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| 1 | VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex显示文摘肺癌症是与高发生和死亡世界范围的大多数破坏疾病之一。河马(Hpo ) 小径是在果蝇和哺乳动物的机关尺寸的一个保存管理者。新兴的证据在癌症开发建议了 Hpo 小径的意义。在这研究,我们通过否定地调整 YAP-TEAD 建筑群的形成在肺 carcinogenesis 作为新奇肿瘤 suppressor 识别 VGLL4, Hpo 的核心部件小径。我们 VGLL4 经常被观察低层的数据表演在老鼠和人的肺癌症标本表示了。VGLL4 的宫外的表示显著地在 vitro 压制肺癌症房间的生长。更重要地, VGLL4 显著地在 de novo 老鼠模型禁止肺癌症前进。我们进一步发现 VGLL4 禁止 YAP-TEAD transcriptional 建筑群的活动。我们 VGLL4 直接在绑定与笨蛋竞争到 TEAD 并且执行的数据表演它通过二 TDU 域的生长禁止的函数。一起,我们的学习证明 VGLL4 是为通过否定地调整 YAP-TEAD 复杂形成并且这样的肺癌症的新奇肿瘤 suppressor Hpo 小径。 | Wenjing Zhang Yijun Gao Peixue Li Zhubing Shi Tong Guo Fei Li Xiangkun Han Yan Feng Chao Zheng Zuoyun Wang Fuming Li Haiquan Chen Zhaocai Zhou Lei Zhang Hongbin Ji | 2014 | Cell Research2014，24，3： | 25 |
| 2 | Political turnover and economic performance: the incentive role of personnel control in China显示文摘 | Hongbin Li Li-An Zhou | 2004 | Journal of Public Economics2004，，9： | 24 |
| 3 | Long non-coding RNAs in cancer显示文摘Long non-coding RNAs (lncRNAs) are a group of RNA transcripts that exceed 200 nt in length, yet lack significant open reading frames (ORFs) [1–4]. In contrast | GONG ZhaoJian ZHANG ShanShan ZHANG WenLing HUANG HongBin LI Qiao DENG Hao MA Jian ZHOU Ming XIANG Juan Juan WU MingHua LI XiaYu XIONG Wei LI XiaoLing LI Yong ZENG ZhaoYang LI GuiYuan | 2012 | Science China(Life Sciences)2012，55，12： | 22 |
| 4 | Responses of grassland vegetation to climatic variations on different temporal scales in Hulun Buir Grassland in the past 30 years显示文摘全球温暖特别在过去的 20 年里导致了重要植被变化。在内部蒙古的 Hulun Buir 草地,世界之一三个大草原,正在经历突出的温暖并且弄干的一个过程。为气候的变化的更好的理解在植被动力学上调查气候的变化(温度和降水) 的效果是必要的。NDVI (规范的差别植被索引) ,植物生长的思考特征,植被范围和生物资源,被用作指示物监视植被变化。从 1981 ~ 2006 的 GIMMS NDVI 和从 2000 ~ 2009 的 MODIS NDVI 被采用并且集成于到植被的时间系列特征在 Hulun Buir 改变的摘录的这研究草地。到每年、季节、每月的规模上的气候的变化的植被范围的回答被分析与温度和七个气象学的地点的降水数据结合了。在过去的 30 年里,植被范围是更多与气候的因素相关,并且关联依赖于时间规模。在内部年度的规模上,植被变化更好与降水被相关,建议降雨是为驾驶植被变化的主要因素。在 seasonal-interannual 规模上,在植被范围变化和气候的因素之间的关联证明到水、热的条件变化的植被生长的敏感在不同季节是不同的。当它到在夏天和秋天的降雨的敏感更高时,到在夏天的温度的植被生长的敏感比在另外的季节高,特别在夏天。在 monthly-interannual 规模上,在植被范围变化和气候的因素之间的关联在生长季节期间证明在 4 月和 5 月的温度的植被变化的反应更强壮。这显示温度效果发生在植被生长的早阶段。在植被生长和在当前的月前的月的降水之间的关联,从 5 月更好到 8 月,显示出植被生长的磁滞现象回答到降雨。草变得绿并且开始在草生长上在温度的 4 月,和影响成长是明显的。在 4 月的 NDVI 的增加可能由于气候的温暖那导致一个先进生长季节。在摘要,在植被范围和气候的因素的 monthly-interannual 变化之间的关系大部分在草生长上代表温度和降水的时间的节奏控制。 | ZHANG Geli XU Xingliang ZHOU Caiping ZHANG Hongbin OUYANG Hua | 2011 | Journal of Geographical Sciences2011，21，4： | 20 |
| 5 | Ozone mini-hole occurring over the Tibetan Plateau in December 2003显示文摘By analyzing the total ozone data from TOMS and ground-based observations, it is found that a large area with extremely low ozone occurred over the Tibetan Plateau during December 14-17, 2003. After correcting the bias in TOMS data, the area with the total ozone < 220 DU is found to be over 2500000 km2, and the minimum value is only 190 DU. It is the first time that an ozone mini-hole or an extremely low ozone event is found to occur over the Tibetan Plateau. | BIAN Jianchun WANG Gengchen CHEN Hongbin QI Donglin LUE Daren ZHOU Xiuji | 2006 | Chinese Science Bulletin2006，51，7： | 19 |
