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| 1 | Mitochondrial calcium uniporter protein MCU is involved in oxidative stress-induced cell death显示文摘Mitochondrial 钙 uniporter (MCU ) 是在在真核细胞的房间的 mitochondrial 的保存 Ca 2+ transporter。然而,在氧化导致压力的房间死亡的 MCU 蛋白质的角色仍然保持不清楚。这里,我们证明宫外地表示的 MCU 是在局部性的 mitochondrial HeLa 和主要小脑的小粒神经原(CGN ) 。内长的 MCU 减少 mitochondrial Ca 2+ 举起追随者组织安刺激击倒并且稀释氧化应力在 HeLa 房间和 CGN 导致的房间死亡。我们也发现 MCU 与 VDAC1 交往并且调停在 CGN 的 VDAC1 导致 overexpression 的房间死亡。这发现证明那 MCU-VDAC1 建筑群调整 mitochondrial Ca 2+ 举起和氧化导致压力的 apoptosis,它可能表示为氧化应力的治疗学的目标联系了疾病。 | Yajin Liao Yumin Hao Hong Chen Qing He Zengqiang Yuan Jinbo Cheng | 2015 | Protein & Cell2015，6，6： | 12 |
| 2 | Characterization of PM_(2.5)/PM_(2.5-10) and source tracking in the juncture belt between urban and rural areas of Beijing显示文摘Coarse (PM2.5-10) and fine (PM2.5) atmospheric particulate samples were collected in summer and winter during 2005―2007 in the juncture belt between urban and rural areas of Beijing. Elements, ions, organic/elemental carbon (OC/EC) and polynuclear aromatic hydrocarbons (PAHs) were determined to obtain some latest information about the particulate pollution in the juncture belt of Beijing. Particulate matter levels at this site were high as compared with the levels at other sampling sites in Beijing. Pollution elements, secondary ions and PAHs were enriched in fine particles rather than in coarse particles. An obvious seasonal variation of the chemical composition of PM was observed. Source apportionment results showed that secondary components were the largest mass contributor of PM2.5, accounting for 28%; whereas soil-related sources were the largest contributor of PM2.5-10, explaining about 49% of the total mass. The abnormal levels of soil heavy metals at the electronic waste disassembly site in the upwind villages suggested the potential impact of such activities to the environment. | WANG HaiLin ZHOU YuMin ZHUANG YaHui WANG XiaoKe HAO ZhengPing | 2009 | Chinese Science Bulletin2009，54，14： | 11 |
| 3 | Productivity matching and quantitative prediction of coalbed methane wells based on BP neural network显示文摘It is a great challenge to match and predict the production performance of coalbed methane (CBM) wells in the initial production stage due to heterogeneity of coalbed, uniqueness of CBM production process, complexity of porosity-permeability variation and difficulty in obtaining some key parameters which are critical for the conventional prediction methods (type curve, material balance and numerical simulation). BP neural network, a new intelligent technique, is an effective method to deal with nonlinear, instable and complex system problems and predict the short-term change quantitatively. In this paper a BP neural model for the CBM productivity of high-rank CBM wells in Qinshui Basin was established and used to match the past gas production and predict the futural production performance. The results from two case studies showed that this model has high accuracy and good reliability in matching and predicting gas production with different types and different temporal resolutions, and the accuracy increases as the number of outliers in gas production data decreases. Therefore, the BP network can provide a reliable tool to predict the production performance of CBM wells without clear knowledge of coalbed reservoir and sufficient production data in the early development stage. | LU YuMin TANG DaZhen XU Hao TAO Shu | 2011 | Science China(Technological Sciences)2011，54，5： | 9 |
| 4 | A NEW PUBLIC-KEY ENCRYPTION SCHEME BASED ON LUCAS SEQUENCE显示文摘Investigated the properties of LUCas sequence(LUC), the paper proposed a new variant of (probabilistic) public-key encryption scheme. Security analysis of the proposed encryption schemes shows that its one-wayness is equivalent to partial LUC discrete logarithm problem in ZN, and for the proposed probabilistic encryption scheme, its semantic security is equivalent to decisional LUC Diffie-Hellman problem in ZN. At last, the efficiency of the proposed schemes is briefly analyzed. | Jiang Zhengtao Hao Yanhua Wang Yumin | 2005 | Journal of Electronics(China)2005，22，5： | 2 |
