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| 1 | Genome of Plant Maca (Lepidium meyenil) Illuminates Genomic Basis for High-Altitude Adaptation in the Central Andes显示文摘Maca (Lepidium meyenii Walp, 2n = 8x = 64 ) ,属于 Brassicaceae 家庭,经济植物在秘鲁(4000-4500 m ) 在中央安第斯山脉岭被栽培。认为快速中央安第斯山脉高举发生 5-10 百万年以前(妈) ,一个进化问题关于象 maca 那样的植物怎么在一个短地质的时期以内获得高高度的改编产生。这里,我们报导 maca 的高质量的染色体集会,在里面它二仔细 spaced maca 特定的整个染色体的复制(WGD;6.7 妈) 被识别。在 maca 和密切相关的 Brassicaceae 种类之间的比较 genomic 分析揭示了经由 WGD 涉及不能生活的压力反应,荷尔蒙发信号小径,和第二等的代谢物生合成的 maca 基因和基因家庭的扩大。保留和许多复制基因的随后的功能的分叉可以说明词法、生理的变化(即,小叶形状和自我富饶) 在在高高度的环境的 maca。另外,一些复制 maca 基因在词法改编与功能被识别(即,叶卷应答) 并且不能生活的压力反应(即, GLYCINE 富有的 RNA 有约束力的蛋白质和 DNA-DAMAGE-REPAIR/TOLERATION 2 ) 在积极选择下面。一起, maca 染色体提供有用信息在安第斯山脉在植物的高高度的改编理解 WGD 的重要角色。 | Jing Zhang Yang Tian Liang Yan GuanghuiZhang Xiao Wang Yan Zeng Jiajin Zhang Xiao Ma Yuntao Tan Ni Long Yangzi Wang Yujin Ma Yuqi He Yu Xue Shumei Hao Shengchao Yang Wen Wang Liangsheng Zhang Yang Dong Wei Chen Jun Sheng | 2016 | Molecular Plant2016，9，7： | 9 |
| 2 | Drug repurposing for cancer treatment through global propagation with a greedy algorithm in a multilayer network显示文摘Objective:Drug repurposing,the application of existing therapeutics to new indications,holds promise in achieving rapid clinical effects at a much lower cost than that of de novo drug development.The aim of our study was to perform a more comprehensive drug repurposing prediction of diseases,particularly cancers.Methods:Here,by targeting 4,096 human diseases,including 384 cancers,we propose a greedy computational model based on a heterogeneous multilayer network for the repurposing of 1,419 existing drugs in Drug Bank.We performed additional experimental validation for the dominant repurposed drugs in cancer.Results:The overall performance of the model was well supported by cross-validation and literature mining.Focusing on the top-ranked repurposed drugs in cancers,we verified the anticancer effects of 5 repurposed drugs widely used clinically in drug sensitivity experiments.Because of the distinctive antitumor effects of nifedipine(an antihypertensive agent)and nortriptyline(an antidepressant drug)in prostate cancer,we further explored their underlying mechanisms by using quantitative proteomics.Our analysis revealed that both nifedipine and nortriptyline affected the cancer-related pathways of DNA replication,the cell cycle,and RNA transport.Moreover,in vivo experiments demonstrated that nifedipine and nortriptyline significantly inhibited the growth of prostate tumors in a xenograft model.Conclusions:Our predicted results,which have been released in a public database named The Predictive Database for Drug Repurposing(PAD),provide an informative resource for discovering and ranking drugs that may potentially be repurposed for cancer treatment and determining new therapeutic effects of existing drugs. | Xi Cheng Wensi Zhao Mengdi Zhu Bo Wang Xuege Wang Xiaoyun Yang Yuqi Huang Minjia Tan Jing Li | 2022 | Cancer Biology & Medicine2022，19，1： | 2 |
| 3 | VPAC2 (vasoactive intestinal peptide receptor type 2) receptor deficient mice develop exacerbated experimental autoimmune encephalomyelitis with increased Th1/Th17 and reduced Th2/Treg responses显示文摘 | Yossan-Var Tan Catalina Abad Yuqi Wang Robert Lopez James Waschek | 2014 | Brain Behavior and Immunity2014，，： | 1 |
| 4 | 内侧缰核胆碱能神经元GABAB受体通过突触前兴奋作用调控动物恐惧记忆显示文摘动物的生存依赖于将预警信号和危险联系起来.对预警信号形成恐惧记忆,以便提前做出反应。当预警信号不再与危险相关时,动物逐渐解除这种联系,消退恐惧记忆,以适应新的生存环境。恐惧记忆消退缺陷被认为和人类创伤后应激障碍(PTSD)等精神障碍有紧密关系。目前关于动物恐惧记忆的研究主要集中在杏仁核及其相关脑区。 | 张举恩 Lubin Tan Yuqi Ren Jingwen Liang Rui Lin Qiru Feng Jingfeng Zhou Fei Hu Jing Ren Chao Wei Tao Yu Yinghua Zhuang Bernhard Bettler Fengchao Wang 罗敏敏 | 2017 | 科学新闻2017，19，4： | 1 |