| 6 | Nasopharyngeal carcinoma:Advances in genomics and molecular genetics显示文摘Nasopharyngeal carcinoma (NPC) is a squamous-cell carcinoma that arises in the epithelial lining of the nasopharynx [1]. This neoplasm has a notable ethnic and geographic distribution,being of high prevalence in southern China but rare in other parts of the world [2]. | ZENG ZhaoYang HUANG HongBin ZHANG WenLing XIANC Bo ZHOU Ming ZHOU YanHong MA Jian YI Mei LI XiaYu LI XiaoLing XIONG Wei LI GuiYuan | 2011 | Science China(Life Sciences)2011，54，10： | 13 |
| 7 | Ciliary parathyroid hormone signaling activates transforming growth factor-βto maintain intervertebral disc homeostasis during aging显示文摘Degenerative disc disease(DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus(NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor(PTH1 R) to the cilia and enhances parathyroid hormone(PTH) signaling in NP cells. PTH induces transcription of integrin α_vβ_6 to activate the transforming growth factor(TGF)-β-connective tissue growth factor(CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH(iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-β activity, CCN2, and aggrecan. PTH1 R is expressed in both mouse and human NP cells. Importantly,knockout PTH1 R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1 R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. | Liwei Zheng Yong Cao Shuangfei Ni Huabin Qi Zemin Ling Xin Xu Xuenong Zou Tianding Wu Ruoxian Deng Bo Hu Bo Gao Hao Chen Yusheng Li Jianxi Zhu Francis Tintani Shadpour Demehri Amit Jain Khaled M.Kebaish Shenghui Liao Cheryle A.Séguin Janet L.Crane Mei Wan Hongbin Lu Paul D.Sponseller Lee H.RileyIII Xuedong Zhou Jianzhong Hu Xu Cao | 2018 | Bone Research2018，6，3： | 13 |
| 8 | A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity显示文摘由调整 transcriptional 激活剂 Yorkie (Yki ) 的活动的河马(Hpo ) 小径控制织物生长和机关尺寸,它在原子核与抄写因素 Scalloped (Sd ) 联系下游地支持指向基因表示。这里,我们识别新奇蛋白质 Sd-Binding-Protein (SdBP )/Tgi,它直接通过它的 TDU 域为绑定与 Yki 竞争到 Sd 并且禁止 Sd-Yki transcriptional 活动。我们也发现 SdBP 经由它的 PPXY 主题与 Yki WW 领域通过协会在原子核保留 Yki。一起,我们作为 Hpo 小径的一个新奇部件识别 SdBP,否定地调整 Sd-Yki 的 transcriptional 活动限制织物生长。 | Tong Guo Yi Lu Peixue Li Meng-Xin Yin Dekang Lv Wenjing Zhang Huizhen Wang Zhaocai Zhou Hongbin Ji Yun Zhao Lei Zhang | 2013 | Cell Research2013，23，10： | 13 |
| 9 | The record of cultivated rice from archaeobiological evidence in northwestern China 5000 years ago显示文摘Pollen, plant seeds and phytoliths from an AMS dated sediment profile at the Xishanping site indicate that the cultivation of rice might start no later than 5070 cal. a BP in the region of Tianshui, Gansu Province. It continued from 5070 to 4300 cal. a BP. This is so far the oldest and the most northwestern record of cultivated rice in Neolithic China, which extends the known region of prehistoric rice cultivation at least 2° longitude to the west. This finding provides important evidence for reconstructing the cultivation region of rice at 5000 a BP (an important time period), and its spreading history in East Asia, during the Neolithic. | LI XiaoQiang ZHOU XinYing ZHANG HongBin ZHOU Jie SHANG Xue DODSON John | 2007 | Chinese Science Bulletin2007，52，10： | 11 |