| 5 | Production characteristics and the key factors in high-rank coalbed methane fields: A case study on the Fanzhuang Block, Southern Qinshui Basin, China显示文摘 | Yumin Lv Dazhen Tang Hao Xu Haohan Luo | 2012 | International Journal of Coal Geology2012，，： | 2 |
| 6 | A new immunomodulatory therapy for severe sepsis:Ulinastatin Plus Thymosin αl显示文摘 | Li Yumin Chen Hao Li Xun | | 0，，1： | 1 |
| 7 | Optimization ofJob-Shop Scheduling Based on Simulation! 显示文摘 | MA Yumin FAN Liuqun ZHANG Weimin ZHANG Hao | 2007 | Journal of SystemSimulation (S1004-731X)2007，19，19： | 1 |
| 8 | Efficiency enhancement in dye-sensitized solar cells by interfacial modification of conducting glass/mesoporous TiO 2 using a novel ZnO compact blocking film显示文摘 | Yumin Liu Xiaohua Sun Qidong Tai Hao Hu Bolei Chen Niu Huang Bobby Sebo Xing-zhong Zhao | 2010 | Journal of Power Sources2010，，1： | 1 |
| 9 | Analysis of Lymph Node Metastases of 1,526 Cases with Thoracic Esophageal and Cardiac Carcinomas: A Random Sampling Report froni the Fourth Hospital of Hebei Medical University from 1996 to 2004显示文摘OBJECTIVE To summarize the regular pattern and state oflymph node metastasis of patients with esophageal and cardiaccarcinomas,so as to analyze factors influencing lymph nodemetastasis.METHODS Clinical data collected from 1,526 thoracicesophageal and cardiac carcinoma patients who were admitted inthe Fourth Hospital of Hebei Medical University during a periodfrom January 1996 to December 2004,were randomly selectedand an Access Database of the patient's information was set up.Eight clinico-pathologic factors,including the patient's age,tumorlocation and size,pathological classification,the depth of tumorinvasion,vascular tumor embolus (VTE),the state of surroundingorgan encroachment and the status of tumor residues,wereidentified.A correlation between these factors and metastases wasstatistically analyzed using SPSS13.0 software.RESULTS Lymph node metastatic sites from esophagealcarcinomas included the thoracic and abdominal cavity.Lymphnode metastasis from the superior esophageal carcinomasmainly occurred in the neck and thoracic cavity.There was atwo-way lymph node metastasis in the patients with the middleesophageal carcinoma.The inferior esophageal carcinomas mainlymetastasized to the paraesophageal,paragastric cardia,and leftgastric artery lymph nodes.The rate and degree of the metastasisfrom the inferior esophageal carcinomas were significantly highercompared to those of the superior and the middle esophagealcarcinomas (P<0.0125).The degree of abdominal lymph node metastasis fromcarcinomas of the gastric cardia was significantly higher comparedwith that of esophageal carcinomas.In the group with carcinomaof the gastric cardia,the rate and degree of the lymph nodemetastases in the paragastric cardia and left gastric artery weresignificantly higher compared to the group with esophagealcarcinoma (P<0.05).Paraesophageal lymph node metastasis fromcarcinomas of the gastric cardia in the thoracic cavity frequentlyoccurred,too,and the degree of the metastasis was similar to thatof esophageal carcinoma.There was no significant difference inthe rate and degree of the paraesophageal lymph-node metastasisbetween the group with carcinoma of the gastric cardia comparedto those with esophageal carcinoma (P>0.05).Multifactoriallogistic regression analysis showed that the tumor size,depth oftumor encroachment,VTE,and tumor residues could all bringabout obvious impact on lymph-node metastases (P<0.05).CONCLUSION Lymph node metastasis from superioresophageal carcinomas mainly occurs in the neck and thoraciccavity.The middle esophageal carcinomas presented a two-waylymph-node metastasis (both the upwards and the downwards),and the lymph node metastasis from inferior esophagealcarcinomas mainly occurred in the thoracic and abdominal cavities.The metastases of carcinoma of the gastriccardia were most