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| 1 | A Pilot Study of the Therapeutic Efficacy and Mechanism of Artesunate in the MRL/lpr Murine Model of Systemic Lupus Erythematosus显示文摘Recent evidence indicates that artesunate has immunomodulatory properties that might be useful for treating autoimmune disease.In this study,we conducted a pilot study and explored the effect and mechanism of artesunate on the treatment of systemic lupus erythematosus using an MRL/lpr murine model.MRL/lpr mice were divided into control,cyclophosphamide(CTX)and artesunate treatment groups.Blood was collected to measure serum levels of creatinine,antinuclear antibody(ANA)and anti-double-stranded DNA(anti-dsDNA)antibody.Twenty-four-hour urine was collected to measure levels of proteinuria.The concentration of monocyte chemotactic protein-1(MCP-1)in serum and urine was measured.The expression of MCP-1 in kidney was detected by Western blot and immunohistochemistry assay,respectively.The expression of B cell activating factor(BAFF)in spleen was determined by real time-PCR and immunoblotting.We found that artesunate significantly increased the survival rate,body weight and blood leukocyte counts,and reduced the serum levels of ANA and anti-dsDNA antibody titer,24 h urinary protein,and serum creatinine.Our results indicated that artesunate could decrease MCP-1,major pro-inflammation cytokine,in serum,urine and kidney.We also found that the level of BAFF,the major B cell activation factor,was decreased in artesunate treated MRL/lpr mice.Its efficacy was comparable with that of CTX in this study.Taken together,we have demonstrated that artesunate can inhibit the progression of disease and reverse the pathologic lesion of lupus nephritis. | Ouyang Jin Huayong Zhang Zhifeng Gu Shengnan Zhao Ting Xu Kangxing Zhou Bo Jiang Jie Wang Xiaofeng Zeng Lingyun Sun | 2009 | Cellular & Molecular Immunology2009，6，6： | 20 |
| 2 | Focal depths for moderate-sized aftershocks of the Wenchuan M_S8.0 earthquake and their implications显示文摘Sliding-window cross-correlation method is firstly adopted to identify sPn phase, and to constrain focal depth from regional seismograms, by measuring the time separation between sPn and Pn phases. We present the focal depths of the 17 moderate-sized aftershocks (MS≥5.0) of the Wenchuan MS8.0 earth-quake, using the data recorded by the regional seismic broadband networks of Shaanxi, Qinghai, Gansu, Yunnan and Sichuan. Our results show focal depths of aftershocks range from 8 to 20 km, and tend to cluster at two average depths, separate at 32.5°N, i.e., 11 km to the south and 17 km to the north, indicating that these aftershocks are origin of upper-to-middle crust. Combined with other results, we suggest that the Longmenshan fault is not a through-going crustal fault and the Pingwu-Qingchuan fault may be not the northward extension of the Longmenshan thrust fault. | ZHANG RuiQing WU QingJu LI YongHua DING ZhiFeng ZENG RongSheng | 2008 | Science China Earth Sciences2008，51，12： | 14 |
