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| 1 | Progress on shelf and slope circulation in the northern South China Sea显示文摘Influenced by the seasonally reversed monsoons, water exchange through straits, and topography, the shelf and slope circulation in the northern South China Sea(NSCS) is complex and changeable. The typical current system in the NSCS consists of the slope current, South China Sea warm current(SCSWC), coastal current, and associated upwelling(in summer) and downwelling(in winter). This paper reviews recent advances in the study of NSCS shelf and slope circulation since the 1990 s,and summarizes the roles of Kuroshio intrusion, the monsoons, topography, and the buoyancy effect of the Pearl River plume in the shelf and slope current system of the NSCS. We also point out some potential scientific issues that require further study, such as the dynamic connection between the internal basin and shelf areas of the NSCS, the persistence of the SCSWC in winter, the temporo-spatial characteristics of downwelling during winter in the NSCS, and its material and energy transport. | Yeqiang SHU Qiang WANG Tingting ZU | 2018 | Science China Earth Sciences2018，61，5： | 11 |
| 2 | Grazing alters environmental control mechanisms of evapotranspiration in an alpine meadow of the tibetan Plateau显示文摘Aims Evapotranspiration(Et)is an important component of the terrestrial water cycle and is easily affected by external disturbances,such as climate change and grazing.Identifying Et responses to grazing is instructive for determining grazing activity and informative for understanding the water cycle.Methods this study utilized 2 years(2014 and 2017)of eddy covariance data to test how grazing regulated Et for an alpine meadow ecosystem on the tibetan Plateau(tP)by path analysis.Important Findings Radiation dominated Et with a decision coefficient of 64-74%.the soil water content(SWc)worked as the limiting factor in the fenced site.However,in the grazing site,the limiting factor was the vapor pressure deficit(VPD).Grazing had large effects on Et because it greatly affected the water conditions.the SWc and VPD were enhanced by 14.63%and 4.36%in the grazing site,respectively.therefore,sufficient water was supplied to Et,especially during drought,and strengthened the transpiration pull.As a result,a favorable micrometeorological environment was created for Et.Grazing shifted the limiting factor of Et from the SWc to VPD,which weakened the limiting effect of the water conditions on Et and advanced the Et peak time.In addition,grazing altered the compositions of Et by changing the community structure,which directly resulted in an increased Et.In summary,grazing enhanced Et through altering the community structure and micrometeorological environments.the findings of this study further improve our understanding of the driving mechanisms of grazing on Et and will improve our predictions for the global water cycle. | Tingting An Mingjie Xu Tao Zhang Chengqun Yu Yingge Li Ning Chen Jiaxing Zu Junxiang Li Juntao Zhu Yi Sun Tingting Zhao Guirui Yu | 2019 | Journal of Plant Ecology2019，12，5： | 3 |
| 3 | Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies:a phase I clinical study显示文摘Chimeric antigen receptor(CAR)-T cell therapy against T cell malignancies faces major challenges including fratricide between CAR-T cells and product contamination from the blasts.Allogeneic CAR-T cells,generated from healthy donor T cells,can provide ready-to-use,blast-free therapeutic products,but their application could be complicated by graft-versus-host disease(GvHD)and host rejection.Here we developed healthy donor-derived,CD7-targeting CAR-T cells(RD13-01)with genetic modifications to resist fratricide,GvHD and allogeneic rejection,as well as to potentiate antitumor function.A phase I clinical trial(NCT04538599)was conducted with twelve patients recruited(eleven with T cell leukemia/lymphoma,and one with CD7-expressing acute myeloid leukemia).All patients achieved pre-set end points and eleven proceeded to efficacy evaluation.No dose-limiting toxicity,GvHD,immune effector cell-associated neurotoxicity or severe cytokine release syndrome(grade≥3)were observed.28 days post infusion,81.8%of