commonly found in the abdominalcavity,with frequent paraesophageal lymph-nodemetastasis.The sufficient attention should be paidto neck lymph node clearance in cases of esophagealcarcinoma.What is of the greatest concern is theclearance of the left gastric artery lymph nodes,andalso in cases of gastric cardia carcinoma,clearance,the paraesophageal lymph nodes.With an increasein the tumor size and depth of tumor encroachment,and occurrence of VTE and tumor residual cells,therisk of lymph node metastasis is significantly raised (P<0.05). | Wei Liu Xishan Hao Yong Chen Haixin Li Shijie Wang Peizhong Wang Hng Jin Liyun Guan Qian Fan Linan Song Yumin Ping Xianli Meng Rui Wang Junfeng Liu Xiaoling Wang | 2008 | Chinese Journal of Clinical Oncology2008，5，6： | 1 |
| 10 | Delivery of an Rhs-family nuclease effector reveals direct penetration of the gram-positive cell envelope by a type VI secretion system in Acidovorax citrulli显示文摘The type VI secretion system(T6SS)is a double-tubular nanomachine widely found in gram-negative bacteria.Its spear-like Hcp tube is capable of penetrating a neighboring cell for cytosol-to-cytosol protein delivery.However,gram-positive bacteria have been considered impenetrable to such T6SS action.Here we report that the T6SS of a plant pathogen,Acidovorax citrulli(AC),could deliver an Rhsfamily nuclease effector RhsB to kill not only gram-negative but also gram-positive bacteria.Using bioinformatic,biochemical,and genetic assays,we systematically identified T6SS-secreted effectors and determined that RhsB is a crucial antibacterial effector.RhsB contains an N-terminal PAAR domain,a middle Rhs domain,and an unknown C-terminal domain.RhsB is subject to self-cleavage at both its N-and C-terminal domains and its secretion requires the upstream-encoded chaperone EagT2 and VgrG3.The toxic Cterminus of RhsB exhibits DNase activities and such toxicity is neutralized by either of the two downstream immunity proteins,RimB1 and RimB2.Deletion of rhsB significantly impairs the ability of killing Bacillus subtilis while ectopic expression of immunity proteins RimB1 or RimB2 confers protection.We demonstrate that the AC T6SS not only can effectively outcompete Escherichia coli and B.subtilis in planta but also is highly potent in killing other bacterial and fungal species.Collectively,these findings highlight the greatly expanded capabilities of T6SS in modulating microbiome compositions in complex environments. | Tong-Tong Pei Yumin Kan Zeng-Hang Wang Ming-Xuan Tang Hao Li Shuangquan Yan Yang Cui Hao-Yu Zheng Han Luo Xiaoye Liang Tao Dong | 2022 | mLife2022，1，1： | 1 |
| 11 | A new immunomodulatory therapy for severe sepsis:Ulinastatin Plus Thymosin{alpha}1显示文摘 | Li Yumin Chen Hao Li Xun | 2009 | J Intensive Care Med2009，24，1： | 1 |
| 12 | Production characteristics and the key factors in high-rank coalbed methane fields:a case study on Fanzhuang Block,southern Qinshui Basin,China显示文摘 | Lyn Yumin Tang Dazhen Xu Hao | 2012 | International Journal of Coal Geology2012，9697，： | 1 |
| 13 | A new immuno- modulatory therapy for severe sepsis: Ulinastatin Plus Thymosin | alphat | 显示文摘 | Li Yumin Chen Hao Li Xun | 2009 | J Intensive Care Med2009，24，1： | 1 |
| 14 | Generation of Calhm1 knockout mouse and characterization of calhm1 gene expression显示文摘Alzheimer’s disease(AD)is the most common neurode-generative disease among elderly people worldwide.Several genes have been validated to be associated with AD,and calcium homeostasis modulator 1(Calhm1)is the latest suspected one.To investigate the biological and pathological function of Calhm1 systematically,we generated a Calhm1 conventional knockout mouse.However,both the male and female of elderly Calhm1 knockout(KO)mice showed similar ability to their wild type littermates in spatial learning and memory retrieving.Surprisingly,we found that Calhm1 mRNA could not be detected in mouse brains at different ages,although it is expressed in the human brain tissues.We further found that CpG islands(CGIs)of both mouse and human Calhm1 were hypermethylated,whereas CGI of mouse Calhm2 was hypomethylated.In addition,transcriptional active marker H3K4Di occupied on promoters of human Calhm1 and mouse Calhm2 at a considerable level in brain tissues,while the occupancy of H3K4Di on pro-moter of mouse Calhm1 was rare.In sum,we found that mouse Calhm1 was of rare abundance in brain tissues.So it might not be suitable to utilize the knockout murine model to explore biological function of Calhm1 in the pathogenesis of AD. | Junbing Wu Shengyi Peng Rong Wu Yumin Hao Guangju Ji Zengqiang Yuan | 2012 | Protein & Cell2012，3，6： | 1 |
