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| 1 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 2 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 3 | Electrochemical detection of DNA hybridization using methylene blue and electro-deposited zirconia thin films on gold electrodes 显示文摘 | Zhu N Zhang A Wang Q | 2004 | Analytica Chimica Acta2004，510，2： | 1 |
| 4 | Analysis of the 9- fluorenylmethoxycarbonyl hydrazide labelling of neutral and sialic acid-containing oligosaccharides by reversed-phase high- performance liquid chromatography显示文摘 | Zhang Z D Zhang R N Liu G Q | 1996 | J Chromatogr A1996，728，12： | 1 |
| 5 | Transforming growth factor-beta down-regulates apolipoprotein M in HepG2 cells显示文摘 | Xu N Hurtig M Zhang XY Ye Q Nilsson-Ehle P | 2004 | Biochim Biophys Acta2004，1683，13： | 1 |
| 6 | Insights into the chemistry of new particle formation and growth events in Pittsburgh based on aerosol mass spectrometry 显示文摘 | Zhang Q Stanier C O Canagaratna M R Jayne J T Worsnop D R Pandis S N Jimenez J L | 2004 | Environ Sci Technol2004，38，18： | 1 |
| 7 | Galloping of bundle conductor 显示文摘 | Zhang Q Popplewell N Shah H | 2000 | Sound and Vibration2000，234，1： | 1 |
| 8 | A coupling simulation based on a hydrodynamics and water quality model of the Pearl River,China 显示文摘 | Zhang N Q Wcstrich B Jiang S M | 2011 | Journal of Hydrology2011，396，： | 1 |
| 9 | Anal Chim Acta显示文摘 | Cao D S Hu Q N Xu Q S Yang Y N Zhao J C Lu H M Zhang L X Liang Y Z | 2011 | 692(1-2):502011，692，12： | 1 |
| 10 | Catalytic dechlorination of 2, 4-dichlorophenol by Pd/Fe bimetallic nanopartieles in the presence of humic acid 显示文摘 | Zhang Z Shen Q Cissoko N | 2010 | Journal of Hazardous Materials2010，182，13： | 1 |
| 11 | Impact of the Madden-Julian Oscillation on summer rainfall in Southeast China显示文摘 | ZHANG L N WANG B Z ZENG Q C | 2009 | J Climate2009，22，2： | 1 |
| 12 | Three dimensional simulation for an open channel flow with a constriction 显示文摘 | SHANKAR N J CHAN E S ZHANG Q Y | 2001 | Journal of Hydraulic Reserach2001，39，2： | 1 |
| 13 | 查看详情显示文摘 | Zhang J P Yang H P Han K L Deng W Q He G Z Lou N Q | | 0，，： | 1 |
| 14 | Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells显示文摘 | LI N ZHANG Q GAO S | 2013 | Scien- tific Reports2013，3，16： | 1 |
| 15 | Stem cell therapy is a promising tool for refractory angina: a meta-analysis of randomized controlled trials显示文摘 | Li N Yang Y J Zhang Q | 2013 | Can J Cardiol2013，29，8： | 1 |
| 16 | Silk fibroin/chon- droitin sulfate/hyaluronic acid ternary scaffolds for dermal tissue reconstruction 显示文摘 | Yan S Q Zhang Q Wang J N | 2013 | Acta Biomater2013，，9： | 1 |
| 17 | Dual catalysis mechanism of alcohol solvent and Cu catalyst for a new methanol synthesis method显示文摘 | Yang R Q Zhang Y T subaki N | 2005 | Catal Com2005，6，4： | 1 |
| 18 | Development and characterization of a Triticum aestivum-Haynaldia villosa translocation line T4VS·4DL conferring resistance to wheat spindle streak mosaic virus显示文摘 | ZHANG Q P LI Q WANG X WANG H Y LANG S P WANG Y N WANG S L CHEN P D LIU D J | 2005 | Euphytica2005，145，： | 1 |
| 19 | Modelling dynamic urban expansion processes incorporating a potential model with cellular automata显示文摘 | He C Y Okada N Zhang Q F | 2008 | Landscape and Urban Planning2008，86，1： | 1 |
| 20 | Dielectric resonator antenna element and subarray with unequal crossstub 显示文摘 | ZHANG L N ZHONG S S Xu S Q | 2008 | Microwave and Optical Technology Letters2008，50，8： | 1 |
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