| 5 | Berberine alleviates non-alcoholic hepatic steatosis partially by promoting SIRT1 deacetylation of CPT1A in mice显示文摘Background:Berberine effectively alleviates non-alcoholic fatty liver disease(NAFLD).Nevertheless,the mechanism is incompletely comprehended.It has been reported that SIRT1 mediates lipid metabolism in liver and berberine promotes the expression of SIRT1 in hepatocytes.We hypothesized that SIRT1 mediated the effect of berberine on NAFLD.Methods:The effects of berberine on NAFLD were evaluated in C57BL/6J mice fed a high-fat diet(HFD)and in mouse primary hepatocytes and cell lines exposed to palmitate.The change of fatty acid oxidation(FAO)and the activity of CPT1A were observed in HepG2 cells.Quantitative real-time polymerase chain reaction and Western blot were employed to observe the expression of SIRT1 and lipid metabolism-related molecules.The interaction between SIRT1 and CPT1A was investigated by using co-immunoprecipitation assay in HEK293T cells.Results:Berberine treatment attenuated hepatic steatosis,reduced triglyceride(190.1611.2 lmol/g liver vs 113.667.6 lmol/g liver,P<0.001)and cholesterol(11.362.5 lmol/g liver vs 6.360.4 lmol/g liver,P<0.001)concentration in the liver,and improved lipid and glucose metabolism disorders compared with the HFD group.The expression of SIRT1 was reduced in the liver of NAFLD patients and mouse models.Berberine increased the expression of SIRT1 and promoted the protein level of CPT1A and its activity in HepG2 cells.SIRT1 overexpression mimicked the effect of berberine on reducing triglyceride levels in HepG2 cells,whereas SIRT1 knock-down attenuated the effect of berberine.Mechanistically,berberine increased the expression of SIRT1.SIRT1 deacetylated CPT1A at the Lys675 site,which suppressed its ubiquitin-dependent degradation,thereby promoting FAO and alleviating non-alcoholic liver steatosis.Conclusions:Berberine promoted SIRT1 deacetylation of CPT1A at the Lys675 site,which reduced the ubiquitin-dependent degradation of CPT1A and ameliorated non-alcoholic liver steatosis. | Peng Wang Ruikai Li Yuqi Li Siwei Tan Jie Jiang Huiling Liu Xiuqing Wei | 2023 | Gastroenterology Report2023，11，1： | 0 |
| 6 | Integrative multi-omics and drug-response characterization of patient-derived prostate cancer primary cells显示文摘Prostate cancer(PCa)is the second most prevalent malignancy in males across the world.A greater knowledge of the relationship between protein abundance and drug responses would benefit precision treatment for PCa.Herein,we establish 35 Chinese PCa primary cell models to capture specific characteristics among PCa patients,including gene mutations,mRNA/protein/surface protein distributions,and pharmaceutical responses.The multi-omics analyses identify Anterior Gradient 2(AGR2)as a pre-operative prognostic biomarker in PCa.Through the drug library screening,we describe crizotinib as a selective compound for malignant PCa primary cells.We further perform the pharmacoproteome analysis and identify 14,372 significant protein-drug correlations.Surprisingly,the diminished AGR2 enhances the inhibition activity of crizotinib via ALK/c-MET-AKT axis activation which is validated by PC3 and xenograft model.Our integrated multi-omics approach yields a comprehensive understanding of PCa biomarkers and pharmacological responses,allowing for more precise diagnosis and therapies. | Ziruoyu Wang Yanan Li Wensi Zhao Shuai Jiang Yuqi Huang Jun Hou Xuelu Zhang Zhaoyu Zhai Chen Yang Jiaqi Wang Jiying Zhu Jianbo