patients(9/11)showed objective responses and the complete response rate was 63.6%(7/11,including the patient with AML).3 of the responding patients were bridged to allogeneic hematopoietic stem cell transplantation.With a median follow-up of 10.5 months,4 patients remained in complete remission.Cytomegalovirus(CMV)and/or Epstein-Barr virus(EBV)reactivation was observed in several patients,and one died from EBV-associated diffuse large B-cell lymphoma(DLBCL).Expansion of CD7-negative normal T cells was detected post infusion.In summary,we present the first report of a Phase I clinical trial using healthy donor-derived CD7-targeting allogeneic CAR-T cells to treat CD7^(+)hematological malignancies.Our results demonstrated the encouraging safety and efficacy profiles of the RD13-01 allogeneic CAR-T cells for CD7^(+)tumors. | Yongxian Hu Yali Zhou Mingming Zhang Houli Zhao Guoqing Wei Wengang Ge Qu Cui Qitian Mu Gong Chen Lu Han Tingting Guo Jiazhen Cui Xiaoyan Jiang Xiujun Zheng Shuhui Yu Xiaolong Li Xingwang Zhang Mingxi Chen Xiuju Li Ming Gao Kang Wang Cheng Zu Hao Zhang Xiaohong He Yanbin Wang Dongrui Wang Jiangtao Ren He Huang | 2022 | Cell Research2022，32，11： | 2 |
| 4 | Gaseous emissions from compressed natural gas buses in urban road and highway tests in China显示文摘The natural gas vehicle market is rapidly developing throughout the world, and the majority of such vehicles operate on compressed natural gas(CNG). However, most studies on the emission characteristics of CNG vehicles rely on laboratory chassis dynamometer measurements, which do not accurately represent actual road driving conditions. To further investigate the emission characteristics of CNG vehicles, two CNG city buses and two CNG coaches were tested on public urban roads and highway sections. Our results show that when speeds of 0–10 km/hr were increased to 10–20 km/hr, the CO_2, CO, nitrogen oxide(NO_x), and total hydrocarbon(THC) emission factors decreased by(71.6 ± 4.3)%,(65.6 ± 9.5)%,(64.9 ± 9.2)% and(67.8 ± 0.3)%, respectively. In this study, The Beijing city buses with stricter emission standards(Euro Ⅳ) did not have lower emission factors than the Chongqing coaches with Euro Ⅱ emission standards. Both the higher emission factors at 0–10 km/hr speeds and the higher percentage of driving in the low-speed regime during the entire road cycle may have contributed to the higher CO_2 and CO emission factors of these city buses. Additionally, compared with the emission factors produced in the urban road tests, the CO emission factors of the CNG buses in highway tests decreased the most(by 83.2%), followed by the THC emission factors, which decreased by 67.1%. | Tingting Yue Fahe Chai Jingnan Hu Ming Jia Xiaofeng Bao Zhenhua Li Liqang He Lei Zu | 2016 | Journal of Environmental Sciences2016，28，10： | 2 |
| 5 | Selective cleavage enhanced by acetylating the side chain of lysine显示文摘 | Leixiaomeng Fu Tingting Chen Gaiqing Xue Lily Zu Weihai Fang | 2013 | J Mass Spectrom2013，，1： | 1 |
| 6 | Numerical study of the tide and tidal dynamics in the South China Sea显示文摘 | Zu Tingting Gan Jianping Erofeeva Svetlana Y | 2008 | Deep-Sea Research2008，55，： | 1 |
| 7 | Numerical study of the tide and tidal dynamics in theSouth China Sea显示文摘 | ZU TINGTING GAN JIANPING EROFEEVA S Y | 2008 | Deep-Sea Res:PartⅠ2008，55，13： | 1 |
| 8 | The Origin,Historical Variations,and Distribution of Heavy Metals in the Qiongzhou Strait and Nearby Marine Areas显示文摘We analyzed heavy metal concentrations in a number of surface sediments and cores from the Qiongzhou Strait and surrounding marine areas.The areas of high concentrations are primarily outside the eastern mouth of the Qiongzhou Strait and on the west side of the Leizhou Peninsula,whereas the areas of low concentrations are located primarily in the eastern Qiongzhou Strait.The maximum Cd,Pb and Zn concentrations in the samples collected in our study do not exceed the official standards for marine sediments,whereas the concentrations of Cr and Cu slightly exceed the standards.Correlations exist between the concentrations of Cu,Pb,Zn,Cr and Cd,and the concentrations of these metals are positively correlated with the mean particle size(φ value),indicating that the finer sediments have adsorbed