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2篇 您的检索式：作者名="Yuya Yoshimura"

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		题名	作者	年代	出处	被引量
	1	Ca2- induced permeability transition can be observed even in yeast mitochondria under optimized experimental conditions 显示文摘	Akiko Yamada Takenori Yamamoto Yuya Yoshimura	2009	Biochimica et Biophysica Acta2009，1787，：	1
	2	Anti-EGFR antibody monotherapy for colorectal cancer with severe hyperbilirubinemia: A case report显示文摘BACKGROUND Hyperbilirubinemia with hepatic metastases is a common complication and a poor prognostic factor for colorectal cancer(CRC).Effective drainage is often im-possible before initiating systemic chemotherapy,owing to the liver’s diffuse metastatic involvement.Moreover,an appropriate chemotherapeutic approach for the treatment of hyperbilirubinemia is currently unavailable.CASE SUMMARY The patient,a man in his 50s,presented with progressive fatigue and severe jaundice.Computed tomography revealed multiple hepatic masses with thick-ened walls in the sigmoid colon,which was pathologically confirmed as a well-differentiated adenocarcinoma.No RAS or BRAF mutations were detected.The Eastern Cooperative Oncology Group(ECOG)performance status(PS)score was 2.Biliary drainage was impossible due to the absence of a dilated bile duct,and panitumumab monotherapy was promptly initiated.Subsequently,the bilirubin level decreased and then normalized,and the patient’s PS improved to zero ECOG score after four cycles of therapy without significant adverse events.CONCLUSION Anti-EGFR antibody monotherapy is a safe and effective treatment for RAS wild-type CRC and hepatic metastases with severe hyperbilirubinemia.	Toshiaki Tsurui Yuya Hirasawa Yutaro Kubota Kiyoshi Yoshimura Takuya Tsunoda	2024	World Journal of Gastrointestinal Oncology2024，16，2：	0

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