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| 1 | Chikungunya virus,epidemiology,clinics and phylogenesis:A review显示文摘Chikungunva virus is a mosquito-transmitted alphavirus that causes chikungunva fever,a febrile illness associated with severe arthralgia and rash.Chikungunva virus is transmitted by culicine mosquitoes:Chikungunya virus replicates in the skin,disseminates to liver,muscle,joints.lymphoid tissue and brain,presumably through the blood.Phylogenetic studies showed that the Indian Ocean and the Indian subcontinent epidemics were caused by two different introductions of distinct strains of East/Central/South African genotype of CHIKV.The paraphyletic grouping of African CHIK viruses supports the historical evidence that the virus was introduced into Asia from Africa.Phylogenetic analysis divided Chikungunva virus isolates into three distinct genotypes based on geographical origins:the first,the West Africa genotype,consisted of isolates from Senegal and Nigeria;the second contained strains from East/Central/South African genotype,while the third contained solely Asian.The most recent common ancestor for the recent epidemic,which ravaged Indian Ocean islands and Indian subcontinent in 2004- 2007.was found to date in 2002.Asian lineage dated about 1952 and exhibits similar spread patterns of the recent Indian Ocean outbreak lineage,with successive epidemics detected along an eastward path.Asian group splitted into two clades:an Indian lineage and a south east lineage.Outbreaks of Chikungunya virus fever in Asia have not been associated necessarily with outbreaks in Africa.Phylogenetic tools can reconstruct geographic spread of Chikungunva virus during the epidemics wave.The good management of patients with acute Chikungunva virus infection is essential for public health in susceptible areas with current Aedes spp activity. | Alessandra Lo Presti Alessia Lai Eleonora Cella Gianguglielmo Zehender Massimo Ciccozzi | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，12： | 8 |
| 2 | Enigmatic origin of hepatitis B virus:An ancient travelling companion or a recent encounter?显示文摘Hepatitis B virus(HBV)is the leading cause of liver disease and infects an estimated 240 million people worldwide.It is characterised by a high degree of genetic heterogeneity because of the use of a reverse transcriptase during viral replication.The ten genotypes(A-J)that have been described so far further segregate into a number of subgenotypes which have distinct ethno-geographic distribution.Genotypes A and D are ubiquitous and the most prevalent genotypes in Europe(mainly represented by subgenotypes D1-3 and A2);genotypes B and C are restricted to eastern Asia and Oceania;genotype E to central and western Africa;and genotypes H and F(classified into 4 subgenotypes)to Latin America and Alaska.This review summarises the data obtained by studying the global phylodynamics and phylogeography of HBV genotypes,particularly those concerning the origin and dispersion histories of genotypes A,D,E and F and their subgenotypes.The lack of any consensus concerning the HBV substitution rate and the conflicting data obtained using different calibration approaches make the time of origin and divergence of the various genotypes and subgenotypes largely uncertain.It is hypothesised that HBV evolutionary rates are time dependent,and that the changes depend on the main transmission routes of the genotypes and the dynamics of the infected populations. | Gianguglielmo Zehender Erika Ebranati Elena Gabanelli Chiara Sorrentino Alessra Lo Presti Elisabetta Tanzi Massimo Ciccozzi Massimo Galli | 2014 | World Journal of Gastroenterology2014，20，24： | 3 |
| 3 | Zika virus spreading in South America: evolutionary analysis of emerging neutralizing resistant Phe279Ser strains显示文摘Objective: To investigate the genetic diversity of Zika virus(ZIKV) and the relationships existing among these circulating viruses worldwide. To evaluate the genetic polymorphisms harboured from ZIKV that can have an influence on the virus circulation. Methods: Three different ZIKV dataset were built. The first dataset included 63 E gene sequences, the second one 22 NS3 sequences and the third dataset was composed of 108 NS5 gene sequences. Phylogenetic and selective pressure analysis was performed. The edited nucleic acid alignment from the Envelope dataset was used to generate a conceptual translation to the corresponding