the fungus heading towards extinction. By genome sequencing, we establish that unlike related insect pathogens O. sinensis contains two compatible mating-type genes in its genome and is self-fertile, i.e. homothallic. However, sexual processes are only initiated under native environmental conditions. O. sinensis resembles biotrophic plant pathogens in having a genome shaped by retrotransposon-driven expansions. The resulting changes in gene content suggest that O. sinensis has a biphasic pathogenic mechanism beginning with stealth pathogenesis in early host instars. O. sinensis is the first psychrophilic fungus sequenced and is adapted to extreme cold with putative antifreeze proteins and mechanisms for increasing lipid accumulation and fatty acid unsaturation. We hypothesize that for the inbreeding O. sinensis the massive proliferation of retrotransposons provides a tradeoff between the advantages of increased genetic variation independent of sexual recombination and deletion of genes dispensable for its specialized pathogenic lifestyle. | HU Xiao ZHANG YongJie XIAO GuoHua ZHENG Peng XIA YongLiang ZHANG XingYu ST LEGER Raymond J LIU XingZhong WANG ChengShu | 2013 | Chinese Science Bulletin2013，58，23： | 26 |
| 2 | 胎儿期恰逢1959~1961年饥荒的中国成人精神分裂症的发病率显示文摘背景:精神分裂症是一种常见的中度精神障碍。子宫内营养缺乏可增大患精神分裂症的危险。其主要依据来自1944~1945年荷兰饥饿冬天(Dutch Hunger Winter)研究,当时食品摄入在短期内极剧下降。这项有关饥荒期间受孕人群的大型队列研究显示,发生精神分裂症的危险增大两倍。
目的:确定经受1959~1961年大饥荒的中国人是否有相似的结果。
设计、地点及参试者:发生精神分裂症危险的调查于安徽省芜湖地区进行,这是当初受灾最重的地区之一。对饥荒之前、饥荒期间和饥荒以后出生的人群发病率进行比较。芜湖及其周围6个县是由一所精神病院负责的。对1971~2001年所有的精神病病历记录均进行检查。精神分裂症患者的临床和社会人口学资料由对自然灾害暴露情况不知情的研究者摘录。有关饥荒年出生人数和死亡人数的数据是有效可用的,累积死亡率根据以后的人口学调查进行估计。
主要观测指标:饥荒的证据已经核实,计算未校正的以及对死亡率进行校正后的发生精神分裂症的相对危险度。
结果:安徽省的出生率(每1000人)在饥荒期问降低了约80%,从1958年的28.28降至1959年的20.97、1960年的8.61和1961年的11.06。在饥荒期间出生的人,晚年发生精神分裂症的校正后危险明显增高,从1959年的0.84%增至1960年的2.15%和1961年的1.81%。死亡率校正相对危险在1960年出生者为2.30(95%可信区间,1.99~2.05),1961年出生者为1.93(95%可信区间,1.68~2.23)。
结论:我们的调查重复了荷兰不同种族人群的数据,结果显示,出生前遭受饥荒可增高晚年患精神分裂症的危险。 | David St Clair Mingqing Xu Peng Wang Yaqin Yu Yourong Fang Feng Zhang Xiaoying Zheng Niufan Gu Guoyin Feng Pak Sham Lin He 张继志(译) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 3 |
| 3 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 4 | Improving photoreduction of CO2 with water to CH4 in a novel concentrated solar reactor显示文摘CO_2 photoreduction is an attractive process which allows the storage of solar energy and synthesis of solar fuels. Many different photocatalytic systems have been developed, while the alternative photo-reactors are still insufficiently investigated. In this work, photoreduction of CO_2 with H_2O into CH_4 was investigated in a modified concentrating solar reactor, using TiO_2 and Pt/TiO_2 as the catalysts. The TiO_2 and Pt/TiO_2 samples were extensively characterized by different techniques including powder X-ray diffraction(XRD), N_2 adsorption/desorption and UV–vis absorption. The catalytic performance of the TiO_2 and Pt/TiO_2 samples in the gas phase was evaluated under unconcentrated and concentrated Xe-lamp light and nature solar light with different concentrating ratios. Various parameters of the reaction system and the catalysts were investigated and optimized to maximize the catalytic performance of CO_2 reduction system. Compared with the normal light irradiation, the