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| 1 | TGIF2 promotes the progression of lung adenocarcinoma by bridging EGFR/RAS/ERK signaling to cancer cell stemness显示文摘TGF-β-induced factor homeobox 2(TGIF2)is a transcription regulator that plays essential roles in the regulation of development and cell fate decisions.Aberrant expression of TGIF family proteins has been observed in several cancers,including ovarian,esophageal,and colorectal cancers.Here,we report that TGIF2 mediates the EGFR–RAS–ERK signaling pathway to enhance the stemness of lung adenocarcinoma(LUAD)cells and,therefore,promote the progression and metastasis of LUAD.We found that high TGIF2 expression was closely correlated with tumor growth,lymph node metastasis,and survival of patients with LUAD.Mice bearing TGIF2-silenced H1299 xenografts developed smaller tumors and fewer lung metastases.Importantly,silencing TGIF2 decreased the cancer stem cell(CSC)-like properties in A549 and H1299 cells.Furthermore,we identified that TGIF2 binding to the OCT4 promoter promotes its expression.In both LUAD cells and in vivo LUAD mouse models,we revealed that EGFR–RAS–ERK signaling phosphorylated TGIF2 and increased its stability,which was important for TGIF2-promoted LUAD stemness since phosphorylation-deficient TGIF2 mutants lost these functions.Thus,our study revealed that an important factor,TGIF2,bridges EGFR signaling to the CSC characteristics of LUAD cells,which can be utilized as an effective target for LUAD therapy. | Renle Du Wenzhi Shen Yi Liu Wenjuan Gao Wei Zhou Jun Li Shuangtao Zhao Chong Chen Yanan Chen Yanhua Liu Peiqing Sun Rong Xiang Yi Shi Yunping Luo | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 7 |
| 2 | Comparison of surgical indications for hysterectomy by age and approach in 4653 Chinese women显示文摘约 100 万子宫切除每年在中国被执行。然而,关于指示的国家数据和为子宫切除的外科的途径正在缺乏。这研究的目的是在中国女人为子宫切除在不同年龄组和不同外科的途径的相对优点为子宫切除检验外科的指示。从从 2004 ~ 2009 在 Tongji 医院里执行的子宫切除的 4653 个盒子的临床的数据被分析。子宫切除最通常 4049 年在女人之中被执行(2299;49.4%) 。总的来说, colporrhagia 和腹的疼痛是为子宫切除的二个很普通的指示。由年龄组的最普通的指示如下:恶意的卵巢的瘤, 70 年。恶意的原因论的比例也到年龄变化了,在女人是最高的变老 P < 0.05 ) 。两个都,流血和输血体积的数量要求了在阴道途径是更小的,没有其它之间的重要差别。使用的外科的途径也与外科的范围有关。外科的指示和双边的 oophorectomy 的率到年龄变化了。以两个都操作时间和流血和要求的输血体积的数量,阴道途径比所有另外的外科的途径优异。 | Jingjing Jiang Ting Ding Aiyue Luo Yunping Lu Ding Ma Shixuan Wang | 2014 | Frontiers of Medicine2014，8，4： | 2 |
| 3 | Tumor‐Associated Macrophages Regulate Murine Breast Cancer Stem Cells Through a Novel Paracrine EGFR/Stat3/Sox‐2 Signaling Pathway显示文摘 | Jian Yang Debbie Liao Cong Chen Yan Liu Tsung‐Hsien Chuang Rong Xiang Dorothy Markowitz Ralph A. Reisfeld Yunping Luo | 2013 | STEM CELLS2013，，2： | 2 |
| 4 | DNA- based vaccines activate innate and adaptive an titumor immunity by engaging the NKG2D receptor显示文摘 | Zhou He Luo Yunping Lo Jengfan | 2005 | Proc Nail Acad Sci USA2005，102，10： | 1 |
| 5 | DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the NKG2D receptor显示文摘 | Zhou He Luo Yunping Lo Jeng-fan | 2005 | Proc Natl Acad Sci USA2005，102，10： | 1 |
| 6 | Targeting macrophages in cancer immunotherapy显示文摘Immunotherapy is regarded as the most promising treatment for cancers.Various cancer immunotherapies,including adoptive cellular immunotherapy,tumor vaccines,antibodies,immune checkpoint inhibitors,and small-molecule inhibitors,have achieved certain successes.In this review,we summarize the role of macrophages in current immunotherapies and the advantages of targeting macrophages.To better understand and make better use of this type of cell,their development and differentiation characteristics,categories,typical markers,and functions were collated at the beginning of the review.Therapeutic strategies based on or combined with macrophages have the potential to improve the treatment efficacy of cancer therapies. | Zhaojun Duan Yunping Luo | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 1 |
