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| 1 | 肠道菌群在功能性便秘中的作用显示文摘功能性便秘非常常见,但其发病机制尚不明了。越来越多的证据显示,功能性便秘与肠道微生态失调有关,而肠道微生态与肠道转运之间很可能存在相互影响。本文对功能性便秘发生过程中肠道微生态所发挥作用的证据进行了总结。肠道微生态通过胆酸、短链脂肪酸、5-羟色胺和甲烷等相关微生物代谢活动调控结肠动力、结肠黏膜分泌和吸收,进而促使功能性便秘的发生。作为肠道微生态影响功能性便秘的证据支持,用益生菌、益生元、合生元和中药治疗功能性便秘时,常可观察到患者肠道微生态在菌种组成和功能上的改变。深入研究功能性便秘的病理发生,阐明微生态制剂治疗功能性便秘的药理机制,将为功能性便秘的新型治疗方法提供理论基础。 | Shengsheng Zhang Ruixin Wang Danyan Li Luqing Zhao Lixin Zhu | 2021 | Gastroenterology Report2021，9，5： | 13 |
| 2 | Effect of substrate cooling on the epitaxial growth of Ni-based single-crystal superalloy fabricated by direct energy deposition显示文摘The columnar-to-equiaxed transition(CET)or the formation of stray grains in the laser melting deposition is the least desirable for the repair of single-crystal blades.In this work,the forced water-cooling was conducted on a single-crystal Rene N5 substrate during the direct energy deposition(DED).The single track remelting,one-layer,two-layer,and eight-layer depositions were investigated to explore the grain growth mechanism.The solidification conditions of the DED process,including temperature field,temperature gradient,and solidification speed,were numerically analyzed by a finite element model.The single-track remelting results showed that the fraction of columnar crystal regions increases from55.81%in the air-cooled sample to 77.14%in the water-cooled one.The single-track deposits of one-and two-layer have the same trend,where the proportion of columnar crystal height was higher under the forced water-cooled condition.The electron backscattered diffraction(EBSD)grain-structure maps of an eight-layer deposit show that the epitaxial growth height increases from 1 mm in the air-cooling sample to 1.5 mm in the water-cooling one.The numerical results showed that the tempe rature gradient in[0011 direction was significantly increased by using forced water-cooling.In conclusion,the in-situ substrate cooling can become a potential method to promote epitaxial growth during DED via the influence on CET occurrence. | Jianwen Nie Chaoyue Chen Longtao Liu Xiaodong Wang Ruixin Zhao Sansan Shuai Jiang Wang Zhongming Ren | 2021 | Journal of Materials Science & Technology2021，，3： | 6 |
| 3 | Cold spray additive manufacturing of Invar 36 alloy:microstructure,thermal expansion and mechanical properties显示文摘In this work,the Invar 36 alloys were manufactured using cold spray(CS)additive manufacturing technique.The systematic investigations were made on the microstructural evolution,thermal expansion and mechanical properties under as-sprayed(AS)and heat-treated(HT)conditions.XRD(X-ray diffraction)and ICP-AES(inductively coupled plasma atomic emission spectroscopy)analyses show that no phase transformation,oxidation,nor element content change have occurred.The X-ray computed tomography(XCT)exhibited a near fully dense structure with a porosity of 0.025%in the helium-produced sample under as-sprayed condition,whereas the nitrogen-produced samples produced at 5 MPa and 800℃show more irregular pore defects.He-AS sample shows a more prominent grain refinement than that of nitrogen samples due to the more extensive plastic deformation.The post heat-treatment exhibited a promoted grain growth,inter-particle diffusion,as well as the formation of annealing twins.Between25℃and 200℃,the nitrogen samples possessed lower CTE(coefficient of thermal expansion)values(1.53×10^(-6)/℃)compared with those produced by casting and laser additive manufacturing.The He-AS samples exhibited a noticeable negative CTE value between 25℃and 200℃,which may due to the significant compressive residual stress(-272 MPa)compensating its displacement with temperature increase during CTE test.The N2-HT and He-HT Invar 36 samples present a notable balance between strength and ductility.In conclusion,the CS technique can be considered as a potential method to produce the Invar36 component with high thermal and mechanical performance. | Chaoyue Chen Yingchun Xie Longtao Liu Ruixin Zhao Xiaoli Jin Shanqing Li Renzhong Huang Jiang Wang Hanlin Liao Zhongming Ren | 2021 | Journal of Materials Science & Technology2021，，13： | 4 |
