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| 1 | In vitro effect of pantoprazole on lower esophageal sphincter tone in rats显示文摘AIM:To investigate the in vitro effects of pantoprazole on rat lower esophageal sphincter(LES)tone.METHODS:Rats weighing 250-300 g,provided by the Yeditepe University Experimental Research Center(Yü-DETAM),were used throughout the study.They were anesthetized before decapitation.LES tissues whose mucosal lining were removed were placed in a stan-dard 30-mL organ bath with a modif ied Krebs solution and continuously aerated with 95% oxygen-5% carbon dioxide gas mixture and kept at room temperature.The tissues were allowed to stabilize for 60 min.Sub-sequently,the contractile response to 10-6 mol/L carba-chol was obtained.Different concentrations of freshly prepared pantoprazole were added directly to the tis-sue bath to generate cumulative concentrations of 5×10-6 mol/L,5×10-5 mol/L,and 1.5×10-4 mol/L.Activi-ties were recorded on an online computer via a 4-channeltransducer data acquisition system using the software BSL PRO v 3.7,which also analyzed the data.RESULTS:Pantoprazole at 5×10-6 mol/L caused a small,but statistically insignif icant,relaxation in the car-bachol-contracted LES(2.23% vs 3.95%).The 5×10-5 mol/L concentration,however,caused a signif icant relax-ation of 10.47% compared with the control.1.5×10-4 mol/L concentration of pantoprazol caused a 19.89% relaxation in the carbachol contracted LES(P<0.001).CONCLUSION:This is the fi rst study to demonstrate that pantoprazole has a relaxing effect in isolated LESs.These results might have signif icant clinical implications for the subset of patients using proton pump inhibitors who do not receive full symptomatic alleviation from gastroesophageal reflux disease. | Mustafa Duman Mahmut zer Enver Rean Yeliz Demirci Ali E Atιcι Tahsin Dalgι Erdal B Bostancι Ece Gen | 2011 | World Journal of Gastroenterology2011，17，46： | 3 |
| 2 | siRNA inhibition of te lomerase enhances the anti-cancer effect of doxorubi-tin in breast cancer cells显示文摘 | Dong X J Liu AD Zer C | 2009 | BMC Cancer2009，，9： | 1 |
| 3 | siRNA inhibition of telomerase enhances the anti-cancer effect of doxorubicin in breast cancer cells显示文摘 | Dong XJ Liu A Zer C | 2009 | BMC Cancer2009，9，133： | 1 |
| 4 | Papillary renal cellcarcinoma within a renal oncocytoma: Case report of very rarecoexistence显示文摘 | ZER C GREN MR EGILMEZ T | 2014 | Can Urol Assoc J2014，8，1112： | 1 |
| 5 | Association of laryngopharyngeal manifestations and gatroesophageal reflux显示文摘 | Sema Zer Toros Ahmet Burak Toros Ozlem Doganer Yüksel Leyla Ozel C?nar Akkaynak Bar?s Naiboglu | 2009 | European Archives of Oto - Rhino - Laryngology2009，，3： | 1 |
| 6 | Transeriptomes of purified gastric ECL and parietal cells: identification of a novel pathway regula- ting acid secretion显示文摘 | Lambreeht NW Yakubov I Zer C | 2006 | Physiol Genomies2006，25，1： | 1 |
| 7 | Prognostic signifieance of microvascular obstruction by magnetic imaging in patients with acute myocardial infarction显示文摘 | WU K C ZER HOUNI E A JUDD R M | 1998 | Circulation1998，97，8： | 1 |
| 8 | Protein microarray sensi- tive and effective immunodetection for drug residues 显示文摘 | Zhong L Zhang W Zer C | 2010 | BMC Biotechnology2010，，10： | 1 |
| 9 | LIN28 alters cell fate succession and acts independently of the let-7 mi- eroRNA during neurogliogenesis in vitro显示文摘 | Ba!zer E Heine C Jiang Q | 2010 | Devel- opment2010，137，6： | 1 |
| 10 | Modeling of the classification behavior of the diaphragms used in multi-chamber cement mills显示文摘 | (OI) ZER C E ERG (U) N S L BENZER A H | | 0，，： | 1 |
| 11 | siRNA inhibition of telomer- ase enhances the anti-cancer effect of doxorubicin in breast cancer cells显示文摘 | Dong X Liu A Zer C | 2009 | BMC Cancer2009，9，： | 1 |
| 12 | Effect of Strategic Leader- ship Styles on Firm Performance: A Study in a Turk- ish SME显示文摘 | ZER F TINAZTEPE C | 2014 | Proeedia-Social and Behavioral Sciences2014，150，77： | 1 |
| 13 | Prevalence and risk factors for erectile dysfunction in 2869 men using a validated questionnaire 显示文摘 | Ponhol zer A Temml C Mock K | 2005 | Eur Urol2005，47，： | 1 |
| 14 | siRNA inhibition of tefomerase enhances the and cancer effect of doxorubiein in breast cancer cells 显示文摘 | Dong X Liu A Zer C | 2009 | BMC Cancer2009，5，9： | 1 |
| 15 | Investigations on the activation of recombinant microbial pro-transglutaminase: in contrast to proteinase K, dispase removes the histidine- tag 显示文摘 | Sommer C Hertel T C Schme|zer C E H et a/ | 2012 | Amino Acids2012，42，2： | 1 |
| 16 | The Effects of Rate-restricted Feeding Regimes in Cycles on Digestive En-zymes of Gilthead Sea-bream,Sparus aurata显示文摘 | Orhan Tufan Eroldoan Cüneyt Süzer | | 0，，： | 1 |
| 17 | Protein microarray: Sensitive and effective immunodetection for drug residues显示文摘 | Zhong L Zhang W Zer C | 2010 | BMC Biotechn ol2010，10，1： | 1 |
| 18 | Soil clogging in vertical flow reed beds-mechanisms,parameters,consequences and solutions显示文摘 | PLAT ZER C MAUCH K | 1997 | Water Science and Technology1997，35，5： | 1 |
| 19 | A rapid HPLC method for determination of Sudan dyes and Para Red in red chilli pepper显示文摘 | Ertas E Zer H Alasalvar C | 2007 | Food Chemistry2007，105，2： | 1 |
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