| 3 | In-situ fabrication of PtSe2/GaN heterojunction for self-powered deep ultraviolet photodetector with ultrahigh current on/off ratio and detectivity显示文摘The research of ultraviolet photodetectors(UV PDs)have been attracting extensive attention,due to their important applications in many areas.In this study,PtSe2/GaN heterojunction is in-situ fabricated by synthesis of large-area vertically standing two-dimensional(2D)PtSe2 film on n-GaN substrate.The PtSe2/GaN heterojunction device demonstrates excellent photoresponse properties under illumination by deep UV light of 265 nm at zero bias voltage.Further analysis reveals that a high responsivity of 193 mA·W^-1,an ultrahigh specific detectivity of 3.8 × 10^14 Jones,linear dynamic range of 155d B and current on/off ratio of^10^8,as well as fast response speeds of 45/102μs were obtained at zero bias voltage.Moreover,this device response quickly to the pulse laser of 266 nm with a rise time of 172 ns.Such high-performanee PtSe2/GaN heteroj u nction UV PD demonstrated in this work is far superior to previously reported results,suggesting that it has great potential for deep UV detection. | Ranran Zhuo Longhui Zeng Huiyu Yuan Di Wu Yuange Wang Zhifeng Shi Tingting Xu Yongtao Tian Xinjian Li Yuen Hong Tsang | 2019 | Nano Research2019，12，1： | 11 |
| 4 | The Nano-Macro Pore Network and the Characteristics of Petroleum Migration and Accumulation in Chang 8 Tight Sandstone Reservoir in Heshui,Ordos Basin显示文摘Tight oil generally refers to the oil stored in the tight sandstone reservoir or tight carbonate reservoir that the overburden matrix permeability is less than or equal to 0.1mD(equivalent of about air permeability less than 1.0 mD)(Zeng et al.,2014).The tight oil resources are widely distributed in China,among them the Chang 6-Chang 8 of Yanchang formation in Ordos basin is an important tight | QIAO Juncheng ZENG Jianhui YANG Zhifeng FENG Xiao YAO Jingli LUO Anxiang | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 4 |
| 5 | Highly sensitive solar-blind deep ultraviolet photodetector based on graphene/PtSe_(2)/β-Ga_(2)O_(3)2D/3D Schottky junction with ultrafast speed显示文摘There is an emerging need for high-sensitivity solar-blind deep ultraviolet(DUV)photodetectors with an ultra-fast response speed.Although nanoscale devices based on Ga_(2)O_(3)nanostructures have been developed,their practical applications are greatly limited by their slow response speed as well as low specific detectivity.Here,the successful fabrication of two-/three-dimensional(2D/3D)graphene(Gr)/PtSe2/β-Ga_(2)O_(3)Schottky junction devices for high-sensitivity solar-blind DUV photodetectors is demonstrated.Benefitting from the high-quality 2D/3D Schottky junction,the vertically stacked structure,and the superior-quality transparent graphene electrode for effective carrier collection,the photodetector is highly sensitive to DUV light illumination and achieves a high responsivity of 76.2 mA/W,a large on/off current ratio of~105,along with an ultra-high ultraviolet(UV)/visible rejection ratio of 1.8×104.More importantly,it has an ultra-fast response time of 12µs and a remarkable specific detectivity of~1013 Jones.Finally,an excellent DUV imaging capability has been identified based on the Gr/PtSe2/β-Ga_(2)O_(3)Schottky junction photodetector,demonstrating its great potential application in DUV imaging systems. | Di Wu Zhihui Zhao Wei Lu Lukas Rogée Longhui Zeng Pei Lin Zhifeng Shi Yongtao Tian Xinjian Li Yuen Hong Tsang | 2021 | Nano Research2021，14，6： | 4 |