| 4 | Spatio-temporal Evolution and Driving Factors of the High-quality Development of Provincial Tourism in China显示文摘Accelerating the promotion of high-quality development of tourism(HQDT) is of great significance to the sustainable development of tourism. This paper defined the concept of HQDT, and then built an evaluation system for HQDT measurement to analyze the spatio-temporal evolution characteristics of China’s HQDT based on provincial panel data from 2010 to 2019, using Geodetector to explore the similarities and differences between driving factors of HQDT and tourism development scale(TDS). The results show that:1) Taking the development concepts of innovation, coordination, green, openness and sharing as the guidance, and considering the organic unity of quantity and quality, the evaluation index system of the HQDT consists of six dimensions of economic stability, innovation driving, coordination and linkage, green and sustainability, openness and cooperation, and sharing and harmony, which respectively represent the basis, momentum, means, orientation, direction and purpose of the HQDT;2) The level of China’s HQDT shows an upward trend, presenting the characteristics of eastern region > central region > western region > northeastern region in 2019. The regional differences in China’s HQDT show a downward trend, and the intra-regional differences have replaced the inter-regional differences as the main source of regional differences;3) China’s HQDT shows the characteristics of higher in the east and lower in the west along the Hu line, while the improvement speed of HQDT shows the characteristics of faster in the west and slower in the east, making the decline of east-west differentiation of China’s HQDT and the movement of the gravity center towards southwest;4) Both HQDT and TDS are obviously driven by tourism capital investment and regional consumption. In terms of differences, the HQDT is more driven by government guidance, innovation driving force, and opening up, while the main driving factors of TDS are more biased toward capital elements and hardware facilities, including informatization, tourism resource, traffic, and eco-environment. | WANG Xinyue WANG Mengmeng LU Xuejing GUO Lizhen ZHAO Ruixin JI Ranran | 2022 | Chinese Geographical Science2022，32，5： | 2 |
| 5 | Multi-component hydrogen-bonding salts formed between imidazole and aromatic acids:Synthons cooperation and crystal structures显示文摘Imidazole base was crystallized with different aromatic carboxylic acids 2,4-dihydroxybenzoic acid, 5-chlorosalicylic acid, and 1,8-naphthalic acid, affording three new binary molecular organic salts of [(C 3 H 5 N 2 + )·(C 7 H 5 O 4 )] (1), [(C 3 H 5 N 2 + )·(C 7 H 4 O 3 Cl )] C 7 H 5 O 3 Cl (2), and [(C 3 H 5 N 2 + ) (C 12 H 7 O 4 )] (3). Proton transfer occurs from the COOH of carboxylic acid to nitrogen of imidazole in all complexes (1-3), leading to the hydrogen bond N-H…O in all structures. To our knowledge, the recognition pattern between the carboxylic acid group and imidazole (acid-imidazole synthon) is less well-studied so far. The cooperation among COOH, COO and imidazolium cation functional groups for the observed hydrogen bond synthons is examined in the three structures. Generally, the strong N-H…O and O-H…O hydrogen bonds define supramolecular architecture and connectivity within chains, while weaker C-H…O hydrogen bonds play the dominant role in controlling the interactions between layers in these novel organic salts. Thermal stability of these compounds has been investigated by thermogravimetric analysis (TGA) of mass loss. | WANG Lei ZHAO Lei LIU Meng CHEN RuiXin YANG Yu GU YuanXiang | 2012 | Science China Chemistry2012，55，10： | 2 |
| 6 | Novel non-noble metal electrocatalysts synthesized by heat-treatment of iron terpyridine complexes for the oxygen reduction reaction显示文摘 | Jiatang Wang Shang Li Guangwen Zhu Wei Zhao Ruixin Chen Mu Pan | 2013 | Journal of Power Sources2013，，： | 1 |
| 7 | Co-crystallization of glycine anhydride with the hydroxybenzoic acids: Controlled formation of dimers via synthons cooperation and structural characterization显示文摘The results of crystallographic analyses on 1:1 and 1:4 well-defined co-crystals formed between glycine anhydride and each of 4-hydroxybenzoic acid and 3,5-dihydroxybenzoic acid are described. Neutral molecules are connected via heteromeric O-H···O and N-H···O contacts leading to different packing arrangements of supramolecular chains. On the basis of the molecular structures of glycine anhydride and carboxylic acid guests, the hydrogen bonds are arranged to give centrosymmetric synthons V and VII which are noteworthy for their robustness. Hydrogen-bond interactions between glycine anhydride and aromatic acid provide sufficient driving force to direct molecular recognition and crystal packing. Utilization of the orientation of functional groups of the building blocks, the acidity, and weak interactions provides a route for the creation of novel supra- molecular architectures in the crystal lattice. Both two co-crystals contain the expected hydrogen-bonded motifs, and there has been no proton transfer from either of the two carboxylic acids to the aza compound moiety. This demonstrates that glycine anhydride is very capable of affecting the construction of binary co-crystals in a predictable and rationale manner. It is noted that synthons VⅢ and IX are fairly large, but the real challenge in crystal engineering is to find a big enough synthon that occurs often enough. Thermal stability of these compounds has been investigated by thermogravimetric analysis (TGA) of mass loss. | WANG Lei ZHAO Lei LIU WeiMing CHEN RuiXin GU YuanXiang YANG Yu | 2012 | Science China Chemistry2012，55，11： | 1 |