| 15 | Dynamic variation effects of coal permeability during the coalbed methane development process in the Qinshui Basin, China显示文摘 | Shu Tao Yanbin Wang Dazhen Tang Hao Xu Yumin Lv Wei He Yong Li | 2012 | International Journal of Coal Geology2012，，： | 1 |
| 16 | Strain distribution and electronic structures of the InAs/GaAs quantum ring molecule in an applied electric field显示文摘The strain distribution and electronic structures of the InAs/GaAs quantum ring molecule are calculated via the finite element method.In our model,three identical InAs quantum rings are aligned vertically and embedded in the cubic GaAs barrier.Considering the band edge modification induced by the strain,the electronic ground state and the dependence of ground state energy on geometric parameters of the quantum ring molecule are investigated.The change of localization of the wavefunction resulting from the applied electric field along the growth direction is observed.The ground state energy decreases as the electric field intensity increases in a parabolic-like mode.The electric field changes the monotonic dependence of the energy level on the inter-ring distance into a non-monotonic one.However,the electric field has no effect on the relationships between the energy level and other geometric parameters such as the inner radius and outer radius. | JIA BoYong,YU ZhongYuan,LIU YuMin,YAO WenJie,YE Han & FENG Hao Key Laboratory of Information Photonics and Optical Communications(Beijing University of Posts and Telecommunications),Ministry of Education,Beijing 100876,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，9： | 0 |
| 17 | Self-fueling ferroptosis-inducing microreactors based on p H-responsive Lipiodol Pickering emulsions enable transarterial ferro-embolization therapy显示文摘Lipiodol chemotherapeutic emulsions remain one of the main choices for the treatment of unresectable hepatocellular carcinoma(HCC) via transarterial chemoembolization(TACE). However, the limited stability of Lipiodol chemotherapeutic emulsions would lead to rapid drug diffusion, which would reduce the therapeutic benefit and cause systemic toxicity of administrated chemotherapeutics. Therefore, the development of enhanced Lipiodol-based formulations is of great significance to enable effective and safe TACE treatment. Herein, a stable water-in-oil Lipiodol Pickering emulsion(LPE) stabilized by pH-dissociable calcium carbonate nanoparticles and hemin is prepared and utilized for efficient encapsulation of lipoxygenase(LOX). The obtained LOX-loaded CaCO_(3)&hemin-stabilized LPE(LHCa-LPE) showing greatly improved emulsion stability could work as a pH-responsive and self-fueling microreactor to convert polyunsaturated fatty acids(PUFAs), a main component of Lipiodol, to cytotoxic lipid radicals through the cascading catalytic reaction driven by LOX and hemin, thus inducing ferroptosis of cancer cells. As a result, such LHCa-LPE upon transcatheter embolization can effectively suppress the progression of orthotopic N1S1 HCC in rats. This study highlights a concise strategy to prepare pH-responsive and stable LPE-based self-fueling microreactors, which could serve as bifunctional embolic and ferroptosis-inducing agents to enable proof-of-concept transarterial ferro-embolization therapy of HCC. | Chunjie Wang Lei Zhang Zhijuan Yang Dongxu Zhao Zheng Deng Jialu Xu Yumin Wu Yu Hao Ziliang Dong Liangzhu Feng Zhuang Liu | 2024 | National Science Review2024，11，1： | 0 |