greater amounts of heavy metal elements than the coarser sediments.An evaluation of the potential environmental risks demonstrates that certain indices of heavy metal pollution and environmental risks are relatively low and may be assigned low risk levels,thereby indicating that,in terms of heavy metals,the marine sedimentary environment in this region is only mildly impacted.Our analysis of the contaminant origins shows that the heavy metals in this region primarily originate in the Pearl River Estuary and that a small amount of them is derived from local runoff.The elevated heavy metal concentrations from the upper sections of the cores started 130 years ago,which indicats that heavy metals in the surface sediments are primarily due to human activities associated with industrialization. | ZHANG Zhiqiang CHEN Liang WANG Weiping LI Tuanjie ZU Tingting | 2017 | Journal of Ocean University of China2017，16，2： | 1 |
| 9 | Comparison of summer chlorophyll a concentration in the South China Sea and the Arabian Sea using remote sensing data显示文摘The South China Sea(SCS) and the Arabian Sea(AS) are both located roughly in the north tropical zone with a range of similar latitude(0°–24°N). Monsoon winds play similar roles in the upper oceanic circulations of the both seas. But the distinct patterns of chlorophyll a(Chl a) concentration are observed between the SCS and the AS.The Chl a concentration in the SCS is generally lower than that in the AS in summer(June–August); the summer Chl a concentration in the AS shows stronger interannual variation, compared with that in the SCS; Moderate resolution imaging spectroradiometer(MODIS)-derived data present higher atmospheric aerosol deposition and stronger wind speed in the AS. And it has also been found that good correlations exist between the index of the dust precipitation indicated by aerosol optical thickness(AOT) and the Chl a concentration, or between wind and Chl a concentration. These imply that the wind and the dust precipitation bring more nutrients into the AS from the sky, the sub-layer or coast regions, inducing higher Chl a concentration. The results indicate that the wind velocity and the dust precipitation can play important roles in the Chl a concentration for the AS and the SCS in summer. However aerosol impact is weak on the biological productivity in the west SCS and wind-induced upwelling is the main source. | YAO Jinglong YANG Lei SHU Yeqiang ZENG Lili SHI Rui CHEN Ju ZU Tingting CHEN Chuqun | 2017 | Acta Oceanologica Sinica2017，36，11： | 1 |
| 10 | Interannual variability of eddy kinetic energy in the South China Sea related to two types of winter circulation events显示文摘Interannual variations of the eddy kinetic energy(EKE)related to two types of winter circulation events(“O”and“U”)were investigated based on the outputs of the Ocean General Circulation Model(OGCM)for the Earth Simulator(OFES)and the corresponding energetic analyses.Results show that the EKE is strong and extends eastward to offshore the Vietnam coast about 2°,associated with the weaker South China Sea western boundary current(SCSwbc)in“O”type years,while the EKE is weak and high value that can be attained is narrowed along the coast,associated with the stronger SCSwbc in“U”type years.The energy budget shows that the wind stress and barotropic/baroclinic instability are important factors to regulate the EKE in“U”and“O”years.For“U”years,under a strong winter monsoon forcing,the SCSwbc strengthen,the directly wind work and barotropic conversion from the mean kinetic energy(MKE)to EKE are weak,thus the EKE decrease corresponding to the baroclinic conversion from the kinetic energy to potential energy.However,the situation is reversed in“O”years.Under the influence of El Niño events,wind stress forces can weaken SCSwbc and enhance EKE in pattern“O”,whereas La Niña events have relatively weaker influences.The barotropic conversion rate in“O”type is nearly eight times of the“U”type.The pressure work and advection term are the main sources to greatly suppress EKE in the SCSwbc region. | Wenlian LI Qinyan LIU Wendong FANG Tingting ZU Haiying CHEN | 2023 | Journal of Oceanology and Limnology2023，41，3： | 0 |
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