| 8 | Selective Laser Melting of Carbon-Free Mar-M509 Co-Based Superalloy:Microstructure,Micro-Cracks,and Mechanical Anisotropy显示文摘In this work,the microstructural evolution,micro-crack formation,and mechanical anisotropy of the selective laser melted(SLM)carbon-free Mar-M509 Co-based superalloy were systematically studied under different linear energy densities(LED).Observation shows that the SLM Mar-M509 superalloy possesses a fully dense structure,whereas some microcracks exist along the building direction.The electron backscatter diffraction results reveal that dominant columnar grains tend to elongate along the building direction parallel to the XZ plane.Meanwhile,both a<001>near fiber texture and a{100}<001>near sheet texture are observed in different specimens.For the specimen with fiber texture,a high misorientation angle exists among different columnar grains,which aggravated the generation of micro-cracks under thermal stress.Higher LED results in higher micro-crack density in the SLM specimen due to higher thermal stress.Mar-M509 specimen fabricated under lower LED exhibits higher tensile strength due to more significant grain refinement.More prominent anisotropy of tensile performance was found in the high LED specimen,which can be attributed to the higher density of micro-cracks and crystallographic texture.Furthermore,the SLM Mar-M509 superalloy exhibits better mechanical properties than the traditional cast technique.In summary,this work can contribute to the development and the future application of SLM-fabricated Co-based superalloy. | Xiaodong Wang Chaoyue Chen Ruixin Zhao Longtao Liu Sansan Shuai Tao Hu Jiang Wang Zhongming Ren | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，3： | 1 |
| 9 | Nonlinear optical material of a low-dimensional coordination polymer:Synthesis,structure,NLO and fluorescence properties显示文摘Employing unsymmetrical 2-mercapto-5-methyl-1,3,4-thiadiazole and 2,2′-bipyridine as mixed ligands, a new low-dimensional coordination polymer [Zn(MMTA) 2 (2,2′-bipy)] n (MMTA = 2-mercapto-5-methyl-1,3,4-thiadiazole, 2,2′-bipy = 2,2′-bipyridine), has been synthesized under solvothermal condition and characterized by single crystal X-ray diffraction. This compound crys- tallizes in the noncentrosymmetric space group Cc, with cell parameters: a = 8.291(4) , b = 15.483(9) , c = 15.620(6) , = 96.00(5)°, V = 1994.1(2) 3 , and Z = 4. The mixed ligands link the zinc center into a mononuclear unit, which is futher linked by weak C-H···N and C-H···S hydrogen bonds into a three-dimensional noncentrosymmetric framework. The compound exhibits intense photoluminescence and distinct NLO properties at room temperature. The intensity of the green light produced by the powder sample of the compound is about 3.2 times that produced by KDP powder. On the basis of the results of TG analysis, the structure is thermally stable up to ~260 °C. | WANG Lei ZHAO Lei LIU Meng CHEN RuiXin YANG Yu GU YuanXiang | 2012 | Science China Chemistry2012，55，10： | 1 |
| 10 | The Opportunity and Challenge of the Development of Artificial Intelligence to Human Labor Liberation显示文摘With the development and application of artificial intelligence(AI)technology,it has promoted the upgrading and development of the industry.However,AI also brings intangible impact to the actual survival of human beings.Stephen·Hawking,the renowned physicist,has repeatedly warned,making it all the more urgent to reflect on the negative effects of artificial intelligence.Therefore,the review of AI should consider from the perspective of historical development,scientifically explain its changes in the way of human labor and social life,as well as the great significance of such changes to the liberation of human labor. | Ruixin Zhang Chunyu Zhao | 2020 | Journal of Contemporary Educational Research2020，4，8： | 0 |
| 11 | Regional Renewable Energy Optimization Based on Economic Benefits and Carbon Emissions显示文摘With increasing renewable energy utilization,the industry needs an accurate tool to select and size renewable energy equipment and evaluate the corresponding renewable energy plans.This study aims to bring new insights into sustainable and energy-efficient urban planning by developing a practical method for optimizing the production of renewable energy and carbon emission in urban areas.First,we provide a detailed formulation to calculate the renewable energy demand based on total energy demand.Second,we construct a dual-objective optimization model that represents the life cycle cost and carbon emission of renewable energy systems,after which we apply the differential evolution algorithmto solve the optimization result.Finally,we conduct a case study in Qingdao,China,to demonstrate the effectiveness of this optimizationmodel.Compared to the baseline design,the proposedmodel reduced annual costs and annual carbon emissions by 14.39%and 72.65%,respectively.These results revealed that dual-objective optimization is an effective method to optimize economic benefits and reduce carbon emissions.Overall,this study will assist energy planners in evaluating the impacts of urban renewable energy projects on the economy and carbon emissions during the planning stage. | Cun Wei Yunpeng Zhao Mingyang Cong Zhigang Zhou Jingzan Yan Ruixin Wang Zhuoyang Li Jing Liu | 2023 | Energy Engineering2023，120，6： | 0 |