TiO_2 and Pt/TiO_2 samples show higher photocatalytic activity(about 6–7 times) for reducing CO_2 into CH_4 under concentrated Xe-lamp light and nature solar light. In the range of experimental light intensity, it is found that the concentration of the light makes it suitable for the catalytic reaction, and increases the utilization efficiency of the TiO_2 and Pt/TiO_2 samples while does not decrease the quantum efficiency. | Sisi Han Yinfei Chen Stéphane Abanades Zekai Zhang | 2017 | Journal of Energy Chemistry2017，26，4： | 2 |
| 5 | The arachnoid sleeve enveloping the pituitary stalk: anatomical and histologic study 显示文摘 | Qi ST Zhang XA Long H | 2010 | Neurosurgery2010，66，3： | 1 |
| 6 | A rare case of bile duct cyst显示文摘 | Wang QG Zhang ST | 2009 | World J Gastroenterol2009，15，20： | 1 |
| 7 | Histopathologic and clinical subtypes of autoimmune pancreatitis: the honolulu consensus document显示文摘 | Chari ST Kloeppel G Zhang L | 2010 | Pancreatology2010，10，6： | 1 |
| 8 | Linking grazing response of species abundance to functional traits in the Tibetan alpine meadow显示文摘 | Niu KC Zhang ST Zhao BB | | 0，，： | 1 |
| 9 | Clinical spectrum of chromosome 6 linked autosomal dominant drusen and macular degeneration显示文摘 | Stefko ST Zhang K Gorin MB | | 0，，： | 1 |
| 10 | Growth factors secreted by bronchial epithelial cells control myofibroblast proliferation:an in vitro co-culture model of airway remodeling in asthma显示文摘 | Zhang S Smartt H Holgate ST | 1999 | Lab Invest1999，79，4： | 1 |
| 11 | TiO2 Nanotubes as animal drug delivery system and in vitro controlled release显示文摘 | Lai ST Zhang W Liu F | 2013 | Journal of Nanoscience and Nanotechnology2013，13，1： | 1 |
| 12 | In vivo dynamic MRI tracking of rat T - cells labeled with superparamagnetic iron oxide particles 显示文摘 | Yeh TC Zhang W Ildstad ST | 1995 | Magn Reson Med1995，33，3： | 1 |
| 13 | Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes显示文摘 | Jin DK Shido K Kopp HG Petit I Shmelkov SV Young LM Hooper AT Amano H Avecilla ST Heissig B Hattori K Zhang F | 2006 | Nat Med2006，12，： | 1 |
| 14 | Engineering Propionibacterium acidipropionici for enhanced propionic acid tolerance and fermentation 显示文摘 | ZHANG A YANG ST | 2009 | Biotechnol Bioeng2009，104，4： | 1 |
| 15 | A novel transcription factor,T-bet,directs Thl lineage commitment显示文摘 | Szabo S J Kim ST Costa GL Zhang X Fathman CG Glimcher LH | | 0，，06： | 1 |
| 16 | Initial severity rating of idiopathic clubfeet is an outcome predictor at age two years显示文摘 | Zhang W Richards BS Faulks ST | | 0，，01： | 1 |
| 17 | Local ex vivo gene therapy with bone marrow stromal cells expressing human BMP4 promotes endosteal bone formation in mice显示文摘 | Zhang XS Linkhart TA Chen ST | | 0，，： | 1 |
| 18 | Fever with thrombocytopenia associated with a novel bunyavirus in China显示文摘 | Yu XJ Liang MF Zhang ST | 2011 | New England Journal of Medicine2011，364，16： | 1 |
| 19 | Sythesis of branched polyethylene from ethylene stock by an in- terference- free tandem catalysis of TiClJMgC12 and iron catalyst显示文摘 | Zhang ZC Lu ZX Chen ST | | 0，，： | 1 |
| 20 | Expression of maerophage migration inhibitory factor in esophageal squamous cell carcinoma and effects of bile acids and NSAIDs显示文摘 | Xia HH Zhang ST Lam SK | 2005 | Carcinogenesis2005，26，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员