| 10 | Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer显示文摘MicroRNAs (miRNAs ) 玩在在各种各样的癌症的发展和前进的关键角色。不正常的 miR-9 表示仍然保持模糊,并且卵巢的癌症的变形前进上的一致都没被到达。在这研究,从生物信息学分析的结果证明 E-cadherin mRNA 的 3-UTR 被 miR-9 直接调整。酶记者试金结果证实 miR-9 能直接指向这 3-UTR。在卵巢的癌症织物的 miR-9 和 E-cadherin 表示被 qRT-PCR 确定。移植和侵略被在 SKOV3 和 A2780 愈合弯屈和 Transwell 系统试金检测。qRT-PCR 和西方的污点被执行检测上皮 ? 间充质的联系转变的 mRNA 和蛋白质。Immunofluorescence 技术被用来分析表示和 E-cadherin, N-cadherin,和 vimentin 的 subcellular 本地化。结果证明 miR-9 经常与配对的主要的相比是在变形浆液的卵巢的癌症织物的 upregulated。miR-9 的 Upregulation 能 downregulate E-cadherin 的表示但是 upregulate 间充质的标记(N-cadherin 和 vimentin ) 的表示。miR-9 的 Overexpression 能在卵巢的癌症支持房间移植和侵略,并且这些进程能有效地经由 miR-9 禁止者被禁止。因此,我们的学习证明 miR-9 可以经由指向 E-cadherin 和一条新奇潜在的治疗学的途径控制卵巢的癌症的转移支持卵巢的癌症转移。 | Bo Zhou Hongbin Xu Meng Xia Chaoyang Sun Na Li Ensong Guo Lili Guo Wanying Shan Hao Lu Yifan Wu Yuan Li Degui Yang Danhui Weng Li Meng Junbo Hu Ding Ma Gang Chen Kezhen Li | 2017 | Frontiers of Medicine2017，11，2： | 10 |
| 11 | A novel nonviral nanoparticle gene vector: Poly-L-lysine- silica nanoparticles显示文摘DNA delivery is a core technology for gene structure and function research as well as clinical settings. The ability to safely and efficiently targeted transfer foreign DNA into cells is a fundamental goal in biotechnology. With the development of nanobiotechnology, nanoparticle gene vectors brought about new hope to reach the goal. In our research, silica nanoparticles (SiNP) were synthesized first in a microemulsion system polyoxyethylene nonylphenyl ether (OP-10)/cyclohexane/ammonium hydroxide, at the same time the effects of SiNP size and its distribution were elucidated by orthogonal analysis; then poly-L-lysine (PLL) was linked on the surface of SiNP by nanoparticle surface energy and electrostatically binding; lastly a novel complex nanomate-rial-poly-L-lysine-silica nanoparticles (PLL-SiNP) wasprepared. The analysis of plasmid DNA binding and DNase I enzymatic degradation discovered that PLL-SiNP could bind DNA, and protect it against enzymatic degradation. Cell transfection showed that | Shiguo Zhu Hongbin Lu Juanjuan Xiang Ke Tang Bicheng Zhang Ming Zhou Chen Tan Guiyuan Li | 2002 | Chinese Science Bulletin2002，47，8： | 9 |
| 12 | CFD investigation and PIV validation of flow field in a compact return diffuser under strong part-load conditions显示文摘The internal flow fields in a compact return diffuser under strong part-load conditions are investigated both numerically and experimentally.For numerical simulation,three-dimensional unsteady Reynolds-Averaged Navier–Stokes equations are solved on high-quality structured grids in conjunction with the shear stress transport k–turbulence model by employing the computational fluid dynamics(CFD)software ANSYS-Fluent 14.5.For flow field measurements,a special test rig is designed and the two-dimensional particle image velocimetry(PIV)measurements are conducted in the diffuser midplane to capture the complex flow field and for validation of the CFD results.The analysis of the results has been focused on the flow structure in the diffuser,especially under part-load conditions.The detailed comparison between CFD and PIV results is performed.Vortical flow and recirculation flow patterns in the diffuser are captured and analyzed.Large flow separation and backflow appear under the part-load flow conditions.This paper provides a good data set for developing as well as evaluating the accuracy of various CFD models for capturing the complex flow field in a compact return diffuser used with multistage pumps. | ZHOU Ling SHI WeiDong CAO WeiDong YANG HongBin | 2015 | Science China(Technological Sciences)2015，58，3： | 8 |
