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| 1 | Efficient IL-2R signaling differentially affects the stability,function,and composition of the regulatory T-cell pool显示文摘Signaling via interleukin-2 receptor(IL-2R)is a requisite for regulatory T(Treg)cell identity and function.However,it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis,lineage stability and function in both resting and inflammatory conditions.Here,we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25,theα-chain of IL-2R,which resulted in diminished receptor expression and reduced IL-2R signaling.Under noninflammatory conditions,Cd25Y129H mice harbored substantially lower numbers of peripheral Treg cells with stable Foxp3 expression that prevented the development of spontaneous autoimmune disease.In contrast,Cd25^(Y^(129H))Treg cells failed to efficiently induce immune suppression and lost lineage commitment in a T-cell transfer colitis model,indicating that unimpaired IL-2R signaling is critical for Treg cell function in inflammatory environments.Moreover,single-cell RNA sequencing of Treg cells revealed that impaired IL-2R signaling profoundly affected the balance of central and effector Treg cell subsets.Thus,partial loss of IL-2R signaling differentially interferes with the maintenance,heterogeneity,and suppressive function of the Treg cell pool. | Marc Permanyer Berislav Bošnjak Silke Glage Michaela Friedrichsen Stefan Floess Jochen Huehn Gwendolyn E.Patzer Ivan Odak Nadine Eckert Razieh Zargari Laura Ospina-Quintero Hristo Georgiev Reinhold Förster | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
| 2 | The role of the yeast plasma membrane SPS nutrient sensor in the metabolic response to extracellular amino acids显示文摘 | Forsberg H Gilstring C F Zargari A | 2001 | Mol Microbiol2001，42，1： | 1 |
| 3 | Uric acid and coronary ar- tery disease,two sides of a single coin:a determinant of antioxidant system or a factor in metabolic syndrome 显示文摘 | Bagheri B Zargari M Meshkini F | 2016 | J Clin Diagn Res2016，10，2： | 1 |
| 4 | An active damping method using inductor-current feedback control for high power PWM current-source rectifier显示文摘 | Liu F R Wu B Zargari N R | 2011 | IEEE Transactions on Power Electronics2011，26，9： | 1 |
| 5 | Paederus dermatitis in northern Iran : a report of 156 : cases显示文摘 | Zargari O Kimyai Asadi A Fathalikhani F | 2003 | Internat Dermatol2003，42，8： | 1 |
| 6 | An efficient fast intra mode decision method based on orthogonal modes elimination显示文摘 | Pejman H Zargari F | 2012 | IEEE Transactions on Consumer Electronics2012，58，4： | 1 |
| 7 | An active damping method using inductor-current feedback control for high-power PWM current-source rectifier显示文摘 | Liu F Wu B Zargari N R | 2011 | IEEE Transactions on Power Electronics2011，26，9： | 1 |
| 8 | A fast and efficient compressed domain JPEG 2000 image retrieval method 显示文摘 | Zargari F Mosleh M Ghanbari M | 2008 | IEEE Trans Consum Electron2008，54，4： | 1 |
| 9 | Fox-Fordyce disease exacerbated by hyperhidrosis显示文摘 | Alikhan A Gorouhi F Zargari O | 2010 | Pediatr Dermatol2010，27，2： | 1 |
| 10 | An Active Damping Method Using Inductor-current Feedback Control for High-power PWM Current-source Rectifier 显示文摘 | Liu F Wu B Zargari N R | 2011 | IEEE Transactions on Power Electronics2011，26，9： | 1 |
| 11 | Paederus dermatitis in northern Iran: a report of 156 eases 显示文摘 | Zargari O Asadi AK Fathalikhani F | 2003 | Int J Dermatol2003，42，8： | 1 |
| 12 | Design PID-like fuzzy controller with minimum rule base and math- ematical proposed on-line tunable gain: applied to robot manipulator显示文摘 | PILTAN F SULAIMAN N ZARGARI A | 2011 | International Journal of Artificial in- telligence and expert system2011，2，4： | 1 |
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