| 6 | Structure regulation for ultra-high luminescence quantum yield lanthanide complex and simultaneous detection of cancer marker and ferrous ion显示文摘The exploitation of a highly selective and sensitive probe to detect both cancer marker and metal ion is of great importance.In this work,the 'one stone two bird' agent of 1,10-phenanthroline(phen) is designed to disrupt the polymeric lanthanide MOFs(LnMOFs,[Ln(CHO_(2))_(3)]n,Ln=Tb,la;Eu,1 b,CHO_(2)=formic acid) {[Ln(CHO_(2))_(4)·(C_(2) H_(8) N)]n,Ln=Y,2 a;Gd,2 b;Dy,2 c,C_(2)H_(8) N=dimethylamine}) into a soluble mononuclear species [Ln(phen)_(2)(NO_(3))_(3),Ln=Tb,3 a;Eu,3 b] as well as to provide an antenna for efficient photons absorption,resulting in an ultra-high luminescence quantum yield(QY,90%) europium complex.The luminescence QY is among the highest record of monomeric(zero-dimensional) lanthanide complexes.Furthermore,mononuclear Tb3+complex(3 a) functions as a multiplex sensor towards both Fe^(2+)and cancer marker of 5-hydroxyindole-3-acetic acid(5-HIAA).Importantly,the limit of detection(LOD)for sensing 5-HIAA is an ultra-sensitive value of 1 × 10 s mol/L,which is even lower than that necessary for the early diagnosis of carcinoid tumors.More interestingly,sensing results in simulated urine reveals that 3 a has potential application for early diagnosis in the clinic. | Min Liu Zhifeng Li Jianhui Xiong Yefei Jiang Ting Tang Jinkai Qiu Junwei Yao Seik Weng Ng Chenghui Zeng | 2021 | Journal of Rare Earths2021，39，10： | 3 |
| 7 | Rifampicin inhibits apoptosis in rotenone-induced differentiated PC12 cells by ameliorating mitochondrial oxidative stress显示文摘BACKGROUND:Previous studies have shown that rifampicin exhibits neuroprotective effects,but the precise mechanisms remain unclear.Rifampicin is thought to exert the neuroprotective effect as a hydroxyl free radical scavenger.OBJECTIVE:To investigate the protective effects of rifampicin pretreatment on rotenone-induced mitochondrial oxidative stress in differentiated PC12 cells.DESIGN,TIME AND SETTING:A repeated measure,cell-based study was performed at the Department of Neurology,Second Affiliated Hospital,Sun Yat-sen University,China between December 2007 and November 2008.MATERIALS:PC12 cells were a kind gift from the Physiology Laboratory of Zhongshan Medical School,Sun Yat-sen University,China.Rotenone and rifampicin were purchased from Sigma,USA.METHODS:PC12 cells were differentiated by culturing with 100 ng/mL 7S nerve growth factor for 9 days in Dulbecco's modified Eagle's medium/Nutrient Mix F12(DMEM/F12) supplemented with 10% fetal bovine serum.The cells were assigned to six groups according to various treatment conditions:control,cultured with normal media;rifampicin group,treated with 300 μmol/L rotenone for 26 hours;rotenone group,treated with 2.5 μmol/L rotenone for 24 hours;rifampicin pretreatment groups,pretreated with 100,200,and 300 μmol/L rifampicin for 2 hours,respectively,followed by 2.5 μmol/L rotenone for 24 hours.MAIN OUTCOME MEASURES:Mitochondrial membrane potential was measured by fluorescence microscopy and flow cytometry,respectively,using rhodamine123 staining.Intracellular reactive oxygen species formation was analyzed by flow cytometry using 2',7'-dichlorofluorescin-diacetate staining,and intracellular reduced glutathione was measured with a microplate reader.Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.Cell apoptosis was detected by Hoechst 33342 staining and flow cytometry.RESULTS:Increased apoptosis in rotenone-induced,differentiated,PC12 cells was accompanied by the loss of mitochondrial transmembrane potential,the formation of reactive oxygen species,and reduced glutathione depletion(P<0.01).Rotenone-induced mitochondrial dysfunction was blocked in a dose-dependent manner by rifampicin(P<0.05 or P<0.01).CONCLUSION:Pretreatment of differentiated PC12 cells with rifampicin blocked rotenone-induced apoptosis by ameliorating mitochondrial dysfunction and oxidative stress. | Shiwen Chen Yuanlin Sun Zhifeng Zeng Enxiang Tao | 2010 | Neural Regeneration Research2010，5，4： | 2 |