| 13 | Political connections, financing and firm performance: Evidence from Chinese private firms显示文摘 | Hongbin Li Lingsheng Meng Qian Wang Li-An Zhou | 2007 | Journal of Development Economics2007，，2： | 6 |
| 14 | RRx-001 ameliorates inflammatory diseases by acting as a potent covalent NLRP3 inhibitor显示文摘The NLRP3 inflammasome plays a crucial role in innate immune-mediated inflammation and contributes to the pathogenesis of multiple autoinflammatory,metabolic and neurodegenerative diseases,but medications targeting the NLRP3 inflammasome are not available for clinical use.RRx-001 is a well-tolerated anticancer agent currently being investigated in phase III clinical trials,but its effects on inflammatory diseases are not known.Here,we show that RRx-001 is a highly selective and potent NLRP3 inhibitor that has strong beneficial effects on NLRP3-driven inflammatory diseases.RRx-001 inhibits the activation of the canonical,noncanonical,and alternative NLRP3 inflammasomes but not the AIM2,NLRC4 or Pyrin inflammasomes.Mechanistically,RRx-001 covalently binds to cysteine 409 of NLRP3 via its bromoacetyl group and therefore blocks the NLRP3-NEK7 interaction,which is critical for the assembly and activation of the NLRP3 inflammasome.More importantly,RRx-001 treatment attenuates the symptoms of lipopolysaccharide(LPS)-induced systemic inflammation,dextran sulfate sodium(DSS)-induced colitis and experimental autoimmune encephalomyelitis(EAE)in mice.Thus,our study identifies RRx-001 as a new potential therapeutic agent for NLRP3-driven diseases. | Yun Chen Hongbin He Bolong Lin Yun Chen Xianming Deng Wei Jiang Rongbin Zhou | 2021 | Cellular & Molecular Immunology2021，18，6： | 5 |
| 15 | Numerical and Experimental Investigations on Tunable Low-frequency Locally Resonant Metamaterials显示文摘In this paper,a tunable locally resonant metamaterial is proposed for low-frequency band gaps.The local resonator composed of two pairs of folded slender beams and a proof mass is designed based on the theory of compliant mechanism.The design optimization on geometric parameters is carried out to fulfil the quasi-zero-stiffness property.The locally resonant metamaterial is formed by periodically arranged unit cells,and the transmittance of longitudinal wave is studied through three aspects:numerical predictions,finite element simulations and experimental tests.The variation trends revealed by these three methods match well with one another:the band gap moves to lower frequency and both its depth and width get smaller and smaller with the increase of pre-compression(Δ).The band gap overlays the frequency range of 73.10–92.38 Hz and 16.78–19.49 Hz atΔ=0mm andΔ=10mm,respectively,providing a wide range of tunability.Besides,the ultralow-frequency band gap can be achieved asΔapproaches 10 mm.This study may provide an avenue for achieving the tunable ultralow-frequency locally resonant band gap. | Qida Lin Jiaxi Zhou Hongbin Pan Daolin Xu Guilin Wen | 2021 | Acta Mechanica Solida Sinica2021，34，5： | 4 |
