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| 1 | Efficient IL-2R signaling differentially affects the stability,function,and composition of the regulatory T-cell pool显示文摘Signaling via interleukin-2 receptor(IL-2R)is a requisite for regulatory T(Treg)cell identity and function.However,it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis,lineage stability and function in both resting and inflammatory conditions.Here,we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25,theα-chain of IL-2R,which resulted in diminished receptor expression and reduced IL-2R signaling.Under noninflammatory conditions,Cd25Y129H mice harbored substantially lower numbers of peripheral Treg cells with stable Foxp3 expression that prevented the development of spontaneous autoimmune disease.In contrast,Cd25^(Y^(129H))Treg cells failed to efficiently induce immune suppression and lost lineage commitment in a T-cell transfer colitis model,indicating that unimpaired IL-2R signaling is critical for Treg cell function in inflammatory environments.Moreover,single-cell RNA sequencing of Treg cells revealed that impaired IL-2R signaling profoundly affected the balance of central and effector Treg cell subsets.Thus,partial loss of IL-2R signaling differentially interferes with the maintenance,heterogeneity,and suppressive function of the Treg cell pool. | Marc Permanyer Berislav Bošnjak Silke Glage Michaela Friedrichsen Stefan Floess Jochen Huehn Gwendolyn E.Patzer Ivan Odak Nadine Eckert Razieh Zargari Laura Ospina-Quintero Hristo Georgiev Reinhold Förster | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
| 2 | Polyacrylamide hydrogel application in sand control with compressive strength testing显示文摘Sand production is one of the major problems in sandstone reservoirs. Different mechanical and chemical methods have been proposed to control sand production. In this paper, we propose a chemical method based on using polyacrylamide/chromium triacetate hydrogel to investigate sand production in a synthetic sandpack system. To this end, a series of bulk experiments including the bottle test and rheological analysis along with compression tests were conducted. Experimental results indicated that the compressive strength of the sandpack was increased as much as 30 times by injecting 0.5 pore volume of hydrogel. Also, it was found that the increases in cross-linker and polymer concentrations exhibited a positive impact on the compressive strength of the sandpack, mostly by cross-linker concentration(48 psi). Hydrogel with a higher value of cross-linker could retain its viscoelastic properties against the strain which was a maximum of 122% for 0.5 weight ratio of cross-linker/polymer. The presence of salts, in particular divalent cations, has a detrimental effect on the hydrogel stability. The maximum strain value applied on hydrogel in the presence of CaCl_2 was only about 201% as compared to 1010% in the presence of distilled water. Finally, thermogravimetric analysis and its derivative showed that the hydrogel could retain its structure up to 300 °C. The results of this study revealed the potential application of the hydrogel to control sand production. | Mahsa Baghban Salehi Asefe Mousavi Moghadam Samira Zargari MarANDi | 2019 | Petroleum Science2019，16，1： | 2 |
| 3 | The role of the yeast plasma membrane SPS nutrient sensor in the metabolic response to extracellular amino acids显示文摘 | Forsberg H Gilstring C F Zargari A | 2001 | Mol Microbiol2001，42，1： | 1 |
| 4 | Selective cloning of allergens from the skin colonizing yeast Malassezia furfur by phage surface display technology显示文摘 | Lindborg M Magnusson CG Zargari A | 1999 | J Invest Dermatol1999，113，2： | 1 |
| 5 | A multilevel thyristor rec- tifier with improved power factor显示文摘 | ZARGARI N R XIAO Yuan WU Bin | 1997 | IEEE Transactions on Indus- try Applications1997，33，5： | 1 |
| 6 | A TwoSwitch high-performance Current Regulated DC/AC Converter Module显示文摘 | Phoivos D Ziogas Geza Joos | 1995 | IEEE Trans on Industry Applications1995，31，3： | 1 |
| 7 | A Non-invasive Optical Fiber Sensor for Detection of Partial Discharges in GIS Systems 显示文摘 | ZARGARI A BLACKBURN T R | 2000 | IEEE Transactions Power Delivery2000，16，4： | 1 |
| 8 | Performance investigation of a current-con- trolled voltage-regulated PMW rectifier in rotating in rotating and stationary frames 显示文摘 | ZARGARI N R JOOS G | 1995 | IEEE transactions on Industrial Electronics1995，42，4： | 1 |
| 9 | Performance Investigation of a Current-Controlled Voltage-Regulated PWM Rectifier in Simultaneous Wind Speed Measurements显示文摘 | Zargari K | 1984 | IEEE Transacion on Power Apparatus and Systems1984，，5： | 1 |
| 10 | A new current source converter using a Symmetric Gate Commutated Thyristor(SGCT)显示文摘 | ZARGARI N RIZZO S XIAO Y | 2001 | IEEE Transactions on Industry Applications2001，37，3： | 1 |
| 11 | Uptake of the yeast malassezia furfur and its allergenic components by hu- man immature CDla+ dendritic cells显示文摘 | Buentke E Zargari A Heftier LC | 2000 | Clin Exp Allergy2000，30，12： | 1 |
| 12 | Performance investigation of a currentcontrolled voltage-regulated PWM rectifier in rotating and stationary frames显示文摘 | Zargari N R Joos G | 1995 | IEEE Transactions on Industrial Electronics1995，42，4： | 1 |
| 13 | A Two -Switch High - Performance Current Regulated DC/AC Converter Module显示文摘 | Navid Zargari R Phoivos Ziogas D Geza joos | 1995 | IEEE1995，，： | 1 |
| 14 | The prevalence and significance of fissured tongue and geographical tongue in psoriatic patients 显示文摘 | Zargari O | 2006 | Clin Exp Dermatol2006，31，2： | 1 |
| 15 | A multi-level thyristor rectifier with improved power factor 显示文摘 | ZARGARI N R YUAN X BIN W | 1997 | IEEE Trans on Industrial Applications1997，33，5： | 1 |
| 16 | A computa-tional intelligence-based approach for short-term traffic flowprediction 显示文摘 | ZARGARI S A SIABIL S Z ALAVI A H | 2012 | Expert Systems2012，29，2： | 1 |
| 17 | Damping of PWM current-source rectifier using a hybrid combination ap- proach Power Electronics 显示文摘 | Li Yunwei Wu Bin Zargari N R | 2007 | IEEE Transactions on2007，22，4： | 1 |
| 18 | Two switch high performance current regulated DC/AC converter module 显示文摘 | Zargari Zargari N R | 1995 | IEEE Transaction on Industry Applications1995，31，3： | 1 |
| 19 | Mohaghegh S D Field development strategies for bakken shale formation显示文摘 | Zargari S | 2010 | SPE1390322010，，： | 1 |
| 20 | Selective cloning of allergens from the skin colonizing yeast Malassezia furfur by phage surface display technology显示文摘 | Magnusson CG Zargari A | 1999 | J Invest Dermatol1999，113，2： | 1 |
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