Pan Wei Jiang Zengxia Li Mingliang Ye Minjia Tan Haowen Jiang Yongjun Dang | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 7 | Catalytic enantioselective synthesis of β-amino alcohols by nitrene insertion显示文摘Chiral β-amino alcohols are important building blocks for the synthesis of drugs, natural products, chiral auxiliaries, chiral ligands and chiral organocatalysts. The catalytic asymmetric β-amination of alcohols offers a direct strategy to access this class of molecules. Herein, we report a general intramolecular C(sp^(3))–H nitrene insertion method for the synthesis of chiral oxazolidin-2-ones as precursors of chiral β-amino alcohols. Specifically, the ring-closing C(sp^(3))–H amination of N-benzoyloxycarbamates with 2 mol% of a chiral ruthenium catalyst provides cyclic carbamates in up to 99% yield and with up to 99% ee.The method is applicable to benzylic, allylic, and propargylic C–H bonds and can even be applied to completely non-activated C(sp^(3))–H bonds, although with somewhat reduced yields and stereoselectivities. The obtained cyclic carbamates can subsequently be hydrolyzed to obtain chiral β-amino alcohols. The method is very practical as the catalyst can be easily synthesized on a gram scale and can be recycled after the reaction for further use. The synthetic value of the new method is demonstrated with the asymmetric synthesis of a chiral oxazolidin-2-one as intermediate for the synthesis of the natural product aurantioclavine and chiral β-amino alcohols that are intermediates for the synthesis of chiral amino acids, indane-derived chiral Box-ligands, and the natural products dihydrohamacanthin A and dragmacidin A. | Zijun Zhou Yuqi Tan Xiang Shen Sergei Ivlev Eric Meggers | 2021 | Science China Chemistry2021，64，3： | 0 |
| 8 | Effect of Microstructural Characteristics on Fracture Toughness in Direct Energy Deposited Novel Ti-6Al-4V-1Mo Alloy显示文摘Meeting the damage tolerance requirements for engineering-grade titanium alloys pose a significant challenge in achieving high fracture toughness in direct energy deposition(DED)titanium alloys.This work primarily investigated the relationship between the microstructure and the fracture toughness of DED new Ti-6Al-4V-1Mo alloy.Two types of microstructures were designed via two process strategies:high-line energy density(HE)and low-line energy density(LE).Relative to LE samples,HE samples possess larger-sized microstructural characteristics(coarser grain boundaryα(α_(GB)),largerαcolonies,and coarserαlaths).Lessα/βphase boundaries were formed by coarserαlaths in the HE samples,increasing the movement of dislocations,resulting in tensile strength decreasing from 1007.1 MPa(LE)to 930.8 MPa(HE)and elongation increasing from 10.8%(LE)to 15.7%(HE).Also,HE samples exhibited an excellent fracture toughness of 114.0 MPa m^(1/2),significantly higher than that of LE samples(76.8 MPa m^(1/2)).An analysis of crack propagation paths was conducted to investigate the factors contributing to toughening.The primary factor enhancing toughness is the frequent obstruction of cracks by coarseαGB and largeαcolonies in HE samples.Particularly,the pretty large-angle deflections induced by the superposition effect of coarseαGB and largeαcolonies play a vital of significant role.These factors induced the long and tortuous high-energy pathways,which resulted in ultimately improved fracture toughness.The discovered microstructural toughening mechanisms can serve as a reference for future studies involving titanium alloys,offering insights on how to enhance fracture toughness by achieving similar characteristics. | Chao Xia Kexin Zhao Xin Zhou Yuqi He Panpan Gao Hengxin Zhang Guangrui Gao Fengying Zhang Hua Tan | 2024 | Acta Metallurgica Sinica(English Letters)2024，37，1： | 0 |