| 16 | OPTIMAL COMBINATIONAL OF QUOTA-SHARE AND STOP-LOSS REINSURANCE CONTRACTS UNDER VAR AND CTE WITH A CONSTRAINED REINSURANCE PREMIUM显示文摘这份报纸考虑最小化 VaR 和 CTE 的问题一保险公司由控制 combinational 限额份额和站损失再保险策略保留了风险。与抑制再保险奖赏,作者分别地在站损失再保险和站损失 after-quota-share 再保险的盒子以后在限额份额的情况中给保留的风险的明确的再保险形式和最小的 VaR 和 CTE。最后,作者断定在站损失以后的限额份额比在限额份额以后的站损失是更好的再保险策略与一样的抑制再保险奖赏最小化 VaR 和 CTE。并且纯站损失再保险与一个高级规章的要求为一个保险公司被比较喜欢。 | Ming ZHOU Hongbin DONG Jingfeng XU | 2011 | Journal of Systems Science & Complexity2011，24，1： | 4 |
| 17 | Highly efficient pure white polymer light-emitting devices based on poly(N-vinylcarbazole) doped with blue and red phosphorescent dyes显示文摘Efficient white-polymer-light-emitting devices (WPLEDs) have been fabricated with a single emitting layer containing a hole-transporting host polymer,poly(N-vinylcarbzole),and an electron-transporting auxiliary,1,3-bis[(4-tert-butylphenyl)-1,3,4-oxadiazolyl]-phenylene,codoped with two phosphorescent dyes:Iridium(III)bis (2-(4,6-difluorophenyl)-pyridinato-N,C2') picolinate (FIrpic) and home-made Ir-G2 for blue and red emission,respectively.With the structure of ITO/PEDOT:PSS 4083(40 nm)/emission layer(80 nm)/Ba(4 nm)/Al(120 nm),the device showed a maximal luminous efficiency (LE) of 13.5 cd A-1(corresponding to an external quantum efficiency (EQE) of 6.8%),and a peak power efficiency (PE) of 6.5 lm W-1 at 6.0 V.Meanwhile,the device exhibited pure white emission with Commission Internationale de l'Eclairage (CIE) coordinates of (0.34,0.35) at a current density of 12 mA cm-2,which is very close to the equi-energy white point with CIE coordinates of (0.33,0.33).The device performance can be further optimized when more balanced hole/electron injection is achieved by incorporating a lower conducting type anode buffer layer (PEDOT:PSS) and incorporating poly[(9,9-bis(3'-(N,N-dimethylamino)propyl)-2,7-fluorenene)-alt-2,7-(9,9-dioctyfluorene)] (PFN) as an electron injection layer at the cathode.The optimized device showed an LE of 24.6 cd A-1 (with an EQE of 14.1%),while the peak power efficiency reached 12.66 lm W-1.Moreover,the WPLEDs showed good electroluminescence (EL) stability over a wide range of operating current density and luminance. | HU SuJun ZOU JianHua ZHOU GuiJiang LI DongYun WU HongBin SU ShiJian WONG Wai-Yeung YANG Wei PENG JunBiao CAO Yong | 2011 | Science China Chemistry2011，54，4： | 4 |
| 18 | Facile one-step synthesis of Cu_2O@Cu sub-microspheres composites as anode materials for lithium ion batteries显示文摘Cu_2O@Cu sub-microspheres composites with a narrow particle size distribution from 300 to 500 nm was successfully fabricated by one-step synthesis through the direct thermal decomposition of copper nitrate(Cu(NO_3)_2) in octadecylamine(ODA) solvent. As anode materials for lithium ion batteries, the Cu_2 O@Cu composites obviously possess high specific capacity, excellent cyclic stability and rate capability. The coulombic efficiency is about 84% in the 1 st cycle and increases significantly up to 97.8% during successive cycles at various current densities. Even under a high current density of 500 m A g^(-1), the discharge capacity of Cu_2 O@Cu composites remains up to 200 m Ah g^(-1). The excellent electrochemical properties are ascribed to the synergistic effect between high electronic conductivity and volume-buffering capacity of metallic copper composited with Cu_2 O. | Huijie Zhou Hongbin Zhao Xuan Zhang Hongwei Cheng Xionggang Lu Qian Xu | 2018 | Journal of Materials Science & Technology2018，34，7： | 3 |
