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| 1 | Piper sarmentosum as an antioxidant on oxidative stress in human umbilical vein endothelial cells induced by hydrogen peroxide显示文摘Endothelial cell death due to increased reactive oxygen species(ROS) may contribute to the initial endothelial injury,which promotes atherosclerotic lesion formation.Piper sarmentosum(PS),a natural product,has been shown to have an antioxidant property,which is hypothesized to inhibit production of ROS and prevent cell injury.Thus,the present study was designed to determine the effects of PS on the hydrogen peroxide(H2O2)-induced oxidative cell damage in cultured human umbilical vein endothelial cells(HUVECs).In this experiment,HUVECs were obtained by collagenase perfusion of the large vein in the umbilical cord and cultured in medium M200 supplemented with low serum growth supplementation(LSGS).HUVECs were treated with various concentrations of H2O2(0-1000 μmol/L) and it was observed that 180 μmol/L H2O2 reduced cell viability by 50% as denoted by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay.Using the above concentration as the positive control,the H2O2-induced HUVECs were concomitantly treated with various concentrations(100,150,250 and 300 μg/ml) of three different extracts(aqueous,methanol and hexane) of PS.Malondialdehyde(MDA),superoxide dismutase(SOD),catalase(CAT) and glutathione peroxidase(GPX) levels showed a significant increase(P<0.05) in HUVECs compared to the negative control.However,PS extracts showed a protective effect on HUVECs from H2O2-induced cell apoptosis with a significant reduction in MDA,SOD,CAT and GPX levels(P<0.05).Furthermore,PS had exhibited ferric reducing antioxidant power with its high phenolic content.Hence,it was concluded that PS plays a beneficial role in reducing oxidative stress in H2O2-induced HUVECs. | Abdul Hamid HAFIZAH Zakaria ZAITON Amom ZULKHAIRI Adenan MOHD ILHAM Megat Mohd Nordin NOR ANITA Abdullah Mahdy ZALEHA | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，5： | 13 |
| 2 | Value of CT pulmonary arteriography and venography in the evaluation of venous thromboembolism in a multiracial Asian population显示文摘 | Yeong Ji Lee Rozman Zakaria Zaleha Abdul Manaf Zahiah Mohamed Yeong Yeh Lee | 2013 | Chinese Medical Journal2013，，11： | 6 |
| 3 | Correlation of serum insulin like growth factor-I with retinopathy in Malaysian pregnant diabetics显示文摘AIM:To study the association of serum insulin-like growth factor-I(IGF-I) with diabetic retinopathy.· METHODS:Serum IGF-1 levels were measured in 25 pregnant diabetic patients and 25 pregnant non-diabetic patients who were matched for age,ethnicity,parity and period of gestation.Fundus examination was performed in both groups at 28,32 and 36 weeks of gestation.RESULTS:The serum IGF-I level was significantly elevated in pregnant diabetics compared to pregnant non-diabetics(366±199μg/L vs 184±89μg/L,(P=0.0001) at 24 weeks,535±251μg/L vs 356±89μg/L,(P=0.007) at 32 weeks and 404±166μg/L vs 264±113μg/L,(P=0.003) at 36 weeks of gestation).The pregnant diabetics with established diabetes had significantly higher IGF-1 level than gestational diabetes at 28,32 and 36 weeks of gestation.The serum IGF-I level in pregnant diabetics with retinopathy was significantly higher than in those without retinopathy at all periods of gestation.· CONCLUSION:Increased serum IGF-1 in pregnancy may increase the risks for retinopathy. | S Adzura M Muhaya M Normalina A M Zaleha W P Sharifa Ezat I Tajunisah | 2011 | International Journal of Ophthalmology(English edition)2011，4，1： | 4 |
| 4 | 糖尿病孕妇血清胰岛素样生长因子-1与视网膜病变的关系(英文)显示文摘目的:研究血清胰岛素样生长因子-1(IGF-1)与糖尿病性视网膜病变的联系。方法:对25例怀孕的糖尿病患者及按年龄、种族、胎儿期和妊娠期相匹配的25例怀孕的非糖尿病患者的血清IGF-1水平进行测量。结果:怀孕的糖尿病患者血清IGF-1水平与怀孕的非糖尿病患者血清IGF-1水平相比明显升高,24wk分别是366±199μg/L和184±89μg/L(P=0.0001),32wk分别是535±251μg/L和356±89μg/L(P=0.007)。36wk分别是404±166μg/L和264±113μg/L(P=0.003)。在妊娠的28,32,36wk,有明确糖尿病病史的怀孕的糖尿病患者血清IGF-1水平比妊娠期糖尿病患者血清IGF-1水平有明显的升高。在整个妊娠期怀孕的伴有视网膜病变的糖尿病患者血清IGF-1水平比那些不伴有视网膜病的患者血清IGF-1水平明显升高。结论:在妊娠期提高血清IGF-1水平可能增加患糖尿病性视网膜病变的风险。 | S Adzura M Muhaya M Normalina A M Zaleha W P Sharifa Ezat I Tajunisah | 2011 | 国际眼科杂志2011，11，4： | 2 |