peptide sequences through UGene software. Results: The phylogeographic reconstruction was able to discriminate unambiguously that the Brazilian strains are belonged to the Asian lineage. The structural analysis reveals instead the presence of the Ser residue in the Brazilian sequences(however already observed in other previously reported ZIKV infections) that could suggest the presence of a neutralization-resistant population of viruses. Conclusions: Phylogenetic, evolutionary and selective pressure analysis contributed to improve the knowledge on the circulation of ZIKV. | Marta Giovanetti Teresa Milano Luiz Carlos Alcantara Laura Carcangiu Eleonora Cella Alessia Lai Alessandra Lo Presti Stefano Pascarella Gianguglielmo Zehender Silvia Angeletti Massimo Ciccozzi | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，5： | 2 |
| 4 | Reconstruction of the evolutionary dynamics of the hepatitis C virus 1b epidemic in Turkey显示文摘 | Massimo Ciccozzi Anna-Rita Ciccaglione Alessandra Lo Presti Tulay Yalcinkaya Zeynep Pinar Taskan Michele Equestre Angela Costantino Roberto Bruni Erica Ebranati Marco Salemi Rebecca Gray Giovanni Rezza Massimo Galli Gianguglielmo Zehender | 2011 | Infection, Genetics and Evolution2011，，： | 2 |
| 5 | Prognostic value of the ECG on admission in patients with acute major pulmonary embolism显示文摘 | Geibel A Zehender M Kasper W | 2005 | Eur Respir J2005，25，： | 1 |
| 6 | Meso- scopic light transport by very strong collective multiple scat- tering in nanowire mats显示文摘 | STRUDLEY T ZEHENDER T BLEJEAN C | | Nature Photon0，7，10： | 1 |
| 7 | Right ventricular infarctionas an independent predictor of prognosis after acute inferior myocardialinfarction显示文摘 | ZEHENDER M KASPER W KAUDER E | 1993 | N Engl J Med1993，328，： | 1 |
| 8 | Molecular epidemiology of TT virus in Italy and phylogenesis of viral isolates from subjects at different risk for parenteral exposure 显示文摘 | Zehender G Manzin A De MaddaIena C | 2001 | J Med Virol2001，63，1： | 1 |
| 9 | Levels of terbinafine in plasma,stratum comeum,dermise-pidermis(without stratum comeum),sebum,hair and nailsduring and after 250 mg terbinafine orally once per day forfour weeks显示文摘 | FAERGEMANN J ZEHENDER H DENOUEL J | 1993 | Acta Derm Venereol1993，73，4： | 1 |
| 10 | Prognostic value of the ECG on admission in patients with acute major pulmonary embolism显示文摘 | Geibel A Zehender M Kasper W | 2005 | Eur Respir J2005，25，： | 1 |
| 11 | Myocardial bridging显示文摘 | Zehender M | 1997 | Circulation1997，95，： | 1 |
| 12 | Keratin 9 gene mutational heterogeneity in patients with epidermolytic palmoplantar keratoderma显示文摘 | Hennies HC Zehender D Kunze J | 1994 | Hum Genet1994，93，6： | 1 |
| 13 | High-grade atrioventricular block triggered by spontaneous and stimulation-induced epileptic activity in the left temporal lobe显示文摘 | Altenmuller DM Zehender M Schulze-Bonhage A | 2004 | Epilepsia2004，45，12： | 1 |
| 14 | Right ventricular infarction as an indendent prdictor of prognosis after acute inferiors myocardial infarction显示文摘 | Zehender Kasper Kander | 1993 | N Engl J Med1993，328，： | 1 |
| 15 | Prevalence of circadian variation and spontaneous variability of cardiac disorders and ECG change suggestive of myocardial ischemia in systemic arterial hypertension 显示文摘 | Zehender M Meinertz T Hohnloser S | 1992 | Circulation1992，85，5： | 1 |
| 16 | Dysrhythmias after direct-current cardioversion显示文摘 | Waldecker B Brugada P Zehender M | 1986 | Am J Cardiol1986，57，1： | 1 |
| 17 | Keratin 9 gene mutational heterogeneity in patients with epidermolytic palmoplantar keratoderma 显示文摘 | Hennies HC Zehender D Kunze J | 1994 | Hum Genet1994，93，： | 1 |
| 18 | Origin, evolution, and phylogeography of recent epidemic CHIKV strains显示文摘 | Alessandra Lo Presti Massimo Ciccozzi Eleonora Cella Alessia Lai Francesco Roberto Simonetti Massimo Galli Gianguglielmo Zehender Giovanni Rezza | 2012 | Infection Genetics and Evolution2012，，2： | 1 |
| 19 | Levels of terhinaflne in plasma,stratum corneum,dermisepidermis ( without stratum corneum),sebum, hair and nails during and after 250 mg terbinafine orally once per day for four weeks 显示文摘 | Faergemann J Zehender H Denouel J | 1993 | Acta Derm Venereol1993，73，4： | 1 |
| 20 | Possible Gender-Related Differences in the Risk-to-Benefit Ratio of Thrombolysis for Acute Submassive Pulmonary Embolism显示文摘 | Annette Geibel Manfred Olschewski Manfred Zehender | | 0，，： | 1 |
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