| 12 | Kinematics and Dynamics Analysis of McPherson Suspension Based on Planar 1/4 Vehicle Model显示文摘The nonlinear asymmetric problem of McPherson suspension has become a challenging problem in the process of establishing the system model.This paper presents a planar 1/4-vehicle model that not only takes into account the vertical vibration of the sprung mass(chassis),but also includes:ix spring mass(wheel assembly)sliding and rotation;ii longitudinal wheel mass And its moment of inertia;iii tire damping and lateral defl ection.This dynamic kinematic model provides a solution to two important shortcomings of the traditional 1/4 vehicle model:it explains geometric modeling and tire modeling.This paper provides a systematic development of the planar model and a complete mathematical equation.This analysis model can be applied to hardware in the rapid calculation of ring applications.In addition,the model also gives a repeatable Simulink simulation implementation.The model has been compared with the actual Adams/View simulation to analyze the vibration and rebound motion of the wheel,as well as two related motion parameters:the dynamic characteristics of the camber and the pitch change. | Minghui Ye Guangyan Hu Ruixin Zhao | 2018 | Insight-Mechanics2018，1，1： | 0 |
| 13 | MUTUAL ARTIFICIAL BEE COLONY ALGORITHM FOR MOLECULAR DOCKING显示文摘 | RUIXIN MA XIUJUAN XU LEI ZHAO REN CAO QIANG FANG | 2013 | International Journal of Biomathematics2013，6，6： | 0 |
| 14 | Kinematics and Dynamics Analysis of McPherson Suspension Based on Planar 1/4 Vehicle Model显示文摘The nonlinear asymmetric problem of McPherson suspension has become a challenging problem in the process of establishing the system model. This paper presents a planar 1/4-vehicle model that not only takes into account the vertical vibration of the sprung mass (chassis), but also includes: ix spring mass (wheel assembly) sliding and rotation;ii longitudinal wheel mass And its moment of inertia;iii tire damping and lateral defl ection. This dynamic kinematic model provides a solution to two important shortcomings of the traditional 1/4 vehicle model: it explains geometric modeling and tire modeling. This paper provides a systematic development of the planar model and a complete mathematical equation. This analysis model can be applied to hardware in the rapid calculation of ring applications. In addition, the model also gives a repeatable Simulink simulation implementation. The model has been compared with the actual Adams / View simulation to analyze the vibration and rebound motion of the wheel, as well as two related motion parameters: the dynamic characteristics of the camber and the pitch change. | Minghui Ye Guangyan Hu Ruixin Zhao | 2019 | Insight-Sports Science2019，1，1： | 0 |
| 15 | Kinematics and Dynamics Analysis of McPherson Suspension Based on Planar 1/4 Vehicle Model显示文摘The nonlinear asymmetric problem of McPherson suspension has become a challenging problem in the process of establishing the system model.This paper presents a planar 1/4-vehicle model that not only takes into account the vertical vibration of the sprung mass(chassis),but also includes:ix spring mass(wheel assembly)sliding and rotation;ii longitudinal wheel mass And its moment of inertia;iii tire damping and lateral defl ection.This dynamic kinematic model provides a solution to two important shortcomings of the traditional 1/4 vehicle model:it explains geometric modeling and tire modeling.This paper provides a systematic development of the planar model and a complete mathematical equation.This analysis model can be applied to hardware in the rapid calculation of ring applications.In addition,the model also gives a repeatable Simulink simulation implementation.The model has been compared with the actual Adams/View simulation to analyze the vibration and rebound motion of the wheel,as well as two related motion parameters:the dynamic characteristics of the camber and the pitch change. | Minghui Ye Guangyan Hu Ruixin Zhao | 2017 | Vehicle Dynamics2017，1，1： | 0 |