| 19 | Luminescence tuning of Ce^3+,Pr^3+activated(Y,Gd)AGG system by band gap engineering and energy transfer显示文摘Tuning of phosphor luminescence properties,including the emission energy/intensity and thermal stability,is an important way to develop superior luminescent materials for diverse applications.In this work,we discuss the effect of band gap engineering and energy transfer on the luminescence properties of Ce^3+or Pr^3+doped(Y,Gd)AGG systems,and analyze the underlying reasons for their different phenomena.By using VUV-UV excitation spectra and constructing VRBE schemes,the changes of host band structure,5 d excited level energies and emission thermal stability of Ce^3+and Pr^3+with the incorporation of Gd^3+ions were studied.In addition,the energy transfer dynamics was also investigated in terms of the luminescence decay curves.This work demonstrates a way to tune phosphor luminescence properties by combining band gap engineering and energy transfer tailoring and provides an inspiring discussion on the different results of Ce^3+doping on the Ce^3+and Pr^3+emissions. | Yiyi Ou Weijie Zhou Fengkai Ma Chunmeng Liu Rongfu Zhou Fang Su Yan Huang Pieter Dorenbos Hongbin Liang | 2020 | Journal of Rare Earths2020，38，5： | 3 |
| 20 | The distribution of chlorophyll a in the tropical eastern Indian Ocean in austral summer显示文摘To study the effect of hydrographic factors on the spatial distributions of chlorophyll a (Chl a), an investigation was carried out in the tropical eastern Indian Ocean (80 -100 E along 7 S, and 7 -18 S along 80 E) in December 2010. The fluorescent method was used to obtain total Chl a and size-fractioned Chl a at the 26 stations. The results show that surface Chl a concentration averaged at (0.168 ± 0.095) mg/m 3 s.d. (range: 0.034-0.475 mg/m 3 ), concentrations appeared to be higher in the west for longitudinal variations, and higher in the north for latitudinal variations. Furthermore, the surface Chl a concentration was lower (0.034-0.066 mg/m 3 ) in the region to the south of 16 S. There was a strong subsurface Chl a maximum layer at all stations and the depth of the Chl a maximum increased towards to the east and south along with the respective nitracline. The spatial variation of Chl a was significant: correlation and regression analysis suggests that it was primarily affected by PO 3 4 , N(NO 3 -N+NO 2 -N) and temperature. Size-fractionated Chl a concentration clearly showed that the study area was a typical oligotrophic open ocean, in which picophytoplankton dominated, accounting for approximately 67.8% of total Chl a, followed by nanophytoplankton (24.5%) and microphytoplankton (7.6%). The two larger fractions were sensitive to the limitation of P, while picophytoplankton was primarily affected by temperature. | HONG Lisha WANG Chunsheng ZHOU Yadong CHEN Mianrun LIU Hongbin LIN Zhongyang SONG Xunshu | 2012 | Acta Oceanologica Sinica2012，31，5： | 3 |
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