| 5 | Production of copolymer poly(3-hydroxybutyrate-co- 4-hydroxybutyrate) through a one-step cultivation process显示文摘 | Rahayu A Zaleha Z Yahya A R M | 2008 | Int J Pharm2008，24，11： | 1 |
| 6 | Foreign Direct Investment and the Pollution in Five ASEAN Nations 显示文摘 | Yesmine Mexican Zulkornaln Yusop Zaleha Mohd Noor and Law Siong Hook | 2007 | International Journal of Economics and Manage- ment2007，1，2： | 1 |
| 7 | The Treatment of neck lymphangioma with intralesional injection of bleomycin 显示文摘 | Zulfiqar MA Zaleha AM Zakarla Z | 1999 | Med J Malaysia1999，54，4： | 1 |
| 8 | Bio-Inspired Polarized Skylight-Based Navigation Sensor: A Review 显示文摘 | Salmah B Karman S Zaleha M Diah Ille C Gebeshuber | 2012 | Sensors(S1424-8220)2012，12，14： | 1 |
| 9 | Bilateral ovarian teratoma with squamous cell malignancy in a young woman:a diagnostic and man- agement challenge显示文摘 | Nor Azlin MI Isa MR Zaleha AM | 2005 | Int Med J2005，4，2： | 1 |
| 10 | Entrepreneurship in the tourism industry: Issues in developing countries显示文摘 | Mastura Jaafar Abdul Rashid Abdul-Aziz Siti Aishah Maideen Siti Zaleha Mohd | 2011 | International Journal of Hospitality Management2011，，4： | 1 |
| 11 | Foreign Direct Investment and the Pollution in Five ASEAN Nations显示文摘 | Yasmine Merican Zulkornain Yusop Zaleha Mohd Noor and Law Siong Hook | 2007 | Journal of Economics and Management2007，，1： | 1 |
| 12 | Serum soluble FMS-like tyrosine kinase 1 and placental growth factor concentration as predictors of preeclampsia in high risk pregnant women显示文摘 | Hanita O Alia NN Zaleha AM | 2014 | Malaysian J Pathol2014，36，1： | 1 |
| 13 | Asthma and asthma - related symptoms among adults of an acid rain - plagued city in South- west China: prevalence and risk factors 显示文摘 | Yu J Zaleha MI Xu J | 2013 | Polish Journal of Environmental Studies2013，22，3： | 1 |
| 14 | Foreign Direct Investment and the Pol- lution in Five ASEAN Nations 显示文摘 | Yasmlne Merican Zulkomain Yusop Zaleha Mohd Noor and Law Siong Hook | 2003 | Journal of Economics and Management2003，，1： | 1 |
| 15 | Production of copolymer poly (3-hydroxybutyrate-co-4- hydroxybutyrate ) through a one-step cultivation process显示文摘 | RAHAYU A ZALEHA Z AHMAD R | 2008 | Int J Phytorem2008，24，11： | 1 |
| 16 | Corruption Typology: A Review of Literature显示文摘 | Naziru Suleiman Zaleha Othman | 2017 | Chinese Business Review2017，16，2： | 0 |
| 17 | Epithelial Layer Estimation Using Curvatures and Textural Features for Dysplastic Tissue Detection显示文摘Boundary effect in digital pathology is a phenomenon where the tissue shapes of biopsy samples get distorted during the sampling process.The morphological pattern of an epithelial layer is greatly affected.Theoretically,the shape deformation model can normalise the distortions,but it needs a 2D image.Curvatures theory,on the other hand,is not yet tested on digital pathology images.Therefore,this work proposed a curvature detection to reduce the boundary effects and estimates the epithelial layer.The boundary effect on the tissue surfaces is normalised using the frequency of a curve deviates from being a straight line.The epithelial layer’s depth is estimated from the tissue edges and the connected nucleolus only.Then,the textural and spatial features along the estimated layer are used for dysplastic tissue detection.The proposed method achieved better performance compared to the whole tissue regions in terms of detecting dysplastic tissue.The result shows a leap of kappa points from fair to a substantial agreement with the expert’s ground truth classification.The improved results demonstrate that curvatures have been effective in reducing the boundary effects on the epithelial layer of tissue.Thus,quantifying and classifying the morphological patterns for dysplasia can be automated.The textural and spatial features on the detected epithelial layer can capture the changes in tissue. | Afzan Adam Abdul Hadi Abd Rahman Nor Samsiah Sani Zaid Abdi Alkareem Alyessari Nur Jumaadzan Zaleha Mamat Basela Hasan | 2021 | Computers, Materials & Continua2021，，4： | 0 |
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