| 8 | Chiral assembly of achiral pseudoisocyanine with D-and L-phenylalanine显示文摘Supramolecular chirality and molecular self-assembly are important and interesting phenomena in living and non-living systems.In this work,supramolecular chirality of achiral pseudoisocyanine(PIC) J-aggregates was successfully induced by D-,L-phenylalanine(Phe) and other amino acids in NaCl solution.The chiral J-aggregates showed a characteristic,induced circular dichroism(ICD) in the visible region of J-band chromophore which depends on the absolute configuration,concentration and side groups of α-amino acids,as well as temperature.The atomic force microscopy images indicated that the J-aggregates exist in large bundles of entangled nanofibers,and the observed ICD might result from the macroscopic helical arrangement of the assemblies. | ZENG LiXi HE YuJian DAI ZhiFeng WANG Jian WANG CaiQi YANG YongGang | 2009 | Science China Chemistry2009，52，8： | 2 |
| 9 | Quantitative evaluation of heavy metals’ pollution hazards in liquefaction residues of sewage sludge显示文摘 | Huajun Huang Xingzhong Yuan Guangming Zeng Huina Zhu Hui Li Zhifeng Liu Hongwei Jiang Lijian Leng Wenkai Bi | 2011 | Bioresource Technology2011，，22： | 2 |
| 10 | Effective inhibition of human cytomegalovirus gene expression by DNA-based external guide sequences显示文摘调查是否 12 核苷酸基于 DNA 的 miniEGSs 罐头沉默人的 cytomegalovirus (HCMV ) 的表示 UL49 基因高效地,稳定地表示 UL49 基因的一根 HeLa 房间线被构造,通常认为的 miniEGSs (UL49-miniEGSs ) 是在稳定的房间线的 assayed。量的 RTPCR 和西方的污点结果在是有 UL49-miniEGSs 的 transfected 的 HeLa 房间在 UL49 表示水平显示出 67% 的减小。它与分别地是 1 和 7% 的嘲笑和控制 miniEGSs (TK-miniEGSs ) 的显著地不同。为了进一步证实基因沉默,与人的 RNase P 由 UL49-miniEGSs 指导了, UL49-miniEGSs 的异种被构造并且一修改了 5 种族被执行。数据证明基因表示由 UL49-miniEGSs 指导了的 UL49 的抑制是 P 依赖的 RNase,由 RNase P 的 UL49 mRNA 的劈开是地点特定。作为结果,基于 DNA 的 miniEGSs 的长度能沉默基因表示高效地仅仅是 12 nt。是显著地不到到目前为止知道的基因 inactivation 的任何另外的基于 oligonucleotide 的方法。MiniEGSs 可以为病毒的基因的抑制代表新奇指向基因的代理人,另外的人的疾病联系基因表示。 | Zhifeng Zeng Hongjian Li Yueqing Li Yanwei Cui Qi Zhou Yi Zou Guang Yang Tianhong Zhou | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 1 |
| 11 | A review on the lithospheric structures in the Tibetan Plateau and constrains for dynamics显示文摘 | Zeng Rongsheng Ding Zhifeng Wu Qingju | 1995 | PAGEOPH1995，145，： | 1 |
| 12 | A structured hierarchical P2P model based on a rigorous binary tree code algorithm 显示文摘 | LIU HONGJUN LUO PING ZENG ZHIFENG | 2007 | Future Generation Computer System2007，23，2： | 1 |
| 13 | Impact of Phanerochaete chrysosporium inoculation on indigenous bacterial communities during agricultural waste composting显示文摘 | Jiachao Zhang Guangming Zeng Yaoning Chen Man Yu Hongli Huang Changzheng Fan Yi Zhu Hui Li Zhifeng Liu Ming Chen Min Jiang | 2013 | Applied Microbiology and Biotechnology2013，，7： | 1 |
