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| 1 | Establishing the presence or absence of chronic kidney disease:Uses and limitations of formulas estimating the glomerular filtration rate显示文摘The development of formulas estimating glomerular filtration rate(eG FR) from serum creatinine and cystatin C and accounting for certain variables affecting the production rate of these biomarkers, including ethnicity, gender and age, has led to the current scheme of diagnosing and staging chronic kidney disease(CKD),which is based on e GFR values and albuminuria.This scheme has been applied extensively in various populations and has led to the current estimates of prevalence of CKD. In addition, this scheme is applied in clinical studies evaluating the risks of CKD and the efficacy of various interventions directed towards improving its course. Disagreements between creatinine-based and cystatin-based e GFR values and between e GFR values and measured GFR have been reported in various cohorts. These disagreements are the consequence of variations in the rate of production and in factors, other than GFR, affecting the rate of removal of creatinine and cystatin C. The disagreements create limitations for all e GFR formulas developed so far. The main limitations are low sensitivity in detecting early CKD in several subjects, e.g., those with hyperfiltration, and poor prediction of the course of CKD. Research efforts in CKD are currently directed towards identification of biomarkers that are better indices of GFR than the current biomarkers and,particularly, biomarkers of early renal tissue injury. | Ahmed Alaini Deepak Malhotra Helbert Rondon-Berrios Christos P Argyropoulos Zeid J Khitan Dominic SC Raj Mark Rohrscheib Joseph I Shapiro Antonios H Tzamaloukas | 2017 | World Journal of Methodology2017，7，3： | 7 |
| 2 | Fluid balance concepts in medicine:Principles and practice显示文摘The regulation of body fluid balance is a key concern in health and disease and comprises three concepts. The first concept pertains to the relationship between total body water(TBW) and total effective solute and is expressed in terms of the tonicity of the body fluids. Disturbances in tonicity are the main factor responsible for changes in cell volume, which can critically affect brain cell function and survival. Solutes distributed almost exclusively in the extracellular compartment(mainly sodium salts) and in the intracellular compartment(mainly potassium salts) contribute to tonicity, while solutes distributed in TBW have no effect on tonicity. The second body fluid balance concept relates to the regulation and measurement of abnormalities of sodium salt balance and extracellular volume. Estimation of extracellular volume is more complex and error prone than measurement of TBW. A key function of extracellular volume, which is defined as the effective arterial blood volume(EABV), is to ensure adequate perfusion of cells and organs. Other factors, including cardiac output, total and regional capacity of both arteries and veins, Starling forces in the capillaries, and gravity also affect the EABV. Collectively, these factors interact closely with extracellular volume and some of them undergo substantial changes in certain acute and chronic severe illnesses. Their changes result not only in extracellular volume expansion, but in the need for a larger extracellular volume compared with that of healthy individuals. Assessing extracellular volume in severe illness is challenging because the estimates of this volume by commonly used methods are prone to large errors in many illnesses. In addition, the optimal extracellular volume may vary from illness to illness, is only partially based on volume measurements by traditional methods, and has not been determined for each illness. Further research is needed to determine optimal extracellular volume levels in several illnesses. For these reasons, extracellular volume in severe illness merits a separate third concept of body fluid balance. | Maria-Eleni Roumelioti Robert H Glew Zeid J Khitan Helbert Rondon-Berrios Christos P Argyropoulos Deepak Malhotra Dominic S Raj Emmanuel I Agaba Mark Rohrscheib Glen H Murata Joseph I Shapiro Antonios H Tzamaloukas | 2018 | World Journal of Nephrology2018，7，1： | 3 |