| 18 | Analysis of Clinicopathologic Features of Esophageal Carcinoma Patients Undergoing Surgery-a Report of 4,329 Cases显示文摘OBJECTIVE To investigate the clinicopathological features of esophageal carcinoma(EC)patients,and to analyze epidemiologic characteristics and the current situation of esophageal cancioma in the southern area of Hebei Province. METHODS A total of 4329 patients with esophageal cancinoma, undergoing surgery in the Fourth Hospital of Hebei Medical University during a period from January 1996 to December 2005, were selected.Collection and statistical analysis of the pathologic data were performed using a SAS 6.0 so ware package. RESULTS Over the past ten years,there has been a tendency for an increase in the mean age of EC onset(P<0.05),a downtrend in the percentage of squamous cancer(SqCa)(P<0.05)and an uptrend in the frequency of small cell carcinoma(P<0.05).In clinical stages,there was a drop in the percentage of Stage-II squamous EC patients(P<0.05),and an increase in that of Stage- IV patients(P<0.05).There were statistical differences in sex,age, pathologic types,depth of infiltration,ratio of stages and lymph node metastasis,etc.among the superior,middle and inferior segments of the EC diseased region(P<0.05). CONCLUSION It was relatively late for the EC patients from this area to see a doctor,resulting in a drop in the ratio of SqCa and an ascensus in that of small cell cancer.However,due to a low incidence of adenocarcinoma,no obvious ascending tendency was found in the frequency of this carcinoma over the past ten years. | Wei Liu Xishan Hao Ying Jin Haixin Li Linan Song Shijie Wang Peizhong Wang Yong Chen Qian Fan Liyun Guan Yumin Ping Xianli Meng Rui Wang Junfeng Liu Xiaoling Wang | 2008 | Chinese Journal of Clinical Oncology2008，5，2： | 0 |
| 19 | Surgical treatment effects in cancer of the cardia and esophagogastric junction显示文摘Objective: To evaluate the treatment effects of total gastrectomy (TG) and proximal gastrectomy (PG) for cancer of the cardia and esophagogastric junction. Methods: forty-five patients with cancer of the cardia and esophagogastric junc- tion underwent surgical resection. Of them, 29 were treated using proximal gastrectomy and 16 total gastrectomy. The 3-year and 5-year survival rate and the postoperative complication rate and mortality rate were followed up and compared between the two groups. Results: The 3-year and 5-year survival rates of group PG were 44.8% and 20.7%, of group TG were 37.5% and 18.8%, respectively, and the differences were not statistically significant (χ2 = 3.84, P > 0.05; χ2 = 3.89, P > 0.05). The postoperative complication and mortality rate of group PG were 13.7% and 6.8%, of group TG was all 6%, respectively. Conclusion: Proximal and total gastrectomy treatment effects can not significantly influence the prognosis of patients in progressive stage of cancer of cardia and esophagogastric junction. | Yumin Zhou Jiong Pan Yuwei Sheng Hao Liu Ziping Fan | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，3： | 0 |
| 20 | Research on Framework of Digital Process Planning Platform显示文摘Digital factory technology is a research focus in academe and industry,which is an advanced manufacturing tech- nology that is proposed to bridge product development and manufacturing.For applying digital factory technology in machining domain,a concept of digital process planning and its framework are suggested,its components including machining domain knowledge model,machining knowledge base,machining resource base and process planning system are studied.The framework of digital process planning is of value for implementing digital factory technology in machining industry. | MA Yumin~1 FAN Liuqun~2 ZHU Zhihao~1 ZHANG Hao~3 (1.CIMS Research Center,Tongji University,Shanghai 200092,China, 2.College of Chinese-German,Tongji University,Shanghai 200092,China 3.Shanghai University of Electric Power,Shanghai 200090,China) | 2006 | 武汉理工大学学报2006，28，S3： | 0 |
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