| 7 | Targeting tumor-associated macrophages as a novel strategy against breast cancer 显示文摘 | LUO Yunping | 2006 | J Clin Invest2006，116，8： | 1 |
| 8 | The MYB Transcription Factor Superfamily of Arabidopsis: Expression Analysis and Phylogenetic Comparison with the Rice MYB Family显示文摘 | Chen Yanhui Yang Xiaoyuan He Kun Liu Meihua Li Jigang Gao Zhaofeng Lin Zhiqiang Zhang Yunfei Wang Xiaoxiao Qiu Xiaoming Shen Yunping Zhang Li Deng Xiaohui Luo Jingchu Deng Xing-Wang Chen Zhangliang Gu Hongya Qu Li-Jia | 2006 | Plant Molecular Biology2006，，1： | 1 |
| 9 | ADNA vaccine targeting survivin combines apoptosis with suppression of angiogenesis in lung tumor显示文摘 | Rong Xiang Noriko Mizutani Yunping Luo | 2005 | Eradication Cancer Research2005，1565，： | 1 |
| 10 | Fluorination-mitigated high-current degradation of amorphous InGaZnO thin-film transistors显示文摘As growing applications demand higher driving currents of oxide semiconductor thin-film transistors(TFTs),severe instabilities and even hard breakdown under high-current stress(HCS)become critical challenges.In this work,the triggering voltage of HCS-induced self-heating(SH)degradation is defined in the output characteristics of amorphous indium-galliumzinc oxide(a-IGZO)TFTs,and used to quantitatively evaluate the thermal generation process of channel donor defects.The fluorinated a-IGZO(a-IGZO:F)was adopted to effectively retard the triggering of the self-heating(SH)effect,and was supposed to originate from the less population of initial deep-state defects and a slower rate of thermal defect transition in a-IGZO:F.The proposed scheme noticeably enhances the high-current applications of oxide TFTs. | Yanxin Wang Jiye Li Fayang Liu Dongxiang Luo Yunping Wang Shengdong Zhang Lei Lu | 2023 | Journal of Semiconductors2023，44，9： | 0 |
| 11 | TIFA suppresses hepatocellular carcinoma progression via MALT1-dependent and-independent signaling pathways显示文摘TIFA,also called T2BP,was first identified using yeast two-hybrid screening.Our previous work showed that TIFA suppresses hepatocellular carcinoma(HCC)progression via apoptosis and cell cycle arrest.However,the mechanism by which this TIFA suppression occurs remains unclear.Here we demonstrated that TIFA-induced apoptosis demonstrates two distinct time patterns(i.e.,at 48 h and 47 days)when TIFA reconstitution occurs.Moreover,we found that MALT1(a competitor of TIFA)plays a crucial role in short-duration TIFA reconstitution.In this regard,MALT1 silencing with shRNA markedly enhances TIFA-induced apoptosis in vitro and in vivo.In addition,TIFA overexpression triggers JNK and p38 activation in long-duration TIFA reconstitution through TRAF6 binding.In particular,JNK activation leads to TIFA-induced apoptosis while p38 activation governs TIFA-induced cell cycle arrest by p53-p21 signaling in vitro and in vivo.Our data suggest a novel mechanism by which TIFA suppresses HCC progression via both MALT1-dependent and MALT1-independent signaling pathways.This may provide insights into a novel targets where HCC progression may be vulnerable to clinical treatment. | Wenzhi Shen Renle Du Jun Li Xiaohe Luo Shuangtao Zhao Antao Chang Wei Zhou Ruifang Gao Dehong Luo Juan Wang Na Hao Yanhua Liu Yanan Chen Yunping Luo Peiqing Sun Shengyong Yang Na Luo Rong Xiang | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 0 |
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