| 14 | A Method for Software Vulnerability Detection Based on Improved Control Flow Graph显示文摘With the rapid development of software technology, software vulnerability has become a major threat to computer security. The timely detection and repair of potential vulnerabilities in software, are of great significance in reducing system crashes and maintaining system security and integrity. This paper focuses on detecting three common types of vulnerabilities: Unused_Variable, Use_of_Uninitialized_Variable, and Use_After_ Free. We propose a method for software vulnerability detection based on an improved control flow graph(ICFG) and several predicates of vulnerability properties for each type of vulnerability. We also define a set of grammar rules for analyzing and deriving the three mentioned types of vulnerabilities, and design three vulnerability detection algorithms to guide the process of vulnerability detection. In addition, we conduct cases studies of the three mentioned types of vulnerabilities with real vulnerability program segments from Common Weakness Enumeration(CWE). The results of the studies show that the proposed method can detect the vulnerability in the tested program segments. Finally, we conduct manual analysis and experiments on detecting the three types of vulnerability program segments(30 examples for each type) from CWE, to compare the vulnerability detection effectiveness of the proposed method with that of the existing detection tool Cpp Check. The results show that the proposed method performs better. In summary, the method proposed in this paper has certain feasibility and effectiveness in detecting the three mentioned types of vulnerabilities, and it will also have guiding significance for the detection of other common vulnerabilities. | ZHOU Minmin CHEN Jinfu LIU Yisong ACKAH-ARTHUR Hilary CHEN Shujie ZHANG Qingchen ZENG Zhifeng | 2019 | Wuhan University Journal of Natural Sciences2019，24，2： | 1 |
| 15 | REDUCING STAIRCASING ARTIFACTS IN SPECT RECONSTRUCTION BY AN INFIMAL CONVOLUTION REGULARIZATION显示文摘这份报纸的目的是在在 SPECT 重建治好 TV 模型的 staircasing 人工制品调查 infimal 卷绕旋转规则化的能力。我们作为一个凸的三块的优化问题与 infimal 卷绕旋转规则化提出 SPECT 重建的问题并且以涉及它的客观函数的函数的最近操作符由定点方程的一个系统描绘它的解决方案。我们然后基于定点方程开发一个新奇定点最近算法。而且,我们介绍古典 MLEM (最大可能性的的期望最大化) 激发的一个 preconditioning 矩阵算法。我们证明建议算法的集中。数字结果被包括证明 infimal 卷绕旋转规则化能够有效地减少 staircasing 人工制品,当以 signal-to-noise 比率和系数恢复对比维持可比较的图象质量时。 | Zhifeng Wu Si Li Xueying Zeng Andrzej Krol | 2016 | Journal of Computational Mathematics2016，34，6： | 1 |
| 16 | Total concentrations and chemical speciation of heavy metals in liquefaction residues of sewage sludge显示文摘 | Xingzhong Yuan Huajun Huang Guangming Zeng Hui Li Jingyu Wang Chunfei Zhou Huina Zhu Xiaokai Pei Zhifeng Liu Zhantao Liu | 2010 | Bioresource Technology2010，，5： | 1 |
| 17 | A review on the lithospheric structures in the Tibetan Plateau and constraints for dynamics显示文摘 | Rongsheng Zeng Zhifeng Ding Qingju Wu | 1995 | Pure and Applied Geophysics PAGEOPH (-)1995，，3： | 1 |
| 18 | Influence of Mg17Al12 intermetallic compounds on the hot extruded microstructures and mechanical properties of Mg-9AI-IZn alloy 显示文摘 | Li Zhifeng Dong Jie Zeng Xiaoqing | 2007 | Materials Science and Engineering2007，466，： | 1 |
| 19 | 显示文摘 | LI Haifang ZENG Hulie CHEN Zhifeng LIN Jinming | 2009 | Electrophoresis2009，30，6： | 1 |
| 20 | Impact of Phanerochaete chrysosporium inoculation on indigenous bacterial communities during agricultural waste composting显示文摘 | Jiachao Zhang Guangming Zeng Yaoning Chen Man Yu Hongli Huang Changzheng Fan Yi Zhu Hui Li Zhifeng Liu Ming Chen Min Jiang | 2013 | Applied Microbiology and Biotechnology2013，，7： | 1 |
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