| 3 | Hypertonicity:Clinical entities,manifestations and treatment显示文摘Hypertonicity causes severe clinical manifestations and is associated with mortality and severe short-term and longterm neurological sequelae. The main clinical syndromes of hypertonicity are hypernatremia and hyperglycemia.Hypernatremia results from relative excess of body sodium over body water. Loss of water in excess of intake,gain of sodium salts in excess of losses or a combination of the two are the main mechanisms of hypernatremia.Hypernatremia can be hypervolemic,euvolemic or hypovolemic. The management of hypernatremia addresses both a quantitative replacement of water and,if present,sodium deficit,and correction of the underlying pathophysiologic process that led to hypernatremia.Hypertonicity in hyperglycemia has two components,solute gain secondary to glucose accumulation in the extracellular compartment and water loss through hyperglycemic osmotic diuresis in excess of the losses of sodium and potassium. Differentiating between these two components of hypertonicity has major therapeutic implications because the first component will be reversed simply by normalization of serum glucose concentration while the second component will require hypotonic fluid replacement. An estimate of the magnitude of the relative water deficit secondary to osmotic diuresis is obtained by the corrected sodium concentration,which represents a calculated value of the serum sodium concentration that would result from reduction of the serum glucose concentration to a normal level. | Helbert Rondon-Berrios Christos Argyropoulos Todd S Ing Dominic S Raj Deepak Malhotra Emmanuel I Agaba Mark Rohrscheib Zeid J Khitan Glen H Murata Joseph I Shapiro Antonios H Tzamaloukas | 2017 | World Journal of Nephrology2017，6，1： | 2 |
| 4 | Characteristics of an effective design plan system to support reuse in case-based mechanical design显示文摘 | Gao Y S Zeid I Bardasz T | 1998 | Knowledge-Based Systems1998，，10： | 2 |
| 5 | Neonatal alloimmune thrombocy topenia显示文摘 | Zeides I Shaler E | 1994 | Harefuah1994，127，12： | 1 |
| 6 | Response of bean (Phaseolus vulgaris) to exogenous putrescine treatment under salinity stress 显示文摘 | Zeid I M | 2004 | Parkistan JBiol Sci2004，7，5： | 1 |
| 7 | Offsetting operations via closed loop ball approximation显示文摘 | GURBUZ AZ ZEID I | 1995 | Computer-Aided Des1995，27，11： | 1 |
| 8 | Towards the design and development of a knowledge-based universal modular jigs and fixtures design system显示文摘 | KAKISH J ZHANGP L ZEID I | 2003 | Computer-Aided Design2003，35，10： | 1 |
| 9 | Automatic quadrilateral/triangular free-form mesh generation for planar regions显示文摘 | Sezer L Zeid I | 1991 | Int J Number Meth Eng1991，32，7： | 1 |
| 10 | Finger-based multi-touch interface for performing 3D CAD operations显示文摘 | RADHAKRISHNAN S LIN Y ZEID I | 2013 | International Journal of Human Computer Studies2013，71，3： | 1 |
| 11 | Applying analogical problem solving to mechanical design显示文摘 | Bardasz T Zeid I | 1991 | Computer Aided Design1991，23，3： | 1 |
| 12 | Response of alfalfa to putrescine treatment under drought stress显示文摘 | Zeid I M Shedeed Z A | 2006 | Biologia Plantarum2006，50，4： | 1 |
| 13 | Ad hoc localization technique for wireless Sensor networks显示文摘 | N Shah I Zeid | 2005 | The International Society for Optical Engineer ing ( S0277 - 786X)2005，6011，60： | 1 |
| 14 | Alterations in Nitrogen metabolites after putrescine treatment in alfalfa under drought stress显示文摘 | Zeid I M Shedeed Z A | 2007 | Pakistan Journal of Biological Sciences2007，10，9： | 1 |
| 15 | Towards the design and development of a knowledge-based universal modular jigs and fixtures design system 显示文摘 | KAKISH J ZHANG P L ZEID I | 2003 | Computer-Aided Design2003，35，10： | 1 |
| 16 | Case-based reasoning for mechanical design 显示文摘 | Bardasz T Zeid I | 1993 | Artificial Intelligence for Engineering Design Analysis and Manufacturing1993，7，2： | 1 |
| 17 | Recognition of resveratrol by the human estrogen receptor- alpha: a molecular modeling approach to understand its biological actions显示文摘 | E1 - Mowafy A M Abou- Zeid L A Edafiogho I | 2002 | Med PrincPract2002，11，2： | 1 |
| 18 | DEJAVU:case-based reason-ing for mechanical design显示文摘 | BARDASZ T ZEID I | 1993 | Artificial Intelligence for Engineering Design Analysis and Manufacturing1993，7，2： | 1 |
| 19 | Response of Alfalfa to Putrescine Treatment under Drought Stress 显示文摘 | Zeid I M Shedeed Z A | 2006 | Biologia Plantarum2006，50，4： | 1 |
| 20 | Analysis of communication between RFID tags and their reader using statistical simulation model显示文摘 | Parikh P Zeid I Kamarthi S | 2008 | International Journal of Computer Applications in Technology2008，32，2： | 1 |
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