| 9 | Electric Vehicle Charging Capacity of Distribution Network Considering Conventional Load Composition显示文摘At present,the large-scale access to electric vehicles(EVs)is exerting considerable pressure on the distribution network.Hence,it is particularly important to analyze the capacity of the distribution network to accommodate EVs.To this end,we propose a method for analyzing the EV capacity of the distribution network by considering the composition of the conventional load.First,the analysis and pretreatment methods for the distribution network architecture and conventional load are proposed.Second,the charging behavior of an EVis simulated by combining the Monte Carlo method and the trip chain theory.After obtaining the temporal and spatial distribution of the EV charging load,themethod of distribution according to the proportion of the same type of conventional load among the nodes is adopted to integrate the EV charging load with the conventional load of the distribution network.By adjusting the EV ownership,the EV capacity in the distribution network is analyzed and solved on the basis of the following indices:node voltage,branch current,and transformer capacity.Finally,by considering the 10-kV distribution network in some areas of an actual city as an example,we show that the proposed analysis method can obtain a more reasonable number of EVs to be accommodated in the distribution network. | Pengwei Yang Yuqi Cao Jie Tan Junfa Chen Chao Zhang Yan Wang Haifeng Liang | 2023 | Energy Engineering2023，120，3： | 0 |
| 10 | A proteomic landscape of pharmacologic perturbations for functional relevance显示文摘Pharmacological perturbation studies based on protein-level signatures are fundamental for drug discovery. In the present study, we used a mass spectrometry (MS)-based proteomic platform to profile the whole proteome of the breast cancer MCF7 cell line under stress induced by 78 bioactive compounds. The integrated analysis of perturbed signal abundance revealed the connectivity between phenotypic behaviors and molecular features in cancer cells. Our data showed functional relevance in exploring the novel pharmacological activity of phenolic xanthohumol, as well as the noncanonical targets of clinically approved tamoxifen, lovastatin, and their derivatives. Furthermore, the rational design of synergistic inhibition using a combination of histone methyltransferase and topoisomerase was identified based on their complementary drug fingerprints. This study provides rich resources for the proteomic landscape of drug responses for precision therapeutic medicine. | Zhiwei Liu Shangwen Jiang Bingbing Hao Shuyu Xie Yingluo Liu Yuqi Huang Heng Xu Cheng Luo Min Huang Minjia Tan Jun-Yu Xu | 2024 | Journal of Pharmaceutical Analysis2024，14，1： | 0 |
| 11 | Shanghai Autism Early Development:An Integrative Chinese ASD Cohort显示文摘Why Was the Cohort Set Up?Autism spectrum disorder(ASD)is a child neurodevelopmental disorder,the onset of which is generally within 3 years of age,and often leads to lifelong impaired social and cognitive functions,which impose significant mental pressure and economic burdens on the family and society. | Yuan Dai Yuqi Liu Lingli Zhang Tai Ren Hui Wang Juehua Yu Xin Liu Zilin Chen Lin Deng Minyi Tao Hangyu Tan Chu‑Chung Huang Jiaying Zhang Qiang Luo Jianfeng Feng Miao Cao Fei Li | 2022 | Neuroscience Bulletin2022，38，12： | 0 |
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