| 16 | A Pull-Out Test Study on the Working State of Fully Grouted Bolts显示文摘The present study examines the working conditions of fully grouted bolts used for the construction and expansion of high slopes.On the basis of a pull out destructive test,the work load and the ultimate load are obtained on site,and the Flac3d numerical simulation method is employed to determine the axial force distribution and the effective anchor length.The test results show that(1)the Q-S(load-displacement)curve of the bolt displays a certain degree of deformation coupled with the creep of the surrounding rock;(2)the working load of the bolt is closely related to the sliding deformation trend of the slope,while the ultimate load depends on the design parameters of the bolt and the lithology of the slope;(3)the distribution of bolt axial force is characterized by a single peak along the bolt length and the effective anchorage length of the bolt is 3 m;(4)after 20 years,the bolt’s ultimate load has a maximum loss of 31.94%. | Ruixin Zhao Zhongju Feng Guan Jiang Fuchun Wang Yidong Zhang Changan Zhang Zhenbing Wang | 2021 | Fluid Dynamics & Materials Processing2021，17，2： | 0 |
| 17 | Handwashing quality assessment via deep learning:a modelling study for monitoring compliance and standards in hospitals and communities显示文摘Background Hand hygiene can be a simple,inexpensive,and effective method for preventing the spread of infectious diseases.However,a reliable and consistent method for monitoring adherence to the guidelines within and outside healthcare settings is challenging.The aim of this study was to provide an approach for monitoring handwashing compliance and quality in hospitals and communities.Methods We proposed a deep learning algorithm comprising three-dimensional convolutional neural networks(3D CNNs)and used 230 standard handwashing videos recorded by healthcare professionals in the hospital or at home for training and internal validation.An assessment scheme with a probability smoothing method was also proposed to optimize the neural network’s output to identify the handwashing steps,measure the exact duration,and grade the standard level of recognized steps.Twenty-two videos by healthcare professionals in another hospital and 28 videos recorded by civilians in the community were used for external validation.Results Using a deep learning algorithm and an assessment scheme,combined with a probability smoothing method,each handwashing step was recognized(ACC ranged from 90.64%to 98.87%in the hospital and from 87.39%to 96.71%in the community).An assessment scheme measured each step’s exact duration,and the intraclass correlation coefficients were 0.98(95%CI:0.97-0.98)and 0.91(95%CI:0.88-0.93)for the total video duration in the hospital and community,respectively.Furthermore,the system assessed the quality of handwashing,similar to the expert panel(kappa=0.79 in the hospital;kappa=0.65 in the community).Conclusions This work developed an algorithm to directly assess handwashing compliance and quality from videos,which is promising for application in healthcare settings and communities to reduce pathogen transmis-sion. | Ting Wang Jun Xia Tianyi Wu Huanqi Ni Erping Long Ji-Peng Olivia Li Lanqin Zhao Ruoxi Chen Ruixin Wang Yanwu Xu Kai Huang Haotian Lin | 2022 | Intelligent Medicine2022，2，3： | 0 |
| 18 | Ductile and high strength Cu fabricated by solid-state cold spray additive manufacturing显示文摘In this work,pure Cu with excellent strength and ductility(UTS of 271 MPa,elongation to fracture of 43.5%,uniform elongation of 30%)was prepared using cold spray additive manufacturing(CSAM),realizing a breakthrough in the field.An in-depth investigation was conducted to reveal the microstructure evolution,strengthening and ductilization mechanisms of the CSAM Cu,as well as the single splats.The results show that the CSAM Cu possesses a unique heterogeneous microstructure with a bimodal grain structure and extensive infinitely circulating ring-mounted distribution of twinning.Based on the single splat observation,the entire copper particle forms a gradient nano-grained(GNG)structure after high-speed impact deposition.The GNG-structured single splat serves as a unit to build the heterogeneous microstructure with bimodal grain distribution during the successive deposition in CSAM.The results also show that CSAM can achieve synergistic strengthening and ductilization by controlling the grain refinement and dislocation density.This work provides potential for CSAM technique in manufacturing various metallic parts with the desired combination of high strength and good ductility without additional post-treatments. | Chaoyue Chen Yingchun Xie Shuo Yin Wenya Li Xiaotao Luo Xinliang Xie Ruixin Zhao Chunming Deng Jiang Wang Hanlin Liao Min Liu Zhongming Ren | 2023 | Journal of Materials Science & Technology2023，，3： | 0 |
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